Details for: ADAM18

Gene ID: 8749

Symbol: ADAM18

Ensembl ID: ENSG00000168619

Description: ADAM metallopeptidase domain 18

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.2014
    Cell Significance Index: 37.6300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 1.2666
    Cell Significance Index: 16.3900
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.1358
    Cell Significance Index: 15.5800
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.6207
    Cell Significance Index: 8.2800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.3904
    Cell Significance Index: 6.6900
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: 0.2048
    Cell Significance Index: 2.2600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.1802
    Cell Significance Index: 4.3700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.1142
    Cell Significance Index: 2.8500
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0703
    Cell Significance Index: 1.0200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.0680
    Cell Significance Index: 2.1500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0675
    Cell Significance Index: 1.8100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0590
    Cell Significance Index: 0.9600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0327
    Cell Significance Index: 6.5600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0294
    Cell Significance Index: 5.0200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0188
    Cell Significance Index: 0.3100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0107
    Cell Significance Index: 3.8400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0089
    Cell Significance Index: 1.7700
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.0065
    Cell Significance Index: 0.0900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0059
    Cell Significance Index: 9.0500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0039
    Cell Significance Index: 0.4600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0038
    Cell Significance Index: 5.1700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0036
    Cell Significance Index: 0.6500
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.0033
    Cell Significance Index: 0.0400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0032
    Cell Significance Index: 5.9400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0014
    Cell Significance Index: 2.5600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0007
    Cell Significance Index: 0.0100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0001
    Cell Significance Index: -0.0100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0012
    Cell Significance Index: -0.1700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0016
    Cell Significance Index: -1.0200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0018
    Cell Significance Index: -1.3400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0020
    Cell Significance Index: -0.1600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0021
    Cell Significance Index: -1.1300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0022
    Cell Significance Index: -1.2200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0023
    Cell Significance Index: -1.0700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0024
    Cell Significance Index: -1.5100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0035
    Cell Significance Index: -1.0200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0043
    Cell Significance Index: -0.1000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0048
    Cell Significance Index: -0.4900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0049
    Cell Significance Index: -0.1300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0070
    Cell Significance Index: -1.4700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0077
    Cell Significance Index: -0.5200
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0086
    Cell Significance Index: -0.1100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0090
    Cell Significance Index: -1.1100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0091
    Cell Significance Index: -1.2500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0123
    Cell Significance Index: -1.2800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0138
    Cell Significance Index: -0.6100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0146
    Cell Significance Index: -0.9000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0188
    Cell Significance Index: -0.6000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0190
    Cell Significance Index: -0.7200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0192
    Cell Significance Index: -1.0800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0210
    Cell Significance Index: -0.2500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0222
    Cell Significance Index: -1.0500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0255
    Cell Significance Index: -0.6700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0260
    Cell Significance Index: -1.2100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0283
    Cell Significance Index: -0.9900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0292
    Cell Significance Index: -0.6200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0302
    Cell Significance Index: -0.9900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0303
    Cell Significance Index: -0.7800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0305
    Cell Significance Index: -0.8700
  • Cell Name: L5/6 near-projecting glutamatergic neuron of the primary motor cortex (CL4023043)
    Fold Change: -0.0307
    Cell Significance Index: -0.3100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0318
    Cell Significance Index: -0.4700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0333
    Cell Significance Index: -0.6500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0351
    Cell Significance Index: -0.5000
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0353
    Cell Significance Index: -0.4700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0361
    Cell Significance Index: -0.7800
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0382
    Cell Significance Index: -0.5300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0393
