Details for: IGLC7

Gene ID: 28834

Symbol: IGLC7

Ensembl ID: ENSG00000211685

Description: immunoglobulin lambda constant 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 9.8703
    Cell Significance Index: -4.6600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 6.9744
    Cell Significance Index: -4.6800
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 3.3570
    Cell Significance Index: 33.6600
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.5875
    Cell Significance Index: 16.4600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.8545
    Cell Significance Index: 13.2200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0282
    Cell Significance Index: 2.8800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0240
    Cell Significance Index: 1.1200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0188
    Cell Significance Index: 0.5100
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.0087
    Cell Significance Index: 0.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0023
    Cell Significance Index: -4.3900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0027
    Cell Significance Index: -0.3500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0047
    Cell Significance Index: -3.5900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0128
    Cell Significance Index: -0.3200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0211
    Cell Significance Index: -1.3600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0231
    Cell Significance Index: -4.5800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0378
    Cell Significance Index: -1.6400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0441
    Cell Significance Index: -0.5000
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0485
    Cell Significance Index: -0.6700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0659
    Cell Significance Index: -8.5100
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.0672
    Cell Significance Index: -0.7300
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.0736
    Cell Significance Index: -0.8500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0738
    Cell Significance Index: -1.4400
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0849
    Cell Significance Index: -0.8800
  • Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
    Fold Change: -0.0849
    Cell Significance Index: -0.9200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0868
    Cell Significance Index: -11.9200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0894
    Cell Significance Index: -5.4800
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.0923
    Cell Significance Index: -1.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0936
    Cell Significance Index: -18.7700
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0993
    Cell Significance Index: -0.9200
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.1065
    Cell Significance Index: -1.4200
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.1116
    Cell Significance Index: -0.8000
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.1135
    Cell Significance Index: -1.3800
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.1141
    Cell Significance Index: -1.4600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1189
    Cell Significance Index: -8.8600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1237
    Cell Significance Index: -3.3100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1534
    Cell Significance Index: -4.4200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1538
    Cell Significance Index: -3.9300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1614
    Cell Significance Index: -4.3100
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.1645
    Cell Significance Index: -1.0200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1986
    Cell Significance Index: -6.3600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.2059
    Cell Significance Index: -2.9900
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.2210
    Cell Significance Index: -2.8000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2261
    Cell Significance Index: -5.7600
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.2291
    Cell Significance Index: -2.5600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2340
    Cell Significance Index: -8.5900
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.2388
    Cell Significance Index: -2.8100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2411
    Cell Significance Index: -5.8400
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2414
    Cell Significance Index: -4.1000
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.2482
    Cell Significance Index: -3.0700
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.2498
    Cell Significance Index: -3.5800
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.2564
    Cell Significance Index: -3.7500
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.2574
    Cell Significance Index: -3.5700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2607
    Cell Significance Index: -6.5000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2778
    Cell Significance Index: -4.5000
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.2786
    Cell Significance Index: -3.7900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2808
    Cell Significance Index: -5.4900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3035
    Cell Significance Index: -5.6100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3038
    Cell Significance Index: -8.7100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.3048
    Cell Significance Index: -5.2100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.3051
    Cell Significance Index: -3.9900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.3053
    Cell Significance Index: -3.9500
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.3138
    Cell Significance Index: -2.0900
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.3172
    Cell Significance Index: -4.3500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.3197
    Cell Significance Index: -4.6600
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.3228
    Cell Significance Index: -4.5300
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: -0.3242
    Cell Significance Index: -3.5000
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.3245
    Cell Significance Index: -4.6600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3268
    Cell Significance Index: -5.4700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3280
    Cell Significance Index: -5.5300
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.3297
    Cell Significance Index: -3.6400
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.3300
    Cell Significance Index: -4.1700
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.3397
    Cell Significance Index: -2.7300
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.3445
    Cell Significance Index: -4.6500
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.3494
    Cell Significance Index: -4.0200
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.3553
    Cell Significance Index: -3.8200
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.3577
    Cell Significance Index: -3.8200
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.3624
    Cell Significance Index: -4.0300
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.3678
    Cell Significance Index: -4.6200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3680
    Cell Significance Index: -8.9800
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.3684
    Cell Significance Index: -4.1700
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.3698
    Cell Significance Index: -4.3700
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: -0.3718
    Cell Significance Index: -1.8600
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.3736
    Cell Significance Index: -4.4200
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.3739
    Cell Significance Index: -4.5100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3752
    Cell Significance Index: -5.5400
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.3768
    Cell Significance Index: -4.4300
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.3794
    Cell Significance Index: -4.1500
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.3803
    Cell Significance Index: -4.6100
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.3823
    Cell Significance Index: -4.6200
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.3823
    Cell Significance Index: -4.6500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3826
    Cell Significance Index: -17.9800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3852
    Cell Significance Index: -7.9900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3859
    Cell Significance Index: -4.6000
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.3877
    Cell Significance Index: -3.2000
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.3918
    Cell Significance Index: -2.9900
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.3959
    Cell Significance Index: -5.2100
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.3990
    Cell Significance Index: -4.3200
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.4090
    Cell Significance Index: -4.1800
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.4152
    Cell Significance Index: -4.3800
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.4157
    Cell Significance Index: -5.3400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGLC7 is a member of the immunoglobulin lambda constant family, which consists of four constant domains (Cγ2a, Cγ2b, Cγ2c, and Cγ2d). These constant domains determine the effector functions of the lambda light chain, such as complement activation and antibody-dependent cellular cytotoxicity. IGLC7 is specifically associated with the Cγ2a constant domain, which is involved in the production of Igλ antibodies. The gene is expressed in a tissue-specific manner, with high levels found in the brain, immune cells, and epithelial tissues. **Pathways and Functions:** IGLC7 is involved in several key pathways and functions, including: 1. **Adaptive Immune Response:** IGLC7 is essential for the production of Igλ antibodies, which play a crucial role in the adaptive immune response against pathogens. 2. **Antigen Binding:** The lambda light chain, including IGLC7, is responsible for the formation of the antigen-binding site, which recognizes and binds to specific antigens. 3. **B Cell Receptor Signaling Pathway:** IGLC7 is involved in the signaling pathway of B cell receptors, which is critical for the activation and differentiation of B cells. 4. **Immunoglobulin Mediated Immune Response:** IGLC7 contributes to the activation of the complement system, which is essential for the clearance of pathogens and the elimination of immune complexes. **Clinical Significance:** Dysregulation of IGLC7 has been implicated in several autoimmune and immunodeficiency disorders, including: 1. **Autoimmune Diseases:** Alterations in IGLC7 expression have been linked to autoimmune diseases such as lupus and rheumatoid arthritis. 2. **Immunodeficiency Disorders:** Mutations in IGLC7 can lead to immunodeficiency disorders, such as X-linked agammaglobulinemia. 3. **Cancer:** Abnormal expression of IGLC7 has been observed in certain types of cancer, including lymphomas and leukemias. In conclusion, IGLC7 is a critical component of the adaptive immune response, and its dysregulation can have significant consequences for human health. Further research is needed to fully understand the mechanisms of IGLC7 and its role in immune function.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.