Details for: S100A7

Gene ID: 6278

Symbol: S100A7

Ensembl ID: ENSG00000143556

Description: S100 calcium binding protein A7

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 2.98
    Marker Score: 1691
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 2.88
    Marker Score: 18541
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.84
    Marker Score: 3915
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 2.55
    Marker Score: 1462
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.37
    Marker Score: 1247
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.6
    Marker Score: 667
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.29
    Marker Score: 2446
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 1.21
    Marker Score: 797
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.06
    Marker Score: 2696
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.03
    Marker Score: 8051
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71831
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48055
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.95
    Marker Score: 14916
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.94
    Marker Score: 1920
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5357
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.88
    Marker Score: 1431
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5294
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.8
    Marker Score: 6895
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.59
    Marker Score: 468
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.58
    Marker Score: 482
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.52
    Marker Score: 184
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.52
    Marker Score: 229
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.49
    Marker Score: 294.5
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.47
    Marker Score: 120
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 278
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.43
    Marker Score: 624
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.4
    Marker Score: 193
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.39
    Marker Score: 343.5
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.36
    Marker Score: 2369
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.33
    Marker Score: 226
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.29
    Marker Score: 136
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.26
    Marker Score: 299
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.25
    Marker Score: 705
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.21
    Marker Score: 2784
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.2
    Marker Score: 177
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.19
    Marker Score: 126
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.18
    Marker Score: 206
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.17
    Marker Score: 41
  • Cell Name: phagocyte (CL0000234)
    Fold Change: 0.17
    Marker Score: 55
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.17
    Marker Score: 61
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.16
    Marker Score: 106
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.16
    Marker Score: 177
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.14
    Marker Score: 108
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.12
    Marker Score: 198
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.11
    Marker Score: 3695
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.11
    Marker Score: 139
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.1
    Marker Score: 99
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.1
    Marker Score: 183
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.09
    Marker Score: 54
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.09
    Marker Score: 422
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.09
    Marker Score: 48
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.08
    Marker Score: 20
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.08
    Marker Score: 108
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.08
    Marker Score: 125
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.08
    Marker Score: 82
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.07
    Marker Score: 23
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.07
    Marker Score: 346
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.06
    Marker Score: 43
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.06
    Marker Score: 114
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.06
    Marker Score: 64
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.06
    Marker Score: 42
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.06
    Marker Score: 69
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.06
    Marker Score: 54
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.06
    Marker Score: 135
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.06
    Marker Score: 51
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.06
    Marker Score: 59
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.05
    Marker Score: 13
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.05
    Marker Score: 13
  • Cell Name: primary cultured cell (CL0000001)
    Fold Change: 0.05
    Marker Score: 20
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.05
    Marker Score: 20
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.05
    Marker Score: 35
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.05
    Marker Score: 20
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.05
    Marker Score: 31
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.05
    Marker Score: 18
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.05
    Marker Score: 20
  • Cell Name: tongue muscle cell (CL0002673)
    Fold Change: 0.05
    Marker Score: 19
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.05
    Marker Score: 19
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.05
    Marker Score: 96
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.04
    Marker Score: 26
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.04
    Marker Score: 23
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.04
    Marker Score: 17
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.04
    Marker Score: 19.5
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.04
    Marker Score: 83
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.04
    Marker Score: 29
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.04
    Marker Score: 75
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.04
    Marker Score: 38
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.04
    Marker Score: 18

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Other Information

**Key characteristics:** - S100A7 is a calcium-binding protein that belongs to the S100A family of calcium sensors. - It is a secreted protein that is predominantly expressed in myeloid cells, including macrophages, dendritic cells, and neutrophils. - It is also expressed in lymphoid cells, such as T cells and B cells. **Pathways and functions:** - S100A7 is involved in the regulation of angiogenesis, antimicrobial humoral immune response, and inflammation. - It acts as a calcium sensor and regulates the activity of various signaling pathways. - It is involved in the regulation of immune cell migration, activation, and differentiation. - It also plays a role in tissue development and the maintenance of epithelial integrity. **Clinical significance:** - Mutations in the S100A7 gene have been linked to various diseases, including cancer, autoimmune disorders, and inflammatory diseases. - S100A7 inhibitors are being investigated as potential cancer therapeutics. - Understanding the role of S100A7 in disease may lead to the development of new diagnostic and therapeutic strategies. **Additional points:** - S100A7 is a highly conserved protein with significant expression in mammals. - It is a multifunctional protein that can interact with various signaling molecules and regulate their activity. - It is a promising target for cancer immunotherapy due to its role in tumor growth and metastasis.

Genular Protein ID: 469802670

Symbol: S10A7_HUMAN

Name: Protein S100-A7

UniProtKB Accession Codes:

P31151 Q5SY67 Q6FGE3 Q9H1E2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTC 1 CTD 1 ChEBI 9 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 7 EMBL 6 EPD 1 Ensembl 2 EvolutionaryTrace 1 GO 24 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 7 PIR 1 PRIDE 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1940442

Title: Molecular cloning, occurrence, and expression of a novel partially secreted protein 'psoriasin' that is highly up-regulated in psoriatic skin.

PubMed ID: 1940442

DOI: 10.1111/1523-1747.ep12484041

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8526920

Title: Amino acid sequence analysis of human S100A7 (psoriasin) by tandem mass spectrometry.

PubMed ID: 8526920

DOI: 10.1006/bbrc.1995.2772

PubMed ID: 1286667

Title: Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.

PubMed ID: 1286667

DOI: 10.1002/elps.11501301199

PubMed ID: 8618345

Title: Bladder squamous cell carcinomas express psoriasin and externalize it to the urine.

PubMed ID: 8618345

DOI: 10.1097/00005392-199606000-00098

PubMed ID: 12421467

Title: RanBPM interacts with psoriasin in vitro and their expression correlates with specific clinical features in vivo in breast cancer.

PubMed ID: 12421467

DOI: 10.1186/1471-2407-2-28

PubMed ID: 12664160

Title: Genomic and phylogenetic analysis of the S100A7 (psoriasin) gene duplications within the region of the S100 gene cluster on human chromosome 1q21.

PubMed ID: 12664160

DOI: 10.1007/s00239-002-2410-5

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 9562557

Title: EF-hands at atomic resolution: the structure of human psoriasin (S100A7) solved by MAD phasing.

PubMed ID: 9562557

DOI: 10.1016/s0969-2126(98)00049-5

PubMed ID: 10026247

Title: Zinc-binding site of an S100 protein revealed. Two crystal structures of Ca2+-bound human psoriasin (S100A7) in the Zn2+-loaded and Zn2+-free states.

PubMed ID: 10026247

DOI: 10.1021/bi982483d

Sequence Information:

  • Length: 101
  • Mass: 11471
  • Checksum: 02C4CE39BF140971
  • Sequence:
    • MSNTQAERSI IGMIDMFHKY TRRDDKIEKP SLLTMMKENF PNFLSACDKK GTNYLADVFE 
KKDKNEDKKI DFSEFLSLLG DIATDYHKQS HGAAPCSGGS Q

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.