Details for: SERPINB13

Gene ID: 5275

Symbol: SERPINB13

Ensembl ID: ENSG00000197641

Description: serpin family B member 13

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 3.9825
    Cell Significance Index: 5.1500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.4071
    Cell Significance Index: 39.3200
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.9575
    Cell Significance Index: 8.2300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.9169
    Cell Significance Index: 12.5100
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.7174
    Cell Significance Index: 7.4000
  • Cell Name: granular cell of epidermis (CL0002189)
    Fold Change: 0.1194
    Cell Significance Index: 0.1400
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0878
    Cell Significance Index: 1.1100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0529
    Cell Significance Index: 2.7500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0389
    Cell Significance Index: 7.0200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0177
    Cell Significance Index: 0.2500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0050
    Cell Significance Index: 2.1900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0002
    Cell Significance Index: 0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0023
    Cell Significance Index: -4.2500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0039
    Cell Significance Index: -7.2100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0046
    Cell Significance Index: -7.0700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0049
    Cell Significance Index: -3.1300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0055
    Cell Significance Index: -4.0500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0056
    Cell Significance Index: -4.2400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0067
    Cell Significance Index: -0.2900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0072
    Cell Significance Index: -4.0500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0084
    Cell Significance Index: -0.1200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0112
    Cell Significance Index: -4.0300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0115
    Cell Significance Index: -5.2300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0140
    Cell Significance Index: -0.5800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0168
    Cell Significance Index: -0.4300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0185
    Cell Significance Index: -0.9400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0190
    Cell Significance Index: -5.4800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0192
    Cell Significance Index: -4.0500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0194
    Cell Significance Index: -3.8500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0204
    Cell Significance Index: -2.9700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0213
    Cell Significance Index: -4.2700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0233
    Cell Significance Index: -3.9900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0321
    Cell Significance Index: -3.7400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0354
    Cell Significance Index: -4.0500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0479
    Cell Significance Index: -1.1900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0605
    Cell Significance Index: -3.1500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0616
    Cell Significance Index: -4.1400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0646
    Cell Significance Index: -2.9300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0781
    Cell Significance Index: -1.7100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0799
    Cell Significance Index: -3.7300
  • Cell Name: respiratory suprabasal cell (CL4033048)
    Fold Change: -0.0829
    Cell Significance Index: -0.7500
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: -0.0849
    Cell Significance Index: -0.7300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0862
    Cell Significance Index: -1.2400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0929
    Cell Significance Index: -1.3300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0959
    Cell Significance Index: -5.3800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0963
    Cell Significance Index: -2.5800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0964
    Cell Significance Index: -3.5400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0966
    Cell Significance Index: -4.5400
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.1055
    Cell Significance Index: -1.0700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1108
    Cell Significance Index: -3.8800
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.1228
    Cell Significance Index: -0.7600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1251
    Cell Significance Index: -3.3400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1314
    Cell Significance Index: -3.7500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1419
    Cell Significance Index: -0.9600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1445
    Cell Significance Index: -4.7300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1464
    Cell Significance Index: -3.7300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1476
    Cell Significance Index: -4.7000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1481
    Cell Significance Index: -3.7000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1497
    Cell Significance Index: -6.6200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1525
    Cell Significance Index: -1.7300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1563
    Cell Significance Index: -4.1100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1647
    Cell Significance Index: -3.9500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1748
    Cell Significance Index: -6.6200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1754
    Cell Significance Index: -2.9500
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.1761
    Cell Significance Index: -0.9300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1816
