Details for: SULT2A1

Gene ID: 6822

Symbol: SULT2A1

Ensembl ID: ENSG00000105398

Description: sulfotransferase family 2A member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 18.0756
    Cell Significance Index: 484.3400
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 11.9032
    Cell Significance Index: 31.4000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 6.5052
    Cell Significance Index: -1.6500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 6.3641
    Cell Significance Index: 95.3600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 4.8516
    Cell Significance Index: 81.7300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.3914
    Cell Significance Index: 31.2300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.3468
    Cell Significance Index: 446.6200
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 2.2484
    Cell Significance Index: 17.0500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.7790
    Cell Significance Index: 353.0400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.6135
    Cell Significance Index: 96.8700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.3957
    Cell Significance Index: 20.6000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.2278
    Cell Significance Index: 35.3800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.0113
    Cell Significance Index: 17.0100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9805
    Cell Significance Index: 106.6500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7945
    Cell Significance Index: 717.4200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7530
    Cell Significance Index: 74.4900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7510
    Cell Significance Index: 39.0100
  • Cell Name: colonocyte (CL1000347)
    Fold Change: 0.7379
    Cell Significance Index: 4.5600
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.7293
    Cell Significance Index: 4.2000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5834
    Cell Significance Index: 40.3400
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.5782
    Cell Significance Index: 6.3700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4629
    Cell Significance Index: 75.2900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.3192
    Cell Significance Index: 8.2100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.3044
    Cell Significance Index: 7.5900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2101
    Cell Significance Index: 3.6000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2085
    Cell Significance Index: 4.4400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1509
    Cell Significance Index: 3.1300
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.1216
    Cell Significance Index: 0.9600
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.1142
    Cell Significance Index: 0.4300
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.1105
    Cell Significance Index: 1.0900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1016
    Cell Significance Index: 3.5700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1011
    Cell Significance Index: 2.1900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0611
    Cell Significance Index: 0.9200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.0610
    Cell Significance Index: 0.4700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0503
    Cell Significance Index: 0.6000
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 0.0467
    Cell Significance Index: 0.1300
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.0379
    Cell Significance Index: 0.3600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0294
    Cell Significance Index: 1.8600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0285
    Cell Significance Index: 0.4700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0196
    Cell Significance Index: 0.4900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0165
    Cell Significance Index: 0.7500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0133
    Cell Significance Index: 2.6700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0113
    Cell Significance Index: 0.3200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0085
    Cell Significance Index: 1.0500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0077
    Cell Significance Index: 1.3800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0033
    Cell Significance Index: 1.1800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0024
    Cell Significance Index: 0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0014
    Cell Significance Index: 2.5500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0012
    Cell Significance Index: 1.8600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0012
    Cell Significance Index: 0.7200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0011
    Cell Significance Index: 0.0300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0008
    Cell Significance Index: 1.4300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0008
    Cell Significance Index: 1.0400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0014
    Cell Significance Index: -0.2000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0022
    Cell Significance Index: -1.6300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0022
    Cell Significance Index: -1.7000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0023
    Cell Significance Index: -1.4300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0023
    Cell Significance Index: -1.3200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0024
    Cell Significance Index: -1.0700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0029
    Cell Significance Index: -0.4900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0029
    Cell Significance Index: -1.5700
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0032
