Details for: NPY2R

Gene ID: 4887

Symbol: NPY2R

Ensembl ID: ENSG00000185149

Description: neuropeptide Y receptor Y2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.8049
    Cell Significance Index: 28.6400
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.2941
    Cell Significance Index: 3.2400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1667
    Cell Significance Index: 11.2100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0906
    Cell Significance Index: 62.6800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0254
    Cell Significance Index: 5.1000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0212
    Cell Significance Index: 1.5800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0140
    Cell Significance Index: 0.8800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0089
    Cell Significance Index: -3.1800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0105
    Cell Significance Index: -3.0300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0341
    Cell Significance Index: -4.4100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0347
    Cell Significance Index: -1.1400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0477
    Cell Significance Index: -5.4600
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0495
    Cell Significance Index: -0.4900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0687
    Cell Significance Index: -4.2200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0696
    Cell Significance Index: -1.9900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0743
    Cell Significance Index: -3.3700
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0784
    Cell Significance Index: -1.1000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0792
    Cell Significance Index: -3.7200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0840
    Cell Significance Index: -1.0600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0854
    Cell Significance Index: -3.9800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0861
    Cell Significance Index: -1.2900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0868
    Cell Significance Index: -4.8700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1030
    Cell Significance Index: -3.2800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1110
    Cell Significance Index: -3.8900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1472
    Cell Significance Index: -4.2200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1525
    Cell Significance Index: -4.0100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1579
    Cell Significance Index: -1.7200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1605
    Cell Significance Index: -2.2800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1670
    Cell Significance Index: -4.9200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1754
    Cell Significance Index: -4.4700
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1754
    Cell Significance Index: -3.5700
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.1783
    Cell Significance Index: -2.0800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1879
    Cell Significance Index: -5.0400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1986
    Cell Significance Index: -4.9600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1998
    Cell Significance Index: -3.9500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2064
    Cell Significance Index: -4.3200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2066
    Cell Significance Index: -5.1600
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.2086
    Cell Significance Index: -2.4200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2110
    Cell Significance Index: -5.0600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2118
    Cell Significance Index: -3.6200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2122
    Cell Significance Index: -5.1400
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.2141
    Cell Significance Index: -2.7500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2154
    Cell Significance Index: -4.6100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.2164
    Cell Significance Index: -2.8300
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.2165
    Cell Significance Index: -2.0600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2169
    Cell Significance Index: -3.6300
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.2171
    Cell Significance Index: -2.9300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2220
    Cell Significance Index: -4.8600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2263
    Cell Significance Index: -4.8900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2285
    Cell Significance Index: -4.7700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2323
    Cell Significance Index: -4.9300
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.2345
    Cell Significance Index: -3.0200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.2472
    Cell Significance Index: -4.9300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.2479
    Cell Significance Index: -2.3500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2495
    Cell Significance Index: -5.0100
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: -0.2563
    Cell Significance Index: -2.4200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.2576
    Cell Significance Index: -5.0700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2578
    Cell Significance Index: -5.0400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2580
    Cell Significance Index: -4.5600
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.2609
    Cell Significance Index: -2.8900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2644
    Cell Significance Index: -5.1600
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.2802
    Cell Significance Index: -2.8900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.2820
    Cell Significance Index: -3.5000
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.2825
    Cell Significance Index: -3.4100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2834
    Cell Significance Index: -4.9000
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.2873
    Cell Significance Index: -3.6400
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.2895
    Cell Significance Index: -4.2200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2940
    Cell Significance Index: -4.2100
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.2948
    Cell Significance Index: -4.7400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2979
    Cell Significance Index: -5.0100
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2991
    Cell Significance Index: -5.0800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3035
    Cell Significance Index: -4.4800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.3048
    Cell Significance Index: -4.6300
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.3073
    Cell Significance Index: -3.5700
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.3095
    Cell Significance Index: -4.2100
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.3125
    Cell Significance Index: -4.2500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3143
    Cell Significance Index: -5.3000
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.3172
    Cell Significance Index: -3.2900
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.3189
    Cell Significance Index: -4.3000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.3316
    Cell Significance Index: -5.3700
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.3353
    Cell Significance Index: -4.7000
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.3414
    Cell Significance Index: -3.7800
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.3419
    Cell Significance Index: -4.2900
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.3421
    Cell Significance Index: -4.5600
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.3462
    Cell Significance Index: -5.1800
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.3525
    Cell Significance Index: -4.1900
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.3558
    Cell Significance Index: -3.8100
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.3566
    Cell Significance Index: -4.6800
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: -0.3567
    Cell Significance Index: -3.9900
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.3597
    Cell Significance Index: -4.9400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.3620
    Cell Significance Index: -5.6000
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.3633
    Cell Significance Index: -5.0800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3633
    Cell Significance Index: -4.5300
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: -0.3640
    Cell Significance Index: -3.9300
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.3641
    Cell Significance Index: -5.0500
  • Cell Name: sst chodl GABAergic cortical interneuron (CL4023121)
    Fold Change: -0.3665
    Cell Significance Index: -2.5700
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.3681
    Cell Significance Index: -5.1700
  • Cell Name: diffuse bipolar 2 cell (CL4033028)
    Fold Change: -0.3684
    Cell Significance Index: -4.5300
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.3692
    Cell Significance Index: -4.6600
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.3699
    Cell Significance Index: -4.6800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **G protein-coupled receptor (GPCR) structure**: NPY2R belongs to the class A/1 (rhodopsin-like) receptors, characterized by a seven-transmembrane domain structure and the ability to activate G proteins. 2. **Neuropeptide Y (NPY) ligand binding**: NPY2R is a high-affinity receptor for NPY, a peptide hormone involved in various physiological processes, including cardiovascular regulation, anxiety, and stress responses. 3. **Adenylate cyclase inhibition**: Activation of NPY2R leads to the inhibition of adenylate cyclase, resulting in decreased cAMP levels and reduced downstream signaling. 4. **Calcium channel regulation**: NPY2R also modulates calcium channel activity, influencing intracellular calcium levels and cellular excitability. 5. **Expression in multiple cell types**: NPY2R is expressed in various cell types, including endothelial cells, goblet cells, and neurons, highlighting its diverse roles in different tissues. **Pathways and Functions:** 1. **Cardiovascular regulation**: NPY2R plays a crucial role in regulating cardiovascular function, including blood pressure, cardiac output, and vascular tone. 2. **Neurotransmission**: NPY2R is involved in neuronal signaling, modulating neurotransmitter release and synaptic plasticity. 3. **Immune responses**: NPY2R modulates immune responses, influencing the activity of immune cells and the production of cytokines. 4. **Neuroinflammation**: NPY2R is involved in neuroinflammation, regulating the production of pro-inflammatory cytokines and the activation of microglia. 5. **Cancer progression**: NPY2R is overexpressed in various cancers, including colon cancer, and may contribute to cancer progression and metastasis. **Clinical Significance:** 1. **Cardiovascular diseases**: NPY2R has been implicated in cardiovascular diseases, including hypertension, heart failure, and cardiac arrhythmias. 2. **Neurological disorders**: NPY2R is involved in neurological disorders, including anxiety, depression, and neuroinflammation. 3. **Cancer therapy**: NPY2R is a potential therapeutic target for cancer treatment, particularly in colon cancer. 4. **Neuroprotection**: NPY2R may play a role in neuroprotection, regulating neuronal survival and excitability. In conclusion, the Neuropeptide Y2 Receptor is a multifaceted immunomodulator with implications for cardiovascular and neurological diseases. Further research is needed to fully elucidate the signaling pathways and clinical significance of NPY2R, but its potential as a therapeutic target is promising.

