Details for: PPEF2

Gene ID: 5470

Symbol: PPEF2

Ensembl ID: ENSG00000156194

Description: protein phosphatase with EF-hand domain 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 14.7174
    Cell Significance Index: 175.4400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 7.7553
    Cell Significance Index: 488.7900
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.1571
    Cell Significance Index: 19.7800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 1.0161
    Cell Significance Index: 14.8100
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.3380
    Cell Significance Index: 4.2200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.2207
    Cell Significance Index: 5.5000
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.2157
    Cell Significance Index: 3.0300
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.1633
    Cell Significance Index: 1.9800
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.0903
    Cell Significance Index: 0.7500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0623
    Cell Significance Index: 12.5100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0541
    Cell Significance Index: 19.4000
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.0390
    Cell Significance Index: 0.3000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0142
    Cell Significance Index: 9.8500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0053
    Cell Significance Index: 0.0900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0042
    Cell Significance Index: 0.2800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.0030
    Cell Significance Index: 0.0200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0022
    Cell Significance Index: 4.1300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0022
    Cell Significance Index: 2.9900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0016
    Cell Significance Index: 2.4300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0007
    Cell Significance Index: 0.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0007
    Cell Significance Index: 1.3100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0004
    Cell Significance Index: -0.0600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0005
    Cell Significance Index: -0.0100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0012
    Cell Significance Index: -0.7600
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0012
    Cell Significance Index: -0.0200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0027
    Cell Significance Index: -0.7800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0031
    Cell Significance Index: -1.4100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0034
    Cell Significance Index: -2.5300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0035
    Cell Significance Index: -1.9100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0036
    Cell Significance Index: -2.6100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0045
    Cell Significance Index: -2.5400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0051
    Cell Significance Index: -0.8700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0092
    Cell Significance Index: -1.6500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0098
    Cell Significance Index: -0.1400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0138
    Cell Significance Index: -1.8900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0140
    Cell Significance Index: -2.9400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0140
    Cell Significance Index: -0.3900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0146
    Cell Significance Index: -0.2200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0148
    Cell Significance Index: -1.8200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0149
    Cell Significance Index: -0.6600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0160
    Cell Significance Index: -0.4100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0168
    Cell Significance Index: -0.4500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0182
    Cell Significance Index: -2.0900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0190
    Cell Significance Index: -0.7200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0197
    Cell Significance Index: -2.2900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0206
    Cell Significance Index: -2.1500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0240
    Cell Significance Index: -1.8400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0254
    Cell Significance Index: -0.5100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0262
    Cell Significance Index: -1.2200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0268
    Cell Significance Index: -0.5800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0274
    Cell Significance Index: -0.2600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0278
    Cell Significance Index: -1.4600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0279
    Cell Significance Index: -0.8900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0287
    Cell Significance Index: -0.5600
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0291
    Cell Significance Index: -0.3400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0303
    Cell Significance Index: -1.8600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0314
    Cell Significance Index: -1.7600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0335
    Cell Significance Index: -1.0600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0342
    Cell Significance Index: -0.9300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0348
    Cell Significance Index: -1.2200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0350
    Cell Significance Index: -1.8200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0377
    Cell Significance Index: -0.8000
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0379
    Cell Significance Index: -0.5200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0401
    Cell Significance Index: -1.0000
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0402
    Cell Significance Index: -0.6100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0406
    Cell Significance Index: -1.3300
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0414
    Cell Significance Index: -0.5800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0430
    Cell Significance Index: -0.8500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0431
    Cell Significance Index: -1.8800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0470
    Cell Significance Index: -3.0300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0475
    Cell Significance Index: -1.6700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0488
    Cell Significance Index: -2.3000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0504
    Cell Significance Index: -1.2300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0560
    Cell Significance Index: -2.5400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0566
    Cell Significance Index: -1.6300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0583
    Cell Significance Index: -1.2200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0590
    Cell Significance Index: -0.8400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0601
    Cell Significance Index: -0.8200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0613
    Cell Significance Index: -1.5300
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0635
    Cell Significance Index: -0.8200
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.0636
    Cell Significance Index: -0.5600
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0645
    Cell Significance Index: -0.6500
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0646
    Cell Significance Index: -0.6300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0666
    Cell Significance Index: -1.3900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0671
    Cell Significance Index: -0.9500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0674
    Cell Significance Index: -1.9900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0720
    Cell Significance Index: -1.8000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0726
    Cell Significance Index: -1.7400
  • Cell Name: S cone cell (CL0003050)
    Fold Change: -0.0729
    Cell Significance Index: -0.8500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0730
    Cell Significance Index: -1.8600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0742
    Cell Significance Index: -1.1900
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0755
    Cell Significance Index: -0.8900
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0757
    Cell Significance Index: -1.4900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0762
    Cell Significance Index: -0.8300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0781
    Cell Significance Index: -1.6200
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0787
    Cell Significance Index: -0.9900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0806
    Cell Significance Index: -1.1900
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0806
    Cell Significance Index: -0.9100
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0812
    Cell Significance Index: -1.3100
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0817
    Cell Significance Index: -1.1300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PPEF2 is a member of the protein phosphatase family, characterized by the presence of an EF-hand domain, which is crucial for its calcium-binding capabilities. This domain enables PPEF2 to regulate various cellular processes, including signal transduction pathways, cell proliferation, and differentiation. The protein's serine/threonine phosphatase activity allows it to dephosphorylate and regulate downstream targets, thereby modulating cellular responses to environmental stimuli. **Pathways and Functions:** PPEF2 is involved in numerous signaling pathways, including: 1. **Calcium ion binding**: PPEF2's EF-hand domain facilitates calcium ion binding, which regulates the protein's activity and interactions with other molecules. 2. **Visual perception**: PPEF2 is significantly expressed in retinal rod cells and photoreceptor cells, suggesting its involvement in visual signal transduction pathways. 3. **Mitogen-activated protein kinase (MAPK) signaling**: PPEF2 regulates the MAPK cascade, which is crucial for cell proliferation, differentiation, and apoptosis. 4. **Protein dephosphorylation**: PPEF2's phosphatase activity dephosphorylates and regulates various proteins, including those involved in signal transduction and cell migration. **Clinical Significance:** PPEF2's involvement in various cellular processes and signaling pathways has significant implications for human health and disease. Some potential applications of PPEF2 include: 1. **Visual disorders**: PPEF2's role in visual perception suggests its potential involvement in retinal degenerative diseases, such as retinitis pigmentosa. 2. **Neurological disorders**: PPEF2's involvement in MAPK signaling pathways may contribute to the development of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer**: PPEF2's phosphatase activity may regulate cell proliferation and differentiation, making it a potential target for cancer therapy. 4. **Inflammation**: PPEF2's role in regulating immune responses may contribute to the development of inflammatory diseases, such as rheumatoid arthritis. **Significantly Expressed Cells:** PPEF2 is expressed in various cell types, including: 1. **Retinal rod cells** 2. **Eye photoreceptor cells** 3. **Blood vessel endothelial cells** 4. **Plasma cells** 5. **Kidney proximal convoluted tubule epithelial cells** 6. **Cerebral cortex GABAergic interneurons** 7. **Forebrain radial glial cells** 8. **Absorptive cells** 9. **Goblet cells** 10. **Intestinal crypt stem cells of colon** In conclusion, PPEF2 is a multifunctional protein phosphatase with EF-hands 2 that plays a significant role in various cellular processes and signaling pathways. Its involvement in visual perception, MAPK signaling, and protein dephosphorylation makes it a potential target for the diagnosis and treatment of various diseases, including visual disorders, neurological disorders, and cancer. Further research is needed to elucidate the full extent of PPEF2's immunological significance and its potential applications in human health and disease.

