Details for: TAC3

Gene ID: 6866

Symbol: TAC3

Ensembl ID: ENSG00000166863

Description: tachykinin precursor 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 12.2706
    Cell Significance Index: -4.9900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 9.8703
    Cell Significance Index: -4.6600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 2.4373
    Cell Significance Index: 50.5600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.3411
    Cell Significance Index: 32.4900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.9145
    Cell Significance Index: 18.3600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6402
    Cell Significance Index: 121.8400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.5697
    Cell Significance Index: 20.0200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.5364
    Cell Significance Index: 4.9400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4033
    Cell Significance Index: 39.9000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3798
    Cell Significance Index: 342.9500
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.3794
    Cell Significance Index: 4.4100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.3512
    Cell Significance Index: 5.0300
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.2833
    Cell Significance Index: 1.7600
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.2352
    Cell Significance Index: 3.0500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2129
    Cell Significance Index: 34.6300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1839
    Cell Significance Index: 4.4100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1821
    Cell Significance Index: 19.8100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1514
    Cell Significance Index: 3.2800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1492
    Cell Significance Index: 4.3000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1280
    Cell Significance Index: 5.8000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1122
    Cell Significance Index: 5.8300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1037
    Cell Significance Index: 2.7800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1033
    Cell Significance Index: 7.1500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1029
    Cell Significance Index: 6.1800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0867
    Cell Significance Index: 5.3300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0455
    Cell Significance Index: 0.9700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0312
    Cell Significance Index: 6.2000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0132
    Cell Significance Index: 2.6500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0116
    Cell Significance Index: 0.1200
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.0088
    Cell Significance Index: 0.0600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.0015
    Cell Significance Index: 0.0300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0004
    Cell Significance Index: -0.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0004
    Cell Significance Index: -0.1500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0010
    Cell Significance Index: -1.8700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0015
    Cell Significance Index: -2.7600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0020
    Cell Significance Index: -3.0500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0027
    Cell Significance Index: -3.7000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0043
    Cell Significance Index: -3.2100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0056
    Cell Significance Index: -4.2600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0067
    Cell Significance Index: -3.7700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0074
    Cell Significance Index: -4.0600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0079
    Cell Significance Index: -4.9900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0093
    Cell Significance Index: -0.5700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0097
    Cell Significance Index: -4.3900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0106
    Cell Significance Index: -1.9100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0154
    Cell Significance Index: -4.4300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0170
    Cell Significance Index: -2.1800
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: -0.0180
    Cell Significance Index: -0.1300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0206
    Cell Significance Index: -4.3400
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0214
    Cell Significance Index: -0.2500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0216
    Cell Significance Index: -0.5400
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.0229
    Cell Significance Index: -0.1200
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: -0.0232
    Cell Significance Index: -0.1800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0251
    Cell Significance Index: -4.2900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0262
    Cell Significance Index: -0.7300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0276
    Cell Significance Index: -3.7900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0287
    Cell Significance Index: -4.1700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0305
    Cell Significance Index: -3.5600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0311
    Cell Significance Index: -3.8200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0363
    Cell Significance Index: -4.1600
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.0407
    Cell Significance Index: -0.4000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0412
    Cell Significance Index: -4.2900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0433
    Cell Significance Index: -5.1100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0436
    Cell Significance Index: -4.4500
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0436
    Cell Significance Index: -0.6300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0574
    Cell Significance Index: -0.9600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0590
    Cell Significance Index: -3.9700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0599
    Cell Significance Index: -3.1500
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0627
    Cell Significance Index: -0.7500
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0674
