Details for: SHBG

Gene ID: 6462

Symbol: SHBG

Ensembl ID: ENSG00000129214

Description: sex hormone binding globulin

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 6.35
    Marker Score: 3516
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 3.08
    Marker Score: 26014
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.43
    Marker Score: 1281.5
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.86
    Marker Score: 2867
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.73
    Marker Score: 3276
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169563
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 868
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.15
    Marker Score: 2336
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.14
    Marker Score: 2688
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.12
    Marker Score: 362
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.07
    Marker Score: 16797
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71826
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48051
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 506
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 460
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.95
    Marker Score: 643
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5338
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.93
    Marker Score: 292
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 373
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.9
    Marker Score: 374.5
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5288
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.77
    Marker Score: 512
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 701
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.76
    Marker Score: 459
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.73
    Marker Score: 561
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2978
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.63
    Marker Score: 386
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.63
    Marker Score: 302
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.62
    Marker Score: 161
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.57
    Marker Score: 238
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.55
    Marker Score: 354
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.48
    Marker Score: 212
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.44
    Marker Score: 408
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.42
    Marker Score: 238
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.39
    Marker Score: 373
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 371
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.36
    Marker Score: 243
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.24
    Marker Score: 801
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.24
    Marker Score: 93
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.23
    Marker Score: 168
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.19
    Marker Score: 113
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.19
    Marker Score: 115
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.19
    Marker Score: 1942
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.18
    Marker Score: 75
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.18
    Marker Score: 164
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.18
    Marker Score: 874
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.17
    Marker Score: 754
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.17
    Marker Score: 620
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.17
    Marker Score: 84
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.17
    Marker Score: 92
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.17
    Marker Score: 1012
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.15
    Marker Score: 69
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.14
    Marker Score: 53
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.14
    Marker Score: 170
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.13
    Marker Score: 215
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.13
    Marker Score: 29
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.13
    Marker Score: 86
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.13
    Marker Score: 169
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.13
    Marker Score: 160
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.13
    Marker Score: 111
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.13
    Marker Score: 133.5
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.13
    Marker Score: 193
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.12
    Marker Score: 117
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.12
    Marker Score: 54
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.12
    Marker Score: 35
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.12
    Marker Score: 48
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.11
    Marker Score: 479
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.11
    Marker Score: 197
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.11
    Marker Score: 75
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.11
    Marker Score: 41
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.11
    Marker Score: 38
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.1
    Marker Score: 24
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.1
    Marker Score: 2307
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.1
    Marker Score: 36
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.1
    Marker Score: 361
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.1
    Marker Score: 58
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.1
    Marker Score: 116
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.1
    Marker Score: 628
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.1
    Marker Score: 36
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1
    Marker Score: 22
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.1
    Marker Score: 33
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.09
    Marker Score: 105
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.09
    Marker Score: 55
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.09
    Marker Score: 21
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.09
    Marker Score: 22
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.09
    Marker Score: 87
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.09
    Marker Score: 50

