Details for: ICAM1

Gene ID: 3383

Symbol: ICAM1

Ensembl ID: ENSG00000090339

Description: intercellular adhesion molecule 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 3.19
    Marker Score: 3840
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.69
    Marker Score: 91467.5
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.63
    Marker Score: 2243
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.28
    Marker Score: 3300
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.2
    Marker Score: 917
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 2.15
    Marker Score: 926
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.08
    Marker Score: 3520
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.02
    Marker Score: 10639
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.01
    Marker Score: 13102
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.01
    Marker Score: 32213
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2
    Marker Score: 5093
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.99
    Marker Score: 774
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.92
    Marker Score: 9415.5
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.82
    Marker Score: 3630
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.77
    Marker Score: 793
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.76
    Marker Score: 2885
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.64
    Marker Score: 1872
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.62
    Marker Score: 1393
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.53
    Marker Score: 626.5
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.52
    Marker Score: 378
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.51
    Marker Score: 378
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.5
    Marker Score: 9133
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167906
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.43
    Marker Score: 2301
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.41
    Marker Score: 775
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.36
    Marker Score: 5033
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.34
    Marker Score: 476
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.27
    Marker Score: 1364
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.26
    Marker Score: 1263
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.24
    Marker Score: 3203
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.23
    Marker Score: 295
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.21
    Marker Score: 3162
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.2
    Marker Score: 306
  • Cell Name: basophil (CL0000767)
    Fold Change: 1.19
    Marker Score: 567
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.19
    Marker Score: 592
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.19
    Marker Score: 862.5
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.18
    Marker Score: 1062
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.17
    Marker Score: 665
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.15
    Marker Score: 1676
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.13
    Marker Score: 4730
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.13
    Marker Score: 411
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 1.12
    Marker Score: 703
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.07
    Marker Score: 59990.5
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.05
    Marker Score: 438
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.01
    Marker Score: 906
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 1.01
    Marker Score: 266
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1
    Marker Score: 946
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71722
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47947
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.99
    Marker Score: 996
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30395
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.95
    Marker Score: 1860.5
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 485
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.94
    Marker Score: 3610
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 438
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.91
    Marker Score: 1070
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.91
    Marker Score: 240
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2731
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.9
    Marker Score: 1113
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.9
    Marker Score: 191
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.89
    Marker Score: 355
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.86
    Marker Score: 5239
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 309
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.86
    Marker Score: 355
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.85
    Marker Score: 4875
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.84
    Marker Score: 190
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.84
    Marker Score: 3510
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.83
    Marker Score: 572
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.83
    Marker Score: 925
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.82
    Marker Score: 838
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.82
    Marker Score: 276
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.81
    Marker Score: 182
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.81
    Marker Score: 541
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.81
    Marker Score: 1294
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.79
    Marker Score: 2191
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 605
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.79
    Marker Score: 458
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.78
    Marker Score: 1014
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.78
    Marker Score: 1066
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.76
    Marker Score: 315
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.76
    Marker Score: 230
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.76
    Marker Score: 339
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.75
    Marker Score: 1223
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.73
    Marker Score: 317.5
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.73
    Marker Score: 211
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 376
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.71
    Marker Score: 493
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.71
    Marker Score: 2954
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.71
    Marker Score: 647
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.7
    Marker Score: 226
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.69
    Marker Score: 319
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.69
    Marker Score: 396
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.68
    Marker Score: 287
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.67
    Marker Score: 1067
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.66
    Marker Score: 774
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.66
    Marker Score: 640
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.65
    Marker Score: 224
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.65
    Marker Score: 203