    Cell Significance Index: -0.6400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0698
    Cell Significance Index: -1.7400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0717
    Cell Significance Index: -1.0800
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.0719
    Cell Significance Index: -0.6500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0738
    Cell Significance Index: -3.4400
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: -0.0761
    Cell Significance Index: -0.4700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0795
    Cell Significance Index: -4.4600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0870
    Cell Significance Index: -1.5000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0888
    Cell Significance Index: -3.1100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0922
    Cell Significance Index: -1.5200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0940
    Cell Significance Index: -4.1600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0995
    Cell Significance Index: -4.6800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1002
    Cell Significance Index: -3.2800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1014
    Cell Significance Index: -3.2300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1032
    Cell Significance Index: -2.8100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1079
    Cell Significance Index: -3.9600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1120
    Cell Significance Index: -4.2400
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.1120
    Cell Significance Index: -1.1300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1152
    Cell Significance Index: -3.6900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1171
    Cell Significance Index: -3.0100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1214
    Cell Significance Index: -3.8400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1232
    Cell Significance Index: -3.6300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1324
    Cell Significance Index: -2.6400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1327
    Cell Significance Index: -3.3100
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.1338
    Cell Significance Index: -0.6400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1369
    Cell Significance Index: -3.9300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1373
    Cell Significance Index: -3.6100
  • Cell Name: pancreatic epsilon cell (CL0005019)
    Fold Change: -0.1381
    Cell Significance Index: -1.2800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1382
    Cell Significance Index: -1.3100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1393
    Cell Significance Index: -3.0500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1393
    Cell Significance Index: -3.4800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TAC3 is a gene that encodes a precursor protein, which is processed into the mature neuropeptide TAC3. The TAC3 gene is primarily expressed in cells involved in the nervous system, immune system, and cardiovascular system. The protein produced by TAC3 is a member of the tachykinin family, which consists of four peptides: substance P, neurokinin A, neurokinin B, and TAC3. These peptides interact with specific receptors, including the tachykinin receptor 1 (TACR1), tachykinin receptor 2 (TACR2), and tachykinin receptor 3 (TACR3), to modulate various signaling pathways. **Pathways and Functions** The TAC3 gene is involved in several signaling pathways, including: 1. **G-protein coupled receptor signaling pathway**: TAC3 interacts with G-protein coupled receptors (GPCRs) to modulate various cellular responses, including the regulation of blood pressure, pain perception, and immune responses. 2. **Neuropeptide signaling pathway**: TAC3 is a key player in the neuropeptide signaling pathway, which involves the interaction between TAC3 and its receptors to modulate neurotransmission and neuromodulation. 3. **Immune response modulation**: TAC3 has been shown to modulate the immune response by interacting with immune cells, such as plasma cells and granulocytes, to regulate inflammation and immune cell activation. 4. **Cardiovascular regulation**: TAC3 has been implicated in the regulation of blood pressure, which is mediated through its interaction with GPCRs and the renin-angiotensin system. **Clinical Significance** Dysregulation of the TAC3 gene has been implicated in various diseases, including: 1. **Hypertension**: TAC3 has been shown to play a role in the regulation of blood pressure, and alterations in TAC3 expression have been observed in hypertensive patients. 2. **Pain**: TAC3 has been implicated in the regulation of pain perception, and alterations in TAC3 expression have been observed in patients with chronic pain conditions. 3. **Autoimmune diseases**: TAC3 has been shown to modulate the immune response, and alterations in TAC3 expression have been observed in patients with autoimmune diseases, such as multiple sclerosis. 4. **Neurological disorders**: TAC3 has been implicated in the regulation of neurotransmission and neuromodulation, and alterations in TAC3 expression have been observed in patients with neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, the TAC3 gene plays a crucial role in regulating various physiological processes, including blood pressure, pain perception, and immune responses. Further research is needed to fully elucidate the molecular mechanisms underlying the TAC3 gene and its clinical implications.

Genular Protein ID: 2734901842

Symbol: TKNK_HUMAN

Name: Tachykinin-3

UniProtKB Accession Codes:

Q9UHF0 Q6IAG2 Q71BC6 Q71BC9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 14 EMDB 1 Ensembl 9 EvolutionaryTrace 1 ExpressionAtlas 1 GO 7 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 2 RefSeq 2 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10866201

Title: Excessive placental secretion of neurokinin B during the third trimester causes pre-eclampsia.

PubMed ID: 10866201

DOI: 10.1038/35015579

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19079066

Title: TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproduction.

PubMed ID: 19079066

DOI: 10.1038/ng.306

PubMed ID: 23643382

Title: Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism.

PubMed ID: 23643382

DOI: 10.1016/j.ajhg.2013.04.008

Sequence Information:

  • Length: 121
  • Mass: 13438
  • Checksum: 14C9AFE2EE9EDECA
  • Sequence:
    • MRIMLLFTAI LAFSLAQSFG AVCKEPQEEV VPGGGRSKRD PDLYQLLQRL FKSHSSLEGL 
LKALSQASTD PKESTSPEKR DMHDFFVGLM GKRSVQPDSP TDVNQENVPS FGILKYPPRA 
E

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.