PRKACG | ENSG00000165059 | NCBI 5568

Details for: PRKACG

Gene ID: 5568

Symbol: PRKACG

Ensembl ID: ENSG00000165059

Description: protein kinase cAMP-activated catalytic subunit gamma

Associated with

Activation of nmda receptors and postsynaptic events
(R-HSA-442755)
Adaptive immune system
(R-HSA-1280218)
Adora2b mediated anti-inflammatory cytokines production
(R-HSA-9660821)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Aquaporin-mediated transport
(R-HSA-445717)
Axon guidance
(R-HSA-422475)
C-type lectin receptors (clrs)
(R-HSA-5621481)
Ca-dependent events
(R-HSA-111996)
Calmodulin induced events
(R-HSA-111933)
Cam pathway
(R-HSA-111997)
Cd209 (dc-sign) signaling
(R-HSA-5621575)
Cellular responses to mechanical stimuli
(R-HSA-9855142)
Cellular responses to stimuli
(R-HSA-8953897)
Creb1 phosphorylation through the activation of adenylate cyclase
(R-HSA-442720)
Dag and ip3 signaling
(R-HSA-1489509)
Darpp-32 events
(R-HSA-180024)
Degradation of gli1 by the proteasome
(R-HSA-5610780)
Degradation of gli2 by the proteasome
(R-HSA-5610783)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Factors involved in megakaryocyte development and platelet production
(R-HSA-983231)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
G-protein mediated events
(R-HSA-112040)
G alpha (i) signalling events
(R-HSA-418594)
G alpha (s) signalling events
(R-HSA-418555)
Gli3 is processed to gli3r by the proteasome
(R-HSA-5610785)
Glucagon-like peptide-1 (glp1) regulates insulin secretion
(R-HSA-381676)
Glucagon signaling in metabolic regulation
(R-HSA-163359)
Glucose metabolism
(R-HSA-70326)
Glycolysis
(R-HSA-70171)
Gpcr downstream signalling
(R-HSA-388396)
Gper1 signaling
(R-HSA-9634597)
Hdl assembly
(R-HSA-8963896)
Hedgehog 'off' state
(R-HSA-5610787)
Hemostasis
(R-HSA-109582)
High laminar flow shear stress activates signaling by piezo1 and pecam1:cdh5:kdr in endothelial cells
(R-HSA-9856530)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Integration of energy metabolism
(R-HSA-163685)
Intracellular signaling by second messengers
(R-HSA-9006925)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Mapk6/mapk4 signaling
(R-HSA-5687128)
Mapk family signaling cascades
(R-HSA-5683057)
Metabolism
(R-HSA-1430728)
Metabolism of carbohydrates
(R-HSA-71387)
Metabolism of lipids
(R-HSA-556833)
Nervous system development
(R-HSA-9675108)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Opioid signalling
(R-HSA-111885)
Parasitic infection pathways
(R-HSA-9824443)
Pka-mediated phosphorylation of creb
(R-HSA-111931)
Pka-mediated phosphorylation of key metabolic factors
(R-HSA-163358)
Pka activation
(R-HSA-163615)
Pka activation in glucagon signalling
(R-HSA-164378)
Plasma lipoprotein assembly
(R-HSA-8963898)
Plasma lipoprotein assembly, remodeling, and clearance
(R-HSA-174824)
Plc beta mediated events
(R-HSA-112043)
Post nmda receptor activation events
(R-HSA-438064)
Rap1 signalling
(R-HSA-392517)
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
(R-HSA-9634600)
Regulation of insulin secretion
(R-HSA-422356)
Response of endothelial cells to shear stress
(R-HSA-9860931)
Ret signaling
(R-HSA-8853659)
Robo receptors bind akap5
(R-HSA-9010642)
Signaling by gpcr
(R-HSA-372790)
Signaling by hedgehog
(R-HSA-5358351)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by robo receptors
(R-HSA-376176)
Signaling by vegf
(R-HSA-194138)
Transmission across chemical synapses
(R-HSA-112315)
Transport of small molecules
(R-HSA-382551)
Triglyceride catabolism
(R-HSA-163560)
Triglyceride metabolism
(R-HSA-8979227)
Vasopressin regulates renal water homeostasis via aquaporins
(R-HSA-432040)
Vegfa-vegfr2 pathway
(R-HSA-4420097)
Amp-activated protein kinase activity
(GO:0004679)
Atp binding
(GO:0005524)
Camp-dependent protein kinase activity
(GO:0004691)
Camp-dependent protein kinase complex
(GO:0005952)
Ciliary base
(GO:0097546)
Cytosol
(GO:0005829)
High-density lipoprotein particle assembly
(GO:0034380)
Male gonad development
(GO:0008584)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Protein kinase a regulatory subunit binding
(GO:0034237)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Renal water homeostasis
(GO:0003091)
Signal transduction
(GO:0007165)
Spermatogenesis
(GO:0007283)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.9280
Cell Significance Index: 15.0300
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.6213
Cell Significance Index: 10.6200
Cell Name: mast cell (CL0000097)
Fold Change: 0.2523
Cell Significance Index: 3.3200
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.1549
Cell Significance Index: 2.2200
Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.0968
Cell Significance Index: 2.1200
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.0661
Cell Significance Index: 0.9600
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 0.0187
Cell Significance Index: 0.1900
Cell Name: erythroblast (CL0000765)
Fold Change: 0.0147
Cell Significance Index: 0.1800
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 0.0074
Cell Significance Index: 0.0900
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 0.0047
Cell Significance Index: 0.0500
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 0.0034
Cell Significance Index: 0.1000
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.0031
Cell Significance Index: 0.0400
