Details for: TAS2R8

Gene ID: 50836

Symbol: TAS2R8

Ensembl ID: ENSG00000121314

Description: taste 2 receptor member 8

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1891
    Cell Significance Index: 3.0000
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.1473
    Cell Significance Index: 1.3800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.1040
    Cell Significance Index: 1.4800
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.0902
    Cell Significance Index: 1.1800
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.0721
    Cell Significance Index: 0.8700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.0480
    Cell Significance Index: 0.8200
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.0201
    Cell Significance Index: 0.1300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0110
    Cell Significance Index: 3.9500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0100
    Cell Significance Index: 2.0100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0024
    Cell Significance Index: 0.4100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.0006
    Cell Significance Index: 0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0001
    Cell Significance Index: -0.2200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0001
    Cell Significance Index: -0.2600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0002
    Cell Significance Index: -0.2600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0004
    Cell Significance Index: -0.5500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0008
    Cell Significance Index: -0.4500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0008
    Cell Significance Index: -0.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0009
    Cell Significance Index: -0.6600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0011
    Cell Significance Index: -0.6700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0013
    Cell Significance Index: -0.7100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0015
    Cell Significance Index: -0.6900
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0024
    Cell Significance Index: -0.0300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0024
    Cell Significance Index: -0.4700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0028
    Cell Significance Index: -0.1100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0035
    Cell Significance Index: -0.2700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0039
    Cell Significance Index: -0.5300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0039
    Cell Significance Index: -0.8300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0042
    Cell Significance Index: -0.0900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0044
    Cell Significance Index: -0.6400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0053
    Cell Significance Index: -0.0500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0061
    Cell Significance Index: -0.1300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0062
    Cell Significance Index: -0.2900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0062
    Cell Significance Index: -0.7200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0063
    Cell Significance Index: -0.2000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0075
    Cell Significance Index: -0.8600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0086
    Cell Significance Index: -0.4800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0086
    Cell Significance Index: -0.3800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0087
    Cell Significance Index: -0.3300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0091
    Cell Significance Index: -0.3200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0104
    Cell Significance Index: -0.2600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0104
    Cell Significance Index: -0.3400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0120
    Cell Significance Index: -0.2400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0126
    Cell Significance Index: -0.2500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0126
    Cell Significance Index: -0.1800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0136
    Cell Significance Index: -0.6400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0142
    Cell Significance Index: -0.2800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0163
    Cell Significance Index: -0.3400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0196
    Cell Significance Index: -0.6200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0198
    Cell Significance Index: -0.5300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0229
    Cell Significance Index: -0.2500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0230
    Cell Significance Index: -0.6600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0231
    Cell Significance Index: -0.4600
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0270
    Cell Significance Index: -0.3600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0272
    Cell Significance Index: -0.4400
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0274
    Cell Significance Index: -0.3700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0275
    Cell Significance Index: -0.6700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0289
    Cell Significance Index: -0.5000
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0289
    Cell Significance Index: -0.3800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0297
    Cell Significance Index: -0.5800
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0301
    Cell Significance Index: -0.3300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0305
    Cell Significance Index: -0.4500
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: -0.0314
    Cell Significance Index: -0.3800
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0325
    Cell Significance Index: -0.4100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0327
    Cell Significance Index: -0.6900
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0332
    Cell Significance Index: -0.4600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0333
    Cell Significance Index: -0.5600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0335
    Cell Significance Index: -0.4600
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0341
    Cell Significance Index: -0.5800
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0347
    Cell Significance Index: -0.4100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0352
    Cell Significance Index: -0.5000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0355
    Cell Significance Index: -0.4600
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0357
    Cell Significance Index: -0.4900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0364
    Cell Significance Index: -0.5300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0365
    Cell Significance Index: -0.5300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0369
    Cell Significance Index: -0.4600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0371
    Cell Significance Index: -0.5200
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0372
    Cell Significance Index: -0.3600
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0377
    Cell Significance Index: -0.4900
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0379
    Cell Significance Index: -0.6100
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0381
    Cell Significance Index: -0.5800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0382
    Cell Significance Index: -0.6400
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0393
    Cell Significance Index: -0.4700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0396
    Cell Significance Index: -0.5000
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0397
    Cell Significance Index: -0.4400
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0405
    Cell Significance Index: -0.4200
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0406
    Cell Significance Index: -0.4400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0407
    Cell Significance Index: -0.5100
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.0420
    Cell Significance Index: -0.5000
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0421
    Cell Significance Index: -0.6800
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0421
    Cell Significance Index: -0.5900
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0425
    Cell Significance Index: -0.5000
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0428
    Cell Significance Index: -0.5500
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.0431
    Cell Significance Index: -0.5900
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0436
    Cell Significance Index: -0.5300
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0438
    Cell Significance Index: -0.6400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0441
    Cell Significance Index: -0.5700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0441
    Cell Significance Index: -0.6700
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0445
    Cell Significance Index: -0.5300
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0445
    Cell Significance Index: -0.4400
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0450
    Cell Significance Index: -0.5900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Bitter Taste Receptor:** TAS2R8 is a bitter taste receptor that detects specific bitter compounds, such as quinine and caffeine. 2. **Signaling Pathways:** TAS2R8 is involved in GPCR signaling pathways, which are critical for transducing chemical signals into cellular responses. 3. **Cellular Expression:** TAS2R8 is expressed in various cell types, including progenitor cells, endothelial cells, and neurons, highlighting its role in multiple tissues and organs. 4. **Protein Structure:** The TA2R8_HUMAN protein consists of 398 amino acids and contains seven transmembrane domains, characteristic of GPCRs. **Pathways and Functions:** 1. **GPCR Signaling:** TAS2R8 is a member of the GPCR family, which is responsible for transducing chemical signals into cellular responses. The activation of TAS2R8 by bitter compounds triggers a signaling cascade that ultimately leads to the perception of bitter taste. 2. **Taste Perception:** TAS2R8 plays a crucial role in the perception of bitter taste, allowing individuals to detect and avoid toxic or unpleasant compounds. 3. **Cellular Signaling:** TAS2R8 is involved in various cellular signaling pathways, including G alpha (i) signaling events, GPCR downstream signaling, and GPCR ligand binding. 4. **Sensory Perception:** TAS2R8 is part of the sensory perception of sweet, bitter, and umami (glutamate) taste, highlighting its role in the complex processing of taste information. **Clinical Significance:** 1. **Bitter Taste Deficiency:** Variations in the TAS2R8 gene have been associated with bitter taste deficiency, a condition characterized by an inability to perceive bitter compounds. 2. **Food Preferences:** TAS2R8 plays a role in food preferences, as individuals with a functional TAS2R8 gene are more likely to prefer bitter-tasting foods. 3. **Disease Association:** TAS2R8 has been linked to various diseases, including cancer, as altered bitter taste perception may be an early indicator of cancer development. 4. **Pharmacological Applications:** Understanding the functions of TAS2R8 has potential implications for the development of new therapeutic strategies, such as the use of bitter compounds to prevent or treat diseases. In conclusion, TAS2R8 is a critical gene involved in the perception of bitter taste and plays a significant role in various cellular signaling pathways. Further research on TAS2R8 will provide valuable insights into the complexities of taste perception and its relationship to human health.

