Details for: SOX1

Gene ID: 6656

Symbol: SOX1

Ensembl ID: ENSG00000182968

Description: SRY-box transcription factor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.7330
    Cell Significance Index: 17.5800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.5649
    Cell Significance Index: 34.7200
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.3232
    Cell Significance Index: 4.7100
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.2537
    Cell Significance Index: 3.2900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0256
    Cell Significance Index: 1.1600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0062
    Cell Significance Index: 2.2400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0072
    Cell Significance Index: -4.0700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0076
    Cell Significance Index: -5.6100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0088
    Cell Significance Index: -0.4100
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0101
    Cell Significance Index: -0.1000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0105
    Cell Significance Index: -5.7200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0120
    Cell Significance Index: -3.4500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0143
    Cell Significance Index: -0.2000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0145
    Cell Significance Index: -2.9100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0269
    Cell Significance Index: -0.3400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0293
    Cell Significance Index: -6.1800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0321
    Cell Significance Index: -0.4600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0325
    Cell Significance Index: -5.5500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0419
    Cell Significance Index: -5.7500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0506
    Cell Significance Index: -5.9000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0538
    Cell Significance Index: -6.1600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0581
    Cell Significance Index: -3.9100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0583
    Cell Significance Index: -1.1700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0776
    Cell Significance Index: -1.6200
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0780
    Cell Significance Index: -0.9100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0834
    Cell Significance Index: -4.6800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0893
    Cell Significance Index: -1.9300
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0920
    Cell Significance Index: -1.1000
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0962
    Cell Significance Index: -1.1700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0976
    Cell Significance Index: -1.9300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0996
    Cell Significance Index: -4.6800
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.1284
    Cell Significance Index: -1.7800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1338
    Cell Significance Index: -2.8400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1353
    Cell Significance Index: -4.7400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1442
    Cell Significance Index: -4.7200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1475
    Cell Significance Index: -4.2500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1480
    Cell Significance Index: -3.2400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1545
    Cell Significance Index: -4.9200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1564
    Cell Significance Index: -5.0100
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.1609
    Cell Significance Index: -1.1700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1654
    Cell Significance Index: -5.2300
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.1654
    Cell Significance Index: -1.5500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1742
    Cell Significance Index: -4.9700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1770
    Cell Significance Index: -3.0600
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.1833
    Cell Significance Index: -1.8200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1839
    Cell Significance Index: -4.9100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1886
    Cell Significance Index: -4.7100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1911
    Cell Significance Index: -3.8100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1945
    Cell Significance Index: -5.7300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1989
    Cell Significance Index: -5.2300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1996
    Cell Significance Index: -4.1400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2016
    Cell Significance Index: -5.0300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2063
    Cell Significance Index: -5.2600
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.2098
    Cell Significance Index: -2.1400
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.2111
    Cell Significance Index: -2.3900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2139
    Cell Significance Index: -2.3300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.2177
    Cell Significance Index: -2.7500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2222
    Cell Significance Index: -3.8000
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.2263
    Cell Significance Index: -4.7200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2265
    Cell Significance Index: -6.0700
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.2332
    Cell Significance Index: -4.5900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2349
    Cell Significance Index: -5.6900
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.2404
    Cell Significance Index: -1.7300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2419
    Cell Significance Index: -5.1700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.2426
    Cell Significance Index: -2.3000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.2538
    Cell Significance Index: -5.1700
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.2606
    Cell Significance Index: -4.1900
  • Cell Name: medial ganglionic eminence derived GABAergic cortical interneuron (CL4023069)
    Fold Change: -0.2657
    Cell Significance Index: -2.5100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2783
    Cell Significance Index: -4.7700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2854
    Cell Significance Index: -5.5800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2913
    Cell Significance Index: -4.8800
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: -0.2915
    Cell Significance Index: -2.2400
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: -0.2920
    Cell Significance Index: -1.6600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.2924
    Cell Significance Index: -3.9000
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.2971
    Cell Significance Index: -4.4500
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.3003
    Cell Significance Index: -3.2900
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.3023
    Cell Significance Index: -3.9500
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.3088
    Cell Significance Index: -3.4500
  • Cell Name: interneuron (CL0000099)
    Fold Change: -0.3099
    Cell Significance Index: -3.6200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3106
    Cell Significance Index: -5.7400
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.3201
    Cell Significance Index: -2.2200
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.3204
    Cell Significance Index: -4.4800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.3207
    Cell Significance Index: -4.8700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.3228
    Cell Significance Index: -5.4300
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.3244
    Cell Significance Index: -3.8600
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: -0.3245
    Cell Significance Index: -2.6200
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.3308
    Cell Significance Index: -3.2000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.3316
    Cell Significance Index: -5.3700
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.3336
    Cell Significance Index: -3.4600
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.3360
    Cell Significance Index: -4.0900
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.3375
    Cell Significance Index: -4.7300
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.3444
    Cell Significance Index: -4.5200
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: -0.3453
    Cell Significance Index: -4.1800
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.3453
    Cell Significance Index: -4.1900
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.3476
    Cell Significance Index: -4.0000
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.3476
    Cell Significance Index: -3.8100
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.3486
    Cell Significance Index: -4.7000
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.3508
    Cell Significance Index: -4.4500
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.3523
    Cell Significance Index: -4.0600
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.3526
    Cell Significance Index: -3.7200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SOX1 is a transcription factor that belongs to the SOX family, which is characterized by a highly conserved DNA-binding domain. This domain allows SOX1 to bind to specific DNA sequences, thereby regulating the expression of target genes. SOX1 is predominantly expressed in neural progenitor cells, blood vessel endothelial cells, plasma cells, T cells, B cells, goblet cells, and various types of neurons, including GABAergic interneurons. Its expression is also observed in other cell types, such as pericytes and forebrain radial glial cells. **Pathways and Functions:** SOX1 is involved in a wide range of biological processes, including: 1. **Neural Development:** SOX1 plays a crucial role in the development of the nervous system, particularly in the formation of the anterior and posterior neural plates, as well as the specification of ventral spinal cord interneurons. 2. **Cellular Response to Leukemia Inhibitory Factor (LIF):** SOX1 is involved in the regulation of cellular responses to LIF, a cytokine that plays a key role in embryonic development and tissue homeostasis. 3. **Chromatin Organization:** SOX1 regulates chromatin organization and structure, influencing the expression of target genes involved in various biological processes. 4. **Immune Cell Regulation:** SOX1 is expressed in immune cells, including T cells, B cells, and plasma cells, and is involved in the regulation of their development, function, and differentiation. **SOX1 Signaling Pathways:** 1. **Wnt/β-catenin Signaling:** SOX1 interacts with the Wnt/β-catenin signaling pathway, influencing the expression of target genes involved in neural development and cell fate determination. 2. **Notch Signaling:** SOX1 is also involved in the regulation of Notch signaling, a critical pathway involved in cell fate determination and differentiation. 3. **PI3K/AKT Signaling:** SOX1 regulates the PI3K/AKT signaling pathway, influencing the expression of target genes involved in cell survival and proliferation. **Clinical Significance:** Dysregulation of SOX1 has been implicated in various immunological disorders, including: 1. **Autoimmune Diseases:** SOX1 is expressed in autoimmune cells, such as T cells and B cells, and its dysregulation may contribute to the development of autoimmune diseases, such as multiple sclerosis and type 1 diabetes. 2. **Cancer:** SOX1 is involved in the regulation of cellular responses to LIF and is expressed in cancer cells, including those of glioblastoma and leukemia. 3. **Neurological Disorders:** SOX1 is also involved in the regulation of neural development and function, and its dysregulation may contribute to the development of neurological disorders, such as autism spectrum disorder and schizophrenia. In conclusion, SOX1 is a critical transcription factor that plays a pivotal role in neural development, immune cell regulation, and the maintenance of tissue homeostasis. Its dysregulation has been implicated in various immunological disorders, highlighting the importance of SOX1 in understanding the complex interplay between the nervous system and the immune system.

