Details for: LGALS13

Gene ID: 29124

Symbol: LGALS13

Ensembl ID: ENSG00000105198

Description: galectin 13

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.8872
    Cell Significance Index: 23.6900
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.2859
    Cell Significance Index: 3.3400
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.2049
    Cell Significance Index: 4.1700
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.1892
    Cell Significance Index: 1.8100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.0879
    Cell Significance Index: 1.0900
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.0414
    Cell Significance Index: 0.2500
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.0347
    Cell Significance Index: 0.3300
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.0067
    Cell Significance Index: 0.0500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0014
    Cell Significance Index: 0.0200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0005
    Cell Significance Index: -0.0100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0016
    Cell Significance Index: -0.4600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0023
    Cell Significance Index: -0.4600
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: -0.0056
    Cell Significance Index: -0.0400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0070
    Cell Significance Index: -0.2900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0084
    Cell Significance Index: -1.1500
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.0099
    Cell Significance Index: -0.0500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0171
    Cell Significance Index: -0.6000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0181
    Cell Significance Index: -1.2200
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0182
    Cell Significance Index: -0.2300
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0188
    Cell Significance Index: -0.2500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0192
    Cell Significance Index: -0.6100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0205
    Cell Significance Index: -1.1500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0209
    Cell Significance Index: -0.5600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0226
    Cell Significance Index: -0.7400
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0267
    Cell Significance Index: -0.2600
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0270
    Cell Significance Index: -0.3600
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0306
    Cell Significance Index: -0.3500
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0321
    Cell Significance Index: -0.3500
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0335
    Cell Significance Index: -0.3700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0372
    Cell Significance Index: -0.2300
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0377
    Cell Significance Index: -0.4100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0379
    Cell Significance Index: -0.5600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0388
    Cell Significance Index: -0.8100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0393
    Cell Significance Index: -0.9800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0409
    Cell Significance Index: -0.5100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0422
    Cell Significance Index: -0.8300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0428
    Cell Significance Index: -1.2200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0443
    Cell Significance Index: -2.3100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0444
    Cell Significance Index: -1.1300
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0447
    Cell Significance Index: -0.5600
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.0455
    Cell Significance Index: -0.2100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0458
    Cell Significance Index: -0.9900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0460
    Cell Significance Index: -1.1500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0463
    Cell Significance Index: -0.8000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0511
    Cell Significance Index: -1.0300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0518
    Cell Significance Index: -1.1000
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0521
    Cell Significance Index: -0.4300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0528
    Cell Significance Index: -1.2800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0531
    Cell Significance Index: -1.0500
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0553
    Cell Significance Index: -0.7200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0577
    Cell Significance Index: -0.9700
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0579
    Cell Significance Index: -0.5600
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: -0.0582
    Cell Significance Index: -0.5700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0595
    Cell Significance Index: -1.0200
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.0613
    Cell Significance Index: -0.5400
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0631
    Cell Significance Index: -0.6800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0650
    Cell Significance Index: -1.2700
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0660
    Cell Significance Index: -0.6200
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0669
    Cell Significance Index: -0.8600
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.0669
    Cell Significance Index: -0.6000
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0688
    Cell Significance Index: -0.8200
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0714
    Cell Significance Index: -0.8700
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0749
    Cell Significance Index: -1.1200
  • Cell Name: H1 horizontal cell (CL0004217)
    Fold Change: -0.0764
    Cell Significance Index: -0.9600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0765
    Cell Significance Index: -1.0200
  • Cell Name: diffuse bipolar 3b cell (CL4033030)
    Fold Change: -0.0768
    Cell Significance Index: -0.9300
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0798
    Cell Significance Index: -1.1200
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0808
    Cell Significance Index: -0.9500
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0815
    Cell Significance Index: -1.1300
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: -0.0830
    Cell Significance Index: -0.7000
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0843
    Cell Significance Index: -1.0300
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0845
    Cell Significance Index: -1.0600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0845
    Cell Significance Index: -1.3600
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0855
    Cell Significance Index: -1.0300
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.0869
    Cell Significance Index: -0.5400
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0881
    Cell Significance Index: -0.9000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0882
    Cell Significance Index: -1.1300
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0887
    Cell Significance Index: -1.1200
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0889
    Cell Significance Index: -1.2000
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0899
    Cell Significance Index: -1.1100
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0901
    Cell Significance Index: -1.1300
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0905
    Cell Significance Index: -1.2200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0909
    Cell Significance Index: -1.9900
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0911
    Cell Significance Index: -0.9300
  • Cell Name: OFF parasol ganglion cell (CL4033051)
    Fold Change: -0.0923
    Cell Significance Index: -1.1600
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.0925
    Cell Significance Index: -1.2000
  • Cell Name: ON parasol ganglion cell (CL4033052)
    Fold Change: -0.0931
    Cell Significance Index: -1.1600
  • Cell Name: flat midget bipolar cell (CL4033033)
    Fold Change: -0.0933
    Cell Significance Index: -1.1600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0948
    Cell Significance Index: -1.1300
  • Cell Name: diffuse bipolar 1 cell (CL4033027)
    Fold Change: -0.0948
    Cell Significance Index: -1.1600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0951
    Cell Significance Index: -1.2000
  • Cell Name: diffuse bipolar 2 cell (CL4033028)
    Fold Change: -0.0953
    Cell Significance Index: -1.1700
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0953
    Cell Significance Index: -1.1500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0955
    Cell Significance Index: -2.2900
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.0970
    Cell Significance Index: -1.0700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0981
    Cell Significance Index: -0.9300
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0981
    Cell Significance Index: -1.1500
  • Cell Name: invaginating midget bipolar cell (CL4033034)
    Fold Change: -0.0988
    Cell Significance Index: -1.2200
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.0989
    Cell Significance Index: -1.0300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Galectin 13 is a soluble lectin that binds to galactose-containing carbohydrates, including β-galactosides and N-acetyl-β-galactosides. The lectin's carbohydrate-binding specificity is mediated by a conserved cysteine residue, which forms a disulfide bond with a cysteine residue in the carbohydrate binding domain. This unique structural feature allows galectin 13 to interact with a wide range of glycoproteins and glycolipids. Galectin 13 is also characterized by its ability to modulate various signaling pathways, including the JAK/STAT and PI3K/AKT pathways. **Pathways and Functions:** Galectin 13 plays a crucial role in regulating cellular processes, including: 1. **Apoptosis:** Galectin 13 can induce apoptosis in certain cell types by binding to specific glycoproteins, such as Bcl-2 and Bcl-xL. 2. **Cell proliferation:** Galectin 13 can inhibit cell proliferation by binding to glycoproteins involved in cell cycle regulation, such as cyclin D1 and cyclin-dependent kinase 4. 3. **Immune response:** Galectin 13 can modulate immune responses by binding to glycoproteins involved in antigen presentation and T cell activation, such as MHC class II and CD28. 4. **Inflammation:** Galectin 13 can reduce inflammation by binding to glycoproteins involved in inflammatory signaling, such as TNF-α and IL-1β. 5. **Tissue homeostasis:** Galectin 13 can maintain tissue homeostasis by regulating the proliferation and differentiation of stem cells, such as intestinal crypt stem cells. **Clinical Significance:** Galectin 13 has been implicated in various diseases, including: 1. **Cancer:** Galectin 13 expression is often upregulated in cancer cells, where it contributes to tumor progression and metastasis. 2. **Autoimmune diseases:** Galectin 13 has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus, where it contributes to immune system dysregulation. 3. **Neurological disorders:** Galectin 13 expression has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it contributes to neuronal damage and degeneration. 4. **Inflammatory bowel disease:** Galectin 13 has been implicated in inflammatory bowel disease, where it contributes to intestinal inflammation and damage. In conclusion, galectin 13 is a multifaceted lectin that plays a crucial role in regulating various cellular processes, including apoptosis, cell proliferation, and immune response. Its clinical significance is highlighted by its involvement in various diseases, including cancer, autoimmune diseases, neurological disorders, and inflammatory bowel disease. Further research is needed to fully understand the mechanisms by which galectin 13 regulates cellular processes and to explore its therapeutic potential.

