Details for: LGALS13

Gene ID: 29124

Symbol: LGALS13

Ensembl ID: ENSG00000105198

Description: galectin 13

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 8.22
    Marker Score: 52,959
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.14
    Marker Score: 3,161
  • Cell Name: T cell (CL0000084)
    Fold Change: 2.52
    Marker Score: 4,353
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.98
    Marker Score: 2,216
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.27
    Marker Score: 1,207
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7,692
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,727
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,959
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,403
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,342
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,742
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.9
    Marker Score: 523
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.89
    Marker Score: 1,444
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,293
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.86
    Marker Score: 501
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 405
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 713
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.75
    Marker Score: 1,199
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.74
    Marker Score: 709
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.72
    Marker Score: 694
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.68
    Marker Score: 543
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.6
    Marker Score: 1,137
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.59
    Marker Score: 483
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.57
    Marker Score: 714
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.56
    Marker Score: 1,149
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.48
    Marker Score: 285
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.43
    Marker Score: 384
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.41
    Marker Score: 739
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.4
    Marker Score: 495
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.39
    Marker Score: 124
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.36
    Marker Score: 125
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.35
    Marker Score: 126
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.34
    Marker Score: 109
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.33
    Marker Score: 196
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.32
    Marker Score: 4,960
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 0.31
    Marker Score: 100
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.3
    Marker Score: 139
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.28
    Marker Score: 2,337
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.27
    Marker Score: 1,630
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.27
    Marker Score: 125
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.26
    Marker Score: 110
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.25
    Marker Score: 126
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.23
    Marker Score: 126
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.22
    Marker Score: 117
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.2
    Marker Score: 124
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.19
    Marker Score: 550
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.18
    Marker Score: 126
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.18
    Marker Score: 125
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.18
    Marker Score: 98
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.17
    Marker Score: 76
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.17
    Marker Score: 111
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.17
    Marker Score: 674
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.16
    Marker Score: 499
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.16
    Marker Score: 124
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.16
    Marker Score: 76
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 0.16
    Marker Score: 503
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.15
    Marker Score: 138
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.15
    Marker Score: 594
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.14
    Marker Score: 125
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.12
    Marker Score: 140
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.12
    Marker Score: 117
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.11
    Marker Score: 122
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.1
    Marker Score: 126
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.1
    Marker Score: 103
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.09
    Marker Score: 120
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.09
    Marker Score: 122
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.09
    Marker Score: 123
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.08
    Marker Score: 126
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.08
    Marker Score: 125
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.08
    Marker Score: 314
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.07
    Marker Score: 104
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.05
    Marker Score: 105
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.05
    Marker Score: 115
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.05
    Marker Score: 164
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.05
    Marker Score: 110
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.04
    Marker Score: 427
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.04
    Marker Score: 126
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.04
    Marker Score: 125
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.04
    Marker Score: 432
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.04
    Marker Score: 76
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.04
    Marker Score: 84
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.04
    Marker Score: 119
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.04
    Marker Score: 96
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.03
    Marker Score: 119
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.03
    Marker Score: 126
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.03
    Marker Score: 42
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.03
    Marker Score: 119
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.02
    Marker Score: 126
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.02
    Marker Score: 126
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.02
    Marker Score: 124
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.01
    Marker Score: 119
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.01
    Marker Score: 123
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.01
    Marker Score: 116
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.01
    Marker Score: 120
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.01
    Marker Score: 126
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0
    Marker Score: 294
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0
    Marker Score: 76
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0
    Marker Score: 126
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0
    Marker Score: 125

