Details for: TBX22

Gene ID: 50945

Symbol: TBX22

Ensembl ID: ENSG00000122145

Description: T-box transcription factor 22

Associated with

  • Cell fate specification
    (GO:0001708)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleus
    (GO:0005634)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 2.0365
    Cell Significance Index: 19.0500
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.5297
    Cell Significance Index: 19.3600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.7276
    Cell Significance Index: 17.6300
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.6249
    Cell Significance Index: 6.6400
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.3330
    Cell Significance Index: 4.3700
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.1997
    Cell Significance Index: 2.9100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1323
    Cell Significance Index: 15.4200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1297
    Cell Significance Index: 7.2800
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.0748
    Cell Significance Index: 0.5600
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.0635
    Cell Significance Index: 0.5400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0492
    Cell Significance Index: 6.3100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0405
    Cell Significance Index: 0.5800
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.0217
    Cell Significance Index: 0.3100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0143
    Cell Significance Index: 0.2400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0039
    Cell Significance Index: 0.1000
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: 0.0020
    Cell Significance Index: 0.0300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0003
    Cell Significance Index: 0.5500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0003
    Cell Significance Index: 0.4700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0005
    Cell Significance Index: -0.8700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0006
    Cell Significance Index: -0.8200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0010
    Cell Significance Index: -0.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0011
    Cell Significance Index: -0.6200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0014
    Cell Significance Index: -0.9200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0018
    Cell Significance Index: -1.0200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0019
    Cell Significance Index: -1.3600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0021
    Cell Significance Index: -1.5700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0021
    Cell Significance Index: -1.6300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0022
    Cell Significance Index: -1.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0027
    Cell Significance Index: -0.9700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0031
    Cell Significance Index: -0.6200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0034
    Cell Significance Index: -0.9700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0061
    Cell Significance Index: -0.7000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0063
    Cell Significance Index: -1.0700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0074
    Cell Significance Index: -1.3300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0075
    Cell Significance Index: -1.4800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0078
    Cell Significance Index: -1.1300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0083
    Cell Significance Index: -1.1400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0090
    Cell Significance Index: -0.2200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0093
    Cell Significance Index: -0.2500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0108
    Cell Significance Index: -1.3300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0119
    Cell Significance Index: -0.3300
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0121
    Cell Significance Index: -0.1200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0132
    Cell Significance Index: -1.3700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0154
    Cell Significance Index: -0.7200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0160
    Cell Significance Index: -0.2300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0176
    Cell Significance Index: -1.0800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0193
    Cell Significance Index: -1.4800
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0198
    Cell Significance Index: -0.2500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0202
    Cell Significance Index: -1.3600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0230
    Cell Significance Index: -0.8000
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0243
    Cell Significance Index: -0.2700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0248
    Cell Significance Index: -1.6000
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0257
    Cell Significance Index: -0.3600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0299
    Cell Significance Index: -0.2000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0306
    Cell Significance Index: -1.4400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0312
    Cell Significance Index: -1.0000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0316
    Cell Significance Index: -0.9300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0318
    Cell Significance Index: -0.8500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0320
    Cell Significance Index: -1.6200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0336
    Cell Significance Index: -0.8400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0339
    Cell Significance Index: -1.5000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0351
    Cell Significance Index: -1.1100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0355
    Cell Significance Index: -1.1300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0357
    Cell Significance Index: -1.2500
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0374
    Cell Significance Index: -0.4600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0379
    Cell Significance Index: -1.2400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0388
    Cell Significance Index: -0.6400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0398
    Cell Significance Index: -0.9700
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0404
    Cell Significance Index: -0.5100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0405
    Cell Significance Index: -1.6600
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0414
    Cell Significance Index: -0.4400
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -0.0416
    Cell Significance Index: -0.4400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0420
    Cell Significance Index: -0.9700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0425
    Cell Significance Index: -1.6100
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0442
    Cell Significance Index: -0.3800
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.0463
    Cell Significance Index: -0.2900
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0474
    Cell Significance Index: -0.6200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0481
    Cell Significance Index: -1.0200
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0498
    Cell Significance Index: -0.5200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0505
    Cell Significance Index: -1.2100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0511
    Cell Significance Index: -1.0100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0517
    Cell Significance Index: -1.2900
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0520
    Cell Significance Index: -0.6200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0521
    Cell Significance Index: -1.1400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0526
    Cell Significance Index: -1.5000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0534
    Cell Significance Index: -1.5300
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0540
    Cell Significance Index: -0.7200
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.0546
    Cell Significance Index: -0.6500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0547
    Cell Significance Index: -0.7500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0550
    Cell Significance Index: -1.4500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0555
    Cell Significance Index: -0.7900
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: -0.0565
    Cell Significance Index: -0.4400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0569
    Cell Significance Index: -1.1100
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: -0.0572
    Cell Significance Index: -0.5400
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0592
    Cell Significance Index: -0.7500
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.0625
    Cell Significance Index: -0.8500
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0626
    Cell Significance Index: -1.0100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0627
    Cell Significance Index: -1.3600
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0632
    Cell Significance Index: -0.8100
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.0639
    Cell Significance Index: -0.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TBX22 exhibits several key characteristics that distinguish it from other transcription factors. These include: 1. **T-box domain**: TBX22 contains a conserved T-box domain, which is essential for its DNA-binding activity and transcriptional regulatory functions. 2. **DNA-binding specificity**: TBX22 exhibits specificity for DNA sequences, particularly those containing the consensus T-box binding motif (T-Box). 3. **Regulatory functions**: TBX22 acts as a transcriptional activator or repressor, depending on the context and the specific target genes involved. 4. **Cell-type specificity**: TBX22 is expressed in a wide range of cell types, suggesting its involvement in distinct cellular processes and pathophysiological conditions. **Pathways and Functions:** TBX22 is involved in various cellular pathways, including: 1. **Cell fate specification**: TBX22 regulates the differentiation of immune cells, such as T cells and dendritic cells, and non-immunological cells, like epithelial cells and thyroid follicular cells. 2. **Chromatin organization**: TBX22 influences chromatin structure and function, affecting gene expression and transcriptional regulation. 3. **Transcriptional control**: TBX22 modulates the transcription of specific genes, including those involved in immune responses and tissue development. 4. **Regulation of transcription by RNA polymerase II**: TBX22 interacts with RNA polymerase II, a key enzyme in the transcriptional machinery, to regulate gene expression. **Clinical Significance:** TBX22 has significant implications for various diseases and disorders, including: 1. **Autoimmune diseases**: TBX22 has been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and lupus, where it regulates immune cell function and tissue damage. 2. **Cancer**: TBX22 may contribute to cancer development and progression by regulating cell growth, differentiation, and apoptosis. 3. **Neurological disorders**: TBX22 has been linked to neurological disorders, such as multiple sclerosis and Alzheimer's disease, where it influences neural cell development and function. 4. **Immunological disorders**: TBX22 plays a critical role in maintaining immune homeostasis, and its dysregulation can contribute to immunological disorders, such as immunodeficiency and autoimmune diseases. In conclusion, TBX22 is a multifunctional transcription factor with diverse roles in immunological and non-immunological contexts. Its dysregulation can contribute to various diseases and disorders, highlighting the importance of understanding its functions and mechanisms of action.

