Details for: TRBV6 3

Gene ID: 28604

Symbol: TRBV6 3

Ensembl ID: ENSG00000283063

Description: T cell receptor beta variable 6-3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.3361
    Cell Significance Index: 3.3700
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.2274
    Cell Significance Index: 1.2400
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.1396
    Cell Significance Index: 1.5600
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.0087
    Cell Significance Index: -0.0900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0118
    Cell Significance Index: -2.3700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0405
    Cell Significance Index: -2.2700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0470
    Cell Significance Index: -2.1300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0489
    Cell Significance Index: -2.3000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0493
    Cell Significance Index: -1.2000
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0542
    Cell Significance Index: -0.6500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0589
    Cell Significance Index: -1.0000
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0610
    Cell Significance Index: -0.7200
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0625
    Cell Significance Index: -0.8500
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0690
    Cell Significance Index: -0.8200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0710
    Cell Significance Index: -1.7700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0766
    Cell Significance Index: -2.0500
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: -0.0778
    Cell Significance Index: -0.5500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0917
    Cell Significance Index: -2.5000
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.0919
    Cell Significance Index: -0.2800
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0986
    Cell Significance Index: -0.8400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1017
    Cell Significance Index: -2.5900
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1034
    Cell Significance Index: -1.0500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1045
    Cell Significance Index: -1.7600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1087
    Cell Significance Index: -1.5900
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1205
    Cell Significance Index: -1.2500
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.1207
    Cell Significance Index: -0.8300
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1208
    Cell Significance Index: -1.1300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1306
    Cell Significance Index: -1.6500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1310
    Cell Significance Index: -1.9300
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1311
    Cell Significance Index: -1.2600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1350
    Cell Significance Index: -2.6400
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1353
    Cell Significance Index: -1.4600
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1356
    Cell Significance Index: -1.1700
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1371
    Cell Significance Index: -1.3000
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.1373
    Cell Significance Index: -1.1700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1410
    Cell Significance Index: -2.4300
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1457
    Cell Significance Index: -1.4200
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1473
    Cell Significance Index: -2.0200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1477
    Cell Significance Index: -2.7300
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1513
    Cell Significance Index: -1.5400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1530
    Cell Significance Index: -2.5600
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.1543
    Cell Significance Index: -1.3500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1547
    Cell Significance Index: -3.0200
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1552
    Cell Significance Index: -1.9200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1581
    Cell Significance Index: -2.5600
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1582
    Cell Significance Index: -2.1900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1615
    Cell Significance Index: -2.0900
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1621
    Cell Significance Index: -2.0300
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.1623
    Cell Significance Index: -1.5900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1653
    Cell Significance Index: -2.5100
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.1668
    Cell Significance Index: -1.9200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1689
    Cell Significance Index: -1.8400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1696
    Cell Significance Index: -2.4100
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1710
    Cell Significance Index: -1.3300
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1739
    Cell Significance Index: -2.2300
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1741
    Cell Significance Index: -2.0200
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1762
    Cell Significance Index: -2.4200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1770
    Cell Significance Index: -3.0300
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.1771
    Cell Significance Index: -2.1100
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.1783
    Cell Significance Index: -2.1700
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.1802
    Cell Significance Index: -2.2500
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.1803
    Cell Significance Index: -1.4600
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1805
    Cell Significance Index: -2.3800
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.1820
    Cell Significance Index: -1.9300
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.1834
    Cell Significance Index: -1.5200
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1841
    Cell Significance Index: -2.5800
