Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: hepatoblast (CL0005026)
Fold Change: 3.1202
Cell Significance Index: 52.4800 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 2.7191
Cell Significance Index: 72.8600 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 2.0813
Cell Significance Index: 45.0900 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 2.0249
Cell Significance Index: 91.7800 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 1.4486
Cell Significance Index: 35.0900 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.4151
Cell Significance Index: 269.3100 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.0414
Cell Significance Index: 103.0200 - Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 1.0359
Cell Significance Index: 14.2100 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.9941
Cell Significance Index: 14.9800 - Cell Name: cytotoxic T cell (CL0000910)
Fold Change: 0.6108
Cell Significance Index: 8.9000 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.5151
Cell Significance Index: 83.7800 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.4906
Cell Significance Index: 53.3600 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.4862
Cell Significance Index: 8.1900 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.4496
Cell Significance Index: 4.1400 - Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.3966
Cell Significance Index: 6.7800 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.3912
Cell Significance Index: 77.6400 - Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: 0.3638
Cell Significance Index: 3.6700 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.3400
Cell Significance Index: 61.2900 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.3309
Cell Significance Index: 4.7100 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.3205
Cell Significance Index: 10.2700 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.2838
Cell Significance Index: 19.6300 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.2663
Cell Significance Index: 32.7400 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.2180
Cell Significance Index: 13.0900 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.1876
Cell Significance Index: 2.5600 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.1673
Cell Significance Index: 2.4700 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.1629
Cell Significance Index: 8.4600 - Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 0.1345
Cell Significance Index: 0.8300 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.1319
Cell Significance Index: 2.8100 - Cell Name: keratocyte (CL0002363)
Fold Change: 0.0889
Cell Significance Index: 1.4100 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.0820
Cell Significance Index: 1.1900 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.0749
Cell Significance Index: 1.6400 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: 0.0466
Cell Significance Index: 0.7100 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0335
Cell Significance Index: 6.7200 - Cell Name: precursor B cell (CL0000817)
Fold Change: 0.0309
Cell Significance Index: 0.4000 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0216
Cell Significance Index: 40.7000 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0092
Cell Significance Index: 3.2900 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0046
Cell Significance Index: 8.4300 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0023
Cell Significance Index: 3.6100 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0020
Cell Significance Index: 2.6900 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0017
Cell Significance Index: 0.0500 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.0016
Cell Significance Index: 0.1100 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.0013
Cell Significance Index: 0.0300 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0002
Cell Significance Index: -0.0300 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0019
Cell Significance Index: -1.2000 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0021
Cell Significance Index: -1.1600 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0023
Cell Significance Index: -0.3300 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0026
Cell Significance Index: -0.0900 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0026
Cell Significance Index: -1.9300 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0039
Cell Significance Index: -1.7900 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0039
Cell Significance Index: -0.2400 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0042
Cell Significance Index: -2.3500 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0064
Cell Significance Index: -0.1600 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0065
Cell Significance Index: -1.8800 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0091
Cell Significance Index: -0.1300 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.0104
Cell Significance Index: -0.3300 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.0105
Cell Significance Index: -0.2100 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0115