Genular Protein ID: 3018252633

Symbol: TBX22_HUMAN

Name: T-box transcription factor TBX22

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11024289

Title: Molecular characterization of a new human T-box gene (TBX22) located in Xq21.1 encoding a protein containing a truncated T-domain.

PubMed ID: 11024289

DOI: 10.1016/s0378-1119(00)00326-7

PubMed ID: 11559848

Title: The T-box transcription factor gene TBX22 is mutated in X-linked cleft palate and ankyloglossia.

PubMed ID: 11559848

DOI: 10.1038/ng730

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22784330

Title: X-linked CHARGE-like Abruzzo-Erickson syndrome and classic cleft palate with ankyloglossia result from TBX22 splicing mutations.

PubMed ID: 22784330

DOI: 10.1111/j.1399-0004.2012.01930.x

PubMed ID: 12374769

Title: Craniofacial expression of human and murine TBX22 correlates with the cleft palate and ankyloglossia phenotype observed in CPX patients.

PubMed ID: 12374769

DOI: 10.1093/hmg/11.22.2793

PubMed ID: 14729838

Title: TBX22 mutations are a frequent cause of cleft palate.

PubMed ID: 14729838

DOI: 10.1136/jmg.2003.010868

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 23033978

Title: Diagnostic exome sequencing in persons with severe intellectual disability.

PubMed ID: 23033978

DOI: 10.1056/nejmoa1206524

Sequence Information:

  • Length: 520
  • Mass: 57910
  • Checksum: 1502E19245CC2C93
  • Sequence:
  • MALSSRARAF SVEALVGRPS KRKLQDPIQA EQPELREKKG GEEEEERRSS AAGKSEPLEK 
    QPKTEPSTSA SSGCGSDSGY GNSSESLEEK DIQMELQGSE LWKRFHDIGT EMIITKAGRR 
    MFPSVRVKVK GLDPGKQYHV AIDVVPVDSK RYRYVYHSSQ WMVAGNTDHL CIIPRFYVHP 
    DSPCSGETWM RQIISFDRMK LTNNEMDDKG HIILQSMHKY KPRVHVIEQG SSVDLSQIQS 
    LPTEGVKTFS FKETEFTTVT AYQNQQITKL KIERNPFAKG FRDTGRNRGV LDGLLETYPW 
    RPSFTLDFKT FGADTQSGSS GSSPVTSSGG APSPLNSLLS PLCFSPMFHL PTSSLGMPCP 
    EAYLPNVNLP LCYKICPTNF WQQQPLVLPA PERLASSNSS QSLAPLMMEV PMLSSLGVTN 
    SKSGSSEDSS DQYLQAPNST NQMLYGLQSP GNIFLPNSIT PEALSCSFHP SYDFYRYNFS 
    MPSRLISGSN HLKVNDDSQV SFGEGKCNHV HWYPAINHYL

Genular Protein ID: 3698519914

Symbol: B3KUL8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 400
  • Mass: 44748
  • Checksum: DC76A11ADD29E6C3
  • Sequence:
  • MFPSVRVKVK GLDPGKQYHV AIDVVPVDSK RYRYVYHSSQ WMVAGNTDHL CIIPRFYVHP 
    DSPCSGETWM RQIISFDRMK LTNNEMDDKG HIILQSMHKY KPRVHVIEQG SSVDLSQIQS 
    LPTEGVKTFS FKETEFTTVT AYQNQQITKL KIERNPFAKG FRDTGRNRGV LDGLLETYPW 
    RPSFTLDFKT FGADTQSGSS GSSPVTSSGG APSPLNSLLS PLCFSPMFHL PTSSLGMPCP 
    EAYLPNVNLP LCYKICPTNF WQQQPLVLPA PERLASSNSS QSLAPLMMEV PMLSSLGVTN 
    SKSGSSEDSS DQYLQAPNST NQMLYGLQSP GNIFLPNSIT PEALSCSFHP SYDFYRYNFS 
    MPSRLISSSN HLKVNDDSQV SFGEGKCNHV HWYPAINHYL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.