Details for: TRBV28

Gene ID: 28559

Symbol: TRBV28

Ensembl ID: ENSG00000211753

Description: T cell receptor beta variable 28

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.8779
    Cell Significance Index: 10.2400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.3360
    Cell Significance Index: 20.6700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0239
    Cell Significance Index: 0.3400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0022
    Cell Significance Index: -0.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0027
    Cell Significance Index: -5.1400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0040
    Cell Significance Index: -0.1800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0071
    Cell Significance Index: -5.3500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0110
    Cell Significance Index: -1.3500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0130
    Cell Significance Index: -1.6700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0262
    Cell Significance Index: -5.2000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0352
    Cell Significance Index: -1.6400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0362
    Cell Significance Index: -7.2600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0406
    Cell Significance Index: -1.9100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0559
    Cell Significance Index: -7.6800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0584
    Cell Significance Index: -5.9700
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0598
    Cell Significance Index: -0.6000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0689
    Cell Significance Index: -1.7600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0919
    Cell Significance Index: -10.5300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0922
    Cell Significance Index: -5.6500
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.0955
    Cell Significance Index: -1.6400
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.0959
    Cell Significance Index: -0.6900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0990
    Cell Significance Index: -2.6900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1019
    Cell Significance Index: -6.5800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1160
    Cell Significance Index: -5.1300
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.1341
    Cell Significance Index: -1.6300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1355
    Cell Significance Index: -5.1300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1456
    Cell Significance Index: -3.9000
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1532
    Cell Significance Index: -2.1500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1588
    Cell Significance Index: -5.2000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1597
    Cell Significance Index: -1.7400
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1618
    Cell Significance Index: -2.0500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1662
    Cell Significance Index: -4.0300
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.1818
    Cell Significance Index: -1.7400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1827
    Cell Significance Index: -2.0800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2206
    Cell Significance Index: -5.5100
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.2286
    Cell Significance Index: -2.3700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.2335
    Cell Significance Index: -2.9500
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.2353
    Cell Significance Index: -2.8400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2441
    Cell Significance Index: -5.1800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2473
    Cell Significance Index: -6.3000
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.2518
    Cell Significance Index: -2.9100
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.2599
    Cell Significance Index: -2.6900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2614
    Cell Significance Index: -5.1100
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.2743
    Cell Significance Index: -2.9900
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.2800
    Cell Significance Index: -1.7400
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.2874
    Cell Significance Index: -3.5600
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.3011
    Cell Significance Index: -4.3200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3014
    Cell Significance Index: -5.5700
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.3172
    Cell Significance Index: -3.6500
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.3196
    Cell Significance Index: -2.9900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.3225
    Cell Significance Index: -4.7000
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.3229
    Cell Significance Index: -3.3600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3303
    Cell Significance Index: -7.6300
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.3330
    Cell Significance Index: -2.8100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3396
    Cell Significance Index: -5.7200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.3422
    Cell Significance Index: -5.8500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.3448
    Cell Significance Index: -5.5900
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.3482
    Cell Significance Index: -4.2800
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.3494
    Cell Significance Index: -4.5700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.3540
    Cell Significance Index: -5.1400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3607
    Cell Significance Index: -7.0400
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.3667
    Cell Significance Index: -4.4600
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.3674
    Cell Significance Index: -3.7300
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.3715
    Cell Significance Index: -2.8900
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.3748
    Cell Significance Index: -5.1400
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.3928
    Cell Significance Index: -4.3900
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.3944
    Cell Significance Index: -3.4500
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.4005
    Cell Significance Index: -5.0300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.4024
    Cell Significance Index: -5.9400
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.4028
    Cell Significance Index: -2.8900
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.4031
    Cell Significance Index: -5.5900
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.4040
    Cell Significance Index: -3.8300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.4057
    Cell Significance Index: -5.2500
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.4090
    Cell Significance Index: -4.1500
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.4139
    Cell Significance Index: -5.1700
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.4258
    Cell Significance Index: -4.2900
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.4266
    Cell Significance Index: -4.1000
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.4276
    Cell Significance Index: -5.5800
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.4312
    Cell Significance Index: -5.0700
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.4322
    Cell Significance Index: -3.5000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.4374
    Cell Significance Index: -5.7400
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.4392
    Cell Significance Index: -5.7800
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.4392
    Cell Significance Index: -5.1000
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.4404
    Cell Significance Index: -3.8000
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.4429
    Cell Significance Index: -5.3200
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.4464
    Cell Significance Index: -4.8000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.4468
    Cell Significance Index: -4.7900
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.4492
    Cell Significance Index: -7.6300
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.4495
    Cell Significance Index: -4.2200
  • Cell Name: podocyte (CL0000653)
    Fold Change: -0.4520
    Cell Significance Index: -5.1900
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.4529
    Cell Significance Index: -5.0600
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.4553
    Cell Significance Index: -4.6000
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.4564
    Cell Significance Index: -5.3700
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.4586
    Cell Significance Index: -5.2100
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.4599
    Cell Significance Index: -4.7700
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.4625
    Cell Significance Index: -4.9400
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.4625
    Cell Significance Index: -5.6300
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.4645
    Cell Significance Index: -4.9300
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.4650
    Cell Significance Index: -4.8100
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.4688
    Cell Significance Index: -5.5400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRBV28 is a variable region gene that belongs to the T cell receptor beta family. It is characterized by its unique sequence and structure, which enables the formation of diverse T cell receptor chains. The expression of TRBV28 is restricted to specific types of T cells, including alpha-beta cytotoxic T cells, which are essential for the immune response against viral infections and tumor cells. The gene is also expressed in other hematopoietic cells, such as granulocyte monocyte progenitors, CD16-positive and CD56-dim natural killer cells, and precursor B cells. **Pathways and Functions:** TRBV28 is involved in the adaptive immune response, specifically in the recognition and targeting of pathogens by cytotoxic T cells. The gene plays a crucial role in the formation of the T cell receptor complex, which is essential for the activation and function of alpha-beta cytotoxic T cells. The T cell receptor complex is formed by the combination of T cell receptor alpha (TRAA), T cell receptor beta (TRBB), and T cell receptor gamma (TRGC) chains. TRBV28 is specifically paired with TRAA and TRGC to form a functional T cell receptor. The T cell receptor complex recognizes specific peptides presented by major histocompatibility complex (MHC) molecules on the surface of antigen-presenting cells. This recognition triggers a series of signaling events that lead to the activation and proliferation of T cells. TRBV28 is also involved in the regulation of T cell activation and tolerance, ensuring that the immune response is targeted against specific pathogens and not against self-antigens. **Clinical Significance:** Dysregulation of the TRBV28 gene has been implicated in various autoimmune and inflammatory diseases, including multiple sclerosis, rheumatoid arthritis, and psoriasis. Mutations in the TRBV28 gene have been associated with an increased risk of developing these diseases, highlighting the importance of this gene in the regulation of the immune response. Furthermore, TRBV28 has been used as a biomarker for the diagnosis and monitoring of T cell-mediated diseases. The gene is also a target for immunotherapy, with several studies investigating the use of TRBV28-based vaccines and therapies for the treatment of cancer and infectious diseases. In conclusion, the TRBV28 gene plays a critical role in the adaptive immune response, specifically in the recognition and targeting of pathogens by cytotoxic T cells. Its dysregulation has been implicated in various autoimmune and inflammatory diseases, highlighting the importance of this gene in the regulation of the immune response. Further research is needed to fully understand the mechanisms by which TRBV28 regulates the immune response and to explore its potential as a therapeutic target.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.