Details for: NPY

Gene ID: 4852

Symbol: NPY

Ensembl ID: ENSG00000122585

Description: neuropeptide Y

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 62.6184
    Cell Significance Index: -9.7400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 38.4398
    Cell Significance Index: -9.7500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 29.1687
    Cell Significance Index: -11.8500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 28.4259
    Cell Significance Index: -11.7100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 21.0006
    Cell Significance Index: 552.2100
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 12.4621
    Cell Significance Index: 60.6100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 7.8997
    Cell Significance Index: -9.7400
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.8852
    Cell Significance Index: 34.3000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.7178
    Cell Significance Index: 166.6300
  • Cell Name: obsolete somatic cell (CL0002371)
    Fold Change: 1.4906
    Cell Significance Index: 11.2900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.3358
    Cell Significance Index: 33.3100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.2085
    Cell Significance Index: 26.1800
  • Cell Name: sst chodl GABAergic cortical interneuron (CL4023121)
    Fold Change: 1.2037
    Cell Significance Index: 8.4400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1568
    Cell Significance Index: 52.4400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.9702
    Cell Significance Index: 23.5000
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.9691
    Cell Significance Index: 12.2800
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.8813
    Cell Significance Index: 9.1200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.7863
    Cell Significance Index: 10.0700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7823
    Cell Significance Index: 148.8900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6260
    Cell Significance Index: 61.9300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.6160
    Cell Significance Index: 37.8600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.5992
    Cell Significance Index: 9.2700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4849
    Cell Significance Index: 437.8300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4361
    Cell Significance Index: 70.9400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4225
    Cell Significance Index: 27.2600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.2602
    Cell Significance Index: 6.2400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2206
    Cell Significance Index: 24.0000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1970
    Cell Significance Index: 4.2000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1890
    Cell Significance Index: 130.7100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0721
    Cell Significance Index: 4.9900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0550
    Cell Significance Index: 34.3500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0447
    Cell Significance Index: 2.6900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0359
    Cell Significance Index: 0.6000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0236
    Cell Significance Index: 0.5900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.0177
    Cell Significance Index: 10.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0118
    Cell Significance Index: 2.3700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.0048
    Cell Significance Index: 1.0200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0034
    Cell Significance Index: 0.1200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0005
    Cell Significance Index: 0.3800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0043
    Cell Significance Index: -1.5600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0047
    Cell Significance Index: -0.1400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0054
    Cell Significance Index: -10.1600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0059
    Cell Significance Index: -0.2500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0067
    Cell Significance Index: -12.3700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0078
    Cell Significance Index: -12.0800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0088
    Cell Significance Index: -11.9400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0128
    Cell Significance Index: -9.7100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0163
    Cell Significance Index: -8.9200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0180
    Cell Significance Index: -3.0800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0233
    Cell Significance Index: -6.6900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0268
    Cell Significance Index: -12.1700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0325
    Cell Significance Index: -4.1700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0417
    Cell Significance Index: -2.1900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0478
    Cell Significance Index: -1.5300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0536
    Cell Significance Index: -1.0600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0544
    Cell Significance Index: -10.7900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0639
    Cell Significance Index: -7.2900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0714
    Cell Significance Index: -9.8100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0798
    Cell Significance Index: -1.6600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0798
    Cell Significance Index: -9.1400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0831
    Cell Significance Index: -12.0800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0930
    Cell Significance Index: -12.0100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0947
    Cell Significance Index: -11.1700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1228
    Cell Significance Index: -8.2600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1279
    Cell Significance Index: -4.0500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1636
    Cell Significance Index: -12.1900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1779
    Cell Significance Index: -4.7600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1838
    Cell Significance Index: -2.2800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1860
    Cell Significance Index: -10.4400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1904
    Cell Significance Index: -2.0700
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.2020
    Cell Significance Index: -2.6200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2109
    Cell Significance Index: -9.3300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2236
    Cell Significance Index: -4.6800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2269
    Cell Significance Index: -7.4300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2285
    Cell Significance Index: -11.9000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2314
    Cell Significance Index: -7.3700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2469
    Cell Significance Index: -9.3500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2491
    Cell Significance Index: -8.7300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2499
    Cell Significance Index: -11.7500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2619
    Cell Significance Index: -12.2100
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.2966
    Cell Significance Index: -3.0600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3163
    Cell Significance Index: -10.9900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.3272
    Cell Significance Index: -4.7500
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.3324
    Cell Significance Index: -3.4700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3391
    Cell Significance Index: -3.5100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3423
    Cell Significance Index: -9.1400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3434
    Cell Significance Index: -12.6100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3462
    Cell Significance Index: -9.8800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3579
    Cell Significance Index: -5.1300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3670
    Cell Significance Index: -7.7900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3687
    Cell Significance Index: -9.8800
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.3696
    Cell Significance Index: -7.5200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3707
    Cell Significance Index: -8.0100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.3805
    Cell Significance Index: -7.4400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3930
    Cell Significance Index: -7.8900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3962
    Cell Significance Index: -11.6700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4029
    Cell Significance Index: -10.0500
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.4058
    Cell Significance Index: -5.0200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.4073
    Cell Significance Index: -8.5000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4153
    Cell Significance Index: -10.6100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** NPY is characterized by its ability to regulate a wide range of physiological processes, including: 1. **Feeding behavior**: NPY is known to stimulate appetite and promote food intake, making it a key regulator of energy homeostasis. 2. **Blood pressure regulation**: NPY has a vasoconstrictive effect, which helps to regulate blood pressure and maintain cardiovascular homeostasis. 3. **Synaptic transmission**: NPY acts as a neurotransmitter at the synapse, modulating the release of other neurotransmitters, such as dopamine and serotonin. 4. **Neurodevelopment**: NPY is involved in the development and maturation of neurons, particularly in the cerebral cortex and hippocampus. **Pathways and Functions** NPY's signaling pathways involve a complex interplay of GPCRs, cyclic nucleotide second messengers, and other signaling molecules. The main pathways involved in NPY signaling include: 1. **G protein-coupled receptor signaling**: NPY binds to GPCRs, which activate G proteins and trigger a cascade of downstream signaling events. 2. **Cyclic nucleotide second messenger signaling**: NPY stimulates the production of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), which in turn modulate various cellular processes. 3. **Foxo-mediated transcription**: NPY activates the transcription factor Foxo, which regulates the expression of genes involved in metabolism, oxidative stress, and neuronal function. **Clinical Significance** NPY has been implicated in various diseases, including: 1. **Obesity**: NPY's role in regulating appetite and energy homeostasis makes it a potential target for the treatment of obesity. 2. **Hypertension**: NPY's vasoconstrictive effects may contribute to the development of hypertension, making it a potential therapeutic target. 3. **Neurodegenerative diseases**: NPY's involvement in neurodevelopment and synaptic transmission suggests its potential role in neurodegenerative diseases, such as Alzheimer's and Parkinson's. 4. **Cancer**: NPY has been shown to regulate tumor growth and metastasis, making it a potential target for cancer therapy. In conclusion, NPY is a complex peptide that plays a crucial role in various physiological processes, including feeding behavior, blood pressure regulation, and synaptic transmission. Its signaling pathways involve a complex interplay of GPCRs, cyclic nucleotide second messengers, and other signaling molecules. Understanding NPY's mechanisms of action and its clinical significance can provide new insights into the treatment of various diseases and disorders.

