TRAV29DV5 | ENSG00000211810 | NCBI 28653

Details for: TRAV29DV5

Gene ID: 28653

Symbol: TRAV29DV5

Ensembl ID: ENSG00000211810

Description: T cell receptor alpha variable 29/delta variable 5

Associated with

Adaptive immune system
(R-HSA-1280218)
Costimulation by the cd28 family
(R-HSA-388841)
Downstream tcr signaling
(R-HSA-202424)
Generation of second messenger molecules
(R-HSA-202433)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Pd-1 signaling
(R-HSA-389948)
Phosphorylation of cd3 and tcr zeta chains
(R-HSA-202427)
Tcr signaling
(R-HSA-202403)
Translocation of zap-70 to immunological synapse
(R-HSA-202430)
Adaptive immune response
(GO:0002250)
Immune response
(GO:0006955)
Mhc protein binding
(GO:0042287)
Peptide antigen binding
(GO:0042605)
Plasma membrane
(GO:0005886)
T cell receptor complex
(GO:0042101)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: epithelial cell of thymus (CL0002293)
Fold Change: 1.4832
Cell Significance Index: 11.4100
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 0.6217
Cell Significance Index: 3.3900
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.3405
Cell Significance Index: 3.8100
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 0.1969
Cell Significance Index: 0.6000
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 0.0778
Cell Significance Index: 0.7800
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.0368
Cell Significance Index: 0.4400
Cell Name: mature T cell (CL0002419)
Fold Change: -0.0042
Cell Significance Index: -0.0300
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.0055
Cell Significance Index: -0.1400
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0098
Cell Significance Index: -1.9700
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0436
Cell Significance Index: -1.1700
Cell Name: leukocyte (CL0000738)
Fold Change: -0.0530
Cell Significance Index: -0.9000
Cell Name: T cell (CL0000084)
Fold Change: -0.0618
Cell Significance Index: -0.7300
Cell Name: lymphocyte (CL0000542)
Fold Change: -0.0640
Cell Significance Index: -0.8700
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.0642
Cell Significance Index: -1.5600
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.0744
Cell Significance Index: -1.0200
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.0766
Cell Significance Index: -1.9100
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.0813
Cell Significance Index: -1.9500
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.0859
Cell Significance Index: -1.8800
Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.0861
Cell Significance Index: -1.2600
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: -0.0880
Cell Significance Index: -0.7500
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0923
Cell Significance Index: -4.3400
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.0940
Cell Significance Index: -1.6200
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.0959
Cell Significance Index: -1.6200
Cell Name: thymocyte (CL0000893)
Fold Change: -0.0973
Cell Significance Index: -1.2300
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.0995
Cell Significance Index: -1.7000
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: -0.1000
Cell Significance Index: -0.9400
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: -0.1005
Cell Significance Index: -0.8400
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.1048
Cell Significance Index: -2.6700
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.1105
Cell Significance Index: -1.7900
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: -0.1118
Cell Significance Index: -1.0800
Cell Name: neutrophil (CL0000775)
Fold Change: -0.1137
Cell Significance Index: -1.4200
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: -0.1142
Cell Significance Index: -1.3900
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.1170
Cell Significance Index: -1.7300
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: -0.1178
Cell Significance Index: -1.1900
Cell Name: pericyte (CL0000669)
Fold Change: -0.1193
Cell Significance Index: -1.4300
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: -0.1225
Cell Significance Index: -1.2700
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: -0.1253
Cell Significance Index: -1.5500
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: -0.1287
Cell Significance Index: -1.2200
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.1294
Cell Significance Index: -1.6400
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: -0.1358
Cell Significance Index: -1.1000
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: -0.1365
Cell Significance Index: -1.3900
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.1369
Cell Significance Index: -1.7900
Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: -0.1381
Cell Significance Index: -0.9500
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.1384
Cell Significance Index: -1.9700
Cell Name: medium spiny neuron (CL1001474)
Fold Change: -0.1386
Cell Significance Index: -1.8700
Cell Name: GABAergic neuron (CL0000617)
Fold Change: -0.1387
Cell Significance Index: -1.7500
Cell Name: suprabasal keratinocyte (CL4033013)
Fold Change: -0.1393
Cell Significance Index: -2.2400
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: -0.1407
Cell Significance Index: -1.2100
Cell Name: memory T cell (CL0000813)
Fold Change: -0.1412
Cell Significance Index: -1.1700
Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
Fold Change: -0.1418
Cell Significance Index: -1.8900
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.1422
Cell Significance Index: -2.1600
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.1430
Cell Significance Index: -1.8500
Cell Name: T follicular helper cell (CL0002038)
Fold Change: -0.1471
Cell Significance Index: -1.5600
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: -0.1487
Cell Significance Index: -1.7500
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: -0.1507
Cell Significance Index: -1.3000
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: -0.1517
Cell Significance Index: -1.9800
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: -0.1517
Cell Significance Index: -1.5700
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: -0.1523
Cell Significance Index: -1.5800
Cell Name: hepatocyte (CL0000182)
Fold Change: -0.1572
Cell Significance Index: -2.1800