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Other Information

**Key characteristics:** * ICAM1 is a glycoprotein with a molecular weight of approximately 120 kDa. * It is expressed in high levels on activated T cells, B cells, and macrophages. * It is also expressed on stromal cells in the skin, lungs, and gut. * ICAM1 is a homophilic protein, meaning that it binds to other ICAM1 molecules. * It is involved in the regulation of T cell activation, B cell activation, and macrophage activation. **Pathways and functions:** * ICAM1 is involved in the regulation of T cell activation. It is expressed on activated T cells and is critical for their activation. * ICAM1 is also involved in the regulation of B cell activation. It is expressed on activated B cells and is required for their activation. * ICAM1 is also involved in the regulation of macrophage activation. It is expressed on activated macrophages and is required for their activation. **Clinical significance:** * Mutations in the ICAM1 gene have been linked to several human diseases, including cancer, autoimmune disorders, and inflammatory diseases. * ICAM1 is a potential target for cancer immunotherapy. Blocking ICAM1 signaling has been shown to be effective in inhibiting cancer growth and metastasis. **Conclusion:** ICAM1 is a key regulator of immune responses and inflammation. It is expressed in a variety of cell types and is involved in the regulation of T cell activation, B cell activation, and macrophage activation. Mutations in the ICAM1 gene have been linked to several human diseases, including cancer, autoimmune disorders, and inflammatory diseases.

Genular Protein ID: 2072418657

Symbol: ICAM1_HUMAN

Name: Intercellular adhesion molecule 1

UniProtKB Accession Codes:

P05362 B2R6M3 Q5NKV7 Q96B50

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CPTAC 4 CPTC 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EMBL 13 EMDB 2 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 35 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 2 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 22 PDBsum 14 PIR 1 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 5 RefSeq 1 SABIO-RK 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniLectin 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3340213

Title: ICAM, an adhesion ligand of LFA-1, is homologous to the neural cell adhesion molecule NCAM.

PubMed ID: 3340213

DOI: 10.1038/331624a0

PubMed ID: 3349522

Title: Primary structure of ICAM-1 demonstrates interaction between members of the immunoglobulin and integrin supergene families.

PubMed ID: 3349522

DOI: 10.1016/0092-8674(88)90434-5

PubMed ID: 2544880

Title: cDNA cloning reveals that the major group rhinovirus receptor on HeLa cells is intercellular adhesion molecule 1.

PubMed ID: 2544880

DOI: 10.1073/pnas.86.13.4907

PubMed ID: 1680919

Title: Cloning of the human gene for intercellular adhesion molecule 1 and analysis of its 5'-regulatory region. Induction by cytokines and phorbol ester.

PubMed ID: 1680919

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1983003

Title: Structural characteristics of the 5' region of the human ICAM-1 gene.

PubMed ID: 1983003

DOI: 10.1016/s0171-2985(11)80585-1

PubMed ID: 15572059

Title: The potential significance of adaptive evolution and dimerization in chimpanzee intercellular cell adhesion molecules (ICAMs).

PubMed ID: 15572059

DOI: 10.1016/j.jtbi.2004.08.024

PubMed ID: 2538243

Title: The major human rhinovirus receptor is ICAM-1.

PubMed ID: 2538243

DOI: 10.1016/0092-8674(89)90688-0

PubMed ID: 1968231

Title: A soluble form of intercellular adhesion molecule-1 inhibits rhinovirus infection.

PubMed ID: 1968231

DOI: 10.1038/344070a0

PubMed ID: 11173916

Title: MUC1 mucin core protein binds to the domain 1 of ICAM-1.

PubMed ID: 11173916

DOI: 10.1159/000051917

PubMed ID: 11160747

Title: Interaction of coxsackievirus A21 with its cellular receptor, ICAM-1.

PubMed ID: 11160747

DOI: 10.1128/jvi.75.5.2444-2451.2001

PubMed ID: 11413168

Title: A viral protein that selectively downregulates ICAM-1 and B7-2 and modulates T cell costimulation.

PubMed ID: 11413168

DOI: 10.1172/jci12432

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 17174307

Title: MARCH-IX mediates ubiquitination and downregulation of ICAM-1.