    Cell Significance Index: -4.4000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1852
    Cell Significance Index: -4.6200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1894
    Cell Significance Index: -3.5000
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.1926
    Cell Significance Index: -1.9000
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1966
    Cell Significance Index: -2.3400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1971
    Cell Significance Index: -3.3700
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1988
    Cell Significance Index: -2.6000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.2046
    Cell Significance Index: -4.0800
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.2047
    Cell Significance Index: -2.4900
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.2063
    Cell Significance Index: -2.6100
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.2063
    Cell Significance Index: -2.1400
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.2119
    Cell Significance Index: -1.5400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2127
    Cell Significance Index: -4.4400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2135
    Cell Significance Index: -3.6800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2148
    Cell Significance Index: -4.2000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2157
    Cell Significance Index: -4.6600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.2181
    Cell Significance Index: -3.1900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2237
    Cell Significance Index: -6.0900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2243
    Cell Significance Index: -4.7600
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.2253
    Cell Significance Index: -2.7200
  • Cell Name: brush cell (CL0002204)
    Fold Change: -0.2258
    Cell Significance Index: -2.0700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2271
    Cell Significance Index: -4.5600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2297
    Cell Significance Index: -3.8700
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.2298
    Cell Significance Index: -0.5200
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.2307
    Cell Significance Index: -3.7100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2327
    Cell Significance Index: -7.3600
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.2357
    Cell Significance Index: -4.6400
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.2366
    Cell Significance Index: -1.8100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2371
    Cell Significance Index: -3.8400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.2381
    Cell Significance Index: -3.8200
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.2397
    Cell Significance Index: -2.4500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2402
    Cell Significance Index: -4.7500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2440
    Cell Significance Index: -7.0000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.2446
    Cell Significance Index: -3.1700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2465
    Cell Significance Index: -2.2700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Serpin Family Member**: SERPINB13 belongs to the serpin family, a group of proteins characterized by their ability to inhibit serine proteases, which are involved in various cellular processes, including apoptosis, cell signaling, and immune responses. 2. **Multiple Pathway Involvement**: SERPINB13 is implicated in multiple pathways, including proteolysis, transcriptional regulation, and response to UV radiation, highlighting its versatility and importance in maintaining cellular homeostasis. 3. **Tissue-Specific Expression**: SERPINB13 is significantly expressed in stratified epithelial cells, basal cells of the epithelium, and other cell types involved in tissue homeostasis and differentiation. 4. **Protease Inhibition**: SERPINB13 has been shown to inhibit cysteine-type and serine-type endopeptidases, which are involved in various cellular processes, including proteolysis and apoptosis. **Pathways and Functions:** 1. **Proteolysis**: SERPINB13 inhibits cysteine-type and serine-type endopeptidases, which are involved in proteolysis and apoptosis. This inhibition is critical in maintaining cellular balance and preventing disease. 2. **Transcriptional Regulation**: SERPINB13 is involved in transcriptional regulation by Runx1, a transcription factor that regulates gene expression involved in differentiation of keratinocytes. 3. **Response to UV Radiation**: SERPINB13 is involved in response to UV radiation, which is critical in maintaining skin health and preventing skin cancer. 4. **Negative Regulation of Endopeptidase Activity**: SERPINB13 negatively regulates endopeptidase activity, which is critical in maintaining cellular balance and preventing disease. **Clinical Significance:** 1. **Skin Cancer**: SERPINB13's involvement in response to UV radiation highlights its potential role in preventing skin cancer. 2. **Epithelial Tissue Homeostasis**: SERPINB13's expression in stratified epithelial cells and basal cells of the epithelium underscores its importance in maintaining epithelial tissue homeostasis. 3. **Disease Pathways**: SERPINB13's involvement in multiple pathways, including proteolysis, transcriptional regulation, and response to UV radiation, highlights its potential role in preventing and treating various diseases, including cancer, inflammatory diseases, and neurodegenerative disorders. 4. **Potential Therapeutic Targets**: SERPINB13's involvement in multiple pathways makes it a potential therapeutic target for various diseases, including cancer, inflammatory diseases, and neurodegenerative disorders. In conclusion, SERPINB13 is a serpin family member with multiple functions in cell regulation and disease pathways. Its involvement in proteolysis, transcriptional regulation, and response to UV radiation highlights its importance in maintaining cellular balance and preventing disease. Further research is needed to fully understand the role of SERPINB13 in human health and disease, and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 3785037735

