Details for: TRAV1 1

Gene ID: 28693

Symbol: TRAV1 1

Ensembl ID: ENSG00000255569

Description: T cell receptor alpha variable 1-1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.6538
    Cell Significance Index: 40.0600
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.3063
    Cell Significance Index: 1.6700
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.1656
    Cell Significance Index: 1.4900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0083
    Cell Significance Index: -1.6700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0167
    Cell Significance Index: -0.2400
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0171
    Cell Significance Index: -0.2900
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0184
    Cell Significance Index: -0.2500
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0263
    Cell Significance Index: -0.3100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0311
    Cell Significance Index: -1.4500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0324
    Cell Significance Index: -1.6900
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0336
    Cell Significance Index: -0.4900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0351
    Cell Significance Index: -1.6500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0451
    Cell Significance Index: -0.5700
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0464
    Cell Significance Index: -0.4000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0503
    Cell Significance Index: -0.4800
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.0579
    Cell Significance Index: -0.4800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0640
    Cell Significance Index: -1.6300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0731
    Cell Significance Index: -1.1100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0754
    Cell Significance Index: -1.2700
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0779
    Cell Significance Index: -0.7900
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0782
    Cell Significance Index: -0.7900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0818
    Cell Significance Index: -1.4100
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0840
    Cell Significance Index: -0.6800
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.0868
    Cell Significance Index: -0.9000
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0897
    Cell Significance Index: -0.8500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0904
    Cell Significance Index: -1.7800
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0919
    Cell Significance Index: -0.8600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0951
    Cell Significance Index: -1.8600
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0991
    Cell Significance Index: -1.3000
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1009
    Cell Significance Index: -0.9700
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1021
    Cell Significance Index: -1.4900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1023
    Cell Significance Index: -1.8900
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.1070
    Cell Significance Index: -1.7200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1080
    Cell Significance Index: -1.7500
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1089
    Cell Significance Index: -1.5100
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.1128
    Cell Significance Index: -0.9700
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.1138
    Cell Significance Index: -1.3100
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.1154
    Cell Significance Index: -1.1300
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: -0.1167
    Cell Significance Index: -1.1400
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1170
    Cell Significance Index: -1.5400
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1175
    Cell Significance Index: -1.5100
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1176
    Cell Significance Index: -1.2200
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1198
    Cell Significance Index: -1.3900
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1201
    Cell Significance Index: -1.5400
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1211
    Cell Significance Index: -1.2200
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.1212
    Cell Significance Index: -1.3200
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.1227
    Cell Significance Index: -1.2300
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.1235
    Cell Significance Index: -1.5900
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1256
    Cell Significance Index: -1.7600
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1257
    Cell Significance Index: -1.6700
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1261
    Cell Significance Index: -1.5500
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1262
    Cell Significance Index: -1.2300
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.1264
    Cell Significance Index: -1.3700
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.1268
    Cell Significance Index: -1.0700
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.1273
    Cell Significance Index: -1.3500
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1286
    Cell Significance Index: -1.1100
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.1294
    Cell Significance Index: -1.4700
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1298
    Cell Significance Index: -1.0100
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.1299
    Cell Significance Index: -1.4000
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.1307
    Cell Significance Index: -1.4300
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1309
    Cell Significance Index: -1.5700
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1310
    Cell Significance Index: -1.7100
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.1335
    Cell Significance Index: -1.4200
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1340
    Cell Significance Index: -1.5100
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.1358
