Details for: MYOD1

Gene ID: 4654

Symbol: MYOD1

Ensembl ID: ENSG00000129152

Description: myogenic differentiation 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 3.7709
    Cell Significance Index: 64.4600
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 2.6562
    Cell Significance Index: 34.3700
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 2.6226
    Cell Significance Index: 27.8600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 2.4772
    Cell Significance Index: 26.9300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.1472
    Cell Significance Index: 27.9900
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.8863
    Cell Significance Index: 14.3000
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.1178
    Cell Significance Index: 1.2300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0970
    Cell Significance Index: 1.5000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0192
    Cell Significance Index: -6.8800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0327
    Cell Significance Index: -6.4900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0337
    Cell Significance Index: -6.7600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0354
    Cell Significance Index: -0.9100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0506
    Cell Significance Index: -1.0600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0536
    Cell Significance Index: -0.7400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0634
    Cell Significance Index: -2.2200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0637
    Cell Significance Index: -6.5100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0704
    Cell Significance Index: -1.1400
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0834
    Cell Significance Index: -0.9600
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.1145
    Cell Significance Index: -1.3200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1299
    Cell Significance Index: -3.3100
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.1365
    Cell Significance Index: -1.4800
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.1433
    Cell Significance Index: -1.7400
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.1466
    Cell Significance Index: -1.6600
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.1624
    Cell Significance Index: -2.0800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1654
    Cell Significance Index: -8.6900
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1689
    Cell Significance Index: -2.4700
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.1698
    Cell Significance Index: -1.7200
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1700
    Cell Significance Index: -2.0000
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.1701
    Cell Significance Index: -1.6500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1735
    Cell Significance Index: -6.0300
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -0.2056
    Cell Significance Index: -2.1700
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.2076
    Cell Significance Index: -2.4800
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: -0.2077
    Cell Significance Index: -1.6500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2127
    Cell Significance Index: -6.9700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2197
    Cell Significance Index: -6.4700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.2212
    Cell Significance Index: -1.7100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2228
    Cell Significance Index: -5.9700
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.2230
    Cell Significance Index: -2.1500
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.2398
    Cell Significance Index: -2.1300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2434
    Cell Significance Index: -6.4000
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.2499
    Cell Significance Index: -2.4800
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.2547
    Cell Significance Index: -1.5600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2606
    Cell Significance Index: -6.5000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2626
    Cell Significance Index: -3.7600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2628
    Cell Significance Index: -8.3700
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.2727
    Cell Significance Index: -4.0800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2795
    Cell Significance Index: -1.8900
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.2920
    Cell Significance Index: -3.6900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2937
    Cell Significance Index: -4.9200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.2949
    Cell Significance Index: -5.8800
  • Cell Name: peridermal cell (CL0000078)
    Fold Change: -0.3046
    Cell Significance Index: -1.9000
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.3049
    Cell Significance Index: -1.7900
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.3054
    Cell Significance Index: -4.0000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3078
    Cell Significance Index: -6.7400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3093
    Cell Significance Index: -8.2600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3198
    Cell Significance Index: -6.9100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3228
    Cell Significance Index: -6.4800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.3389
    Cell Significance Index: -4.9200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3414
    Cell Significance Index: -7.2500
  • Cell Name: reticulocyte (CL0000558)
    Fold Change: -0.3465
    Cell Significance Index: -1.8200
  • Cell Name: articular chondrocyte (CL1001607)
    Fold Change: -0.3490
    Cell Significance Index: -1.8900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3545
    Cell Significance Index: -7.0100
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.3740
    Cell Significance Index: -4.9700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4219
    Cell Significance Index: -12.0400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.4260
    Cell Significance Index: -5.0300
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.4323
    Cell Significance Index: -4.5600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.4727
    Cell Significance Index: -7.9500
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.4816
    Cell Significance Index: -6.6800
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.4875
    Cell Significance Index: -4.7900
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.4936
    Cell Significance Index: -6.5800
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -0.4989
    Cell Significance Index: -5.7200
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.5052
    Cell Significance Index: -6.4900
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.5067
    Cell Significance Index: -5.7100
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: -0.5152
    Cell Significance Index: -6.0200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.5154
    Cell Significance Index: -6.6000
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.5177
    Cell Significance Index: -4.4000
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.5298
    Cell Significance Index: -6.2900
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.5383
    Cell Significance Index: -6.7200
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: -0.5528
    Cell Significance Index: -6.0900
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.5593
    Cell Significance Index: -6.7800
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.5604
    Cell Significance Index: -7.6200
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.5668
    Cell Significance Index: -6.2500
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.5735
    Cell Significance Index: -6.6000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.5814
    Cell Significance Index: -7.6300
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.5822
    Cell Significance Index: -5.5300
  • Cell Name: hypertrophic chondrocyte (CL0000743)
    Fold Change: -0.5842
    Cell Significance Index: -1.8100
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.5854
    Cell Significance Index: -7.6400
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.5881
    Cell Significance Index: -8.0000
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.5906
    Cell Significance Index: -7.9700
  • Cell Name: podocyte (CL0000653)
    Fold Change: -0.5937
    Cell Significance Index: -6.8100
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.5937
    Cell Significance Index: -7.9200
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.5949
    Cell Significance Index: -7.4500
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.5979
    Cell Significance Index: -6.7900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.6023
    Cell Significance Index: -7.6000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.6103
    Cell Significance Index: -9.0100
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.6152
    Cell Significance Index: -6.8300
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.6266
    Cell Significance Index: -7.2800
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.6423
    Cell Significance Index: -6.8100
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.6450
    Cell Significance Index: -6.2400
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.6466
    Cell Significance Index: -6.6700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** * MYOD1 is a member of the basic helix-loop-helix (bHLH) transcription factor family. * It is highly expressed in muscle cells, particularly during embryonic development and in adult skeletal muscle tissue. * MYOD1 is a potent transcriptional activator that regulates the expression of muscle-specific genes. * It interacts with other transcription factors, such as MRF4 and Myf5, to coordinate the myogenic program. * MYOD1 is also involved in the regulation of alternative splicing and RNA polymerase II-specific transcription. **Pathways and Functions:** * MYOD1 is involved in the regulation of cellular responses to various stimuli, including estradiol, glucocorticoids, oxygen levels, starvation, and tumor necrosis factor. * It plays a crucial role in the development and differentiation of skeletal muscle tissue, regulating the expression of muscle-specific genes and promoting myotube differentiation. * MYOD1 is also involved in the regulation of muscle cell proliferation and differentiation, with negative regulatory effects on myoblast proliferation. * It interacts with other transcription factors to regulate the expression of genes involved in muscle fiber development and adaptation. * MYOD1 is also implicated in the regulation of immune cell development, including the differentiation of monocytes, dendritic cells, and megakaryocytes. **Clinical Significance:** * MYOD1 mutations have been associated with muscular dystrophy and other myopathies, highlighting the importance of MYOD1 in muscle development and function. * Alterations in MYOD1 expression have been linked to various diseases, including cancer, where it can act as a tumor suppressor or oncogene. * Understanding the role of MYOD1 in muscle cell differentiation and development has implications for the development of novel therapeutic strategies for muscle-related disorders. * MYOD1 may also play a role in the regulation of immune responses, with potential implications for the treatment of autoimmune diseases. **Conclusion:** MYOD1 is a critical transcription factor that regulates muscle cell differentiation, development, and regeneration. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the molecular mechanisms underlying MYOD1 function. Further studies are required to fully elucidate the role of MYOD1 in human health and disease, and to explore its potential as a therapeutic target for the treatment of muscle-related disorders.