Symbol: SPB13_HUMAN

Name: Serpin B13

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10512713

Title: Cloning and characterization of hurpin (Protease Inhibitor 13): a new skin specific, UV-repressible serine proteinase inhibitor of the ovalbumin serpin family.

PubMed ID: 10512713

DOI: 10.1006/jmbi.1999.3159

PubMed ID: 10527881

Title: Identification and cDNA cloning of headpin, a novel differentially expressed serpin that maps to chromosome 18q.

PubMed ID: 10527881

DOI: 10.1006/bbrc.1999.1453

PubMed ID: 11004515

Title: Genomic cloning, mapping, structure and promoter analysis of HEADPIN, a serpin which is down-regulated in head and neck cancer cells.

PubMed ID: 11004515

DOI: 10.1016/s0167-4781(00)00100-7

PubMed ID: 11313015

Title: Sequence, organization, chromosomal localization and alternative splicing of the human serine protease inhibitor gene hurpin (PI13), which is up-regulated in psoriasis.

PubMed ID: 11313015

DOI: 10.1089/104454901300068924

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 391
  • Mass: 44276
  • Checksum: 2CA88558D4BC2B09
  • Sequence:
  • MDSLGAVSTR LGFDLFKELK KTNDGNIFFS PVGILTAIGM VLLGTRGATA SQLEEVFHSE 
    KETKSSRIKA EEKEVIENTE AVHQQFQKFL TEISKLTNDY ELNITNRLFG EKTYLFLQKY 
    LDYVEKYYHA SLEPVDFVNA ADESRKKINS WVESKTNEKI KDLFPDGSIS SSTKLVLVNM 
    VYFKGQWDRE FKKENTKEEK FWMNKSTSKS VQMMTQSHSF SFTFLEDLQA KILGIPYKNN 
    DLSMFVLLPN DIDGLEKIID KISPEKLVEW TSPGHMEERK VNLHLPRFEV EDGYDLEAVL 
    AAMGMGDAFS EHKADYSGMS SGSGLYAQKF LHSSFVAVTE EGTEAAAATG IGFTVTSAPG 
    HENVHCNHPF LFFIRHNESN SILFFGRFSS P

Genular Protein ID: 514908976

Symbol: A0A0A0MQW3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 400
  • Mass: 45287
  • Checksum: DBAABC071296E0D3
  • Sequence:
  • MDSLGAVSTR LGFDLFKELK KTNDGNIFFS PVGILTAIGM VLLGTRGATA SQLEEVFHSE 
    KETKSSRIKA EEKEVVRIKA EGKEIENTEA VHQQFQKFLT EISKLTNDYE LNITNRLFGE 
    KTYLFLQKYL DYVEKYYHAS LEPVDFVNAA DESRKKINSW VESKTNEKIK DLFPDGSISS 
    STKLVLVNMV YFKGQWDREF KKENTKEEKF WMNKSTSKSV QMMTQSHSFS FTFLEDLQAK 
    ILGIPYKNND LSMFVLLPND IDGLEKIIDK ISPEKLVEWT SPGHMEERKV NLHLPRFEVE 
    DGYDLEAVLA AMGMGDAFSE HKADYSGMSS GSGLYAQKFL HSSFVAVTEE GTEAAAATGI 
    GFTVTSAPGH ENVHCNHPFL FFIRHNESNS ILFFGRFSSP

Genular Protein ID: 1468065788

Symbol: B7Z447_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 400
  • Mass: 45301
  • Checksum: DAAEA006DA8A610F
  • Sequence:
  • MDSLGAVSTR LGFDLFKELK KTNDGNIFFS PVGILTAIGM VLLGTRGATA SQLEEVFHSE 
    KETKSSRIKA EEKEVVRIKA EGKEIENTEA VHQQFQKFLT EISKLTNDYE LNITNRLFGE 
    KTYLFLQKYL DYVEKYYHAS LEPVDFVNAA DESRKKINSW VESKTNEKIK DLFPDGSISS 
    STKLVLVNMV YFKGQWDREF KKENTKEEKF WMNKSTSKSV QMMTQSHSFS FTFLEDLQAK 
    ILGIPYKNND LSMFVLLPND IDGLEKIIDK ISPEKLVEWT SPGHMEERKV NLHLPRFEVE 
    DSYDLEAVLA AMGMGDAFSE HKADYSGMSS GSGLYAQKFL HSSFVAVTEE GTEAAAATGI 
    GFTVTSAPGH ENVHCNHPFP FFIRHNESNS ILFFGRFSSP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.