Genular Protein ID: 2745982570

Symbol: NPY_HUMAN

Name: Pro-neuropeptide Y

UniProtKB Accession Codes:

P01303

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 5 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EMBL 7 EMDB 4 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 6589611

Title: Cloning, characterization, and DNA sequence of a human cDNA encoding neuropeptide tyrosine.

PubMed ID: 6589611

DOI: 10.1073/pnas.81.14.4577

PubMed ID: 2427515

Title: Characterization, sequence, and expression of the cloned human neuropeptide Y gene.

PubMed ID: 2427515

DOI: 10.1016/s0021-9258(18)67189-3

PubMed ID: 3753985

Title: Genes encoding pancreatic polypeptide and neuropeptide Y are on human chromosomes 17 and 7.

PubMed ID: 3753985

DOI: 10.1172/jci112357

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3839058

Title: Presence of the predicted C-flanking peptide of neuropeptide Y (CPON) in tissue extracts.

PubMed ID: 3839058

DOI: 10.1016/0143-4179(85)90100-3

PubMed ID: 21314817

Title: Neuropeptide Y, B-type natriuretic peptide, substance P and peptide YY are novel substrates of fibroblast activation protein-alpha.

PubMed ID: 21314817

DOI: 10.1111/j.1742-4658.2011.08051.x

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 1425680

Title: Solution conformation of human neuropeptide Y by 1H nuclear magnetic resonance and restrained molecular dynamics.

PubMed ID: 1425680

DOI: 10.1111/j.1432-1033.1992.tb17346.x

PubMed ID: 9008359

Title: Solution structure of human neuropeptide Y.

PubMed ID: 9008359

DOI: 10.1007/bf00228141

PubMed ID: 10561544

Title: Helical structure and self-association in a 13 residue neuropeptide Y Y2 receptor agonist: relationship to biological activity.

PubMed ID: 10561544

DOI: 10.1016/s0167-4838(99)00214-9

Sequence Information:

  • Length: 97
  • Mass: 10851
  • Checksum: 832CF124321718F2
  • Sequence:
    • MLGNKRLGLS GLTLALSLLV CLGALAEAYP SKPDNPGEDA PAEDMARYYS ALRHYINLIT 
RQRYGKRSSP ETLISDLLMR ESTENVPRTR LEDPAMW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.