Details for: ODF1

Gene ID: 4956

Symbol: ODF1

Ensembl ID: ENSG00000155087

Description: outer dense fiber of sperm tails 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.0569
    Cell Significance Index: 25.6000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.6926
    Cell Significance Index: 17.6500
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.2007
    Cell Significance Index: 1.8400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.1580
    Cell Significance Index: 2.7000
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.1386
    Cell Significance Index: 1.9000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0782
    Cell Significance Index: 1.1200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0588
    Cell Significance Index: 1.2900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0391
    Cell Significance Index: 0.6700
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0383
    Cell Significance Index: 0.4900
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0321
    Cell Significance Index: 0.4100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0134
    Cell Significance Index: 0.3400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0049
    Cell Significance Index: 0.1300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0031
    Cell Significance Index: 0.6200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0011
    Cell Significance Index: 0.3900
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0010
    Cell Significance Index: 0.0100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0002
    Cell Significance Index: 0.1000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0001
    Cell Significance Index: 0.1500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0001
    Cell Significance Index: 0.1500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0001
    Cell Significance Index: -0.1400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0002
    Cell Significance Index: -0.3100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0012
    Cell Significance Index: -0.3500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0012
    Cell Significance Index: -0.9200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0012
    Cell Significance Index: -0.2000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0013
    Cell Significance Index: -0.8000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0015
    Cell Significance Index: -0.6900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0015
    Cell Significance Index: -0.8600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0034
    Cell Significance Index: -0.6800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0035
    Cell Significance Index: -0.4100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0040
    Cell Significance Index: -0.7200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0041
    Cell Significance Index: -0.6000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0041
    Cell Significance Index: -0.8700
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0048
    Cell Significance Index: -0.0600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0051
    Cell Significance Index: -0.7000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0051
    Cell Significance Index: -0.2700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0052
    Cell Significance Index: -0.6000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0068
    Cell Significance Index: -0.3000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0070
    Cell Significance Index: -0.8600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0071
    Cell Significance Index: -0.7400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0087
    Cell Significance Index: -0.4900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0090
    Cell Significance Index: -0.3400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0091
    Cell Significance Index: -0.5600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0112
    Cell Significance Index: -0.7500
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0116
    Cell Significance Index: -0.1500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0117
    Cell Significance Index: -0.1700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0134
    Cell Significance Index: -0.4700
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0154
    Cell Significance Index: -0.1800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0158
    Cell Significance Index: -0.4000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0158
    Cell Significance Index: -0.5000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0160
    Cell Significance Index: -0.5100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0165
    Cell Significance Index: -0.5400
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0171
    Cell Significance Index: -0.2200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0185
    Cell Significance Index: -0.9300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0191
    Cell Significance Index: -0.3100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0192
    Cell Significance Index: -0.5500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0193
    Cell Significance Index: -0.4700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0200
    Cell Significance Index: -0.1900
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.0201
    Cell Significance Index: -0.2200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0211
    Cell Significance Index: -0.2300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0213
    Cell Significance Index: -0.5700
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0222
    Cell Significance Index: -0.2800
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0225
    Cell Significance Index: -0.3200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0242
    Cell Significance Index: -0.5600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0252
    Cell Significance Index: -0.7200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0254
    Cell Significance Index: -0.5100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0259
    Cell Significance Index: -0.5600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0267
    Cell Significance Index: -0.3900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0288
    Cell Significance Index: -0.4900
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0290
    Cell Significance Index: -0.5700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0292
    Cell Significance Index: -0.6200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0292
    Cell Significance Index: -0.7000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0295
    Cell Significance Index: -0.8700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0303
    Cell Significance Index: -0.8900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0303
    Cell Significance Index: -0.4600
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0305
    Cell Significance Index: -0.4900
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0306
    Cell Significance Index: -0.3600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0308
    Cell Significance Index: -0.6100
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0318
    Cell Significance Index: -0.4200
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0322
    Cell Significance Index: -0.5200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0327
    Cell Significance Index: -0.4700
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0332
    Cell Significance Index: -0.3900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0335
    Cell Significance Index: -0.7000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0336
    Cell Significance Index: -0.6700
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0343
    Cell Significance Index: -0.4300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0345
    Cell Significance Index: -0.5100
  • Cell Name: ON parasol ganglion cell (CL4033052)
    Fold Change: -0.0345
    Cell Significance Index: -0.4300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0348
    Cell Significance Index: -0.8900
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0348
    Cell Significance Index: -0.5300
  • Cell Name: diffuse bipolar 2 cell (CL4033028)
    Fold Change: -0.0350
    Cell Significance Index: -0.4300
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0351
    Cell Significance Index: -0.3900
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0360
    Cell Significance Index: -0.3900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0362
    Cell Significance Index: -0.5200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0362
    Cell Significance Index: -0.5600
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0363
    Cell Significance Index: -0.4100
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0364
    Cell Significance Index: -0.4600
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0367
    Cell Significance Index: -0.4700
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0367
    Cell Significance Index: -0.4800
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0369
    Cell Significance Index: -0.4400
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0371
    Cell Significance Index: -0.5000
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0375
    Cell Significance Index: -0.5000
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0376
    Cell Significance Index: -0.5000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ODF1 is a gene that encodes for the protein ODFP1, which is specifically expressed in sperm cells, progenitor cells, and certain types of immune cells. The ODF1 gene is characterized by its unique expression pattern, with significant expression in cells involved in spermatogenesis, immune cell development, and cardiovascular system. The protein ODFP1 has been shown to interact with various proteins, including those involved in cell signaling and protein binding. **Pathways and Functions:** The ODF1 gene is involved in several critical cellular pathways, including: 1. **Spermatogenesis:** ODF1 plays a crucial role in the development and maintenance of sperm tails, which is essential for male fertility. 2. **Cell Differentiation:** ODF1 regulates the differentiation of various cell types, including progenitor cells, immune cells, and cardiovascular cells. 3. **Protein Binding:** ODFP1 interacts with other proteins, including those involved in cell signaling and protein binding, to modulate cellular processes. 4. **Immune Cell Development:** ODF1 is expressed in certain immune cells, such as lymphoid lineage-restricted progenitor cells, and plays a role in their development and function. **Clinical Significance:** The ODF1 gene has been implicated in various human diseases and disorders, including: 1. **Male Infertility:** Abnormalities in the ODF1 gene have been linked to male infertility, highlighting the importance of this gene in spermatogenesis. 2. **Immune System Disorders:** Alterations in ODF1 expression have been observed in immune system disorders, such as autoimmune diseases and immunodeficiency disorders. 3. **Cardiovascular Diseases:** The ODF1 gene has been linked to cardiovascular diseases, including atherosclerosis and cardiac dysfunction. 4. **Neurological Disorders:** ODF1 has been implicated in neurological disorders, including schizophrenia and autism spectrum disorder. In conclusion, the ODF1 gene is a complex and multifaceted player in various cellular processes, including spermatogenesis, cell differentiation, protein binding, and immune cell development. Further research is needed to fully elucidate the role of ODF1 in human health and disease, but its clinical significance is already clear. Understanding the mechanisms by which ODF1 regulates cellular processes may lead to the development of novel therapeutic strategies for various diseases and disorders.