Genular Protein ID: 2861081444

Symbol: TA2R8_HUMAN

Name: Taste receptor type 2 member 8

UniProtKB Accession Codes:

Q9NYW2 Q4KN29 Q645Y2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EMBL 7 Ensembl 3 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 3 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10761934

Title: A novel family of mammalian taste receptors.

PubMed ID: 10761934

DOI: 10.1016/s0092-8674(00)80705-9

PubMed ID: 15496549

Title: Evolution of bitter taste receptors in humans and apes.

PubMed ID: 15496549

DOI: 10.1093/molbev/msi027

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10761935

Title: T2Rs function as bitter taste receptors.

PubMed ID: 10761935

DOI: 10.1016/s0092-8674(00)80706-0

PubMed ID: 12139982

Title: Receptors for bitter and sweet taste.

PubMed ID: 12139982

DOI: 10.1016/s0959-4388(02)00345-8

PubMed ID: 11696554

Title: Molecular mechanisms of bitter and sweet taste transduction.

PubMed ID: 11696554

DOI: 10.1074/jbc.r100054200

PubMed ID: 12581520

Title: Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.

PubMed ID: 12581520

DOI: 10.1016/s0092-8674(03)00071-0

Sequence Information:

  • Length: 309
  • Mass: 35877
  • Checksum: 5E3D94B726A52413
  • Sequence:
    • MFSPADNIFI ILITGEFILG ILGNGYIALV NWIDWIKKKK ISTVDYILTN LVIARICLIS 
VMVVNGIVIV LNPDVYTKNK QQIVIFTFWT FANYLNMWIT TCLNVFYFLK IASSSHPLFL 
WLKWKIDMVV HWILLGCFAI SLLVSLIAAI VLSCDYRFHA IAKHKRNITE MFHVSKIPYF 
EPLTLFNLFA IVPFIVSLIS FFLLVRSLWR HTKQIKLYAT GSRDPSTEVH VRAIKTMTSF 
IFFFFLYYIS SILMTFSYLM TKYKLAVEFG EIAAILYPLG HSLILIVLNN KLRQTFVRML 
TCRKIACMI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.