Genular Protein ID: 210605231

Symbol: PP13_HUMAN

Name: Galactoside-binding soluble lectin 13

UniProtKB Accession Codes:

Q9UHV8 C5HZ15

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 11 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniLectin 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 10527825

Title: Isolation and sequence analysis of a cDNA encoding human placental tissue protein 13 (PP13), a new lysophospholipase, homologue of human eosinophil Charcot-Leyden crystal protein.

PubMed ID: 10527825

DOI: 10.1053/plac.1999.0436

PubMed ID: 19497882

Title: A primate subfamily of galectins expressed at the maternal-fetal interface that promote immune cell death.

PubMed ID: 19497882

DOI: 10.1073/pnas.0903568106

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6856484

Title: Purification and characterization of two new soluble placental tissue proteins (PP13 and PP17).

PubMed ID: 6856484

PubMed ID: 11742106

Title: Homology modelling and molecular dynamics studies of human placental tissue protein 13 (galectin-13).

PubMed ID: 11742106

DOI: 10.1093/protein/14.11.875

PubMed ID: 29343868

Title: Galectin-13, a different prototype galectin, does not bind beta-galacto-sides and forms dimers via intermolecular disulfide bridges between Cys-136 and Cys-138.

PubMed ID: 29343868

DOI: 10.1038/s41598-018-19465-0

Sequence Information:

  • Length: 139
  • Mass: 16119
  • Checksum: D1FE26D66C1F5FD0
  • Sequence:
    • MSSLPVPYKL PVSLSVGSCV IIKGTPIHSF INDPQLQVDF YTDMDEDSDI AFRFRVHFGN 
HVVMNRREFG IWMLEETTDY VPFEDGKQFE LCIYVHYNEY EIKVNGIRIY GFVHRIPPSF 
VKMVQVSRDI SLTSVCVCN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.