Details for: TRBV20 1

Gene ID: 28567

Symbol: TRBV20 1

Ensembl ID: ENSG00000211747

Description: T cell receptor beta variable 20-1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.9214
    Cell Significance Index: 15.9300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.5552
    Cell Significance Index: 8.5900
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.1509
    Cell Significance Index: 0.4600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0894
    Cell Significance Index: 1.2700
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.0320
    Cell Significance Index: -0.2300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0579
    Cell Significance Index: -11.6100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1067
    Cell Significance Index: -10.9000
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1401
    Cell Significance Index: -1.6800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1447
    Cell Significance Index: -6.8000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1761
    Cell Significance Index: -11.3600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2038
    Cell Significance Index: -5.0900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2329
    Cell Significance Index: -6.2200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2785
    Cell Significance Index: -7.5800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2951
    Cell Significance Index: -7.9000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3018
    Cell Significance Index: -13.3500
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.3050
    Cell Significance Index: -5.2400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3525
    Cell Significance Index: -13.3500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4001
    Cell Significance Index: -10.5200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4017
    Cell Significance Index: -5.9300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4123
    Cell Significance Index: -13.1300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.4188
    Cell Significance Index: -5.2900
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.4237
    Cell Significance Index: -4.1500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4305
    Cell Significance Index: -12.6800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.4515
    Cell Significance Index: -11.2600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.4521
    Cell Significance Index: -10.9500
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.4629
    Cell Significance Index: -5.5200
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.4705
    Cell Significance Index: -4.5600
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.4726
    Cell Significance Index: -6.4900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.4823
    Cell Significance Index: -5.2600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.4937
    Cell Significance Index: -8.5100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4956
    Cell Significance Index: -12.6600
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.5005
    Cell Significance Index: -8.5000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.5044
    Cell Significance Index: -12.8500
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.5214
    Cell Significance Index: -4.7400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.5278
    Cell Significance Index: -10.3200
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.5400
    Cell Significance Index: -5.6000
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.5468
    Cell Significance Index: -5.3300
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.5468
    Cell Significance Index: -5.2900
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.5575
    Cell Significance Index: -7.8300
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.5603
    Cell Significance Index: -5.2500
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.5607
    Cell Significance Index: -4.5400
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.5645
    Cell Significance Index: -7.6800
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.5717
    Cell Significance Index: -6.7500
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.5777
    Cell Significance Index: -7.7000
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.5813
    Cell Significance Index: -5.3800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5854
    Cell Significance Index: -10.8200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.5859
    Cell Significance Index: -16.8800
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: -0.5909
    Cell Significance Index: -4.5400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.6005
    Cell Significance Index: -10.0500
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.6059
    Cell Significance Index: -7.5000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6059
    Cell Significance Index: -12.8600
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.6355
    Cell Significance Index: -6.4200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.6471
    Cell Significance Index: -12.8000
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.6471
    Cell Significance Index: -4.2100
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.6733
    Cell Significance Index: -5.8100
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.6805
    Cell Significance Index: -5.8000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.6936
    Cell Significance Index: -10.1100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.7082
    Cell Significance Index: -11.4700
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.7102
    Cell Significance Index: -9.0000
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.7145
    Cell Significance Index: -4.2400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.7190
    Cell Significance Index: -12.2900
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.7228
    Cell Significance Index: -5.9900
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.7428
    Cell Significance Index: -5.9100
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.7438
    Cell Significance Index: -11.9600
  • Cell Name: urothelial cell (CL0000731)
    Fold Change: -0.7442
    Cell Significance Index: -5.1900
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.7453
    Cell Significance Index: -7.7100
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.7959
    Cell Significance Index: -8.0800
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.8061
    Cell Significance Index: -10.5200
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.8068
    Cell Significance Index: -10.3700
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.8112
    Cell Significance Index: -9.4100
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.8167
    Cell Significance Index: -7.8500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.8214
    Cell Significance Index: -10.5200
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.8255
    Cell Significance Index: -9.5000
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.8317
    Cell Significance Index: -10.0400
  • Cell Name: group 3 innate lymphoid cell, human (CL0001078)
    Fold Change: -0.8325
    Cell Significance Index: -7.8000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.8331
    Cell Significance Index: -10.7800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.8390
    Cell Significance Index: -11.5100
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.8402
    Cell Significance Index: -7.8600
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.8446
    Cell Significance Index: -8.5700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.8474
    Cell Significance Index: -12.8700
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.8483
    Cell Significance Index: -11.8900
  • Cell Name: immature alpha-beta T cell (CL0000790)
    Fold Change: -0.8560
    Cell Significance Index: -6.3800
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.8625
    Cell Significance Index: -11.2800
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.8725
    Cell Significance Index: -10.3100
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.8786
    Cell Significance Index: -10.4300
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.8809
    Cell Significance Index: -8.2700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.8832
    Cell Significance Index: -11.1600
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.8882
    Cell Significance Index: -9.5500
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.8913
    Cell Significance Index: -8.9800
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.8934
    Cell Significance Index: -7.6100
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.8941
    Cell Significance Index: -6.1500
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.8978
    Cell Significance Index: -9.5200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.9071
    Cell Significance Index: -13.1700
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.9084
    Cell Significance Index: -7.9500
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.9117
    Cell Significance Index: -9.2500
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.9144
    Cell Significance Index: -11.0300
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.9174
    Cell Significance Index: -10.5000
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.9184
    Cell Significance Index: -7.7500
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.9219
    Cell Significance Index: -8.7400
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.9342
    Cell Significance Index: -11.6700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **T cell receptor beta chain**: TRBV20.1 is a beta chain of the TCR, which is a complex of proteins that recognizes and binds to peptide-MHC complexes on the surface of antigen-presenting cells. 2. **Specific recognition**: TRBV20.1 recognizes unique peptide-MHC complexes, allowing it to distinguish between self and non-self antigens. 3. **Adaptive immune response**: TRBV20.1 is involved in the adaptive immune response, which is a highly specific and targeted response to pathogens and tumor cells. 4. **Expression in various immune cells**: TRBV20.1 is expressed in multiple immune cell types, including CD8-positive T cells, alpha-beta cytotoxic T cells, and mucosal invariant T cells. **Pathways and Functions:** 1. **Adaptive immune response pathway**: TRBV20.1 is involved in the adaptive immune response pathway, which is a complex network of signaling pathways that enable immune cells to recognize and respond to specific pathogens and tumor cells. 2. **Cell surface receptor signaling pathway**: TRBV20.1 is a cell surface receptor that signals through the TCR complex, leading to the activation of downstream signaling pathways. 3. **Plasma membrane**: TRBV20.1 is embedded in the plasma membrane of immune cells, allowing it to interact with peptide-MHC complexes and other immune molecules. 4. **T cell receptor complex**: TRBV20.1 is part of the TCR complex, which is a heterodimer of alpha and beta chains that recognizes and binds to peptide-MHC complexes. **Clinical Significance:** The TRBV20.1 gene has significant clinical implications, particularly in the context of cancer immunotherapy. The unique recognition properties of TRBV20.1 allow it to target specific tumor cells, making it a promising candidate for cancer immunotherapy. Additionally, the expression of TRBV20.1 in various immune cell types suggests its potential role in the prevention and treatment of infectious diseases and autoimmune disorders. In conclusion, TRBV20.1 is a critical component of the adaptive immune response, enabling immune cells to recognize and respond to specific pathogens and tumor cells. Further research on the TRBV20.1 gene is needed to fully understand its clinical significance and potential applications in cancer immunotherapy and infectious disease prevention.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.