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 0.0000
Cell Significance Index: 0.0000
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0005
Cell Significance Index: -0.3200
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0006
Cell Significance Index: -0.1800
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0006
Cell Significance Index: -0.3400
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0010
Cell Significance Index: -0.2000
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0018
Cell Significance Index: -0.0900
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0021
Cell Significance Index: -0.2400
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0021
Cell Significance Index: -0.3500
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0024
Cell Significance Index: -0.3500
Cell Name: myelocyte (CL0002193)
Fold Change: -0.0028
Cell Significance Index: -0.0300
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0030
Cell Significance Index: -0.2000
Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: -0.0030
Cell Significance Index: -0.0300
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0030
Cell Significance Index: -0.1200
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.0032
Cell Significance Index: -0.0900
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.0036
Cell Significance Index: -0.0500
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0039
Cell Significance Index: -0.2100
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0043
Cell Significance Index: -0.2800
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0054
Cell Significance Index: -0.1900
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.0055
Cell Significance Index: -0.0700
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0055
Cell Significance Index: -0.3100
Cell Name: pro-B cell (CL0000826)
Fold Change: -0.0056
Cell Significance Index: -0.0600
Cell Name: epithelial cell (CL0000066)
Fold Change: -0.0057
Cell Significance Index: -0.0600
Cell Name: germ cell (CL0000586)
Fold Change: -0.0060
Cell Significance Index: -0.0500
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0060
Cell Significance Index: -0.1900
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0064
Cell Significance Index: -0.2100
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.0069
Cell Significance Index: -0.0900
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.0070
Cell Significance Index: -0.2000
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0076
Cell Significance Index: -0.2000
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.0081
Cell Significance Index: -0.1200
Cell Name: neural progenitor cell (CL0011020)
Fold Change: -0.0087
Cell Significance Index: -0.0900
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.0088
Cell Significance Index: -0.2100
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0089
Cell Significance Index: -0.4200
Cell Name: IgA plasma cell (CL0000987)
Fold Change: -0.0090
Cell Significance Index: -0.0600
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.0093
Cell Significance Index: -0.2000
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.0094
Cell Significance Index: -0.2400
Cell Name: promonocyte (CL0000559)
Fold Change: -0.0094
Cell Significance Index: -0.1000
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.0095
Cell Significance Index: -0.1900
Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -0.0100
Cell Significance Index: -0.2000
Cell Name: primitive red blood cell (CL0002355)
Fold Change: -0.0102
Cell Significance Index: -0.1200
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -0.0102
Cell Significance Index: -0.2000
Cell Name: ciliated cell (CL0000064)
Fold Change: -0.0102
Cell Significance Index: -0.1100
Cell Name: progenitor cell (CL0011026)
Fold Change: -0.0104
Cell Significance Index: -0.1100
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.0104
Cell Significance Index: -0.2100
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.0108
Cell Significance Index: -0.2300
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.0110
Cell Significance Index: -0.2200
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.0110
Cell Significance Index: -0.1900
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: -0.0118
Cell Significance Index: -0.1400
Cell Name: medium spiny neuron (CL1001474)
Fold Change: -0.0119
Cell Significance Index: -0.1600
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: -0.0123
Cell Significance Index: -0.1600
Cell Name: microglial cell (CL0000129)
Fold Change: -0.0136
Cell Significance Index: -0.1600
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: -0.0138
Cell Significance Index: -0.1400
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: -0.0149
Cell Significance Index: -0.2000
Cell Name: T cell (CL0000084)
Fold Change: -0.0152
Cell Significance Index: -0.1800
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.0156
Cell Significance Index: -0.2000
Cell Name: GABAergic neuron (CL0000617)
Fold Change: -0.0158
Cell Significance Index: -0.2000
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: -0.0159
Cell Significance Index: -0.1900
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.0163
Cell Significance Index: -0.2400
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: -0.0168
