Details for: TRBV4 1

Gene ID: 28617

Symbol: TRBV4 1

Ensembl ID: ENSG00000211710

Description: T cell receptor beta variable 4-1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.5612
    Cell Significance Index: 3.0600
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.3181
    Cell Significance Index: 3.5600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 0.2495
    Cell Significance Index: -0.7700
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.2211
    Cell Significance Index: 1.6500
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.0092
    Cell Significance Index: 0.1100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0003
    Cell Significance Index: 0.0100
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0061
    Cell Significance Index: -0.0600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0105
    Cell Significance Index: -2.1000
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0154
    Cell Significance Index: -0.2200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0241
    Cell Significance Index: -0.4100
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0282
    Cell Significance Index: -0.2600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0325
    Cell Significance Index: -0.4800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0340
    Cell Significance Index: -2.6100
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0383
    Cell Significance Index: -0.6500
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0415
    Cell Significance Index: -0.5100
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0419
    Cell Significance Index: -0.5700
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0449
    Cell Significance Index: -0.5300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0460
    Cell Significance Index: -1.1200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0464
    Cell Significance Index: -1.2400
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0610
    Cell Significance Index: -0.5200
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0614
    Cell Significance Index: -0.8500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0679
    Cell Significance Index: -0.7400
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0713
    Cell Significance Index: -0.7200
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.0732
    Cell Significance Index: -0.6700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0736
    Cell Significance Index: -1.8800
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0740
    Cell Significance Index: -0.8800
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0756
    Cell Significance Index: -0.5200
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0765
    Cell Significance Index: -0.9100
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0779
    Cell Significance Index: -0.7900
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0790
    Cell Significance Index: -0.6400
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0794
    Cell Significance Index: -0.9400
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0814
    Cell Significance Index: -0.7400
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.0863
    Cell Significance Index: -0.9100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0899
    Cell Significance Index: -1.5500
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1048
    Cell Significance Index: -1.3700
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.1052
    Cell Significance Index: -1.2700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1060
    Cell Significance Index: -1.0100
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1076
    Cell Significance Index: -1.0200
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.1082
    Cell Significance Index: -1.0600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1091
    Cell Significance Index: -2.7800
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.1110
    Cell Significance Index: -0.9200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1112
    Cell Significance Index: -1.9000
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.1119
    Cell Significance Index: -1.3500
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1172
    Cell Significance Index: -1.4500
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.1175
    Cell Significance Index: -1.0100
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1183
    Cell Significance Index: -1.6600
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1244
    Cell Significance Index: -1.2900
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: -0.1249
    Cell Significance Index: -1.2200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1274
    Cell Significance Index: -1.8500
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1306
    Cell Significance Index: -1.6900
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.1345
    Cell Significance Index: -0.4100
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1373
    Cell Significance Index: -1.7400
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.1395
    Cell Significance Index: -1.5100
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1407
    Cell Significance Index: -1.6600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1420
    Cell Significance Index: -2.3000
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.1528
    Cell Significance Index: -1.8600
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1544
    Cell Significance Index: -1.6600
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.1567
    Cell Significance Index: -1.8200
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.1586
    Cell Significance Index: -1.6100
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1600
    Cell Significance Index: -1.6100
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1602
    Cell Significance Index: -1.5400
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1646
    Cell Significance Index: -1.5400
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.1664
    Cell Significance Index: -1.8200
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.1667
    Cell Significance Index: -1.7000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1678
    Cell Significance Index: -3.2800
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.1689
    Cell Significance Index: -1.3500
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1693
    Cell Significance Index: -2.0300
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.1711
    Cell Significance Index: -1.4300
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1746
    Cell Significance Index: -2.0300
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: -0.1753
    Cell Significance Index: -0.6100
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.1754
    Cell Significance Index: -0.6600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1758
    Cell Significance Index: -3.2500
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.1761
    Cell Significance Index: -1.8700
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1794
    Cell Significance Index: -2.4600
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.1799
    Cell Significance Index: -1.9600
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1812
    Cell Significance Index: -1.4100
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.1822
    Cell Significance Index: -1.8500
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1824
    Cell Significance Index: -2.4000
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1824
    Cell Significance Index: -2.6200
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1834
    Cell Significance Index: -2.1100
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.1848
    Cell Significance Index: -1.9600
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: -0.1848
    Cell Significance Index: -0.5000
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1860
    Cell Significance Index: -1.6100
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.1865
    Cell Significance Index: -1.8700
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.1896
    Cell Significance Index: -1.8700
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1930
    Cell Significance Index: -2.4800
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.1936
    Cell Significance Index: -2.1500
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1939
    Cell Significance Index: -1.8900
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: -0.1967
    Cell Significance Index: -1.9400
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.1974
    Cell Significance Index: -2.1400
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1988
    Cell Significance Index: -2.2400
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.2005
    Cell Significance Index: -2.2300
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.2009
    Cell Significance Index: -2.4700
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.2017
    Cell Significance Index: -2.9400
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.2018
    Cell Significance Index: -2.5500
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.2051
    Cell Significance Index: -2.0800
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.2057
    Cell Significance Index: -2.5700
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.2090
    Cell Significance Index: -1.2400
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.2092
    Cell Significance Index: -2.7800
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.2095
    Cell Significance Index: -2.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRBV4-1 is a type of TCR beta chain variable region, which is essential for the recognition and binding of antigens by T cells. The variable region is responsible for the specificity and diversity of the TCR, allowing it to recognize a wide range of antigens. TRBV4-1 is expressed in specific cell types, including effector CD8-positive T cells, which are critical for cell-mediated immunity, and central memory CD4-positive T cells, which are essential for long-term immune memory. **Pathways and Functions:** The TRBV4-1 gene is involved in several key pathways, including: 1. **Adaptive Immune Response:** TRBV4-1 plays a crucial role in the adaptive immune response by facilitating the recognition and binding of antigens by T cells. This process involves the recognition of peptide-MHC complexes by TCRs, which triggers a signaling cascade that ultimately leads to T cell activation and proliferation. 2. **Cell Surface Receptor Signaling Pathway:** TRBV4-1 is a key component of the T cell receptor complex, which is a complex of proteins that spans the cell surface and cytoplasm. The TRBV4-1 gene is involved in the signaling pathways that occur upon T cell receptor activation, which leads to the activation of downstream signaling molecules and the subsequent immune response. 3. **Plasma Membrane Signaling Pathway:** TRBV4-1 is also involved in signaling pathways that occur at the plasma membrane, which is the outermost layer of the cell. This signaling pathway is critical for the regulation of various cellular processes, including cell proliferation, differentiation, and survival. **Clinical Significance:** The TRBV4-1 gene has significant clinical implications, particularly in the context of immune-related disorders. Abnormalities in the TRBV4-1 gene have been associated with various autoimmune diseases, including multiple sclerosis, rheumatoid arthritis, and type 1 diabetes. Additionally, the TRBV4-1 gene has been implicated in the pathogenesis of cancer, including leukemia and lymphoma, where it plays a role in the regulation of T cell function and immune evasion. In conclusion, the TRBV4-1 gene is a critical component of the adaptive immune response, and its dysregulation has significant clinical implications. Further research is needed to fully understand the function and clinical significance of TRBV4-1, and to explore its potential as a therapeutic target for immune-related disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.