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Other Information

**Key Characteristics:** SHBG is a glycoprotein with a molecular weight of approximately 58 kDa, composed of two identical subunits. It is primarily produced by the liver and secreted into the bloodstream, where it binds to sex hormones, such as testosterone and estradiol, thereby regulating their availability and effects on target tissues. SHBG also interacts with other proteins, including androgen receptors, insulin-like growth factor-1 (IGF-1), and growth factor receptors, modulating their activity and signaling pathways. **Pathways and Functions:** SHBG is involved in several key pathways, including: 1. **Androgen binding:** SHBG binds to androgens, such as testosterone and dihydrotestosterone, regulating their activity and availability for target tissues, including immune cells. 2. **Extracellular exosome:** SHBG is secreted into exosomes, which are small vesicles that carry proteins, lipids, and nucleic acids, influencing intercellular communication and immune responses. 3. **Protein binding:** SHBG interacts with various proteins, including growth factors, cytokines, and receptors, modulating their activity and signaling pathways. 4. **Steroid binding:** SHBG binds to sex hormones, regulating their availability and effects on target tissues. SHBG's functions include: * Regulating immune cell function and inflammation * Modulating the activity of growth factors and cytokines * Influencing cell signaling pathways, including those involved in cell growth, differentiation, and survival * Regulating the availability and effects of sex hormones on target tissues **Clinical Significance:** SHBG's dysregulation has been implicated in various diseases, including: 1. **Hypogonadism:** SHBG levels are often decreased in men with hypogonadism, leading to reduced testosterone availability and decreased libido. 2. **Polycystic ovary syndrome (PCOS):** SHBG levels are often elevated in women with PCOS, contributing to insulin resistance and metabolic dysregulation. 3. **Autoimmune diseases:** SHBG's role in regulating immune cell function and inflammation makes it a potential target for therapeutic interventions in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 4. **Cancer:** SHBG's interaction with growth factors and cytokines may influence tumor growth and metastasis, making it a potential biomarker for cancer diagnosis and prognosis. In conclusion, SHBG is a multifaceted protein that plays a crucial role in regulating immune responses, steroid metabolism, and cell signaling. Its dysregulation has significant clinical implications, making it an important area of research for the development of novel therapeutic interventions.

Genular Protein ID: 3306835218

Symbol: SHBG_HUMAN

Name: Sex steroid-binding protein

UniProtKB Accession Codes:

P04278 B0FWH4 B4DYU0 E9PGW1 F5H5Z8 I3L1N7 P14689 Q16616 Q3MIL0 Q6ISD2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 70 DrugCentral 1 EMBL 14 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 16 PDBsum 13 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 7 RNAct 1 RefSeq 8 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2587256

Title: Characterization of the human sex hormone binding globulin (SHBG) gene and demonstration of two transcripts in both liver and testis.

PubMed ID: 2587256

DOI: 10.1093/nar/17.22.9245

PubMed ID: 2608061

Title: The human sex hormone-binding globulin gene contains exons for androgen-binding protein and two other testicular messenger RNAs.

PubMed ID: 2608061

DOI: 10.1210/mend-3-11-1869

PubMed ID: 15028279

Title: PCR isolation and cloning of novel splice variant mRNAs from known drug target genes.

PubMed ID: 15028279

DOI: 10.1016/j.ygeno.2003.09.023

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3569533

Title: The cDNA-deduced primary structure of human sex hormone-binding globulin and location of its steroid-binding domain.

PubMed ID: 3569533

DOI: 10.1016/0014-5793(87)80121-7

PubMed ID: 2956126

Title: A cDNA coding for human sex hormone binding globulin. Homology to vitamin K-dependent protein S.

PubMed ID: 2956126

DOI: 10.1016/0014-5793(87)80890-6

PubMed ID: 2956125

Title: Characterization of a cDNA coding for sex steroid-binding protein of human plasma.

PubMed ID: 2956125

DOI: 10.1016/0014-5793(87)80261-2

PubMed ID: 3702459

Title: Physicochemical characteristics of human sex hormone binding globulin: evidence for two identical subunits.

PubMed ID: 3702459

DOI: 10.1016/0022-4731(86)90442-5

PubMed ID: 3542030

Title: Amino acid sequence of the sex steroid binding protein of human blood plasma.

PubMed ID: 3542030

DOI: 10.1021/bi00371a048

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 1400872

Title: Molecular analyses of a human sex hormone-binding globulin variant: evidence for an additional carbohydrate chain.

PubMed ID: 1400872

DOI: 10.1210/jcem.75.4.1400872

PubMed ID: 10675319

Title: Crystal structure of human sex hormone-binding globulin: steroid transport by a laminin G-like domain.