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: -0.1582
Cell Significance Index: -1.9000
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: -0.1591
Cell Significance Index: -2.4200
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: -0.1593
Cell Significance Index: -1.6100
Cell Name: group 3 innate lymphoid cell (CL0001071)
Fold Change: -0.1607
Cell Significance Index: -1.5700
Cell Name: vein endothelial cell (CL0002543)
Fold Change: -0.1607
Cell Significance Index: -1.7400
Cell Name: type I NK T cell (CL0000921)
Fold Change: -0.1621
Cell Significance Index: -1.5800
Cell Name: mesothelial cell (CL0000077)
Fold Change: -0.1633
Cell Significance Index: -1.9900
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.1644
Cell Significance Index: -3.2200
Cell Name: fibroblast of lung (CL0002553)
Fold Change: -0.1649
Cell Significance Index: -1.9600
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.1650
Cell Significance Index: -3.0500
Cell Name: pulmonary alveolar type 1 cell (CL0002062)
Fold Change: -0.1667
Cell Significance Index: -1.8300
Cell Name: brain vascular cell (CL4023072)
Fold Change: -0.1672
Cell Significance Index: -1.9100
Cell Name: alveolar adventitial fibroblast (CL4028006)
Fold Change: -0.1675
Cell Significance Index: -1.8600
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: -0.1676
Cell Significance Index: -2.2000
Cell Name: promonocyte (CL0000559)
Fold Change: -0.1685
Cell Significance Index: -1.8000
Cell Name: helper T cell (CL0000912)
Fold Change: -0.1689
Cell Significance Index: -2.4000
Cell Name: smooth muscle cell (CL0000192)
Fold Change: -0.1696
Cell Significance Index: -1.9700
Cell Name: mast cell (CL0000097)
Fold Change: -0.1702
Cell Significance Index: -2.2400
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: -0.1728
Cell Significance Index: -1.8700
Cell Name: cytotoxic T cell (CL0000910)
Fold Change: -0.1729
Cell Significance Index: -2.5200
Cell Name: regulatory T cell (CL0000815)
Fold Change: -0.1741
Cell Significance Index: -2.0200
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: -0.1759
Cell Significance Index: -2.2600
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: -0.1787
Cell Significance Index: -2.0300
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.1799
Cell Significance Index: -1.9600
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: -0.1799
Cell Significance Index: -1.9400
Cell Name: oligodendrocyte (CL0000128)
Fold Change: -0.1800
Cell Significance Index: -1.9300
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: -0.1801
Cell Significance Index: -1.9700
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: -0.1825
Cell Significance Index: -2.2200
Cell Name: fast muscle cell (CL0000190)
Fold Change: -0.1825
Cell Significance Index: -2.3900
Cell Name: pro-B cell (CL0000826)
Fold Change: -0.1832
Cell Significance Index: -1.9700
Cell Name: endothelial cell (CL0000115)
Fold Change: -0.1863
Cell Significance Index: -2.2900
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: -0.1902
Cell Significance Index: -1.4800
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: -0.1908
Cell Significance Index: -2.2300
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: -0.1934
Cell Significance Index: -1.9300
Cell Name: club cell (CL0000158)
Fold Change: -0.1946
Cell Significance Index: -2.1200
Cell Name: naive regulatory T cell (CL0002677)
Fold Change: -0.1956
Cell Significance Index: -1.7600
Cell Name: mature NK T cell (CL0000814)
Fold Change: -0.1997
Cell Significance Index: -2.2500
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: -0.2010
Cell Significance Index: -2.7600
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: -0.2013
Cell Significance Index: -2.1700
Cell Name: monocyte (CL0000576)
Fold Change: -0.2016
Cell Significance Index: -2.3200
Cell Name: endothelial cell of artery (CL1000413)
Fold Change: -0.2059
Cell Significance Index: -2.1700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics:** 1. **T cell receptor complex:** TRAV29DV5 is a part of the T cell receptor (TCR) complex, which is essential for recognizing and binding to antigens. 2. **Variable region:** The TRAV29 and TRVD5 fragments are part of the variable region of the TCR, which determines the specificity of the T cell response. 3. **Significantly expressed cells:** TRAV29DV5 is expressed in various cell types, including goblet cells, CD8-positive T cells, and hematopoietic cells, highlighting its widespread role in the immune system. 4. **Pathway involvement:** TRAV29DV5 is involved in multiple signaling pathways, including downstream TCR signaling, costimulation by the CD28 family, and phospholipase C-mediated signaling. **Pathways and Functions:** 1. **Adaptive immune response:** TRAV29DV5 plays a crucial role in the adaptive immune response, enabling T cells to recognize and respond to antigens. 2. **T cell receptor signaling:** The TRAV29 and TRVD5 fragments are involved in downstream signaling events, including the activation of Zap-70 and the translocation of Zap-70 to the immunological synapse. 3. **Costimulation:** TRAV29DV5 is also involved in costimulation, which is essential for T cell activation and proliferation. 4. **Regulation of immune responses:** The dysregulation of TRAV29DV5 may lead to an imbalance in immune responses, resulting in autoimmune diseases or impaired immune function. **Clinical Significance:** 1. **Autoimmune diseases:** Abnormalities in TRAV29DV5 expression may contribute to the development of autoimmune diseases, such as multiple sclerosis or type 1 diabetes. 2. **Cancer:** The dysregulation of TRAV29DV5 may also play a role in cancer development, particularly in hematological malignancies. 3. **Immunodeficiency:** Impaired TRAV29DV5 function may lead to immunodeficiency, making individuals susceptible to infections. 4. **Vaccine development:** Understanding the role of TRAV29DV5 in T cell recognition and activation may inform the development of more effective vaccines. In conclusion, TRAV29DV5 is a critical component of the adaptive immune system, and its dysregulation may have significant implications for immune system function and disease. Further research is needed to fully elucidate the role of TRAV29DV5 in the adaptive immune response and to explore its potential as a therapeutic target for autoimmune and cancer diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.