Details for: UBQLN3

Gene ID: 50613

Symbol: UBQLN3

Ensembl ID: ENSG00000175520

Description: ubiquilin 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.1792
    Cell Significance Index: 1.0600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.1347
    Cell Significance Index: 1.9200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.1063
    Cell Significance Index: 1.5700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0760
    Cell Significance Index: 1.2100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0614
    Cell Significance Index: 0.8800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.0515
    Cell Significance Index: 0.8800
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: 0.0484
    Cell Significance Index: 0.9700
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0368
    Cell Significance Index: 0.4700
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.0310
    Cell Significance Index: 0.4300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0187
    Cell Significance Index: 0.3200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0167
    Cell Significance Index: 0.7800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.0073
    Cell Significance Index: 0.0800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0027
    Cell Significance Index: 0.1400
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.0018
    Cell Significance Index: 0.0200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0005
    Cell Significance Index: -0.1800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0008
    Cell Significance Index: -0.6200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0009
    Cell Significance Index: -0.2700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0014
    Cell Significance Index: -0.7500
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0015
    Cell Significance Index: -0.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0023
    Cell Significance Index: -0.4700
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0026
    Cell Significance Index: -0.0300
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0027
    Cell Significance Index: -0.0300
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0030
    Cell Significance Index: -0.0300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0031
    Cell Significance Index: -0.3600
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0034
    Cell Significance Index: -0.0400
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.0053
    Cell Significance Index: -0.0600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0069
    Cell Significance Index: -0.2400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0069
    Cell Significance Index: -0.1900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0076
    Cell Significance Index: -0.1900
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0076
    Cell Significance Index: -0.1000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0080
    Cell Significance Index: -0.2000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0084
    Cell Significance Index: -0.4700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0085
    Cell Significance Index: -0.2700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0086
    Cell Significance Index: -0.4500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0092
    Cell Significance Index: -0.3000
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0102
    Cell Significance Index: -0.1100
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0115
    Cell Significance Index: -0.1300
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0120
    Cell Significance Index: -0.1800
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0122
    Cell Significance Index: -0.1100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0127
    Cell Significance Index: -0.6000
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0130
    Cell Significance Index: -0.1500
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0133
    Cell Significance Index: -0.1600
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0141
    Cell Significance Index: -0.1900
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.0147
    Cell Significance Index: -0.1600
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0148
    Cell Significance Index: -0.1900
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0148
    Cell Significance Index: -0.2000
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0148
    Cell Significance Index: -0.1300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0149
    Cell Significance Index: -0.3100
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: -0.0157
    Cell Significance Index: -0.1700
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0163
    Cell Significance Index: -0.1900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0163
    Cell Significance Index: -0.8200
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0170
    Cell Significance Index: -0.2000
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.0172
    Cell Significance Index: -0.2000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0177
    Cell Significance Index: -0.3700
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0183
    Cell Significance Index: -0.1700
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0183
    Cell Significance Index: -0.2300
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: -0.0185
    Cell Significance Index: -0.1800
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0187
    Cell Significance Index: -0.2000
  • Cell Name: podocyte (CL0000653)
    Fold Change: -0.0187
    Cell Significance Index: -0.2200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0190
    Cell Significance Index: -0.5100
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0192
    Cell Significance Index: -0.2200
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.0195
    Cell Significance Index: -0.2100
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.0199
    Cell Significance Index: -0.2200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0200
    Cell Significance Index: -0.3500
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0200
    Cell Significance Index: -0.2400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0203
    Cell Significance Index: -0.4700
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0203
    Cell Significance Index: -0.4100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0206
    Cell Significance Index: -0.5900
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0210
    Cell Significance Index: -0.2100
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: -0.0210
    Cell Significance Index: -0.2300
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.0214
    Cell Significance Index: -0.2000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0214
    Cell Significance Index: -0.5700
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.0215
    Cell Significance Index: -0.2100
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0218
    Cell Significance Index: -0.2800
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0222
    Cell Significance Index: -0.1700
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: -0.0223
    Cell Significance Index: -0.2400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0227
    Cell Significance Index: -0.4500
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.0229
    Cell Significance Index: -0.2200
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0231
    Cell Significance Index: -0.1800
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0234
    Cell Significance Index: -0.2200
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0242
    Cell Significance Index: -0.2500
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.0242
    Cell Significance Index: -0.2000
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.0247
    Cell Significance Index: -0.2400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0249
    Cell Significance Index: -0.6400
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0258
    Cell Significance Index: -0.3000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0261
    Cell Significance Index: -0.2800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0268
    Cell Significance Index: -0.5800
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0271
    Cell Significance Index: -0.1800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0274
    Cell Significance Index: -0.5500
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0275
    Cell Significance Index: -0.3000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0277
    Cell Significance Index: -0.5900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0291
    Cell Significance Index: -0.4500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0293
    Cell Significance Index: -0.5800
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0294
    Cell Significance Index: -0.3000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0297
    Cell Significance Index: -0.5800
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0298
    Cell Significance Index: -0.2800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0309
    Cell Significance Index: -0.5200
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0315
    Cell Significance Index: -0.4200
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0317
    Cell Significance Index: -0.3900
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0320
    Cell Significance Index: -0.3400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** UBQLN3 is a ubiquitin-binding protein that interacts with ubiquitin-conjugated proteins, modulating their degradation by the proteasome. The UBQLN3 protein is characterized by its ability to bind to ubiquitin-conjugated proteins through its ubiquitin-binding domain, which is essential for its function. Additionally, UBQLN3 has been shown to interact with various cellular components, including actin, tubulin, and microtubule-associated proteins, highlighting its role in maintaining cytoskeletal dynamics. **Pathways and Functions** UBQLN3 is involved in several cellular pathways, including: 1. **Regulation of proteasomal ubiquitin-dependent protein catabolic process**: UBQLN3 modulates the activity of the proteasome, a key enzyme responsible for protein degradation. 2. **Polyubiquitin modification-dependent protein binding**: UBQLN3 interacts with ubiquitin-conjugated proteins, influencing their degradation and cellular processes. 3. **Protein binding**: UBQLN3 binds to various proteins, including actin, tubulin, and microtubule-associated proteins, maintaining cytoskeletal dynamics. 4. **Cytosol**: UBQLN3 is localized to the cytosol, where it interacts with other cellular components and modulates cellular processes. **Clinical Significance** UBQLN3 has been implicated in various clinical conditions, including: 1. **Neurodegenerative diseases**: UBQLN3 has been associated with neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, where dysregulation of protein homeostasis contributes to disease progression. 2. **Autoimmune diseases**: UBQLN3 has been implicated in autoimmune diseases, such as multiple sclerosis, where dysregulation of immune responses contributes to disease pathology. 3. **Cancer**: UBQLN3 has been shown to play a role in cancer development and progression, where dysregulation of protein homeostasis contributes to tumorigenesis. In conclusion, UBQLN3 is a complex gene that plays a multifaceted role in immune regulation and disease. Further research is necessary to fully elucidate the mechanisms underlying UBQLN3-mediated processes and to explore its therapeutic potential in various clinical conditions.

