Details for: IGLV4 69

Gene ID: 28784

Symbol: IGLV4 69

Ensembl ID: ENSG00000211637

Description: immunoglobulin lambda variable 4-69

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 8.7054
    Cell Significance Index: -4.1100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.2572
    Cell Significance Index: 3.9800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0284
    Cell Significance Index: 5.4100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0247
    Cell Significance Index: 3.1700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0275
    Cell Significance Index: -0.7500
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0337
    Cell Significance Index: -0.4100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0375
    Cell Significance Index: -0.9400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0520
    Cell Significance Index: -6.7200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0576
    Cell Significance Index: -1.4000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0584
    Cell Significance Index: -4.4900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0685
    Cell Significance Index: -4.2000
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0835
    Cell Significance Index: -0.8600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0973
    Cell Significance Index: -7.2500
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.1020
    Cell Significance Index: -1.1300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1079
    Cell Significance Index: -2.8900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1107
    Cell Significance Index: -5.1600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1146
    Cell Significance Index: -13.1300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1174
    Cell Significance Index: -1.7100
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.1283
    Cell Significance Index: -0.7900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1370
    Cell Significance Index: -3.4900
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.1405
    Cell Significance Index: -1.1600
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1519
    Cell Significance Index: -1.9300
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.1543
    Cell Significance Index: -1.7300
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.1836
    Cell Significance Index: -2.1700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1863
    Cell Significance Index: -6.8400
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.1967
    Cell Significance Index: -1.7700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2053
    Cell Significance Index: -3.5100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2056
    Cell Significance Index: -4.0200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2067
    Cell Significance Index: -3.8200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2075
    Cell Significance Index: -3.3600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.2140
    Cell Significance Index: -2.9400
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.2158
    Cell Significance Index: -2.2100
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.2282
    Cell Significance Index: -2.5500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2324
    Cell Significance Index: -3.8900
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.2410
    Cell Significance Index: -1.6100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2454
    Cell Significance Index: -7.0700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2533
    Cell Significance Index: -7.2600
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.2705
    Cell Significance Index: -3.6800
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.2712
    Cell Significance Index: -3.3600
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2903
    Cell Significance Index: -4.9300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.2968
    Cell Significance Index: -3.8400
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.3001
    Cell Significance Index: -4.2100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3064
    Cell Significance Index: -7.0800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.3081
    Cell Significance Index: -4.4300
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.3094
    Cell Significance Index: -3.5600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.3104
    Cell Significance Index: -4.0600
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.3130
    Cell Significance Index: -3.6800
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.3203
    Cell Significance Index: -2.7300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.3241
    Cell Significance Index: -4.0900
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.3257
    Cell Significance Index: -3.4600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.3391
    Cell Significance Index: -4.9600
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.3430
    Cell Significance Index: -4.1700
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.3431
    Cell Significance Index: -4.4000
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.3448
    Cell Significance Index: -7.1900
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.3465
    Cell Significance Index: -4.1800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.3488
    Cell Significance Index: -3.8000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3504
    Cell Significance Index: -3.9800
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.3599
    Cell Significance Index: -3.8800
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.3615
    Cell Significance Index: -3.4700
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.3628
    Cell Significance Index: -3.8200
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.3666
    Cell Significance Index: -4.1500
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.3688
    Cell Significance Index: -3.2900
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.3690
    Cell Significance Index: -4.2900
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.3700
    Cell Significance Index: -4.0800
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.3701
    Cell Significance Index: -4.0600
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.3810
    Cell Significance Index: -5.0000
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.3820
    Cell Significance Index: -3.0700
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.3852
    Cell Significance Index: -4.2700
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.3884
    Cell Significance Index: -4.5900
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.3898
    Cell Significance Index: -5.1800
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.4000
    Cell Significance Index: -4.3400
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.4002
    Cell Significance Index: -5.0000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.4023
    Cell Significance Index: -7.1100
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.4073
    Cell Significance Index: -4.1900
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.4114
    Cell Significance Index: -5.3700
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.4141
    Cell Significance Index: -4.3400
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.4164
    Cell Significance Index: -4.4300
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.4171
    Cell Significance Index: -4.4600
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.4180
    Cell Significance Index: -4.8100
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.4186
    Cell Significance Index: -5.8100
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.4195
    Cell Significance Index: -4.5700
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.4223
    Cell Significance Index: -5.0200
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.4230
    Cell Significance Index: -4.5000
  • Cell Name: alveolar type 1 fibroblast cell (CL4028004)
    Fold Change: -0.4238
    Cell Significance Index: -4.4900
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.4245
    Cell Significance Index: -3.9400
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.4283
    Cell Significance Index: -4.1900
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: -0.4339
    Cell Significance Index: -4.2800
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.4354
    Cell Significance Index: -5.7300
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.4361
    Cell Significance Index: -4.4300
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.4375
    Cell Significance Index: -5.1700
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.4393
    Cell Significance Index: -4.4900
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.4408
    Cell Significance Index: -4.7400
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: -0.4422
    Cell Significance Index: -4.1200
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.4433
    Cell Significance Index: -3.9600
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.4447
    Cell Significance Index: -4.0400
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.4484
    Cell Significance Index: -4.2700
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.4486
    Cell Significance Index: -4.5200
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.4495
    Cell Significance Index: -4.3200
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.4508
    Cell Significance Index: -5.0800
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.4508
    Cell Significance Index: -4.7800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGLV4-69 is a member of the immunoglobulin variable (IGV) gene family, which is responsible for encoding the variable regions of the light chains of immunoglobulins. Lambda light chains, like IGLV4-69, are composed of two polypeptide chains: a heavy chain (λH) and a light chain (λL). The λL chain is encoded by the IGLV4-69 gene, which is specifically expressed in certain cell types, including natural killer cells, granulocytes, and monocytes. **Pathways and Functions:** IGLV4-69 is involved in the adaptive immune response, which is a complex process that involves the activation of immune cells, such as T cells and B cells. The production of immunoglobulins, including those encoded by IGLV4-69, is crucial for recognizing and binding to specific antigens. This binding event triggers a series of signaling cascades that ultimately lead to the activation of immune cells and the elimination of pathogens. IGLV4-69 is also involved in the production of immunoglobulin complexes, which are formed when immunoglobulins bind to antigens. These complexes can be deposited in tissues, such as the kidneys and joints, where they can trigger inflammatory responses and contribute to tissue damage. **Clinical Significance:** IGLV4-69 has been implicated in various diseases, including autoimmune disorders and cancers. For example, alterations in the expression of IGLV4-69 have been observed in patients with rheumatoid arthritis, a chronic autoimmune disease characterized by joint inflammation and damage. Additionally, IGLV4-69 has been associated with certain types of cancer, including leukemia and lymphoma. In these diseases, the expression of IGLV4-69 can contribute to the development and progression of cancer by promoting the production of immunoglobulins that can bind to and neutralize tumor antigens. Furthermore, IGLV4-69 has been studied as a potential biomarker for disease diagnosis and monitoring. For example, elevated levels of IGLV4-69 have been observed in patients with autoimmune disorders, making it a potential candidate for monitoring disease activity and response to treatment. In conclusion, IGLV4-69 is a critical gene that plays a pivotal role in the human immune system. Its involvement in the adaptive immune response, immunoglobulin production, and disease pathogenesis highlights its importance in understanding the mechanisms of immune function and its potential applications in disease diagnosis and treatment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.