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1846
    Cell Significance Index: -1.8600
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.1856
    Cell Significance Index: -1.9600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1896
    Cell Significance Index: -2.4800
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.1917
    Cell Significance Index: -2.1700
  • Cell Name: immature alpha-beta T cell (CL0000790)
    Fold Change: -0.1933
    Cell Significance Index: -1.4400
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1985
    Cell Significance Index: -2.5500
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.1987
    Cell Significance Index: -2.2900
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1988
    Cell Significance Index: -2.2400
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.2006
    Cell Significance Index: -2.3600
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.2011
    Cell Significance Index: -1.8400
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.2019
    Cell Significance Index: -2.4000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.2024
    Cell Significance Index: -2.9500
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.2045
    Cell Significance Index: -1.8400
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.2047
    Cell Significance Index: -2.2300
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.2051
    Cell Significance Index: -2.2200
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.2071
    Cell Significance Index: -2.5200
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.2075
    Cell Significance Index: -2.2700
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.2082
    Cell Significance Index: -1.7400
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.2088
    Cell Significance Index: -2.7400
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.2092
    Cell Significance Index: -2.4900
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.2093
    Cell Significance Index: -1.8000
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.2099
    Cell Significance Index: -2.5800
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.2099
    Cell Significance Index: -2.7400
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.2107
    Cell Significance Index: -2.4900
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.2123
    Cell Significance Index: -2.5200
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.2133
    Cell Significance Index: -2.2300
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.2145
    Cell Significance Index: -2.1800
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.2150
    Cell Significance Index: -2.5000
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.2152
    Cell Significance Index: -2.8600
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.2164
    Cell Significance Index: -2.5000
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.2166
    Cell Significance Index: -2.5600
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.2177
    Cell Significance Index: -2.0900
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.2179
    Cell Significance Index: -2.3500
  • Cell Name: DN4 thymocyte (CL0000808)
    Fold Change: -0.2197
    Cell Significance Index: -1.6600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRBV6-3 is a member of the TCR beta family, which is responsible for recognizing antigens presented by major histocompatibility complex (MHC) molecules on the surface of antigen-presenting cells. The TCR beta chain is composed of two variable regions (Vβ) and three constant regions (Cβ), which are linked by disulfide bonds. TRBV6-3 is expressed in various T cell subsets, including alpha-beta cytotoxic T cells, which are essential for eliminating virus-infected cells and tumor cells. **Pathways and Functions:** TRBV6-3 is involved in the adaptive immune response, which is a complex process that involves the activation of immune cells, the production of cytokines, and the elimination of pathogens. The TCR beta chain plays a central role in this process, as it recognizes antigens presented by MHC molecules and triggers a signaling cascade that activates T cells. The signaling pathway involves the activation of various kinases, which phosphorylate and activate downstream transcription factors, leading to the expression of genes involved in immune responses. TRBV6-3 is also involved in the regulation of T cell activation, proliferation, and differentiation. The TCR beta chain interacts with co-receptors, such as CD4 and CD8, which are essential for the activation of T cells. The TCR beta chain also interacts with MHC molecules, which present antigens to T cells, and with other co-stimulatory molecules, such as CD28 and CD40L, which provide additional signals for T cell activation. **Clinical Significance:** Dysregulation of TRBV6-3 and other TCR beta chains has been implicated in various diseases, including autoimmune disorders, such as multiple sclerosis and type 1 diabetes, and cancers, such as leukemia and lymphoma. Alterations in TCR beta chain expression and function have also been observed in patients with chronic infections, such as HIV-1 and tuberculosis. Furthermore, TRBV6-3 has been shown to be involved in the regulation of immune responses to vaccines and immunotherapies. For example, the TCR beta chain has been shown to play a role in the recognition of tumor antigens presented by MHC molecules, and in the activation of cytotoxic T cells that eliminate tumor cells. In conclusion, TRBV6-3 is a critical component of the adaptive immune system, playing a pivotal role in the recognition and elimination of pathogens. Its dysregulation has been implicated in various diseases, and its role in the regulation of immune responses to vaccines and immunotherapies has significant implications for the development of novel immunotherapies. **Significantly expressed cells:** * Granulocyte monocyte progenitor cell * Early T lineage precursor * Precursor B cell * Neutrophil progenitor cell * Neutrophil * Common myeloid progenitor * Pro-B cell * Fraction A pre-pro B cell * Mast cell * CD8-positive * Alpha-beta cytotoxic T cell **Pathways/Ontology:** * Adaptive immune response * Cell surface receptor signaling pathway * Plasma membrane * T cell receptor complex

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.