Details for: TRBV5 3

Gene ID: 28612

Symbol: TRBV5 3

Ensembl ID: ENSG00000211715

Description: T cell receptor beta variable 5-3 (non-functional)

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.1723
    Cell Significance Index: 28.4000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.3180
    Cell Significance Index: 4.6400
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.2995
    Cell Significance Index: 3.9100
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.0423
    Cell Significance Index: 0.5000
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.0362
    Cell Significance Index: 0.4100
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0162
    Cell Significance Index: 0.2100
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0010
    Cell Significance Index: -0.0100
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0027
    Cell Significance Index: -0.0400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0043
    Cell Significance Index: -0.0700
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0059
    Cell Significance Index: -0.0700
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0068
    Cell Significance Index: -0.0600
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0085
    Cell Significance Index: -0.1000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0108
    Cell Significance Index: -0.1400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0128
    Cell Significance Index: -0.2500
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0167
    Cell Significance Index: -0.1800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0168
    Cell Significance Index: -0.4500
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0208
    Cell Significance Index: -0.2600
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0217
    Cell Significance Index: -0.2400
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0222
    Cell Significance Index: -0.3000
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0227
    Cell Significance Index: -0.2700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0270
    Cell Significance Index: -0.4100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0279
    Cell Significance Index: -0.7100
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0290
    Cell Significance Index: -0.3600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0299
    Cell Significance Index: -0.4100
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0307
    Cell Significance Index: -0.3800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0311
    Cell Significance Index: -0.6600
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0313
    Cell Significance Index: -0.3600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0339
    Cell Significance Index: -0.6700
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0362
    Cell Significance Index: -0.3900
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0394
    Cell Significance Index: -0.3700
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0395
    Cell Significance Index: -0.5200
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0398
    Cell Significance Index: -0.4700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0426
    Cell Significance Index: -0.4500
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0450
    Cell Significance Index: -0.5300
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0464
    Cell Significance Index: -0.4400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0466
    Cell Significance Index: -0.5100
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0473
    Cell Significance Index: -0.5100
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0484
    Cell Significance Index: -0.5100
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0507
    Cell Significance Index: -0.4700
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.0523
    Cell Significance Index: -0.4100
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0528
    Cell Significance Index: -0.4500
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0530
    Cell Significance Index: -0.6200
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0545
    Cell Significance Index: -0.5100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0548
    Cell Significance Index: -0.7800
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0580
    Cell Significance Index: -0.4900
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0581
    Cell Significance Index: -0.5000
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0584
    Cell Significance Index: -0.5900
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0591
    Cell Significance Index: -0.6000
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0603
    Cell Significance Index: -0.5200
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0608
    Cell Significance Index: -0.7000
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0611
    Cell Significance Index: -0.8600
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0614
    Cell Significance Index: -0.5900
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0617
    Cell Significance Index: -0.6400
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0622
    Cell Significance Index: -0.5800
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0622
    Cell Significance Index: -0.6600
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0631
    Cell Significance Index: -0.6200
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0633
    Cell Significance Index: -0.4900
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0637
    Cell Significance Index: -0.4900
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0639
    Cell Significance Index: -0.7200
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.0639
    Cell Significance Index: -0.5300
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0656
    Cell Significance Index: -0.7100
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0660
    Cell Significance Index: -0.6700
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: -0.0662
    Cell Significance Index: -0.5400
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.0682
    Cell Significance Index: -0.6300
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0710
    Cell Significance Index: -0.7200
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0711
    Cell Significance Index: -0.7100
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.0729
    Cell Significance Index: -0.7500
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0756
    Cell Significance Index: -0.5200
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: -0.0757
    Cell Significance Index: -0.7400
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.0782
    Cell Significance Index: -0.7100
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0789
    Cell Significance Index: -0.6900
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0806
    Cell Significance Index: -0.7500
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.0814
    Cell Significance Index: -0.6800
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0818
    Cell Significance Index: -0.6900
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.0821
    Cell Significance Index: -0.7000
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0827
    Cell Significance Index: -0.6700
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0851
    Cell Significance Index: -0.7500
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0854
    Cell Significance Index: -0.7600
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.0863
    Cell Significance Index: -0.6900
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0968
    Cell Significance Index: -0.7200
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.0992
    Cell Significance Index: -0.3700
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: -0.1025
    Cell Significance Index: -0.7100
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: -0.1049
    Cell Significance Index: -0.2800
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.1102
    Cell Significance Index: -0.5900
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.1128
    Cell Significance Index: -0.6200
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.1199
    Cell Significance Index: -0.9100
  • Cell Name: CD4-negative, CD8-negative, alpha-beta intraepithelial T cell (CL0000935)
    Fold Change: -0.1516
    Cell Significance Index: -0.6300
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.2198
    Cell Significance Index: -0.6700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Non-functional variant:** TRBV5-3 is a non-functional variant of the T cell receptor beta gene, which implies that it does not encode a functional TCR. 2. **Significant expression:** TRBV5-3 is significantly expressed in various immune cells, including macrophages, dendritic cells, and B cells. 3. **Cell surface receptor signaling pathway:** TRBV5-3 is involved in the cell surface receptor signaling pathway, which is crucial for the activation and regulation of immune cells. 4. **Adaptive immune response:** TRBV5-3 is associated with the adaptive immune response, which is a specific and targeted response to pathogens or antigens. **Pathways and Functions:** 1. **Adaptive immune response pathway:** TRBV5-3 is involved in the adaptive immune response pathway, which involves the activation and regulation of immune cells, such as T cells and B cells. 2. **Cell surface receptor signaling pathway:** TRBV5-3 is part of the cell surface receptor signaling pathway, which allows immune cells to recognize and respond to specific antigens. 3. **Regulation of immune responses:** Despite its non-functional status, TRBV5-3 may play a role in regulating immune responses by modulating the activity of immune cells. **Clinical Significance:** 1. **Immunological tolerance:** TRBV5-3 may play a role in immunological tolerance, which is the ability of the immune system to distinguish between self and non-self antigens. 2. **Autoimmune diseases:** The non-functional status of TRBV5-3 may contribute to the development of autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Cancer immunology:** TRBV5-3 may also have implications for cancer immunology, as it may influence the ability of the immune system to recognize and respond to tumor antigens. In conclusion, the TRBV5-3 gene is a non-functional variant that is significantly expressed in various immune cells. Its role in regulating immune responses and its association with the adaptive immune response pathway make it an important gene to study in the context of immunology. Further research is needed to fully understand the function and clinical significance of TRBV5-3.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.