    Cell Significance Index: -0.0200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0038
    Cell Significance Index: -1.0800
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: -0.0057
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0080
    Cell Significance Index: -1.6800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0089
    Cell Significance Index: -0.6800
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0094
    Cell Significance Index: -0.1300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0097
    Cell Significance Index: -1.1200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0101
    Cell Significance Index: -1.3900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0105
    Cell Significance Index: -1.2200
  • Cell Name: parietal cell (CL0000162)
    Fold Change: -0.0106
    Cell Significance Index: -0.1000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0119
    Cell Significance Index: -0.3800
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0121
    Cell Significance Index: -0.1300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0140
    Cell Significance Index: -0.6200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0141
    Cell Significance Index: -0.9500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0147
    Cell Significance Index: -1.5300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0148
    Cell Significance Index: -0.9100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0174
    Cell Significance Index: -0.6600
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0192
    Cell Significance Index: -0.2400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0230
    Cell Significance Index: -2.3500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0238
    Cell Significance Index: -1.4600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0241
    Cell Significance Index: -0.3500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0246
    Cell Significance Index: -0.4800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0250
    Cell Significance Index: -0.6100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0273
    Cell Significance Index: -1.2800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0280
    Cell Significance Index: -1.5700
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.0291
    Cell Significance Index: -0.3000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0298
    Cell Significance Index: -0.9500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0330
    Cell Significance Index: -1.0800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0330
    Cell Significance Index: -1.5500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0334
    Cell Significance Index: -1.1700
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.0335
    Cell Significance Index: -0.3400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0341
    Cell Significance Index: -1.7900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0354
    Cell Significance Index: -1.5400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0355
    Cell Significance Index: -0.9500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0356
    Cell Significance Index: -0.9500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0379
    Cell Significance Index: -1.3900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0389
    Cell Significance Index: -2.5100
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0392
    Cell Significance Index: -0.4300
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0400
    Cell Significance Index: -0.4900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Sulfotransferase Activity:** SULT2A1 exhibits sulfotransferase activity, catalyzing the transfer of a sulfonate group from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to various substrates, resulting in their sulfonation. 2. **Metabolic Pathways:** SULT2A1 is involved in a range of metabolic processes, including lipid catabolism, cholesterol metabolism, bile acid catabolism, and steroid metabolism. 3. **Tissue Distribution:** SULT2A1 is expressed in various tissues, including the adrenal gland, liver, colon, and immune cells, highlighting its broad functional scope. 4. **Regulatory Mechanisms:** SULT2A1 is subject to regulation by various mechanisms, including transcriptional control by PPARα and post-translational modifications. **Pathways and Functions:** 1. **Lipid Metabolism:** SULT2A1 plays a critical role in lipid catabolism, regulating the breakdown of triglycerides, cholesterol, and bile acids. 2. **Steroid Metabolism:** SULT2A1 is involved in the sulfonation of steroids, influencing their activity and regulating hormone homeostasis. 3. **Xenobiotic Metabolism:** SULT2A1 detoxifies xenobiotics, including environmental pollutants and pharmaceuticals, by sulfonating and rendering them more soluble and excretable. 4. **Immune System Regulation:** SULT2A1 is expressed in immune cells, where it modulates immune responses and regulates the activity of cytokines and chemokines. **Clinical Significance:** 1. **Disease Association:** Altered expression or activity of SULT2A1 has been linked to various diseases, including liver disease, cancer, and metabolic disorders. 2. **Pharmacokinetics:** SULT2A1 influences the pharmacokinetics of certain drugs, including paracetamol and ethanol, by affecting their sulfonation and metabolism. 3. **Toxicity Assessment:** SULT2A1 is a useful biomarker for assessing exposure to environmental pollutants and predicting toxicity. 4. **Therapeutic Targeting:** SULT2A1's role in regulating lipid metabolism and immune responses makes it a potential target for therapeutic interventions in metabolic and autoimmune diseases. In conclusion, SULT2A1 is a multifunctional enzyme with far-reaching implications for metabolic processes, disease pathways, and clinical outcomes. Further research is needed to fully elucidate its mechanisms of action and to explore its therapeutic potential in various diseases.

