Details for: LPA

Gene ID: 4018

Symbol: LPA

Ensembl ID: ENSG00000198670

Description: lipoprotein(a)

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 3.77
    Marker Score: 3612
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 2.57
    Marker Score: 8226
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.42
    Marker Score: 2678
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2
    Marker Score: 1989
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.93
    Marker Score: 2150
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.74
    Marker Score: 2405
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1167
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.33
    Marker Score: 2513
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.31
    Marker Score: 7031
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.28
    Marker Score: 5513
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 853
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 1.24
    Marker Score: 2017
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.17
    Marker Score: 487
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4803
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 503
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.05
    Marker Score: 6753
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.01
    Marker Score: 2044
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71812.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48037
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 509
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.95
    Marker Score: 568
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 374
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5318
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.92
    Marker Score: 6121
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5280
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.85
    Marker Score: 493
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.8
    Marker Score: 846.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1261
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.77
    Marker Score: 12085
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 693
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.76
    Marker Score: 316
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.73
    Marker Score: 495
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 462
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.71
    Marker Score: 468.5
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.67
    Marker Score: 392
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.67
    Marker Score: 352
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.64
    Marker Score: 708
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.64
    Marker Score: 239.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.61
    Marker Score: 488
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.53
    Marker Score: 184
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.53
    Marker Score: 1726
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.52
    Marker Score: 248
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.48
    Marker Score: 1408.5
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.45
    Marker Score: 7954.5
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.44
    Marker Score: 470.5
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.36
    Marker Score: 136
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.33
    Marker Score: 1342
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.32
    Marker Score: 2694
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3
    Marker Score: 117
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3
    Marker Score: 1259
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.29
    Marker Score: 172.5
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.29
    Marker Score: 461
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.28
    Marker Score: 129
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.28
    Marker Score: 163.5
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.28
    Marker Score: 122
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.27
    Marker Score: 85
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.27
    Marker Score: 86
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.26
    Marker Score: 1089
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.25
    Marker Score: 583
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.25
    Marker Score: 110
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.22
    Marker Score: 758
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.2
    Marker Score: 111
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.19
    Marker Score: 7230
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.17
    Marker Score: 1429
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.16
    Marker Score: 51
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.16
    Marker Score: 329.5
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.16
    Marker Score: 32
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.15
    Marker Score: 90
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.15
    Marker Score: 548
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.15
    Marker Score: 85
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.15
    Marker Score: 32
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.14
    Marker Score: 76
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.14
    Marker Score: 51
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.14
    Marker Score: 107
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.13
    Marker Score: 127
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.13
    Marker Score: 77
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.13
    Marker Score: 38
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.13
    Marker Score: 127
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.13
    Marker Score: 34
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.12
    Marker Score: 35
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.12
    Marker Score: 37
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.12
    Marker Score: 321
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.12
    Marker Score: 38
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.12
    Marker Score: 35
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.12
    Marker Score: 48.5
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.12
    Marker Score: 1216
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.12
    Marker Score: 37
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.12
    Marker Score: 7073
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.11
    Marker Score: 198
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.11
    Marker Score: 29

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Other Information

**Key characteristics:** - LPA is a glycoprotein with a molecular weight of approximately 120 kDa. - It is expressed in many tissues, including the liver, heart, and peripheral tissues. - LPA is a glycoprotein that is involved in the assembly and secretion of HDL. - It is a key component of the high-density lipoprotein (HDL) particle, which is responsible for transporting cholesterol from the liver to peripheral tissues. **Pathways and functions:** - LPA is involved in the assembly and secretion of HDL. - HDL is a protein that is produced by the liver and transported to peripheral tissues. - HDL binds to low-density lipoprotein (LDL) particles, which carry cholesterol from the liver to peripheral tissues. - HDL then transports cholesterol to peripheral tissues, where it is deposited in cells. - LPA is also involved in the reverse cholesterol transport (RCT) pathway, which is responsible for removing cholesterol from peripheral tissues and transporting it to the liver. **Clinical significance:** - Mutations in the LPA gene have been linked to the development of a number of diseases, including atherosclerosis, heart disease, and stroke. - In atherosclerosis, mutations in the LPA gene can lead to the buildup of cholesterol in the arteries, which can cause plaque formation and eventually lead to heart disease and stroke. - LPA is a potential therapeutic target for the treatment of atherosclerosis and other cardiovascular diseases.