Genular Protein ID: 180154708

Symbol: SOX1_HUMAN

Name: Transcription factor SOX-1

UniProtKB Accession Codes:

O00570 Q5W0Q1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9337405

Title: Cloning and mapping of the human SOX1: a highly conserved gene expressed in the developing brain.

PubMed ID: 9337405

DOI: 10.1007/s003359900597

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

Sequence Information:

  • Length: 391
  • Mass: 39023
  • Checksum: DD519BA97CF5E052
  • Sequence:
    • MYSMMMETDL HSPGGAQAPT NLSGPAGAGG GGGGGGGGGG GGGAKANQDR VKRPMNAFMV 
WSRGQRRKMA QENPKMHNSE ISKRLGAEWK VMSEAEKRPF IDEAKRLRAL HMKEHPDYKY 
RPRRKTKTLL KKDKYSLAGG LLAAGAGGGG AAVAMGVGVG VGAAAVGQRL ESPGGAAGGG 
YAHVNGWANG AYPGSVAAAA AAAAMMQEAQ LAYGQHPGAG GAHPHAHPAH PHPHHPHAHP 
HNPQPMHRYD MGALQYSPIS NSQGYMSASP SGYGGLPYGA AAAAAAAAGG AHQNSAVAAA 
AAAAAASSGA LGALGSLVKS EPSGSPPAPA HSRAPCPGDL REMISMYLPA GEGGDPAAAA 
AAAAQSRLHS LPQHYQGAGA GVNGTVPLTH I

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.