Genular Protein ID: 1751154851

Symbol: UBQL3_HUMAN

Name: Ubiquilin-3

UniProtKB Accession Codes:

Q9H347 Q9NRE0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 4 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11121057

Title: Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters.

PubMed ID: 11121057

DOI: 10.1073/pnas.97.26.14560

PubMed ID: 10831842

Title: Molecular cloning, chromosome mapping and characterization of UBQLN3 a testis-specific gene that contains an ubiquitin-like domain.

PubMed ID: 10831842

DOI: 10.1016/s0378-1119(00)00122-0

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 24674348

Title: The ubiquilin gene family: evolutionary patterns and functional insights.

PubMed ID: 24674348

DOI: 10.1186/1471-2148-14-63

Sequence Information:

  • Length: 655
  • Mass: 70841
  • Checksum: 6961DA801CE91F27
  • Sequence:
    • MAKGGEALPQ GSPAPVQDPH LIKVTVKTPK DKEDFSVTDT CTIQQLKEEI SQRFKAHPDQ 
LVLIFAGKIL KDPDSLAQCG VRDGLTVHLV IKRQHRAMGN ECPAASVPTQ GPSPGSLPQP 
SSIYPADGPP AFSLGLLTGL SRLGLAYRGF PDQPSSLMRQ HVSVPEFVTQ LIDDPFIPGL 
LSNTGLVRQL VLDNPHMQQL IQHNPEIGHI LNNPEIMRQT LEFLRNPAMM QEMIRSQDRV 
LSNLESIPGG YNVLCTMYTD IMDPMLNAVQ EQFGGNPFAT ATTDNATTTT SQPSRMENCD 
PLPNPWTSTH GGSGSRQGRQ DGDQDAPDIR NRFPNFLGII RLYDYLQQLH ENPQSLGTYL 
QGTASALSQS QEPPPSVNRV PPSSPSSQEP GSGQPLPEES VAIKGRSSCP AFLRYPTENS 
TGQGGDQDGA GKSSTGHSTN LPDLVSGLGD SANRVPFAPL SFSPTAAIPG IPEPPWLPSP 
AYPRSLRPDG MNPAPQLQDE IQPQLPLLMH LQAAMANPRA LQALRQIEQG LQVLATEAPR 
LLLWFMPCLA GTGSVAGGIE SREDPLMSED PLPNPPPEVF PALDSAELGF LSPPFLHMLQ 
DLVSTNPQQL QPEAHFQVQL EQLRSMGFLN REANLQALIA TGGDVDAAVE KLRQS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.