Details for: KRT35

Gene ID: 3886

Symbol: KRT35

Ensembl ID: ENSG00000197079

Description: keratin 35

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granular cell of epidermis (CL0002189)
    Fold Change: 8.3394
    Cell Significance Index: 9.6000
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.5285
    Cell Significance Index: 7.7300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.1315
    Cell Significance Index: 2.1300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1225
    Cell Significance Index: 54.1800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.0755
    Cell Significance Index: 1.2900
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0432
    Cell Significance Index: 0.4300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0370
    Cell Significance Index: 1.9200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0181
    Cell Significance Index: 0.4700
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.0155
    Cell Significance Index: 0.2000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.0104
    Cell Significance Index: 0.2600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0104
    Cell Significance Index: 0.7400
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0011
    Cell Significance Index: 0.0100
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0010
    Cell Significance Index: -0.0100
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0014
    Cell Significance Index: -0.0100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0081
    Cell Significance Index: -1.6100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0084
    Cell Significance Index: -0.1100
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0087
    Cell Significance Index: -0.1100
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0093
    Cell Significance Index: -0.1100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0095
    Cell Significance Index: -0.1400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0106
    Cell Significance Index: -1.0800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0117
    Cell Significance Index: -1.6100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0129
    Cell Significance Index: -2.6000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0131
    Cell Significance Index: -2.3700
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0137
    Cell Significance Index: -0.1100
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0146
    Cell Significance Index: -0.1600
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0149
    Cell Significance Index: -0.1900
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: -0.0152
    Cell Significance Index: -0.1400
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.0156
    Cell Significance Index: -0.1500
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0179
    Cell Significance Index: -0.1900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0191
    Cell Significance Index: -2.7800
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0205
    Cell Significance Index: -0.1400
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0207
    Cell Significance Index: -0.2400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0219
    Cell Significance Index: -0.5900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0222
    Cell Significance Index: -2.7300
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0240
    Cell Significance Index: -0.2600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0385
    Cell Significance Index: -1.8100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0463
    Cell Significance Index: -0.6400
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0500
    Cell Significance Index: -0.6600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0511
    Cell Significance Index: -1.3900
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0518
    Cell Significance Index: -0.6900
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0521
    Cell Significance Index: -0.4300
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0539
    Cell Significance Index: -0.5900
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.0566
    Cell Significance Index: -0.4500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0573
    Cell Significance Index: -0.8200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0680
    Cell Significance Index: -1.1800
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0696
    Cell Significance Index: -0.7100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0698
    Cell Significance Index: -1.8700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0711
    Cell Significance Index: -2.4900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0725
    Cell Significance Index: -2.6600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0773
    Cell Significance Index: -1.9700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0798
    Cell Significance Index: -2.5400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0806
    Cell Significance Index: -2.6400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0903
    Cell Significance Index: -2.6600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0948
    Cell Significance Index: -1.8900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0950
    Cell Significance Index: -1.3500
  • Cell Name: supporting cell (CL0000630)
    Fold Change: -0.1039
    Cell Significance Index: -0.4800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1057
    Cell Significance Index: -3.0300
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.1103
    Cell Significance Index: -2.3000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1106
    Cell Significance Index: -2.7600
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1117
    Cell Significance Index: -1.3400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1134
    Cell Significance Index: -2.7200
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.1134
    Cell Significance Index: -1.3400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1159
    Cell Significance Index: -1.7600
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.1166
    Cell Significance Index: -1.2700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1203
    Cell Significance Index: -2.6000
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.1215
    Cell Significance Index: -1.2000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1245
    Cell Significance Index: -1.8200
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1246
    Cell Significance Index: -1.4500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1289
    Cell Significance Index: -2.7400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1345
    Cell Significance Index: -2.6300
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1363
    Cell Significance Index: -1.5100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1375
    Cell Significance Index: -2.7600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1381
    Cell Significance Index: -2.7300
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1433
    Cell Significance Index: -1.6400
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.1461
    Cell Significance Index: -1.9700
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.1499
    Cell Significance Index: -2.4100
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.1502
    Cell Significance Index: -1.9600
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: -0.1522
    Cell Significance Index: -1.6200
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1529
    Cell Significance Index: -2.1000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1637
    Cell Significance Index: -2.7400
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1674
    Cell Significance Index: -2.1500
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: -0.1689
    Cell Significance Index: -0.9400
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.1713
    Cell Significance Index: -1.8200
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1725
    Cell Significance Index: -1.8200
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1748
    Cell Significance Index: -2.4500
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1756
    Cell Significance Index: -2.5500
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1761
    Cell Significance Index: -2.0700
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1801
    Cell Significance Index: -2.3700
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.1847
    Cell Significance Index: -1.9800
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1905
    Cell Significance Index: -2.5000
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1966
    Cell Significance Index: -2.6200
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1983
    Cell Significance Index: -2.3600
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1990
    Cell Significance Index: -2.3800
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.2034
    Cell Significance Index: -1.9100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2056
    Cell Significance Index: -2.2400
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.2061
    Cell Significance Index: -2.6900
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.2068
    Cell Significance Index: -2.9000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2104
    Cell Significance Index: -2.8700
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.2116
    Cell Significance Index: -2.6700
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.2147
    Cell Significance Index: -2.4700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** KRT35 is expressed in a diverse range of cell types, including oligodendrocyte precursor cells, progenitor cells, microglial cells, blood vessel endothelial cells, goblet cells, and intestinal crypt stem cells. 2. **Structural Role:** KRT35 is a type I keratin, which forms a network of intermediate filaments that provides mechanical support and stability to cells. 3. **Functional Importance:** KRT35 is involved in various cellular processes, including morphogenesis, differentiation, keratinization, and protein binding. 4. **Pathway Involvement:** KRT35 is implicated in multiple signaling pathways, including those involved in cell growth, differentiation, and apoptosis. **Pathways and Functions:** 1. **Anatomical Structure Morphogenesis:** KRT35 plays a crucial role in the development and organization of epithelial tissues, influencing cell shape, size, and arrangement. 2. **Cytoskeleton Organization:** KRT35 is a key component of the cytoskeleton, interacting with other intermediate filament proteins to maintain cellular structure and function. 3. **Epithelial Cell Differentiation:** KRT35 is involved in the differentiation of epithelial cells, influencing the acquisition of specific cell types and functions. 4. **Keratinization:** KRT35 is essential for the process of keratinization, which involves the formation of the cornified envelope and the acquisition of skin barrier function. 5. **Protein Binding:** KRT35 interacts with various proteins, including keratins, proteins, and signaling molecules, influencing cellular processes and signaling pathways. **Clinical Significance:** 1. **Neurological Disorders:** Mutations in KRT35 have been associated with neurological disorders, such as neurodegenerative diseases and developmental abnormalities. 2. **Immunological Disorders:** KRT35 is involved in the regulation of immune responses, and dysregulation of KRT35 expression has been implicated in autoimmune diseases and inflammatory disorders. 3. **Cancer:** KRT35 is often overexpressed in cancer cells, influencing tumor progression, metastasis, and resistance to therapy. 4. **Wound Healing:** KRT35 plays a crucial role in wound healing, influencing the organization of epithelial cells and the formation of the cornified envelope. In conclusion, KRT35 is a multifunctional protein that plays a critical role in maintaining the structural and functional integrity of epithelial cells. Its involvement in various cellular processes and signaling pathways highlights its importance in immunological contexts. Further research is needed to fully elucidate the clinical significance of KRT35 and its potential as a therapeutic target for immunological disorders.