Genular Protein ID: 1288431564

Symbol: MYOD1_HUMAN

Name: Myoblast determination protein 1

UniProtKB Accession Codes:

P15172 O75321

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 GO 49 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1850513

Title: Human MyoD: cDNA and deduced amino acid sequence.

PubMed ID: 1850513

DOI: 10.1093/nar/19.5.1148

PubMed ID: 9546368

Title: Methylation alterations of the MyoD1 upstream region are predictive of subclassification of human rhabdomyosarcomas.

PubMed ID: 9546368

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2583111

Title: Differential expression of myogenic determination genes in muscle cells: possible autoactivation by the Myf gene products.

PubMed ID: 2583111

DOI: 10.1002/j.1460-2075.1989.tb08535.x

PubMed ID: 9774340

Title: A novel site for ubiquitination: the N-terminal residue, and not internal lysines of MyoD, is essential for conjugation and degradation of the protein.

PubMed ID: 9774340

DOI: 10.1093/emboj/17.20.5964

PubMed ID: 11532390

Title: Control of muscle development by dueling HATs and HDACs.

PubMed ID: 11532390

DOI: 10.1016/s0959-437x(00)00224-0

PubMed ID: 12037670

Title: Activation of MyoD-dependent transcription by cdk9/cyclin T2.

PubMed ID: 12037670

DOI: 10.1038/sj.onc.1205493

PubMed ID: 16858404

Title: Histone methyltransferase Suv39h1 represses MyoD-stimulated myogenic differentiation.

PubMed ID: 16858404

DOI: 10.1038/sj.emboj.7601229

PubMed ID: 22215600

Title: Lysine methyltransferase G9a methylates the transcription factor MyoD and regulates skeletal muscle differentiation.

PubMed ID: 22215600

DOI: 10.1073/pnas.1111628109

PubMed ID: 24860983

Title: Muscle lim protein isoform negatively regulates striated muscle actin dynamics and differentiation.

PubMed ID: 24860983

DOI: 10.1111/febs.12859

PubMed ID: 26733463

Title: Deficiency of the myogenic factor MyoD causes a perinatally lethal fetal akinesia.

PubMed ID: 26733463

DOI: 10.1136/jmedgenet-2015-103620

PubMed ID: 31260566

Title: A novel bi-allelic loss-of-function variant in MYOD1: Further evidence for gene-disease association and phenotypic variability in MYOD1-related myopathy.

PubMed ID: 31260566

DOI: 10.1111/cge.13596

PubMed ID: 30403323

Title: MYOD1 involvement in myopathy.

PubMed ID: 30403323

DOI: 10.1111/ene.13782

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 320
  • Mass: 34501
  • Checksum: 75E624D2ED5B0B33
  • Sequence:
    • MELLSPPLRD VDLTAPDGSL CSFATTDDFY DDPCFDSPDL RFFEDLDPRL MHVGALLKPE 
EHSHFPAAVH PAPGAREDEH VRAPSGHHQA GRCLLWACKA CKRKTTNADR RKAATMRERR 
RLSKVNEAFE TLKRCTSSNP NQRLPKVEIL RNAIRYIEGL QALLRDQDAA PPGAAAAFYA 
PGPLPPGRGG EHYSGDSDAS SPRSNCSDGM MDYSGPPSGA RRRNCYEGAY YNEAPSEPRP 
GKSAAVSSLD CLSSIVERIS TESPAAPALL LADVPSESPP RRQEAAAPSE GESSGDPTQS 
PDAAPQCPAG ANPNPIYQVL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.