PubMed ID: 10675319

DOI: 10.1093/emboj/19.4.504

PubMed ID: 12065592

Title: Steroid ligands bind human sex hormone-binding globulin in specific orientations and produce distinct changes in protein conformation.

PubMed ID: 12065592

DOI: 10.1074/jbc.m203999200

PubMed ID: 7714097

Title: Molecular characterization of a genetic variant of the steroid hormone-binding globulin gene in heterozygous subjects.

PubMed ID: 7714097

DOI: 10.1210/jcem.80.4.7714097

PubMed ID: 10391209

Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.

PubMed ID: 10391209

DOI: 10.1038/10290

Sequence Information:

  • Length: 402
  • Mass: 43779
  • Checksum: 5A3B1885E4E7A460
  • Sequence:
    • MESRGPLATS RLLLLLLLLL LRHTRQGWAL RPVLPTQSAH DPPAVHLSNG PGQEPIAVMT 
FDLTKITKTS SSFEVRTWDP EGVIFYGDTN PKDDWFMLGL RDGRPEIQLH NHWAQLTVGA 
GPRLDDGRWH QVEVKMEGDS VLLEVDGEEV LRLRQVSGPL TSKRHPIMRI ALGGLLFPAS 
NLRLPLVPAL DGCLRRDSWL DKQAEISASA PTSLRSCDVE SNPGIFLPPG TQAEFNLRDI 
PQPHAEPWAF SLDLGLKQAA GSGHLLALGT PENPSWLSLH LQDQKVVLSS GSGPGLDLPL 
VLGLPLQLKL SMSRVVLSQG SKMKALALPP LGLAPLLNLW AKPQGRLFLG ALPGEDSSTS 
FCLNGLWAQG QRLDVDQALN RSHEIWTHSC PQSPGNGTDA SH

Genular Protein ID: 1762254303

Symbol: I3L145_HUMAN

Name: N/A

UniProtKB Accession Codes:

I3L145

Database IDs:

ARBA 10 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 Ensembl 3 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 2 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 2 SMART 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

  • Length: 344
  • Mass: 37488
  • Checksum: 30087AA6D4E2BCD4
  • Sequence:
    • MTFDLTKITK TSSSFEVRTW DPEGVIFYGD TNPKDDWFML GLRDGRPEIQ LHNHWAQLTV 
GAGPRLDDGR WHQVEVKMEG DSVLLEVDGE EVLRLRQVSG PLTSKRHPIM RIALGGLLFP 
ASNLRLPLVP ALDGCLRRDS WLDKQAEISA SAPTSLRSCD VESNPGIFLP PGTQAEFNLR 
DIPQPHAEPW AFSLDLGLKQ AAGSGHLLAL GTPENPSWLS LHLQDQKVVL SSGSGPGLDL 
PLVLGLPLQL KLSMSRVVLS QGSKMKALAL PPLGLAPLLN LWAKPQGRLF LGALPGEDSS 
TSFCLNGLWA QGQRLDVDQA LNRSHEIWTH SCPQSPGNGT DASH

Genular Protein ID: 4062811208

Symbol: B0FWH2_HUMAN

Name: N/A

UniProtKB Accession Codes:

B0FWH2

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 GenomeRNAi 1 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PeptideAtlas 1 PharmGKB 1 RefSeq 5 SAM 1

Sequence Information:

  • Length: 37
  • Mass: 4234
  • Checksum: 32D1DBD78AAE4F4D
  • Sequence:
    • MESRGPLATS RLLLLLLLLL LRHTRQGWAL RPVLPTQ

Genular Protein ID: 1666549518

Symbol: B0FWH8_HUMAN

Name: N/A

UniProtKB Accession Codes:

B0FWH8

Database IDs:

BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 6 GenomeRNAi 1 NCBI Taxonomy 1 RefSeq 1

Sequence Information:

  • Length: 10
  • Mass: 1079
  • Checksum: D0ED0CB735B33AB6
  • Sequence:
    • MAQDKSLSLS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.