Genular Protein ID: 2965120475

Symbol: APOA_HUMAN

Name: Apolipoprotein(a)

UniProtKB Accession Codes:

P08519 Q5VTD7 Q9UD88

Database IDs:

AGR 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioMuta 1 CCDS 1 CDD 2 CPTAC 2 CTD 1 ChiTaRS 1 DMDM 1 DrugBank 3 EC 1 EMBL 3 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MEROPS 1 MIM 2 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 PANTHER 2 PDB 23 PDBsum 13 PIR 1 PRINTS 2 PRO 1 PROSITE 5 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3670400

Title: cDNA sequence of human apolipoprotein(a) is homologous to plasminogen.

PubMed ID: 3670400

DOI: 10.1038/330132a0

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 7848387

Title: Amplification of human APO(a) kringle 4-37 from blood lymphocyte DNA.

PubMed ID: 7848387

DOI: 10.1016/0925-4439(93)90130-s

PubMed ID: 2531657

Title: Lipoprotein(a) binds to fibronectin and has serine proteinase activity capable of cleaving it.

PubMed ID: 2531657

DOI: 10.1002/j.1460-2075.1989.tb08586.x

PubMed ID: 2530631

Title: The mysteries of lipoprotein(a).

PubMed ID: 2530631

DOI: 10.1126/science.2530631

PubMed ID: 11294842

Title: Structural elucidation of the N- and O-glycans of human apolipoprotein(a): role of o-glycans in conferring protease resistance.

PubMed ID: 11294842

DOI: 10.1074/jbc.m102150200

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 8642595

Title: Crystal structures of apolipoprotein(a) kringle IV37 free and complexed with 6-aminohexanoic acid and with p-aminomethylbenzoic acid: existence of novel and expected binding modes.

PubMed ID: 8642595

DOI: 10.1006/jmbi.1996.0122

PubMed ID: 7918682

Title: A single point mutation (Trp72-->Arg) in human apo(a) kringle 4-37 associated with a lysine binding defect in Lp(a).

PubMed ID: 7918682

DOI: 10.1016/0925-4439(94)90104-x

Sequence Information:

  • Length: 2040
  • Mass: 226546
  • Checksum: AC7D76CE0A0358CD
  • Sequence:
    • MEHKEVVLLL LLFLKSAAPE QSHVVQDCYH GDGQSYRGTY STTVTGRTCQ AWSSMTPHQH 
NRTTENYPNA GLIMNYCRNP DAVAAPYCYT RDPGVRWEYC NLTQCSDAEG TAVAPPTVTP 
VPSLEAPSEQ APTEQRPGVQ ECYHGNGQSY RGTYSTTVTG RTCQAWSSMT PHSHSRTPEY 
YPNAGLIMNY CRNPDAVAAP YCYTRDPGVR WEYCNLTQCS DAEGTAVAPP TVTPVPSLEA 
PSEQAPTEQR PGVQECYHGN GQSYRGTYST TVTGRTCQAW SSMTPHSHSR TPEYYPNAGL 
IMNYCRNPDA VAAPYCYTRD PGVRWEYCNL TQCSDAEGTA VAPPTVTPVP SLEAPSEQAP 
TEQRPGVQEC YHGNGQSYRG TYSTTVTGRT CQAWSSMTPH SHSRTPEYYP NAGLIMNYCR 
NPDAVAAPYC YTRDPGVRWE YCNLTQCSDA EGTAVAPPTV TPVPSLEAPS EQAPTEQRPG 
VQECYHGNGQ SYRGTYSTTV TGRTCQAWSS MTPHSHSRTP EYYPNAGLIM NYCRNPDAVA 
APYCYTRDPG VRWEYCNLTQ CSDAEGTAVA PPTVTPVPSL EAPSEQAPTE QRPGVQECYH 
GNGQSYRGTY STTVTGRTCQ AWSSMTPHSH SRTPEYYPNA GLIMNYCRNP DAVAAPYCYT 
RDPGVRWEYC NLTQCSDAEG TAVAPPTVTP VPSLEAPSEQ APTEQRPGVQ ECYHGNGQSY 
RGTYSTTVTG RTCQAWSSMT PHSHSRTPEY YPNAGLIMNY CRNPDAVAAP YCYTRDPGVR 
WEYCNLTQCS DAEGTAVAPP TVTPVPSLEA PSEQAPTEQR PGVQECYHGN GQSYRGTYST 
TVTGRTCQAW SSMTPHSHSR TPEYYPNAGL IMNYCRNPDP VAAPYCYTRD PSVRWEYCNL 
TQCSDAEGTA VAPPTITPIP SLEAPSEQAP TEQRPGVQEC YHGNGQSYQG TYFITVTGRT 
CQAWSSMTPH SHSRTPAYYP NAGLIKNYCR NPDPVAAPWC YTTDPSVRWE YCNLTRCSDA 
EWTAFVPPNV ILAPSLEAFF EQALTEETPG VQDCYYHYGQ SYRGTYSTTV TGRTCQAWSS 
MTPHQHSRTP ENYPNAGLTR NYCRNPDAEI RPWCYTMDPS VRWEYCNLTQ CLVTESSVLA 
TLTVVPDPST EASSEEAPTE QSPGVQDCYH GDGQSYRGSF STTVTGRTCQ SWSSMTPHWH 
QRTTEYYPNG GLTRNYCRNP DAEISPWCYT MDPNVRWEYC NLTQCPVTES SVLATSTAVS 
EQAPTEQSPT VQDCYHGDGQ SYRGSFSTTV TGRTCQSWSS MTPHWHQRTT EYYPNGGLTR 
NYCRNPDAEI RPWCYTMDPS VRWEYCNLTQ CPVMESTLLT TPTVVPVPST ELPSEEAPTE 
NSTGVQDCYR GDGQSYRGTL STTITGRTCQ SWSSMTPHWH RRIPLYYPNA GLTRNYCRNP 
DAEIRPWCYT MDPSVRWEYC NLTRCPVTES SVLTTPTVAP VPSTEAPSEQ APPEKSPVVQ 
DCYHGDGRSY RGISSTTVTG RTCQSWSSMI PHWHQRTPEN YPNAGLTENY CRNPDSGKQP 
WCYTTDPCVR WEYCNLTQCS ETESGVLETP TVVPVPSMEA HSEAAPTEQT PVVRQCYHGN 
GQSYRGTFST TVTGRTCQSW SSMTPHRHQR TPENYPNDGL TMNYCRNPDA DTGPWCFTMD 
PSIRWEYCNL TRCSDTEGTV VAPPTVIQVP SLGPPSEQDC MFGNGKGYRG KKATTVTGTP 
CQEWAAQEPH RHSTFIPGTN KWAGLEKNYC RNPDGDINGP WCYTMNPRKL FDYCDIPLCA 
SSSFDCGKPQ VEPKKCPGSI VGGCVAHPHS WPWQVSLRTR FGKHFCGGTL ISPEWVLTAA 
HCLKKSSRPS SYKVILGAHQ EVNLESHVQE IEVSRLFLEP TQADIALLKL SRPAVITDKV 
MPACLPSPDY MVTARTECYI TGWGETQGTF GTGLLKEAQL LVIENEVCNH YKYICAEHLA 
RGTDSCQGDS GGPLVCFEKD KYILQGVTSW GLGCARPNKP GVYARVSRFV TWIEGMMRNN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.