Details for: TRBV6 1

Gene ID: 28606

Symbol: TRBV6 1

Ensembl ID: ENSG00000211706

Description: T cell receptor beta variable 6-1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.6364
    Cell Significance Index: 3.4700
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.5617
    Cell Significance Index: 4.8300
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.0097
    Cell Significance Index: 0.0800
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.0042
    Cell Significance Index: 0.0300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0218
    Cell Significance Index: -0.3700
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0249
    Cell Significance Index: -0.2300
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0260
    Cell Significance Index: -0.3800
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0279
    Cell Significance Index: -0.3800
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0288
    Cell Significance Index: -0.3400
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.0427
    Cell Significance Index: -0.1300
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0481
    Cell Significance Index: -0.4100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0528
    Cell Significance Index: -1.2800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0713
    Cell Significance Index: -2.1000
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0802
    Cell Significance Index: -0.8100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0961
    Cell Significance Index: -2.5700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0994
    Cell Significance Index: -4.6700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1084
    Cell Significance Index: -2.7700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1134
    Cell Significance Index: -2.8900
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1165
    Cell Significance Index: -1.0900
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.1221
    Cell Significance Index: -0.8400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1330
    Cell Significance Index: -2.2400
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1368
    Cell Significance Index: -1.3200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1404
    Cell Significance Index: -2.4200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1558
    Cell Significance Index: -2.3000
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.1572
    Cell Significance Index: -1.5400
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.1622
    Cell Significance Index: -1.7200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1626
    Cell Significance Index: -3.1800
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1656
    Cell Significance Index: -1.5700
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1664
    Cell Significance Index: -2.1000
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1682
    Cell Significance Index: -1.6400
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.1690
    Cell Significance Index: -1.4400
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1692
    Cell Significance Index: -1.4600
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1709
    Cell Significance Index: -2.3700
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1737
    Cell Significance Index: -2.0200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1737
    Cell Significance Index: -3.2100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1743
    Cell Significance Index: -2.9800
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.1764
    Cell Significance Index: -2.0300
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.1782
    Cell Significance Index: -1.6200
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.1803
    Cell Significance Index: -2.0200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1832
    Cell Significance Index: -2.3700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1868
    Cell Significance Index: -3.0300
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1871
    Cell Significance Index: -1.9400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1928
    Cell Significance Index: -2.1000
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.1950
    Cell Significance Index: -2.3100
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.1950
    Cell Significance Index: -2.3700
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.2005
    Cell Significance Index: -2.4800
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.2010
    Cell Significance Index: -2.5400
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.2025
    Cell Significance Index: -1.6400
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.2035
    Cell Significance Index: -2.0500
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.2044
    Cell Significance Index: -2.6900
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.2071
    Cell Significance Index: -2.4700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.2082
    Cell Significance Index: -3.3400
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.2104
    Cell Significance Index: -2.5400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.2115
    Cell Significance Index: -2.9000
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.2135
    Cell Significance Index: -2.5100
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.2148
    Cell Significance Index: -2.6400
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.2158
    Cell Significance Index: -2.1900
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.2210
    Cell Significance Index: -2.2800
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.2254
    Cell Significance Index: -2.2600
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.2265
    Cell Significance Index: -2.6700
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.2269
    Cell Significance Index: -2.9200
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.2271
    Cell Significance Index: -2.3000
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.2282
    Cell Significance Index: -3.6700
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.2305
    Cell Significance Index: -2.8800
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.2329
    Cell Significance Index: -2.6800