Cell Significance Index: -0.2000
Cell Name: endothelial cell (CL0000115)
Fold Change: -0.0171
Cell Significance Index: -0.2100
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: -0.0174
Cell Significance Index: -0.1800
Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -0.0174
Cell Significance Index: -0.2200
Cell Name: brain vascular cell (CL4023072)
Fold Change: -0.0175
Cell Significance Index: -0.2000
Cell Name: dendritic cell (CL0000451)
Fold Change: -0.0176
Cell Significance Index: -0.2300
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: -0.0177
Cell Significance Index: -0.1700
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -0.0179
Cell Significance Index: -0.2300
Cell Name: myeloid cell (CL0000763)
Fold Change: -0.0181
Cell Significance Index: -0.2400
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.0184
Cell Significance Index: -0.2000
Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: -0.0185
Cell Significance Index: -0.2500
Cell Name: malignant cell (CL0001064)
Fold Change: -0.0187
Cell Significance Index: -0.1000
Cell Name: cerebellar neuron (CL1001611)
Fold Change: -0.0187
Cell Significance Index: -0.1300
Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: -0.0190
Cell Significance Index: -0.2300
Cell Name: astrocyte (CL0000127)
Fold Change: -0.0192
Cell Significance Index: -0.2200
Cell Name: obsolete animal cell (CL0000548)
Fold Change: -0.0192
Cell Significance Index: -0.2000
Cell Name: amacrine cell (CL0000561)
Fold Change: -0.0192
Cell Significance Index: -0.2400
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.0193
Cell Significance Index: -0.2300
Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
Fold Change: -0.0194
Cell Significance Index: -0.2600
Cell Name: B cell (CL0000236)
Fold Change: -0.0195
Cell Significance Index: -0.2300
Cell Name: late promyelocyte (CL0002151)
Fold Change: -0.0196
Cell Significance Index: -0.1300
Cell Name: fibroblast (CL0000057)
Fold Change: -0.0202
Cell Significance Index: -0.1900
Cell Name: mural cell (CL0008034)
Fold Change: -0.0205
Cell Significance Index: -0.2500
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0206
Cell Significance Index: -0.5500
Cell Name: naive B cell (CL0000788)
Fold Change: -0.0209
Cell Significance Index: -0.2200
Cell Name: megakaryocyte progenitor cell (CL0000553)
Fold Change: -0.0209
Cell Significance Index: -0.1500
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0215
Cell Significance Index: -0.3600
Cell Name: pericyte (CL0000669)
Fold Change: -0.0217
Cell Significance Index: -0.2600
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: -0.0220
Cell Significance Index: -0.2600
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: -0.0231
Cell Significance Index: -0.2400
Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
Fold Change: -0.0231
Cell Significance Index: -0.2100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** PRKACG is a gamma subunit of the protein kinase A (PKA) holoenzyme, which is composed of two catalytic subunits (α and γ) and regulatory subunits (R1 and R2). The gamma subunit is the most abundant subunit of PKA and is responsible for the majority of the enzyme's activity. PRKACG is highly conserved across species, with high sequence identity to other PKA subunits, suggesting its essential role in maintaining cellular homeostasis. **Pathways and Functions:** PRKACG is involved in various signaling pathways, including: 1. **Adaptive Immune System**: PRKACG regulates the production of anti-inflammatory cytokines, such as IL-10, in response to immune stimuli. 2. **Metabolic Regulation**: PRKACG modulates glucose and lipid metabolism by phosphorylating key regulatory enzymes, such as glycogen synthase and acetyl-CoA carboxylase. 3. **Neuronal Signaling**: PRKACG is involved in the regulation of neurotransmitter release and postsynaptic signaling, including the modulation of NMDA receptor activity. 4. **Infectious Disease**: PRKACG regulates the growth and survival of Leishmania parasites by modulating the host's immune response. **Clinical Significance:** PRKACG has been implicated in various diseases, including: 1. **Immune-related disorders**: PRKACG dysfunction has been linked to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Metabolic disorders**: PRKACG plays a critical role in the regulation of glucose and lipid metabolism, making it a potential target for the treatment of metabolic disorders, such as type 2 diabetes and obesity. 3. **Neurological disorders**: PRKACG is involved in the regulation of neuronal signaling, making it a potential target for the treatment of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Cancer**: PRKACG has been implicated in the regulation of cancer cell growth and survival, making it a potential target for cancer therapy. In conclusion, PRKACG is a multifaceted gene that plays a critical role in various physiological processes, including immune responses, metabolism, and neuronal function. Its dysregulation has been implicated in various diseases, making it a potential target for therapeutic intervention. Further research is needed to fully elucidate the mechanisms by which PRKACG regulates cellular processes and to explore its potential as a therapeutic target.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

