Details for: S100A7

Gene ID: 6278

Symbol: S100A7

Ensembl ID: ENSG00000143556

Description: S100 calcium binding protein A7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 15.5697
    Cell Significance Index: 133.7900
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 3.2203
    Cell Significance Index: 40.6900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 2.9784
    Cell Significance Index: 38.5400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 2.4327
    Cell Significance Index: 33.3600
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.4266
    Cell Significance Index: 9.4700
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.8912
    Cell Significance Index: 6.7900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5210
    Cell Significance Index: 230.3400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2538
    Cell Significance Index: 32.5400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.2305
    Cell Significance Index: 1.8400
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 0.1777
    Cell Significance Index: 1.2800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1595
    Cell Significance Index: 4.4600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1118
    Cell Significance Index: 7.9100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0834
    Cell Significance Index: 0.9500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.0404
    Cell Significance Index: 0.6900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0200
    Cell Significance Index: 2.5800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0077
    Cell Significance Index: 2.2100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0015
    Cell Significance Index: -0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0026
    Cell Significance Index: -4.9300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0042
    Cell Significance Index: -7.6700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0050
    Cell Significance Index: -7.6400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0056
    Cell Significance Index: -7.6100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0059
    Cell Significance Index: -3.7300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0062
    Cell Significance Index: -4.6800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0064
    Cell Significance Index: -4.7300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0091
    Cell Significance Index: -4.9800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0098
    Cell Significance Index: -5.5500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0108
    Cell Significance Index: -4.8800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0108
    Cell Significance Index: -3.8700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0110
    Cell Significance Index: -2.2200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0136
    Cell Significance Index: -0.6900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0153
    Cell Significance Index: -1.7900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0167
    Cell Significance Index: -0.6900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0200
    Cell Significance Index: -3.6100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0222
    Cell Significance Index: -4.6800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0237
    Cell Significance Index: -0.3600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0241
    Cell Significance Index: -3.5000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0277
    Cell Significance Index: -3.4100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0310
    Cell Significance Index: -3.1700
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0311
    Cell Significance Index: -0.3300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0312
    Cell Significance Index: -5.3200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0330
    Cell Significance Index: -1.5500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0349
    Cell Significance Index: -4.7900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0350
    Cell Significance Index: -4.1300
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0376
    Cell Significance Index: -0.3200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0398
    Cell Significance Index: -4.5600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0617
    Cell Significance Index: -1.5400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0705
    Cell Significance Index: -4.7400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0740
    Cell Significance Index: -3.4500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0793
    Cell Significance Index: -2.9100
  • Cell Name: eosinophil (CL0000771)
    Fold Change: -0.0794
    Cell Significance Index: -0.7000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0825
    Cell Significance Index: -6.1500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0873
    Cell Significance Index: -2.2300
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0987
    Cell Significance Index: -1.2000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0989
    Cell Significance Index: -1.5300
  • Cell Name: brush cell of tracheobronchial tree (CL0002075)
    Fold Change: -0.1006
    Cell Significance Index: -0.9100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1037
    Cell Significance Index: -1.6800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1068
    Cell Significance Index: -3.1500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1073
    Cell Significance Index: -3.7300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1073
    Cell Significance Index: -6.7600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1094
    Cell Significance Index: -1.8400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1102
    Cell Significance Index: -3.1600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1113
    Cell Significance Index: -2.3300
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.1134
    Cell Significance Index: -1.1700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1143
    Cell Significance Index: -1.6600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1166
    Cell Significance Index: -6.1200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1192
    Cell Significance Index: -4.1800
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.1251
    Cell Significance Index: -2.1500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1274
    Cell Significance Index: -1.8100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1320
    Cell Significance Index: -5.8400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1405
    Cell Significance Index: -7.3000
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.1416
    Cell Significance Index: -1.6300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1436
    Cell Significance Index: -4.7000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1456
    Cell Significance Index: -3.7100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1466
    Cell Significance Index: -4.6700
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: -0.1477
    Cell Significance Index: -0.6800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1512
    Cell Significance Index: -3.3100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1553
    Cell Significance Index: -5.8800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1640
    Cell Significance Index: -4.6800
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.1725
    Cell Significance Index: -2.3000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1732
    Cell Significance Index: -4.6400
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1733
    Cell Significance Index: -2.3100
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1773
    Cell Significance Index: -2.0400
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: -0.1794
    Cell Significance Index: -1.7100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1797
    Cell Significance Index: -4.3100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1844
    Cell Significance Index: -4.8500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1872
    Cell Significance Index: -4.6700
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.1880
    Cell Significance Index: -2.2700
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.1930
    Cell Significance Index: -1.9100
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.1943
    Cell Significance Index: -2.1300
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.2001
    Cell Significance Index: -2.2700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2032
    Cell Significance Index: -4.3900
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.2041
    Cell Significance Index: -2.3100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2060
    Cell Significance Index: -2.2400
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.2130
    Cell Significance Index: -2.2900
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.2184
    Cell Significance Index: -2.2300
  • Cell Name: urothelial cell (CL0000731)
    Fold Change: -0.2223
    Cell Significance Index: -1.5500
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.2241
    Cell Significance Index: -1.7100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2251
    Cell Significance Index: -4.5200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2257
    Cell Significance Index: -4.7900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2262
    Cell Significance Index: -4.7200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** S100A7 is a small, acidic protein (~14 kDa) that binds to calcium ions, which is essential for its protein-protein interactions and cellular functions. Its expression is highly regulated, with significant increases in response to inflammatory stimuli, oxidative stress, and tissue injury. S100A7 is also characterized by its ability to interact with various receptors, including the Rage receptor, which is involved in the regulation of immune responses and cell signaling. **Pathways and Functions:** S100A7 is involved in multiple signaling pathways, including: 1. **Angiogenesis:** S100A7 regulates the expression of angiogenic factors, such as vascular endothelial growth factor (VEGF), which is essential for the formation of new blood vessels. 2. **Antimicrobial Humoral Immune Response:** S100A7 interacts with antimicrobial peptides, such as cathelicidins, to regulate the innate immune response against microbial infections. 3. **Cellular Differentiation:** S100A7 plays a crucial role in the differentiation of keratinocytes, megakaryocytes, and other cell types, influencing the development and maintenance of tissue homeostasis. 4. **Calcium-dependent Protein Binding:** S100A7 binds to calcium ions, which is essential for its protein-protein interactions and cellular functions. **Clinical Significance:** Dysregulation of S100A7 has been implicated in various immunological disorders, including: 1. **Psoriasis:** S100A7 is overexpressed in psoriatic skin, where it contributes to the development of inflammation and tissue damage. 2. **Leukemia:** S100A7 is upregulated in certain types of leukemia, where it promotes the proliferation and survival of leukemic cells. 3. **Inflammatory Diseases:** S100A7 is involved in the regulation of inflammatory responses, and its dysregulation has been linked to various inflammatory diseases, such as rheumatoid arthritis and atherosclerosis. In conclusion, S100A7 is a multifaceted protein that plays a critical role in regulating immune responses, cellular differentiation, and tissue homeostasis. Its dysregulation has been implicated in various immunological disorders, highlighting the importance of S100A7 in maintaining the integrity of the immune system and tissue health. Further research is needed to fully elucidate the mechanisms by which S100A7 regulates these processes and to explore its therapeutic potential in immunological disorders.

