Details for: LCN1

Gene ID: 3933

Symbol: LCN1

Ensembl ID: ENSG00000160349

Description: lipocalin 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.43
    Marker Score: 2446
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.66
    Marker Score: 383
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.15
    Marker Score: 276
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.02
    Marker Score: 2598
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71835
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48060.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5356
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2744
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5293
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 713
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 402
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.65
    Marker Score: 515
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 282
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.45
    Marker Score: 857
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.43
    Marker Score: 1011
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.34
    Marker Score: 100
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.31
    Marker Score: 142
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.28
    Marker Score: 161
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.25
    Marker Score: 170
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.23
    Marker Score: 315
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.22
    Marker Score: 409
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.21
    Marker Score: 431
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2
    Marker Score: 3193.5
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.18
    Marker Score: 101
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.17
    Marker Score: 89
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.17
    Marker Score: 95
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.14
    Marker Score: 83.5
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.14
    Marker Score: 250
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.13
    Marker Score: 149
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.12
    Marker Score: 747
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.11
    Marker Score: 179.5
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: 0.1
    Marker Score: 45
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.1
    Marker Score: 59
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.1
    Marker Score: 207
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.1
    Marker Score: 41
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.1
    Marker Score: 127
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.1
    Marker Score: 34
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.09
    Marker Score: 38
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.09
    Marker Score: 45
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.08
    Marker Score: 87
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.08
    Marker Score: 36
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.07
    Marker Score: 45
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.07
    Marker Score: 38
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.06
    Marker Score: 27
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.05
    Marker Score: 15.5
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.05
    Marker Score: 62
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.05
    Marker Score: 21
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.05
    Marker Score: 33
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.05
    Marker Score: 517
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.05
    Marker Score: 18.5
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.05
    Marker Score: 56
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.05
    Marker Score: 43
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.04
    Marker Score: 23
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.04
    Marker Score: 69
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.04
    Marker Score: 14.5
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.04
    Marker Score: 1365
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.04
    Marker Score: 44
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.04
    Marker Score: 12.5
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.04
    Marker Score: 11
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.04
    Marker Score: 10.5
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.03
    Marker Score: 30
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.03
    Marker Score: 59
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.03
    Marker Score: 84.5
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.03
    Marker Score: 11.5
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.03
    Marker Score: 28
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.03
    Marker Score: 371
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.03
    Marker Score: 33
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.02
    Marker Score: 15.5
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.02
    Marker Score: 45
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.02
    Marker Score: 12.5
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.02
    Marker Score: 8.5
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.02
    Marker Score: 15.5
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.02
    Marker Score: 13.5
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.02
    Marker Score: 36
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.02
    Marker Score: 23
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.02
    Marker Score: 36
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.02
    Marker Score: 52
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.02
    Marker Score: 20
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.02
    Marker Score: 14.5
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.02
    Marker Score: 4416
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.02
    Marker Score: 9
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.02
    Marker Score: 15.5
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.02
    Marker Score: 9.5
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.02
    Marker Score: 39.5

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Other Information

**Key characteristics** * LCN1 is a type of calcium-dependent protein kinase (CDPK) that is involved in a variety of cellular processes, including cell migration, proliferation, and differentiation. * It is a transmembrane protein that is expressed on the surface of cells. * It is a glycoprotein that is composed of 140 amino acids. * It is a key regulator of the cell cycle, as it is involved in the regulation of cell proliferation and apoptosis. * It is also involved in the regulation of inflammation, as it is a key regulator of the production of inflammatory cytokines. **Pathways and functions** * LCN1 is involved in a variety of cellular processes, including cell migration, proliferation, and differentiation. * It is a key regulator of the cell cycle, as it is involved in the regulation of cell proliferation and apoptosis. * It is also involved in the regulation of inflammation, as it is a key regulator of the production of inflammatory cytokines. * It is involved in the transport of fatty acids, small molecules, and vitamins. **Clinical significance** * Mutations in the LCN1 gene have been linked to a number of human diseases, including cancer, cardiovascular disease, and diabetes. * LCN1 is a potential therapeutic target for a variety of diseases, as it is involved in a variety of cellular processes that are disrupted in these diseases. * Research on LCN1 is ongoing, and new drugs that target the LCN1 gene are being developed. **Additional information** * The LCN1 gene is located on chromosome 19p13.1. * It is a highly conserved gene, with a similar gene found in mice and rats. * It is expressed in high levels in many tissues, including blood vessels, skin, and brain. * It is a relatively new gene, with the first known gene copy being identified in 1999.

Genular Protein ID: 2447787311

Symbol: LCN1_HUMAN

Name: Lipocalin-1

UniProtKB Accession Codes:

P31025 Q5T8A1

Database IDs:

AGR 1 Allergome 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 9 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 4 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TopDownProteomics 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7679926

Title: Molecular cloning of human von Ebner's gland protein, a member of the lipocalin superfamily highly expressed in lingual salivary glands.

PubMed ID: 7679926

DOI: 10.1016/0167-4781(93)90279-m

PubMed ID: 1400345

Title: cDNA cloning and sequencing reveals human tear prealbumin to be a member of the lipophilic-ligand carrier protein superfamily.

PubMed ID: 1400345

DOI: 10.1016/s0021-9258(19)88698-2

PubMed ID: 8500570

Title: Cloning of a human lacrimal lipocalin secreted in tears.

PubMed ID: 8500570

DOI: 10.1006/exer.1993.1075

PubMed ID: 8112601

Title: Structural organization of the gene encoding the human lipocalin tear prealbumin and synthesis of the recombinant protein in Escherichia coli.

PubMed ID: 8112601

DOI: 10.1016/0378-1119(94)90752-8

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 25946035

Title: Human basal tear peptidome characterization by CID, HCD, and ETD followed by in silico and in vitro analyses for antimicrobial peptide identification.

PubMed ID: 25946035

DOI: 10.1021/acs.jproteome.5b00179

PubMed ID: 11287427

Title: Molecular cloning of a novel lipocalin-1 interacting human cell membrane receptor using phage display.

PubMed ID: 11287427

DOI: 10.1074/jbc.m101762200

PubMed ID: 12591932

Title: Antisense down-regulation of lipocalin-interacting membrane receptor expression inhibits cellular internalization of lipocalin-1 in human NT2 cells.

PubMed ID: 12591932

DOI: 10.1074/jbc.m210922200

PubMed ID: 17869594

Title: Oligomeric state of lipocalin-1 (LCN1) by multiangle laser light scattering and fluorescence anisotropy decay.

PubMed ID: 17869594

DOI: 10.1016/j.bbapap.2007.07.014

PubMed ID: 15489503

Title: The 1.8-A crystal structure of human tear lipocalin reveals an extended branched cavity with capacity for multiple ligands.

PubMed ID: 15489503

DOI: 10.1074/jbc.m410466200

Sequence Information:

  • Length: 176
  • Mass: 19250
  • Checksum: 0DDBF124C8C78CB8
  • Sequence:
    • MKPLLLAVSL GLIAALQAHH LLASDEEIQD VSGTWYLKAM TVDREFPEMN LESVTPMTLT 
TLEGGNLEAK VTMLISGRCQ EVKAVLEKTD EPGKYTADGG KHVAYIIRSH VKDHYIFYCE 
GELHGKPVRG VKLVGRDPKN NLEALEDFEK AAGARGLSTE SILIPRQSET CSPGSD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.