Genular Protein ID: 1589748231

Symbol: NPY2R_HUMAN

Name: Neuropeptide Y receptor type 2

UniProtKB Accession Codes:

P49146 Q13281 Q13457 Q4W5G7 Q6AZZ6 Q9UE67

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EMBL 11 EMDB 3 Ensembl 2 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7592910

Title: Expression cloning and pharmacological characterization of a human hippocampal neuropeptide Y/peptide YY Y2 receptor subtype.

PubMed ID: 7592910

DOI: 10.1074/jbc.270.45.26758

PubMed ID: 8632753

Title: Expression cloning of a human brain neuropeptide Y Y2 receptor.

PubMed ID: 8632753

PubMed ID: 7559383

Title: Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor.

PubMed ID: 7559383

DOI: 10.1074/jbc.270.39.22661

PubMed ID: 8643460

Title: Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors.

PubMed ID: 8643460

DOI: 10.1073/pnas.93.10.4661

PubMed ID: 8975716

Title: Characterization of the human type 2 neuropeptide Y receptor gene (NPY2R) and localization to the chromosome 4q region containing the type 1 neuropeptide Y receptor gene.

PubMed ID: 8975716

DOI: 10.1006/geno.1996.0642

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 381
  • Mass: 42731
  • Checksum: 7D018C0169597BC7
  • Sequence:
    • MGPIGAEADE NQTVEEMKVE QYGPQTTPRG ELVPDPEPEL IDSTKLIEVQ VVLILAYCSI 
ILLGVIGNSL VIHVVIKFKS MRTVTNFFIA NLAVADLLVN TLCLPFTLTY TLMGEWKMGP 
VLCHLVPYAQ GLAVQVSTIT LTVIALDRHR CIVYHLESKI SKRISFLIIG LAWGISALLA 
SPLAIFREYS LIEIIPDFEI VACTEKWPGE EKSIYGTVYS LSSLLILYVL PLGIISFSYT 
RIWSKLKNHV SPGAANDHYH QRRQKTTKML VCVVVVFAVS WLPLHAFQLA VDIDSQVLDL 
KEYKLIFTVF HIIAMCSTFA NPLLYGWMNS NYRKAFLSAF RCEQRLDAIH SEVSVTFKAK 
KNLEVRKNSG PNDSFTEATN V

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.