PubMed ID: 17174307

DOI: 10.1016/j.febslet.2006.11.075

PubMed ID: 17875742

Title: RhoG regulates endothelial apical cup assembly downstream from ICAM1 engagement and is involved in leukocyte trans-endothelial migration.

PubMed ID: 17875742

DOI: 10.1083/jcb.200612053

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23858057

Title: CD81 controls sustained T cell activation signaling and defines the maturation stages of cognate immunological synapses.

PubMed ID: 23858057

DOI: 10.1128/mcb.00302-13

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 9539702

Title: A dimeric crystal structure for the N-terminal two domains of intercellular adhesion molecule-1.

PubMed ID: 9539702

DOI: 10.1073/pnas.95.8.4134

PubMed ID: 9539703

Title: The structure of the two amino-terminal domains of human ICAM-1 suggests how it functions as a rhinovirus receptor and as an LFA-1 integrin ligand.

PubMed ID: 9539703

DOI: 10.1073/pnas.95.8.4140

PubMed ID: 10562537

Title: Structural studies of two rhinovirus serotypes complexed with fragments of their cellular receptor.

PubMed ID: 10562537

DOI: 10.1093/emboj/18.22.6249

PubMed ID: 12526797

Title: Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation.

PubMed ID: 12526797

DOI: 10.1016/s0092-8674(02)01257-6

PubMed ID: 15099525

Title: Structural basis for dimerization of ICAM-1 on the cell surface.

PubMed ID: 15099525

DOI: 10.1016/s1097-2765(04)00204-7

PubMed ID: 16004874

Title: The crystal structure of coxsackievirus A21 and its interaction with ICAM-1.

PubMed ID: 16004874

DOI: 10.1016/j.str.2005.04.011

PubMed ID: 7525451

Title: Polymorphisms and linkage analysis for ICAM-1 and the selectin gene cluster.

PubMed ID: 7525451

DOI: 10.1006/geno.1994.1303

PubMed ID: 8557254

Title: DNA polymorphisms in adhesion molecule genes -- a new risk factor for early atherosclerosis.

PubMed ID: 8557254

DOI: 10.1007/bf00218826

PubMed ID: 9259284

Title: A high frequency African coding polymorphism in the N-terminal domain of ICAM-1 predisposing to cerebral malaria in Kenya.

PubMed ID: 9259284

DOI: 10.1093/hmg/6.8.1357

PubMed ID: 10391210

Title: Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis.

PubMed ID: 10391210

DOI: 10.1038/10297

Sequence Information:

  • Length: 532
  • Mass: 57825
  • Checksum: 550089365A733AFB
  • Sequence:
    • MAPSSPRPAL PALLVLLGAL FPGPGNAQTS VSPSKVILPR GGSVLVTCST SCDQPKLLGI 
ETPLPKKELL LPGNNRKVYE LSNVQEDSQP MCYSNCPDGQ STAKTFLTVY WTPERVELAP 
LPSWQPVGKN LTLRCQVEGG APRANLTVVL LRGEKELKRE PAVGEPAEVT TTVLVRRDHH 
GANFSCRTEL DLRPQGLELF ENTSAPYQLQ TFVLPATPPQ LVSPRVLEVD TQGTVVCSLD 
GLFPVSEAQV HLALGDQRLN PTVTYGNDSF SAKASVSVTA EDEGTQRLTC AVILGNQSQE 
TLQTVTIYSF PAPNVILTKP EVSEGTEVTV KCEAHPRAKV TLNGVPAQPL GPRAQLLLKA 
TPEDNGRSFS CSATLEVAGQ LIHKNQTREL RVLYGPRLDE RDCPGNWTWP ENSQQTPMCQ 
AWGNPLPELK CLKDGTFPLP IGESVTVTRD LEGTYLCRAR STQGEVTRKV TVNVLSPRYE 
IVIITVVAAA VIMGTAGLST YLYNRQRKIK KYRLQQAQKG TPMKPNTQAT PP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.