Genular Protein ID: 1582142882

Symbol: ST2A1_HUMAN

Name: Sulfotransferase 2A1

UniProtKB Accession Codes:

Q06520

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 59 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 14 EC 2 EMBL 19 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 Rhea 18 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7678732

Title: Cloning and expression of human liver dehydroepiandrosterone sulphotransferase.

PubMed ID: 7678732

DOI: 10.1042/bj2890233

PubMed ID: 1588921

Title: Human liver dehydroepiandrosterone sulfotransferase: molecular cloning and expression of cDNA.

PubMed ID: 1588921

PubMed ID: 7589785

Title: Human fetal adrenal hydroxysteroid sulphotransferase: cDNA cloning, stable expression in V79 cells and functional characterisation of the expressed enzyme.

PubMed ID: 7589785

DOI: 10.1016/0303-7207(95)03585-u

PubMed ID: 7598806

Title: Structural characterization and expression of the human dehydroepiandrosterone sulfotransferase gene.

PubMed ID: 7598806

DOI: 10.1089/dna.1995.14.511

PubMed ID: 7710689

Title: Human dehydroepiandrosterone sulfotransferase gene: molecular cloning and structural characterization.

PubMed ID: 7710689

DOI: 10.1089/dna.1995.14.331

PubMed ID: 1520333

Title: Molecular cloning of the alcohol/hydroxysteroid form (hSTa) of sulfotransferase from human liver.

PubMed ID: 1520333

DOI: 10.1016/s0006-291x(05)81514-1

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2268288

Title: Human liver steroid sulphotransferase sulphates bile acids.

PubMed ID: 2268288

DOI: 10.1042/bj2720597

PubMed ID: 7854148

Title: Activation of benzylic alcohols to mutagens by human hepatic sulphotransferases.

PubMed ID: 7854148

DOI: 10.1093/mutage/9.6.553

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 10854859

Title: Crystal structure of SULT2A3, human hydroxysteroid sulfotransferase.

PubMed ID: 10854859

DOI: 10.1016/s0014-5793(00)01479-4

PubMed ID: 11988089

Title: Crystal structure of human dehydroepiandrosterone sulphotransferase in complex with substrate.

PubMed ID: 11988089

DOI: 10.1042/bj3640165

PubMed ID: 14573603

Title: Identifying androsterone (ADT) as a cognate substrate for human dehydroepiandrosterone sulfotransferase (DHEA-ST) important for steroid homeostasis: structure of the enzyme-ADT complex.

PubMed ID: 14573603

DOI: 10.1074/jbc.m310446200

PubMed ID: 18042734

Title: Identification and characterization of two amino acids critical for the substrate inhibition of human dehydroepiandrosterone sulfotransferase (SULT2A1).

PubMed ID: 18042734

DOI: 10.1124/mol.107.041038

PubMed ID: 19589875

Title: 24-hydroxycholesterol sulfation by human cytosolic sulfotransferases: formation of monosulfates and disulfates, molecular modeling, sulfatase sensitivity, and inhibition of liver x receptor activation.

PubMed ID: 19589875

DOI: 10.1124/dmd.108.025759

PubMed ID: 21187059

Title: Substrate inhibition in human hydroxysteroid sulfotransferase SULT2A1: studies on the formation of catalytically non-productive enzyme complexes.

PubMed ID: 21187059

DOI: 10.1016/j.abb.2010.12.027

PubMed ID: 29671343

Title: Effects of genetic polymorphisms on the sulfation of dehydroepiandrosterone and pregnenolone by human cytosolic sulfotransferase SULT2A1.

PubMed ID: 29671343

DOI: 10.1139/bcb-2017-0341

Sequence Information:

  • Length: 285
  • Mass: 33780
  • Checksum: 06DFF2006B284A08
  • Sequence:
    • MSDDFLWFEG IAFPTMGFRS ETLRKVRDEF VIRDEDVIIL TYPKSGTNWL AEILCLMHSK 
GDAKWIQSVP IWERSPWVES EIGYTALSET ESPRLFSSHL PIQLFPKSFF SSKAKVIYLM 
RNPRDVLVSG YFFWKNMKFI KKPKSWEEYF EWFCQGTVLY GSWFDHIHGW MPMREEKNFL 
LLSYEELKQD TGRTIEKICQ FLGKTLEPEE LNLILKNSSF QSMKENKMSN YSLLSVDYVV 
DKAQLLRKGV SGDWKNHFTV AQAEDFDKLF QEKMADLPRE LFPWE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.