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.2332
    Cell Significance Index: -3.0600
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.2340
    Cell Significance Index: -2.5600
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.2345
    Cell Significance Index: -1.9600
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.2363
    Cell Significance Index: -2.4900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2372
    Cell Significance Index: -3.3700
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.2382
    Cell Significance Index: -3.1100
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.2382
    Cell Significance Index: -2.0100
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.2389
    Cell Significance Index: -2.5900
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.2399
    Cell Significance Index: -3.0400
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.2415
    Cell Significance Index: -3.1100
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.2432
    Cell Significance Index: -2.6500
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.2446
    Cell Significance Index: -1.8200
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.2449
    Cell Significance Index: -2.7600
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.2449
    Cell Significance Index: -2.6400
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.2458
    Cell Significance Index: -2.6100
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.2469
    Cell Significance Index: -2.5600
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.2475
    Cell Significance Index: -1.6100
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.2476
    Cell Significance Index: -2.2900
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.2480
    Cell Significance Index: -2.2700
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.2481
    Cell Significance Index: -1.9300
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.2506
    Cell Significance Index: -3.3300
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.2518
    Cell Significance Index: -2.8600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.2518
    Cell Significance Index: -3.6700
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.2526
    Cell Significance Index: -2.9900
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.2553
    Cell Significance Index: -3.0400
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.2557
    Cell Significance Index: -2.8400
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: -0.2558
    Cell Significance Index: -2.5000
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.2564
    Cell Significance Index: -2.8400
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.2592
    Cell Significance Index: -2.5700
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.2601
    Cell Significance Index: -2.3400
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.2603
    Cell Significance Index: -3.0900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.2616
    Cell Significance Index: -2.4800
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.2623
    Cell Significance Index: -3.1000
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.2646
    Cell Significance Index: -2.6100
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.2680
    Cell Significance Index: -3.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRBV6-1 is a beta chain variable region gene, which is part of the TCR complex that recognizes and binds to specific antigens. The unique combination of variable regions in the TCR determines the specificity of the immune response. TRBV6-1 is characterized by its ability to form a functional TCR complex with other beta chain variable regions, such as TRBV6-2 and TRBV6-3. The expression of TRBV6-1 is restricted to specific T cell subsets, including alpha-beta cytotoxic T cells and central memory CD4-positive T cells. **Pathways and Functions:** TRBV6-1 is involved in the following signaling pathways: 1. **Adaptive Immune Response:** TRBV6-1 plays a crucial role in the adaptive immune response by recognizing and binding to specific antigens, leading to T cell activation and proliferation. 2. **Cell Surface Receptor Signaling Pathway:** TRBV6-1 is part of the TCR complex, which undergoes activation upon binding to antigens, leading to the activation of downstream signaling pathways. 3. **Plasma Membrane:** TRBV6-1 is expressed on the plasma membrane of T cells, where it interacts with other components of the TCR complex to recognize and bind to antigens. **Functions:** The primary function of TRBV6-1 is to recognize and bind to specific antigens, leading to T cell activation and proliferation. This is achieved through the following mechanisms: 1. **Antigen Recognition:** TRBV6-1 binds to specific antigens, leading to the activation of downstream signaling pathways. 2. **T Cell Activation:** TRBV6-1 plays a crucial role in T cell activation, leading to the proliferation and differentiation of T cells. 3. **Immune Response Regulation:** TRBV6-1 regulates the immune response by modulating the activity of T cells, leading to the generation of specific immune responses. **Clinical Significance:** The dysregulation of TRBV6-1 has been implicated in various immune-related disorders, including autoimmune diseases and cancer. Understanding the role of TRBV6-1 in the adaptive immune response has significant implications for the development of novel therapeutic strategies, including: 1. **Immunotherapy:** Targeting TRBV6-1 may provide a novel approach to immunotherapy, allowing for the specific modulation of T cell responses. 2. **Autoimmune Disease Treatment:** Understanding the role of TRBV6-1 in autoimmune diseases may lead to the development of novel treatments targeting specific T cell subsets. 3. **Cancer Immunotherapy:** TRBV6-1 may play a role in cancer immunotherapy, as it is involved in the recognition and binding to tumor antigens. In conclusion, TRBV6-1 is a crucial component of the adaptive immune system, playing a pivotal role in recognizing and responding to antigens. Further research is necessary to fully elucidate the role of TRBV6-1 in the adaptive immune response and its clinical significance in immune-related disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.