Details for: TRAV29DV5

Gene ID: 28653

Symbol: TRAV29DV5

Ensembl ID: ENSG00000211810

Description: T cell receptor alpha variable 29/delta variable 5

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.63
    Marker Score: 10,803
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 1.38
    Marker Score: 1,217
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 874
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.25
    Marker Score: 7,568
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.22
    Marker Score: 3,646
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.07
    Marker Score: 708
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.06
    Marker Score: 32,719
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,399
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,322
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.81
    Marker Score: 735
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,258
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.64
    Marker Score: 390
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.57
    Marker Score: 477
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 234
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 436
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.53
    Marker Score: 1,648
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.51
    Marker Score: 231
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.5
    Marker Score: 478
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 375
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.32
    Marker Score: 251
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.31
    Marker Score: 202
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.3
    Marker Score: 508
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.29
    Marker Score: 567
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.28
    Marker Score: 309
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.28
    Marker Score: 1,207
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.27
    Marker Score: 484
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.25
    Marker Score: 271
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.24
    Marker Score: 591
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.24
    Marker Score: 177
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.24
    Marker Score: 264
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.23
    Marker Score: 181
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.22
    Marker Score: 138
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.22
    Marker Score: 11,736
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.21
    Marker Score: 202
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.2
    Marker Score: 148
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.2
    Marker Score: 61
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.2
    Marker Score: 279
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.19
    Marker Score: 83
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.19
    Marker Score: 175
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.18
    Marker Score: 104
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.18
    Marker Score: 121
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.17
    Marker Score: 99
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.17
    Marker Score: 272
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.16
    Marker Score: 143
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.16
    Marker Score: 361
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.16
    Marker Score: 86
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.15
    Marker Score: 1,800
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.15
    Marker Score: 108
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.14
    Marker Score: 1,349
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.13
    Marker Score: 198
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.13
    Marker Score: 70
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.12
    Marker Score: 125
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.11
    Marker Score: 95
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.11
    Marker Score: 72
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.11
    Marker Score: 312
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.11
    Marker Score: 64
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.1
    Marker Score: 75
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.09
    Marker Score: 55
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.09
    Marker Score: 84
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.09
    Marker Score: 31
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.08
    Marker Score: 72
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 0.08
    Marker Score: 22
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.08
    Marker Score: 59
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 0.08
    Marker Score: 30
  • Cell Name: group 2 innate lymphoid cell (CL0001069)
    Fold Change: 0.07
    Marker Score: 25
  • Cell Name: type II NK T cell (CL0000922)
    Fold Change: 0.07
    Marker Score: 22
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.07
    Marker Score: 47
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 0.07
    Marker Score: 24
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.07
    Marker Score: 136
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.07
    Marker Score: 21
  • Cell Name: enucleated reticulocyte (CL0002422)
    Fold Change: 0.07
    Marker Score: 25
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.06
    Marker Score: 159
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.06
    Marker Score: 32
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.06
    Marker Score: 87
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.06
    Marker Score: 28
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.06
    Marker Score: 75
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.06
    Marker Score: 178
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.05
    Marker Score: 86
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.05
    Marker Score: 25
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.05
    Marker Score: 26
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.05
    Marker Score: 24
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.04
    Marker Score: 20
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.04
    Marker Score: 34
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.04
    Marker Score: 23
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.04
    Marker Score: 156
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.04
    Marker Score: 21
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.04
    Marker Score: 33
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.04
    Marker Score: 22
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.04
    Marker Score: 25
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.04
    Marker Score: 46
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.03
    Marker Score: 28
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.03
    Marker Score: 25
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.03
    Marker Score: 34

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **T cell receptor complex:** TRAV29DV5 is a part of the T cell receptor (TCR) complex, which is essential for recognizing and binding to antigens. 2. **Variable region:** The TRAV29 and TRVD5 fragments are part of the variable region of the TCR, which determines the specificity of the T cell response. 3. **Significantly expressed cells:** TRAV29DV5 is expressed in various cell types, including goblet cells, CD8-positive T cells, and hematopoietic cells, highlighting its widespread role in the immune system. 4. **Pathway involvement:** TRAV29DV5 is involved in multiple signaling pathways, including downstream TCR signaling, costimulation by the CD28 family, and phospholipase C-mediated signaling. **Pathways and Functions:** 1. **Adaptive immune response:** TRAV29DV5 plays a crucial role in the adaptive immune response, enabling T cells to recognize and respond to antigens. 2. **T cell receptor signaling:** The TRAV29 and TRVD5 fragments are involved in downstream signaling events, including the activation of Zap-70 and the translocation of Zap-70 to the immunological synapse. 3. **Costimulation:** TRAV29DV5 is also involved in costimulation, which is essential for T cell activation and proliferation. 4. **Regulation of immune responses:** The dysregulation of TRAV29DV5 may lead to an imbalance in immune responses, resulting in autoimmune diseases or impaired immune function. **Clinical Significance:** 1. **Autoimmune diseases:** Abnormalities in TRAV29DV5 expression may contribute to the development of autoimmune diseases, such as multiple sclerosis or type 1 diabetes. 2. **Cancer:** The dysregulation of TRAV29DV5 may also play a role in cancer development, particularly in hematological malignancies. 3. **Immunodeficiency:** Impaired TRAV29DV5 function may lead to immunodeficiency, making individuals susceptible to infections. 4. **Vaccine development:** Understanding the role of TRAV29DV5 in T cell recognition and activation may inform the development of more effective vaccines. In conclusion, TRAV29DV5 is a critical component of the adaptive immune system, and its dysregulation may have significant implications for immune system function and disease. Further research is needed to fully elucidate the role of TRAV29DV5 in the adaptive immune response and to explore its potential as a therapeutic target for autoimmune and cancer diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.