Details for: GRINA

Gene ID: 2907

Symbol: GRINA

Ensembl ID: ENSG00000178719

Description: glutamate ionotropic receptor NMDA type subunit associated protein 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 4.47
    Marker Score: 3155
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 3.71
    Marker Score: 1087
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 3.25
    Marker Score: 13485.5
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.88
    Marker Score: 161082
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 2.81
    Marker Score: 1703
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.61
    Marker Score: 66949
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.55
    Marker Score: 4961
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 2.4
    Marker Score: 2140
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.27
    Marker Score: 22817.5
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 2.24
    Marker Score: 933
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.12
    Marker Score: 13813
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 2.06
    Marker Score: 12493
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.04
    Marker Score: 2044
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.99
    Marker Score: 5426
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.96
    Marker Score: 2246.5
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.93
    Marker Score: 2048
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.91
    Marker Score: 570
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.88
    Marker Score: 1252
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.82
    Marker Score: 2991
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.81
    Marker Score: 7129
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.78
    Marker Score: 980
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.78
    Marker Score: 3614
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.78
    Marker Score: 863
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.77
    Marker Score: 60274
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.74
    Marker Score: 1872
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.68
    Marker Score: 4182.5
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.65
    Marker Score: 1196
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.64
    Marker Score: 660
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.59
    Marker Score: 366
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 1.58
    Marker Score: 960
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.57
    Marker Score: 4065
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.53
    Marker Score: 6588
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.51
    Marker Score: 4042
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.5
    Marker Score: 505
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.49
    Marker Score: 795
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.49
    Marker Score: 940
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.48
    Marker Score: 419
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.47
    Marker Score: 1652
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.47
    Marker Score: 807
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.45
    Marker Score: 1369
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.44
    Marker Score: 3473
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.44
    Marker Score: 349
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.42
    Marker Score: 1712
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.41
    Marker Score: 1765
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.4
    Marker Score: 15799
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.4
    Marker Score: 3990.5
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.4
    Marker Score: 345
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 1.38
    Marker Score: 475
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.37
    Marker Score: 1290
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.37
    Marker Score: 1439
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.36
    Marker Score: 1889
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.36
    Marker Score: 15768
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.35
    Marker Score: 303
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.34
    Marker Score: 765
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.34
    Marker Score: 795
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.33
    Marker Score: 9920
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.33
    Marker Score: 5138
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.33
    Marker Score: 629
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.32
    Marker Score: 3458
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.3
    Marker Score: 375
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.29
    Marker Score: 459
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.28
    Marker Score: 7600.5
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.28
    Marker Score: 3229
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.28
    Marker Score: 4539
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.26
    Marker Score: 1727
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.25
    Marker Score: 1840
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.23
    Marker Score: 10715
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.23
    Marker Score: 42645
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.22
    Marker Score: 816
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.21
    Marker Score: 1232.5
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.2
    Marker Score: 7848.5
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.2
    Marker Score: 489
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.2
    Marker Score: 1983
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.18
    Marker Score: 2685
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.16
    Marker Score: 799
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.15
    Marker Score: 964
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.15
    Marker Score: 15210
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.15
    Marker Score: 6041
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.14
    Marker Score: 751.5
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.13
    Marker Score: 1022
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.13
    Marker Score: 709
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.13
    Marker Score: 1620
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.11
    Marker Score: 761
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 1.11
    Marker Score: 742
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.1
    Marker Score: 5085
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.1
    Marker Score: 9409
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.09
    Marker Score: 1137
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.09
    Marker Score: 5367.5
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.09
    Marker Score: 826
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.09
    Marker Score: 1021
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.08
    Marker Score: 1919
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.08
    Marker Score: 1729
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.07
    Marker Score: 627
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.07
    Marker Score: 559
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 1.07
    Marker Score: 462
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.07
    Marker Score: 240
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.06
    Marker Score: 1080
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.06
    Marker Score: 1129
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 1.06
    Marker Score: 568
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.06
    Marker Score: 1138

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Other Information

**Key characteristics:** * GRINA is a type I transmembrane protein, meaning it has one extracellular domain and one intracellular domain. * It is a member of the NMDA receptor family of ionotropic receptors. * GRINA is expressed in high levels in monocytes and macrophages, where it is thought to play a role in regulating inflammation and immune responses. * It is also expressed in dendritic cells, where it is thought to be involved in the regulation of immune responses to pathogens. **Pathways and functions:** * GRINA is a key regulator of endoplasmic reticulum (ER) calcium homeostasis. It is expressed in the ER, where it helps to maintain calcium levels within a narrow range. * It also plays a role in the negative regulation of apoptotic signaling pathways. * In the negative regulation of apoptotic signaling pathways, GRINA binds to a protein called prohibitin-1, which leads to the inhibition of apoptosis. * In addition, GRINA is involved in the negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. **Clinical significance:** GRINA is a promising target for the treatment of inflammatory diseases. Studies have shown that GRINAs are expressed in a variety of inflammatory cells, and that blocking GRINA signaling can inhibit inflammatory responses. This suggests that GRINAs may be a potential therapeutic target for a variety of inflammatory diseases, including rheumatoid arthritis, asthma, and inflammatory bowel disease.

Genular Protein ID: 714598771

Symbol: LFG1_HUMAN

Name: Protein lifeguard 1

UniProtKB Accession Codes:

Q7Z429 B3KXM7 O43836 Q8IVW7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 7 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SAM 1 SMR 1 STRING 1 SignaLink 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 12761501

Title: Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.

PubMed ID: 12761501

DOI: 10.1038/sj.onc.1206406

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8406459

Title: Mapping of the human NMDA receptor subunit (NMDAR1) and the proposed NMDA receptor glutamate-binding subunit (NMDARA1) to chromosomes 9q34.3 and chromosome 8, respectively.

PubMed ID: 8406459

DOI: 10.1006/geno.1993.1311

PubMed ID: 19784873

Title: LFG: a candidate apoptosis regulatory gene family.

PubMed ID: 19784873

DOI: 10.1007/s10495-009-0402-2

Sequence Information:

  • Length: 371
  • Mass: 41203
  • Checksum: 62E012DFB0E7DEEB
  • Sequence:
    • MSHEKSFLVS GDNYPPPNPG YPGGPQPPMP PYAQPPYPGA PYPQPPFQPS PYGQPGYPHG 
PSPYPQGGYP QGPYPQGGYP QGPYPQEGYP QGPYPQGGYP QGPYPQSPFP PNPYGQPQVF 
PGQDPDSPQH GNYQEEGPPS YYDNQDFPAT NWDDKSIRQA FIRKVFLVLT LQLSVTLSTV 
SVFTFVAEVK GFVRENVWTY YVSYAVFFIS LIVLSCCGDF RRKHPWNLVA LSVLTASLSY 
MVGMIASFYN TEAVIMAVGI TTAVCFTVVI FSMQTRYDFT SCMGVLLVSM VVLFIFAILC 
IFIRNRILEI VYASLGALLF TCFLAVDTQL LLGNKQLSLS PEEYVFAALN LYTDIINIFL 
YILTIIGRAK E

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.