Genular Protein ID: 280472921

Symbol: KRT35_HUMAN

Name: Keratin, type I cuticular Ha5

UniProtKB Accession Codes:

Q92764 O76012 Q92651

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 9 Gene3D 3 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8823373

Title: Genomic characterization of the human type I cuticular hair keratin hHa2 and identification of an adjacent novel type I hair keratin gene hHa5.

PubMed ID: 8823373

DOI: 10.1111/1523-1747.ep12584243

PubMed ID: 9756910

Title: Characterization of a 190-kilobase pair domain of human type I hair keratin genes.

PubMed ID: 9756910

DOI: 10.1074/jbc.273.41.26683

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

  • Length: 455
  • Mass: 50361
  • Checksum: 3E72080469C8E80B
  • Sequence:
    • MASKCLKAGF SSGSLKSPGG ASGGSTRVSA MYSSSSCKLP SLSPVARSFS ACSVGLGRSS 
YRATSCLPAL CLPAGGFATS YSGGGGWFGE GILTGNEKET MQSLNDRLAG YLEKVRQLEQ 
ENASLESRIR EWCEQQVPYM CPDYQSYFRT IEELQKKTLC SKAENARLVV EIDNAKLAAD 
DFRTKYETEV SLRQLVESDI NGLRRILDDL TLCKSDLEAQ VESLKEELLC LKKNHEEEVN 
SLRCQLGDRL NVEVDAAPPV DLNRVLEEMR CQYETLVENN RRDAEDWLDT QSEELNQQVV 
SSSEQLQSCQ AEIIELRRTV NALEIELQAQ HSMRDALEST LAETEARYSS QLAQMQCMIT 
NVEAQLAEIR ADLERQNQEY QVLLDVRARL ECEINTYRGL LESEDSKLPC NPCAPDYSPS 
KSCLPCLPAA SCGPSAARTN CSPRPICVPC PGGRF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.