Details for: LCN1

Gene ID: 3933

Symbol: LCN1

Ensembl ID: ENSG00000160349

Description: lipocalin 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: adipocyte (CL0000136)
    Fold Change: 14.5835
    Cell Significance Index: 194.4000
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: 10.2894
    Cell Significance Index: 74.0500
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.9366
    Cell Significance Index: 20.7400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.1057
    Cell Significance Index: 69.6900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.9918
    Cell Significance Index: 15.7400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.5441
    Cell Significance Index: 12.5700
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.3933
    Cell Significance Index: 4.2300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.3329
    Cell Significance Index: 5.1500
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.1291
    Cell Significance Index: 0.8000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0393
    Cell Significance Index: 5.0400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0184
    Cell Significance Index: 10.0400
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.0077
    Cell Significance Index: 0.1000
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.0007
    Cell Significance Index: 0.0100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0005
    Cell Significance Index: -0.2800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0020
    Cell Significance Index: -0.3500
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0035
    Cell Significance Index: -0.0400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0080
    Cell Significance Index: -0.3500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0127
    Cell Significance Index: -0.5200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0176
    Cell Significance Index: -27.0900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0180
    Cell Significance Index: -33.1400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0255
    Cell Significance Index: -34.7200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0259
    Cell Significance Index: -0.5400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0287
    Cell Significance Index: -0.6000
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0292
    Cell Significance Index: -0.3200
  • Cell Name: PP cell (CL0000696)
    Fold Change: -0.0308
    Cell Significance Index: -0.3100
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.0343
    Cell Significance Index: -0.3800
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0359
    Cell Significance Index: -0.7300
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0398
    Cell Significance Index: -0.5200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0416
    Cell Significance Index: -0.7200
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0427
    Cell Significance Index: -0.4400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0458
    Cell Significance Index: -9.1900
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.0459
    Cell Significance Index: -0.3300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0566
    Cell Significance Index: -6.4900
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0579
    Cell Significance Index: -0.6100
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.0691
    Cell Significance Index: -0.6700
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0696
    Cell Significance Index: -0.6200
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0707
    Cell Significance Index: -0.6100
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0811
    Cell Significance Index: -0.7700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0813
    Cell Significance Index: -16.1300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0823
    Cell Significance Index: -8.4100
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0845
    Cell Significance Index: -1.1500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0917
    Cell Significance Index: -12.5900
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0935
    Cell Significance Index: -0.6200
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.0987
    Cell Significance Index: -0.6300
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.1124
    Cell Significance Index: -0.6600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1618
    Cell Significance Index: -10.8800
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1755
    Cell Significance Index: -2.9800
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: -0.2034
    Cell Significance Index: -1.9200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2088
    Cell Significance Index: -13.4700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2269
    Cell Significance Index: -7.9500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2391
    Cell Significance Index: -8.3100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.2678
    Cell Significance Index: -5.3400
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.2689
    Cell Significance Index: -2.5200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2838
    Cell Significance Index: -8.3600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2864
    Cell Significance Index: -9.1200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2889
    Cell Significance Index: -9.4600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2899
    Cell Significance Index: -16.2700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2999
    Cell Significance Index: -7.4800
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.3044
    Cell Significance Index: -3.6900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3299
    Cell Significance Index: -8.8400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3317
    Cell Significance Index: -14.6700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3430
    Cell Significance Index: -15.9900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3665
    Cell Significance Index: -10.4600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3841
    Cell Significance Index: -5.2400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.3857
    Cell Significance Index: -3.2400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3874
    Cell Significance Index: -8.3700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3877
    Cell Significance Index: -14.6800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.3907
    Cell Significance Index: -7.6900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3939
    Cell Significance Index: -8.3600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3991
    Cell Significance Index: -14.6500
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.4095
    Cell Significance Index: -4.8200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4237
    Cell Significance Index: -11.1400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4251
    Cell Significance Index: -8.4100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4253
    Cell Significance Index: -10.2000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4380
    Cell Significance Index: -7.3300
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.4523
    Cell Significance Index: -5.3400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4528
    Cell Significance Index: -9.0900
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.4633
    Cell Significance Index: -7.9200
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.4816
    Cell Significance Index: -5.3100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.5249
    Cell Significance Index: -24.6700
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.5328
    Cell Significance Index: -7.0800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.5381
    Cell Significance Index: -13.7100
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: -0.5637
    Cell Significance Index: -6.2100
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.5820
    Cell Significance Index: -7.3300
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.5983
    Cell Significance Index: -7.5700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.6051
    Cell Significance Index: -9.8000
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.6096
    Cell Significance Index: -9.1200
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.6264
    Cell Significance Index: -8.3500
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.6281
    Cell Significance Index: -7.4900
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.6359
    Cell Significance Index: -8.7200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.6393
    Cell Significance Index: -9.5800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.6726
    Cell Significance Index: -9.9300
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.6814
    Cell Significance Index: -8.5500
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.6885
    Cell Significance Index: -8.7200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.6956
    Cell Significance Index: -13.6000
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.6984
    Cell Significance Index: -8.4300
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.7069
    Cell Significance Index: -8.4900
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.7117
    Cell Significance Index: -8.4600
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.7237
    Cell Significance Index: -9.0900
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.7358
    Cell Significance Index: -5.9600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure and Function:** LCN1 is a 25-kDa protein consisting of a single chain of 161 amino acids. Its unique structure allows it to bind to various ligands, including fatty acids, vitamins, and ions, through its four conserved domains. 2. **Cellular Expression:** LCN1 is expressed in a variety of cell types, including endothelial cells, goblet cells, stem cells, and immune cells, such as neutrophils and GABAergic interneurons. 3. **Regulation:** LCN1 expression is tightly regulated by various signaling pathways, including those involved in inflammation, immune response, and cellular stress. 4. **Binding Specificity:** LCN1 exhibits high affinity for binding to fatty acids, small molecules, and ions, including chloride, zinc, and vitamin D. **Pathways and Functions:** 1. **Immune Response:** LCN1 plays a crucial role in modulating the immune response by regulating the production of pro-inflammatory cytokines and chemokines. 2. **Cellular Stress:** LCN1 is involved in protecting cells against oxidative stress and inflammation by regulating the expression of antioxidant enzymes and anti-inflammatory genes. 3. **Protein Quality Control:** LCN1 has been shown to regulate the degradation of misfolded proteins, thereby maintaining protein homeostasis. 4. **Cellular Homeostasis:** LCN1 participates in maintaining cellular homeostasis by regulating the expression of genes involved in cell growth, differentiation, and survival. **Clinical Significance:** 1. **Kidney Injury:** Elevated LCN1 levels have been observed in patients with acute kidney injury, suggesting its potential as a biomarker for kidney damage. 2. **Inflammatory Diseases:** LCN1 has been implicated in various inflammatory diseases, including atherosclerosis, rheumatoid arthritis, and multiple sclerosis. 3. **Cancer:** LCN1 has been shown to regulate cancer cell growth, invasion, and metastasis, highlighting its potential as a therapeutic target. 4. **Neurological Disorders:** LCN1 has been implicated in neurological disorders, including Alzheimer's disease, Parkinson's disease, and stroke, suggesting its potential as a biomarker for disease diagnosis and prognosis. In conclusion, Lipocalin 1 is a multifaceted protein with broad implications in immune response, cellular homeostasis, and disease pathogenesis. Further research is needed to fully elucidate its mechanisms of action and potential therapeutic applications.

