Details for: SERPINB13
Gene ID: 5275
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: SERPINB13
Ensembl ID: ENSG00000197641
Description: serpin family B member 13
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 7.25rCSI 7.56%PRS 88.76
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CSI 5.68rCSI 10.13%PRS 93.65
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CSI 5.54rCSI 8.52%PRS 78.46
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CSI 4.68rCSI 6.01%PRS 91.58
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CSI 2.81rCSI 3.46%PRS 89.82
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CSI 2.36rCSI 3.6%PRS 89.27
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CSI 1.87rCSI 1.94%PRS 91.41
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CSI 1.77rCSI 2.59%PRS 85.29
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CSI 1.49rCSI 10.54%PRS 90.46
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CSI 1.28rCSI 3.04%PRS 87.32
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
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Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3785037735
Symbol: SPB13_HUMAN
Name: Serpin B13
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10512713
Title: Cloning and characterization of hurpin (Protease Inhibitor 13): a new skin specific, UV-repressible serine proteinase inhibitor of the ovalbumin serpin family.
PubMed ID: 10512713
PubMed ID: 10527881
Title: Identification and cDNA cloning of headpin, a novel differentially expressed serpin that maps to chromosome 18q.
PubMed ID: 10527881
PubMed ID: 11004515
Title: Genomic cloning, mapping, structure and promoter analysis of HEADPIN, a serpin which is down-regulated in head and neck cancer cells.
PubMed ID: 11004515
PubMed ID: 11313015
Title: Sequence, organization, chromosomal localization and alternative splicing of the human serine protease inhibitor gene hurpin (PI13), which is up-regulated in psoriasis.
PubMed ID: 11313015
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
Sequence Information:
- Length: 391
- Mass: 44276
- Checksum: 2CA88558D4BC2B09
- Sequence:
MDSLGAVSTR LGFDLFKELK KTNDGNIFFS PVGILTAIGM VLLGTRGATA SQLEEVFHSE KETKSSRIKA EEKEVIENTE AVHQQFQKFL TEISKLTNDY ELNITNRLFG EKTYLFLQKY LDYVEKYYHA SLEPVDFVNA ADESRKKINS WVESKTNEKI KDLFPDGSIS SSTKLVLVNM VYFKGQWDRE FKKENTKEEK FWMNKSTSKS VQMMTQSHSF SFTFLEDLQA KILGIPYKNN DLSMFVLLPN DIDGLEKIID KISPEKLVEW TSPGHMEERK VNLHLPRFEV EDGYDLEAVL AAMGMGDAFS EHKADYSGMS SGSGLYAQKF LHSSFVAVTE EGTEAAAATG IGFTVTSAPG HENVHCNHPF LFFIRHNESN SILFFGRFSS P
Genular Protein ID: 514908976
Symbol: A0A0A0MQW3_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 16177791
Title: DNA sequence and analysis of human chromosome 18.
PubMed ID: 16177791
DOI: 10.1038/nature03983
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
Sequence Information:
- Length: 400
- Mass: 45287
- Checksum: DBAABC071296E0D3
- Sequence:
MDSLGAVSTR LGFDLFKELK KTNDGNIFFS PVGILTAIGM VLLGTRGATA SQLEEVFHSE KETKSSRIKA EEKEVVRIKA EGKEIENTEA VHQQFQKFLT EISKLTNDYE LNITNRLFGE KTYLFLQKYL DYVEKYYHAS LEPVDFVNAA DESRKKINSW VESKTNEKIK DLFPDGSISS STKLVLVNMV YFKGQWDREF KKENTKEEKF WMNKSTSKSV QMMTQSHSFS FTFLEDLQAK ILGIPYKNND LSMFVLLPND IDGLEKIIDK ISPEKLVEWT SPGHMEERKV NLHLPRFEVE DGYDLEAVLA AMGMGDAFSE HKADYSGMSS GSGLYAQKFL HSSFVAVTEE GTEAAAATGI GFTVTSAPGH ENVHCNHPFL FFIRHNESNS ILFFGRFSSP
Genular Protein ID: 1468065788
Symbol: B7Z447_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 400
- Mass: 45301
- Checksum: DAAEA006DA8A610F
- Sequence:
MDSLGAVSTR LGFDLFKELK KTNDGNIFFS PVGILTAIGM VLLGTRGATA SQLEEVFHSE KETKSSRIKA EEKEVVRIKA EGKEIENTEA VHQQFQKFLT EISKLTNDYE LNITNRLFGE KTYLFLQKYL DYVEKYYHAS LEPVDFVNAA DESRKKINSW VESKTNEKIK DLFPDGSISS STKLVLVNMV YFKGQWDREF KKENTKEEKF WMNKSTSKSV QMMTQSHSFS FTFLEDLQAK ILGIPYKNND LSMFVLLPND IDGLEKIIDK ISPEKLVEWT SPGHMEERKV NLHLPRFEVE DSYDLEAVLA AMGMGDAFSE HKADYSGMSS GSGLYAQKFL HSSFVAVTEE GTEAAAATGI GFTVTSAPGH ENVHCNHPFP FFIRHNESNS ILFFGRFSSP