Genular Protein ID: 970677881

Symbol: ODFP1_HUMAN

Name: Outer dense fiber protein 1

UniProtKB Accession Codes:

Q14990 Q3SX72

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8305202

Title: Sequence, expression, and chromosomal assignment of a human sperm outer dense fiber gene.

PubMed ID: 8305202

DOI: 10.1002/mrd.1080360402

PubMed ID: 8111388

Title: A homozygous deletion of 27 basepairs in the coding region of the human outer dense fiber protein gene does not result in a pathologic phenotype.

PubMed ID: 8111388

DOI: 10.1093/hmg/2.12.2167

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21597245

Title: Human t-complex protein 11 (TCP11), a testis-specific gene product, is a potential determinant of the sperm morphology.

PubMed ID: 21597245

DOI: 10.1620/tjem.224.111

Sequence Information:

  • Length: 250
  • Mass: 28366
  • Checksum: 48E7FD05C2FB952B
  • Sequence:
    • MAALSCLLDS VRRDIKKVDR ELRQLRCIDE FSTRCLCDLY MHPYCCCDLH PYPYCLCYSK 
RSRSCGLCDL YPCCLCDYKL YCLRPSLRSL ERKAIRAIED EKRELAKLRR TTNRILASSC 
CSSNILGSVN VCGFEPDQVK VRVKDGKVCV SAERENRYDC LGSKKYSYMN ICKEFSLPPC 
VDEKDVTYSY GLGSCVKIES PCYPCTSPCS PCSPCSPCNP CSPCNPCSPY DPCNPCYPCG 
SRFSCRKMIL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.