Genular Protein ID: 2917728144

Symbol: PPE2_HUMAN

Name: Serine/threonine-protein phosphatase with EF-hands 2

UniProtKB Accession Codes:

O14830 O14831

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 25 ChiTaRS 1 DEPOD 1 DNASU 1 EC 3 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 19 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 Rhea 6 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9326663

Title: Identification and characterization of a conserved family of protein serine/threonine phosphatases homologous to Drosophila retinal degeneration C.

PubMed ID: 9326663

DOI: 10.1073/pnas.94.21.11639

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 753
  • Mass: 86518
  • Checksum: 28ED6E79C5B8906C
  • Sequence:
    • MGSGTSTQHH FAFQNAERAF KAAALIQRWY RRYVARLEMR RRCTWSIFQS IEYAGQQDQV 
KLHDFFSYLM DHFIPSSHND RDFLTRIFTE DRFAQDSEMK KCSDYESIEV PDSYTGPRLS 
FPLLPDHATA LVEAFRLKQQ LHARYVLNLL YETKKHLVQL PNINRVSTCY SEEITVCGDL 
HGQLDDLIFI FYKNGLPSPE RSYVFNGDFV DRGKDSVEIL MILFAFMLVY PKEFHLNRGN 
HEDHMVNLRY GFTKEVMNKY KVHGKEILRT LQDVFCWLPL ATLIDEKVLI LHGGVSDITD 
LELLDKIERS KIVSTMRCKT RQKSEKQMEE KRRANQKSSA QGPIPWFLPE SRSLPSSPLR 
LGSYKAQKTS RSSSIPCSGS LDGRELSRQV RSSVELELER CRQQAGLLVT GEKEEPSRSA 
SEADSEAGEL RKPTQEEWRQ VVDILWSDPM AQEGCKANTI RGGGCYFGPD VTQQLLQKYN 
MQFLIRSHEC KPEGYEFCHN RKVLTIFSAS NYYEVGSNRG AYVKLGPALT PHIVQYQANK 
VTHTLTMRQR ISRVEESALR ALREKLFAHS SDLLSEFKKH DADKVGLITL SDWAAAVESV 
LHLGLPWRML RPQLVNSSAD NMLEYKSWLK NLAKEQLSRE NIQSSLLETL YRNRSNLETI 
FRIIDSDHSG FISLDEFRQT WKLFSSHMNI DITDDCICDL ARSIDFNKDG HIDINEFLEA 
FRLVEKSCPE GDASECPQAT NAKDSGCSSP GAH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.