Genular Protein ID: 469802670

Symbol: S10A7_HUMAN

Name: Protein S100-A7

UniProtKB Accession Codes:

P31151 Q5SY67 Q6FGE3 Q9H1E2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTC 1 CTD 1 ChEBI 9 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 7 EMBL 6 Ensembl 2 EvolutionaryTrace 1 GO 24 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PIR 1 PRIDE 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1940442

Title: Molecular cloning, occurrence, and expression of a novel partially secreted protein 'psoriasin' that is highly up-regulated in psoriatic skin.

PubMed ID: 1940442

DOI: 10.1111/1523-1747.ep12484041

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8526920

Title: Amino acid sequence analysis of human S100A7 (psoriasin) by tandem mass spectrometry.

PubMed ID: 8526920

DOI: 10.1006/bbrc.1995.2772

PubMed ID: 1286667

Title: Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.

PubMed ID: 1286667

DOI: 10.1002/elps.11501301199

PubMed ID: 8618345

Title: Bladder squamous cell carcinomas express psoriasin and externalize it to the urine.

PubMed ID: 8618345

DOI: 10.1097/00005392-199606000-00098

PubMed ID: 12421467

Title: RanBPM interacts with psoriasin in vitro and their expression correlates with specific clinical features in vivo in breast cancer.

PubMed ID: 12421467

DOI: 10.1186/1471-2407-2-28

PubMed ID: 12664160

Title: Genomic and phylogenetic analysis of the S100A7 (psoriasin) gene duplications within the region of the S100 gene cluster on human chromosome 1q21.

PubMed ID: 12664160

DOI: 10.1007/s00239-002-2410-5

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 9562557

Title: EF-hands at atomic resolution: the structure of human psoriasin (S100A7) solved by MAD phasing.

PubMed ID: 9562557

DOI: 10.1016/s0969-2126(98)00049-5

PubMed ID: 10026247

Title: Zinc-binding site of an S100 protein revealed. Two crystal structures of Ca2+-bound human psoriasin (S100A7) in the Zn2+-loaded and Zn2+-free states.

PubMed ID: 10026247

DOI: 10.1021/bi982483d

Sequence Information:

  • Length: 101
  • Mass: 11471
  • Checksum: 02C4CE39BF140971
  • Sequence:
    • MSNTQAERSI IGMIDMFHKY TRRDDKIEKP SLLTMMKENF PNFLSACDKK GTNYLADVFE 
KKDKNEDKKI DFSEFLSLLG DIATDYHKQS HGAAPCSGGS Q

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.