Cell Significance Index: -2.4200 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0151
Cell Significance Index: -1.7300 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0163
Cell Significance Index: -2.2500 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0207
Cell Significance Index: -2.1600 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0215
Cell Significance Index: -1.3200 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0222
Cell Significance Index: -0.9800 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: -0.0230
Cell Significance Index: -0.3500 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0258
Cell Significance Index: -2.6400 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0262
Cell Significance Index: -1.2200 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0263
Cell Significance Index: -0.8600 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0283
Cell Significance Index: -0.9000 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0288
Cell Significance Index: -1.0900 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0309
Cell Significance Index: -0.6400 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0313
Cell Significance Index: -2.4000 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.0331
Cell Significance Index: -0.9800 - Cell Name: hippocampal interneuron (CL1001569)
Fold Change: -0.0332
Cell Significance Index: -0.4300 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: -0.0333
Cell Significance Index: -0.3200 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: -0.0365
Cell Significance Index: -0.2100 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0408
Cell Significance Index: -2.2900 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: -0.0417
Cell Significance Index: -0.3700 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0445
Cell Significance Index: -1.5600 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0446
Cell Significance Index: -1.2500 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.0455
Cell Significance Index: -1.6700 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0465
Cell Significance Index: -2.0200 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0474
Cell Significance Index: -1.2900 - Cell Name: neuron (CL0000540)
Fold Change: -0.0485
Cell Significance Index: -0.4600 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.0488
Cell Significance Index: -1.2200 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0494
Cell Significance Index: -2.3200 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0524
Cell Significance Index: -2.7300 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.0536
Cell Significance Index: -1.5300 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.0635
Cell Significance Index: -1.5500 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.0642
Cell Significance Index: -1.2700 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.0657
Cell Significance Index: -1.4200 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.0661
Cell Significance Index: -1.6500 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.0668
Cell Significance Index: -1.3600 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0720
Cell Significance Index: -1.8500 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0723
Cell Significance Index: -1.9300 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.0758
Cell Significance Index: -1.4800 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.0763
Cell Significance Index: -1.6200 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: -0.0778
Cell Significance Index: -0.6000 - Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
Fold Change: -0.0778
Cell Significance Index: -0.8000 - Cell Name: type II muscle cell (CL0002212)
Fold Change: -0.0781
Cell Significance Index: -1.2600 - Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
Fold Change: -0.0810
Cell Significance Index: -1.0800 - Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.0817
Cell Significance Index: -0.8900
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2965120475
Symbol: APOA_HUMAN
Name: Apolipoprotein(a)
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3670400
Title: cDNA sequence of human apolipoprotein(a) is homologous to plasminogen.
PubMed ID: 3670400
DOI: 10.1038/330132a0
PubMed ID: 14574404
Title: The DNA sequence and analysis of human chromosome 6.
PubMed ID: 14574404
DOI: 10.1038/nature02055
PubMed ID: 7848387
Title: Amplification of human APO(a) kringle 4-37 from blood lymphocyte DNA.
PubMed ID: 7848387
PubMed ID: 2531657
Title: Lipoprotein(a) binds to fibronectin and has serine proteinase activity capable of cleaving it.
PubMed ID: 2531657
PubMed ID: 2530631
PubMed ID: 11294842
Title: Structural elucidation of the N- and O-glycans of human apolipoprotein(a): role of o-glycans in conferring protease resistance.
PubMed ID: 11294842
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 8642595
Title: Crystal structures of apolipoprotein(a) kringle IV37 free and complexed with 6-aminohexanoic acid and with p-aminomethylbenzoic acid: existence of novel and expected binding modes.
PubMed ID: 8642595
PubMed ID: 7918682
Title: A single point mutation (Trp72-->Arg) in human apo(a) kringle 4-37 associated with a lysine binding defect in Lp(a).
