Details for: TRAV25

Gene ID: 28658

Symbol: TRAV25

Ensembl ID: ENSG00000211806

Description: T cell receptor alpha variable 25

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 3.0373
    Cell Significance Index: 23.3600
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.5126
    Cell Significance Index: 2.8000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 0.3235
    Cell Significance Index: -0.9900
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0388
    Cell Significance Index: 0.4900
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.0209
    Cell Significance Index: 0.2100
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.0188
    Cell Significance Index: 0.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0056
    Cell Significance Index: -1.1300
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.0111
    Cell Significance Index: -0.0800
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0212
    Cell Significance Index: -0.3600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0234
    Cell Significance Index: -1.1000
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0241
    Cell Significance Index: -0.2500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0315
    Cell Significance Index: -1.0300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0318
    Cell Significance Index: -0.7700
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0323
    Cell Significance Index: -0.4400
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0325
    Cell Significance Index: -0.4800
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0339
    Cell Significance Index: -0.4000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0389
    Cell Significance Index: -1.0400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0461
    Cell Significance Index: -1.2600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0500
    Cell Significance Index: -1.0800
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0503
    Cell Significance Index: -0.6000
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0507
    Cell Significance Index: -0.5500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0523
    Cell Significance Index: -1.0300
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0541
    Cell Significance Index: -0.5200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0551
    Cell Significance Index: -0.9300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0567
    Cell Significance Index: -1.1300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0625
    Cell Significance Index: -1.2600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0642
    Cell Significance Index: -1.2700
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.0665
    Cell Significance Index: -0.6900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0687
    Cell Significance Index: -1.7500
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.0705
    Cell Significance Index: -0.2200
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0706
    Cell Significance Index: -0.6600
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0723
    Cell Significance Index: -0.7300
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0727
    Cell Significance Index: -0.5000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0735
    Cell Significance Index: -1.1900
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0740
    Cell Significance Index: -1.0200
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0744
    Cell Significance Index: -0.9300
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0763
    Cell Significance Index: -0.6500
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0794
    Cell Significance Index: -0.8600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0798
    Cell Significance Index: -1.1600
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0800
    Cell Significance Index: -0.9900
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0802
    Cell Significance Index: -0.7600
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0817
    Cell Significance Index: -1.0500
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0818
    Cell Significance Index: -0.8300
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0821
    Cell Significance Index: -0.8700
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0825
    Cell Significance Index: -0.9700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0837
    Cell Significance Index: -1.1900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0841
    Cell Significance Index: -1.4500
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0858
    Cell Significance Index: -0.7400
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0871
    Cell Significance Index: -1.0600
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0876
    Cell Significance Index: -1.1000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0893
    Cell Significance Index: -1.7500
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0895
    Cell Significance Index: -0.7700
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0896
    Cell Significance Index: -1.1700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0903
    Cell Significance Index: -1.1200
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0912
    Cell Significance Index: -1.2000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0920
    Cell Significance Index: -1.1900
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.0941
    Cell Significance Index: -0.9000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0942
    Cell Significance Index: -1.6100
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0966
    Cell Significance Index: -1.1200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0985
    Cell Significance Index: -1.4300
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.0989
    Cell Significance Index: -0.8200
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0995
    Cell Significance Index: -1.0500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1001
    Cell Significance Index: -1.8500
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1021
    Cell Significance Index: -1.3400
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.1031
    Cell Significance Index: -1.3900
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.1048
    Cell Significance Index: -1.1500
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1050
    Cell Significance Index: -1.2400
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.1056
    Cell Significance Index: -1.2000
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.1060
    Cell Significance Index: -1.2600
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.1079
    Cell Significance Index: -1.1700
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1091
    Cell Significance Index: -1.2300
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.1106
    Cell Significance Index: -1.2100
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.1109
    Cell Significance Index: -0.9700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1110
    Cell Significance Index: -1.5800
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.1114
    Cell Significance Index: -0.9400
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.1123
    Cell Significance Index: -1.0100
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1134
    Cell Significance Index: -1.4800
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1139
    Cell Significance Index: -1.1100
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.1154
    Cell Significance Index: -1.1300
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1180
    Cell Significance Index: -1.4500
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.1187
    Cell Significance Index: -1.2800
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.1197
    Cell Significance Index: -1.0000
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1204
    Cell Significance Index: -1.6000
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1211
    Cell Significance Index: -1.2200
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.1216
    Cell Significance Index: -1.2600
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1225
    Cell Significance Index: -1.4100
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.1226
    Cell Significance Index: -1.2500
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1227
    Cell Significance Index: -1.4500
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1246
    Cell Significance Index: -1.6300
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.1254
    Cell Significance Index: -0.9900
  • Cell Name: urothelial cell (CL0000731)
    Fold Change: -0.1264
    Cell Significance Index: -0.8800
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.1266
    Cell Significance Index: -1.1600
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.1270
    Cell Significance Index: -1.1800
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.1296
    Cell Significance Index: -1.1700
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.1301
    Cell Significance Index: -1.0400
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1310
    Cell Significance Index: -1.2300
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1311
    Cell Significance Index: -1.0200
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: -0.1315
    Cell Significance Index: -1.2900
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.1317
    Cell Significance Index: -1.3800
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.1336
    Cell Significance Index: -1.7100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Genomic Location:** TRAV25 is situated within the TCR locus, a region of high genomic density that contains numerous genes essential for T cell receptor diversity and function. 2. **Expression Patterns:** TRAV25 is expressed in a wide range of hematopoietic cell types, including granulocyte-monocyte progenitor cells, effector CD8-positive T cells, and precursor B cells. 3. **Cellular Specificity:** TRAV25 is predominantly expressed in cells of the myeloid lineage, including neutrophils, monocytes, and megakaryocytes. 4. **Molecular Mechanisms:** The expression of TRAV25 is regulated by a complex interplay of transcriptional and post-transcriptional mechanisms, involving the coordinated action of transcription factors and microRNAs. **Pathways and Functions:** 1. **Adaptive Immune Response:** TRAV25 plays a critical role in the adaptive immune response by contributing to the diversity of T cell receptors and enabling the recognition of antigens. 2. **Cellular Development:** TRAV25 is essential for the development and maturation of immune cells, including T cells and B cells. 3. **Immune Cell Regulation:** TRAV25 participates in the regulation of immune cell function, including the suppression of excessive immune responses and the maintenance of immune tolerance. 4. **Inflammation and Immune Activation:** TRAV25 is involved in the regulation of inflammatory responses and immune activation, with implications for the pathogenesis of autoimmune and inflammatory diseases. **Clinical Significance:** 1. **Autoimmune Diseases:** Dysregulation of TRAV25 expression has been implicated in the pathogenesis of autoimmune diseases, including rheumatoid arthritis and multiple sclerosis. 2. **Infectious Diseases:** TRAV25 plays a critical role in the recognition and elimination of pathogens, with implications for the development of novel therapeutic strategies against bacterial and viral infections. 3. **Cancer Immunotherapy:** TRAV25 has been identified as a potential target for cancer immunotherapy, with potential applications in the treatment of solid tumors and hematological malignancies. 4. **Vaccine Development:** TRAV25 has been proposed as a potential component of vaccine formulations, with implications for the development of novel vaccines against infectious diseases. In conclusion, TRAV25 is a critical component of the adaptive immune system, playing a pivotal role in the recognition and elimination of pathogens. Further research is necessary to fully elucidate the mechanisms of TRAV25 expression and function, with implications for the development of novel therapeutic strategies against autoimmune and infectious diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.