Genular Protein ID: 2447787311

Symbol: LCN1_HUMAN

Name: Lipocalin-1

UniProtKB Accession Codes:

P31025 Q5T8A1

Database IDs:

AGR 1 Allergome 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 9 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7679926

Title: Molecular cloning of human von Ebner's gland protein, a member of the lipocalin superfamily highly expressed in lingual salivary glands.

PubMed ID: 7679926

DOI: 10.1016/0167-4781(93)90279-m

PubMed ID: 1400345

Title: cDNA cloning and sequencing reveals human tear prealbumin to be a member of the lipophilic-ligand carrier protein superfamily.

PubMed ID: 1400345

DOI: 10.1016/s0021-9258(19)88698-2

PubMed ID: 8500570

Title: Cloning of a human lacrimal lipocalin secreted in tears.

PubMed ID: 8500570

DOI: 10.1006/exer.1993.1075

PubMed ID: 8112601

Title: Structural organization of the gene encoding the human lipocalin tear prealbumin and synthesis of the recombinant protein in Escherichia coli.

PubMed ID: 8112601

DOI: 10.1016/0378-1119(94)90752-8

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 25946035

Title: Human basal tear peptidome characterization by CID, HCD, and ETD followed by in silico and in vitro analyses for antimicrobial peptide identification.

PubMed ID: 25946035

DOI: 10.1021/acs.jproteome.5b00179

PubMed ID: 11287427

Title: Molecular cloning of a novel lipocalin-1 interacting human cell membrane receptor using phage display.

PubMed ID: 11287427

DOI: 10.1074/jbc.m101762200

PubMed ID: 12591932

Title: Antisense down-regulation of lipocalin-interacting membrane receptor expression inhibits cellular internalization of lipocalin-1 in human NT2 cells.

PubMed ID: 12591932

DOI: 10.1074/jbc.m210922200

PubMed ID: 17869594

Title: Oligomeric state of lipocalin-1 (LCN1) by multiangle laser light scattering and fluorescence anisotropy decay.

PubMed ID: 17869594

DOI: 10.1016/j.bbapap.2007.07.014

PubMed ID: 15489503

Title: The 1.8-A crystal structure of human tear lipocalin reveals an extended branched cavity with capacity for multiple ligands.

PubMed ID: 15489503

DOI: 10.1074/jbc.m410466200

Sequence Information:

  • Length: 176
  • Mass: 19250
  • Checksum: 0DDBF124C8C78CB8
  • Sequence:
    • MKPLLLAVSL GLIAALQAHH LLASDEEIQD VSGTWYLKAM TVDREFPEMN LESVTPMTLT 
TLEGGNLEAK VTMLISGRCQ EVKAVLEKTD EPGKYTADGG KHVAYIIRSH VKDHYIFYCE 
GELHGKPVRG VKLVGRDPKN NLEALEDFEK AAGARGLSTE SILIPRQSET CSPGSD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.