cAMP-dependent protein kinase catalytic subunit gamma

Genular Protein ID: 1223958299

Symbol: KAPCG_HUMAN

Name: cAMP-dependent protein kinase catalytic subunit gamma

UniProtKB Accession Codes:

P22612 O60850 Q5VZ02 Q86YI1

Database IDs:

Citations:

PubMed ID: 2342480

Title: Molecular cloning of a tissue-specific protein kinase (C gamma) from human testis -- representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase.

PubMed ID: 2342480

DOI: 10.1210/mend-4-3-465

PubMed ID: 9598317

Title: The gene encoding the C gamma catalytic subunit of cAMP-dependent protein kinase is a transcribed retroposon.

PubMed ID: 9598317

DOI: 10.1006/geno.1998.5240

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 25061177

Title: A new form of macrothrombocytopenia induced by a germ-line mutation in the PRKACG gene.

PubMed ID: 25061177

DOI: 10.1182/blood-2014-01-551820

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

Length: 351
Mass: 40434
Checksum: E66BB4BFB8AF9B50
Sequence:

MGNAPAKKDT EQEESVNEFL AKARGDFLYR WGNPAQNTAS SDQFERLRTL GMGSFGRVML 
VRHQETGGHY AMKILNKQKV VKMKQVEHIL NEKRILQAID FPFLVKLQFS FKDNSYLYLV 
MEYVPGGEMF SRLQRVGRFS EPHACFYAAQ VVLAVQYLHS LDLIHRDLKP ENLLIDQQGY 
LQVTDFGFAK RVKGRTWTLC GTPEYLAPEI ILSKGYNKAV DWWALGVLIY EMAVGFPPFY 
ADQPIQIYEK IVSGRVRFPS KLSSDLKHLL RSLLQVDLTK RFGNLRNGVG DIKNHKWFAT 
TSWIAIYEKK VEAPFIPKYT GPGDASNFDD YEEEELRISI NEKCAKEFSE F

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PRKACG

Associated with

Cells (max top 100)

Other Information

Molecular cloning of a tissue-specific protein kinase (C gamma) from human testis -- representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase. PubMed ID: 2342480

The gene encoding the C gamma catalytic subunit of cAMP-dependent protein kinase is a transcribed retroposon. PubMed ID: 9598317

DNA sequence and analysis of human chromosome 9. PubMed ID: 15164053

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A new form of macrothrombocytopenia induced by a germ-line mutation in the PRKACG gene. PubMed ID: 25061177