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Galectin 13 is a soluble lectin that binds to galactose-containing carbohydrates, including β-galactosides and N-acetyl-β-galactosides. The lectin's carbohydrate-binding specificity is mediated by a conserved cysteine residue, which forms a disulfide bond with a cysteine residue in the carbohydrate binding domain. This unique structural feature allows galectin 13 to interact with a wide range of glycoproteins and glycolipids. Galectin 13 is also characterized by its ability to modulate various signaling pathways, including the JAK/STAT and PI3K/AKT pathways. **Pathways and Functions:** Galectin 13 plays a crucial role in regulating cellular processes, including: 1. **Apoptosis:** Galectin 13 can induce apoptosis in certain cell types by binding to specific glycoproteins, such as Bcl-2 and Bcl-xL. 2. **Cell proliferation:** Galectin 13 can inhibit cell proliferation by binding to glycoproteins involved in cell cycle regulation, such as cyclin D1 and cyclin-dependent kinase 4. 3. **Immune response:** Galectin 13 can modulate immune responses by binding to glycoproteins involved in antigen presentation and T cell activation, such as MHC class II and CD28. 4. **Inflammation:** Galectin 13 can reduce inflammation by binding to glycoproteins involved in inflammatory signaling, such as TNF-α and IL-1β. 5. **Tissue homeostasis:** Galectin 13 can maintain tissue homeostasis by regulating the proliferation and differentiation of stem cells, such as intestinal crypt stem cells. **Clinical Significance:** Galectin 13 has been implicated in various diseases, including: 1. **Cancer:** Galectin 13 expression is often upregulated in cancer cells, where it contributes to tumor progression and metastasis. 2. **Autoimmune diseases:** Galectin 13 has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus, where it contributes to immune system dysregulation. 3. **Neurological disorders:** Galectin 13 expression has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it contributes to neuronal damage and degeneration. 4. **Inflammatory bowel disease:** Galectin 13 has been implicated in inflammatory bowel disease, where it contributes to intestinal inflammation and damage. In conclusion, galectin 13 is a multifaceted lectin that plays a crucial role in regulating various cellular processes, including apoptosis, cell proliferation, and immune response. Its clinical significance is highlighted by its involvement in various diseases, including cancer, autoimmune diseases, neurological disorders, and inflammatory bowel disease. Further research is needed to fully understand the mechanisms by which galectin 13 regulates cellular processes and to explore its therapeutic potential.

Genular Protein ID: 210605231

Symbol: PP13_HUMAN

Name: Galactoside-binding soluble lectin 13

UniProtKB Accession Codes:

Q9UHV8 C5HZ15

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 15 PDBsum 11 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniLectin 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 10527825

Title: Isolation and sequence analysis of a cDNA encoding human placental tissue protein 13 (PP13), a new lysophospholipase, homologue of human eosinophil Charcot-Leyden crystal protein.

PubMed ID: 10527825

DOI: 10.1053/plac.1999.0436

PubMed ID: 19497882

Title: A primate subfamily of galectins expressed at the maternal-fetal interface that promote immune cell death.

PubMed ID: 19497882

DOI: 10.1073/pnas.0903568106

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6856484

Title: Purification and characterization of two new soluble placental tissue proteins (PP13 and PP17).

PubMed ID: 6856484

PubMed ID: 11742106

Title: Homology modelling and molecular dynamics studies of human placental tissue protein 13 (galectin-13).

PubMed ID: 11742106

DOI: 10.1093/protein/14.11.875

PubMed ID: 29343868

Title: Galectin-13, a different prototype galectin, does not bind beta-galacto-sides and forms dimers via intermolecular disulfide bridges between Cys-136 and Cys-138.

PubMed ID: 29343868

DOI: 10.1038/s41598-018-19465-0

Sequence Information:

  • Length: 139
  • Mass: 16119
  • Checksum: D1FE26D66C1F5FD0
  • Sequence:
    • MSSLPVPYKL PVSLSVGSCV IIKGTPIHSF INDPQLQVDF YTDMDEDSDI AFRFRVHFGN 
HVVMNRREFG IWMLEETTDY VPFEDGKQFE LCIYVHYNEY EIKVNGIRIY GFVHRIPPSF 
VKMVQVSRDI SLTSVCVCN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.