    Cell Significance Index: -1.4700
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.1386
    Cell Significance Index: -1.4300
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.1390
    Cell Significance Index: -1.6200
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.1405
    Cell Significance Index: -1.3000
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.1410
    Cell Significance Index: -0.9700
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.1420
    Cell Significance Index: -1.2900
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1428
    Cell Significance Index: -1.6800
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.1429
    Cell Significance Index: -1.4600
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1430
    Cell Significance Index: -1.6900
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: -0.1437
    Cell Significance Index: -1.4200
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1440
    Cell Significance Index: -1.6000
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.1441
    Cell Significance Index: -1.4700
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.1444
    Cell Significance Index: -1.4300
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.1472
    Cell Significance Index: -1.7500
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.1474
    Cell Significance Index: -1.7500
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.1479
    Cell Significance Index: -1.5000
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1479
    Cell Significance Index: -1.5600
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1499
    Cell Significance Index: -1.7300
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1521
    Cell Significance Index: -1.9000
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.1525
    Cell Significance Index: -1.5800
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.1531
    Cell Significance Index: -1.7100
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.1533
    Cell Significance Index: -1.6900
  • Cell Name: lung resident memory CD4-positive, alpha-beta T cell (CL4033038)
    Fold Change: -0.1550
    Cell Significance Index: -1.1700
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.1551
    Cell Significance Index: -1.4000
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.1555
    Cell Significance Index: -1.3300
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.1556
    Cell Significance Index: -1.4400
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: -0.1577
    Cell Significance Index: -1.5400
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.1581
    Cell Significance Index: -1.7500
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.1591
    Cell Significance Index: -1.3300
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.1593
    Cell Significance Index: -1.5900
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.1596
    Cell Significance Index: -1.5100
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.1602
    Cell Significance Index: -1.4200
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: -0.1629
    Cell Significance Index: -1.4200
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1630
    Cell Significance Index: -1.5300
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.1652
    Cell Significance Index: -1.3200
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1655
    Cell Significance Index: -1.6900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRAV1-1 shares a high degree of sequence homology with other TRAV genes, which are part of the TCR alpha chain. The gene is characterized by its unique variable region, which is responsible for antigen recognition and binding. The TCR complex, including TRAV1-1, is composed of multiple chains, including alpha, beta, gamma, delta, and epsilon chains, which interact with each other to form a functional TCR. The structure and function of TRAV1-1 are critical for the proper assembly and activation of T cells. **Pathways and Functions:** TRAV1-1 is involved in several key pathways and functions, including: 1. **Adaptive Immune Response:** TRAV1-1 plays a crucial role in the adaptive immune response by recognizing and binding to specific antigens, thereby facilitating the activation of immune cells. 2. **T Cell Receptor Complex Formation:** TRAV1-1 interacts with other TCR chains to form a functional TCR complex, which is essential for antigen recognition and T cell activation. 3. **Antigen Recognition:** The variable region of TRAV1-1 is responsible for recognizing and binding to specific antigens, which is critical for the activation of immune cells. 4. **T Cell Activation:** The interaction between TRAV1-1 and the TCR complex is essential for the activation of T cells, which involves the activation of signaling pathways and the expression of co-stimulatory molecules. **Clinical Significance:** Understanding the functions and significance of TRAV1-1 has significant implications for the treatment of various immune-related disorders, including: 1. **Cancer Immunotherapy:** TRAV1-1 plays a critical role in the adaptive immune response, and its dysregulation has been implicated in various cancers. Targeting TRAV1-1 may provide a novel therapeutic strategy for cancer treatment. 2. **Autoimmune Diseases:** TRAV1-1 has been implicated in various autoimmune diseases, including rheumatoid arthritis and multiple sclerosis. Understanding the functions of TRAV1-1 may provide insights into the development of novel therapeutic strategies for these diseases. 3. **Immunodeficiency Disorders:** TRAV1-1 is essential for the proper functioning of the adaptive immune response. Mutations or deletions in the TRAV1-1 gene have been implicated in various immunodeficiency disorders, including severe combined immunodeficiency (SCID). In conclusion, TRAV1-1 is a critical component of the adaptive immune response, and its dysregulation has significant implications for the development of various immune-related disorders. Further research is necessary to fully understand the functions and significance of TRAV1-1 and to develop novel therapeutic strategies for immune-related diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.