PubMed ID: 7918682
Sequence Information:
- Length: 2040
- Mass: 226546
- Checksum: AC7D76CE0A0358CD
- Sequence:
MEHKEVVLLL LLFLKSAAPE QSHVVQDCYH GDGQSYRGTY STTVTGRTCQ AWSSMTPHQH NRTTENYPNA GLIMNYCRNP DAVAAPYCYT RDPGVRWEYC NLTQCSDAEG TAVAPPTVTP VPSLEAPSEQ APTEQRPGVQ ECYHGNGQSY RGTYSTTVTG RTCQAWSSMT PHSHSRTPEY YPNAGLIMNY CRNPDAVAAP YCYTRDPGVR WEYCNLTQCS DAEGTAVAPP TVTPVPSLEA PSEQAPTEQR PGVQECYHGN GQSYRGTYST TVTGRTCQAW SSMTPHSHSR TPEYYPNAGL IMNYCRNPDA VAAPYCYTRD PGVRWEYCNL TQCSDAEGTA VAPPTVTPVP SLEAPSEQAP TEQRPGVQEC YHGNGQSYRG TYSTTVTGRT CQAWSSMTPH SHSRTPEYYP NAGLIMNYCR NPDAVAAPYC YTRDPGVRWE YCNLTQCSDA EGTAVAPPTV TPVPSLEAPS EQAPTEQRPG VQECYHGNGQ SYRGTYSTTV TGRTCQAWSS MTPHSHSRTP EYYPNAGLIM NYCRNPDAVA APYCYTRDPG VRWEYCNLTQ CSDAEGTAVA PPTVTPVPSL EAPSEQAPTE QRPGVQECYH GNGQSYRGTY STTVTGRTCQ AWSSMTPHSH SRTPEYYPNA GLIMNYCRNP DAVAAPYCYT RDPGVRWEYC NLTQCSDAEG TAVAPPTVTP VPSLEAPSEQ APTEQRPGVQ ECYHGNGQSY RGTYSTTVTG RTCQAWSSMT PHSHSRTPEY YPNAGLIMNY CRNPDAVAAP YCYTRDPGVR WEYCNLTQCS DAEGTAVAPP TVTPVPSLEA PSEQAPTEQR PGVQECYHGN GQSYRGTYST TVTGRTCQAW SSMTPHSHSR TPEYYPNAGL IMNYCRNPDP VAAPYCYTRD PSVRWEYCNL TQCSDAEGTA VAPPTITPIP SLEAPSEQAP TEQRPGVQEC YHGNGQSYQG TYFITVTGRT CQAWSSMTPH SHSRTPAYYP NAGLIKNYCR NPDPVAAPWC YTTDPSVRWE YCNLTRCSDA EWTAFVPPNV ILAPSLEAFF EQALTEETPG VQDCYYHYGQ SYRGTYSTTV TGRTCQAWSS MTPHQHSRTP ENYPNAGLTR NYCRNPDAEI RPWCYTMDPS VRWEYCNLTQ CLVTESSVLA TLTVVPDPST EASSEEAPTE QSPGVQDCYH GDGQSYRGSF STTVTGRTCQ SWSSMTPHWH QRTTEYYPNG GLTRNYCRNP DAEISPWCYT MDPNVRWEYC NLTQCPVTES SVLATSTAVS EQAPTEQSPT VQDCYHGDGQ SYRGSFSTTV TGRTCQSWSS MTPHWHQRTT EYYPNGGLTR NYCRNPDAEI RPWCYTMDPS VRWEYCNLTQ CPVMESTLLT TPTVVPVPST ELPSEEAPTE NSTGVQDCYR GDGQSYRGTL STTITGRTCQ SWSSMTPHWH RRIPLYYPNA GLTRNYCRNP DAEIRPWCYT MDPSVRWEYC NLTRCPVTES SVLTTPTVAP VPSTEAPSEQ APPEKSPVVQ DCYHGDGRSY RGISSTTVTG RTCQSWSSMI PHWHQRTPEN YPNAGLTENY CRNPDSGKQP WCYTTDPCVR WEYCNLTQCS ETESGVLETP TVVPVPSMEA HSEAAPTEQT PVVRQCYHGN GQSYRGTFST TVTGRTCQSW SSMTPHRHQR TPENYPNDGL TMNYCRNPDA DTGPWCFTMD PSIRWEYCNL TRCSDTEGTV VAPPTVIQVP SLGPPSEQDC MFGNGKGYRG KKATTVTGTP CQEWAAQEPH RHSTFIPGTN KWAGLEKNYC RNPDGDINGP WCYTMNPRKL FDYCDIPLCA SSSFDCGKPQ VEPKKCPGSI VGGCVAHPHS WPWQVSLRTR FGKHFCGGTL ISPEWVLTAA HCLKKSSRPS SYKVILGAHQ EVNLESHVQE IEVSRLFLEP TQADIALLKL SRPAVITDKV MPACLPSPDY MVTARTECYI TGWGETQGTF GTGLLKEAQL LVIENEVCNH YKYICAEHLA RGTDSCQGDS GGPLVCFEKD KYILQGVTSW GLGCARPNKP GVYARVSRFV TWIEGMMRNN
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.