    Cell Significance Index: -0.9600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0399
    Cell Significance Index: -1.1500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0417
    Cell Significance Index: -1.0400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0421
    Cell Significance Index: -1.4800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0426
    Cell Significance Index: -0.8600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0428
    Cell Significance Index: -0.7200
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0434
    Cell Significance Index: -0.6500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0435
    Cell Significance Index: -1.2800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0435
    Cell Significance Index: -0.8600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0459
    Cell Significance Index: -0.5000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0464
    Cell Significance Index: -0.4400
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0476
    Cell Significance Index: -0.6100
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0477
    Cell Significance Index: -0.5600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0477
    Cell Significance Index: -1.1500
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0497
    Cell Significance Index: -0.5800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0511
    Cell Significance Index: -1.0000
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0520
    Cell Significance Index: -0.7300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0520
    Cell Significance Index: -0.7100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0522
    Cell Significance Index: -1.4600
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0526
    Cell Significance Index: -0.4600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0537
    Cell Significance Index: -1.3400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0546
    Cell Significance Index: -1.1400
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0553
    Cell Significance Index: -0.4700
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0570
    Cell Significance Index: -1.1600
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.0598
    Cell Significance Index: -0.8400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0600
    Cell Significance Index: -1.1800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0604
    Cell Significance Index: -1.5400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0610
    Cell Significance Index: -1.0600
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0616
    Cell Significance Index: -0.8300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0616
    Cell Significance Index: -1.5400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0617
    Cell Significance Index: -1.2800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0632
    Cell Significance Index: -0.9600
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0676
    Cell Significance Index: -0.7000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0682
    Cell Significance Index: -1.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ADAM18 is a type II transmembrane protein that contains a disintegrin and metalloproteinase (MDA) domain, a cysteine protease domain, and a transmembrane domain. The MDA domain is responsible for binding to cell surface receptors, while the cysteine protease domain is involved in proteolytic activity. ADAM18 is also known as Disintegrin and metalloproteinase domain-containing protein 18 (ADAM18). **Pathways and Functions:** ADAM18 is involved in various cellular processes, including: 1. **Cell adhesion**: ADAM18 interacts with cell surface receptors, such as Integrin α4β1, to regulate cell adhesion and migration. 2. **Cell differentiation**: ADAM18 is required for the differentiation of hematopoietic stem cells into plasma cells and megakaryocytes. 3. **Proteolysis**: The cysteine protease domain of ADAM18 is involved in the proteolytic cleavage of various substrates, including growth factors and cytokines. 4. **Sperm-egg interaction**: ADAM18 is expressed in the male reproductive tract and is involved in the binding of sperm to the zona pellucida, a critical step in fertilization. 5. **Male gonad development**: ADAM18 is required for the development of male gonads, including the testes and epididymis. **Clinical Significance:** ADAM18 has been implicated in various diseases, including: 1. **Autoimmune disorders**: ADAM18 is expressed on the surface of plasma cells, which are key players in autoimmune responses. Dysregulation of ADAM18 expression may contribute to autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer**: ADAM18 is overexpressed in various types of cancer, including breast, lung, and colon cancer. Its overexpression is associated with poor prognosis and metastasis. 3. **Male infertility**: ADAM18 is required for the binding of sperm to the zona pellucida, and its dysregulation may contribute to male infertility. 4. **Neurological disorders**: ADAM18 is expressed in the brain and is involved in the regulation of neuronal differentiation and migration. Dysregulation of ADAM18 expression may contribute to neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, ADAM18 is a multifunctional protein that plays critical roles in various cellular processes, including cell adhesion, differentiation, proteolysis, and sperm-egg interaction. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of ADAM18 function and its role in human disease.

Genular Protein ID: 1283948828

Symbol: ADA18_HUMAN

Name: Disintegrin and metalloproteinase domain-containing protein 18

UniProtKB Accession Codes:

Q9Y3Q7 B2R9Y0 Q0VAI4 Q6IRW9 Q6UXJ9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 EMBL 8 Ensembl 6 ExpressionAtlas 1 GO 10 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 3 SMART 2 SMR 1 STRING 1 SUPFAM 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21618342

Title: Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma.

PubMed ID: 21618342

DOI: 10.1002/humu.21477

Sequence Information:

  • Length: 739
  • Mass: 82856
  • Checksum: 2D8BE9A975072CDD
  • Sequence:
    • MFLLLALLTE LGRLQAHEGS EGIFLHVTVP RKIKSNDSEV SERKMIYIIT IDGQPYTLHL 
GKQSFLPQNF LVYTYNETGS LHSVSPYFMM HCHYQGYAAE FPNSFVTLSI CSGLRGFLQF 
ENISYGIEPV ESSARFEHII YQMKNNDPNV SILAVNYSHI WQKDQPYKVP LNSQIKNLSK 
LLPQYLEIYI IVEKALYDYM GSEMMAVTQK IVQVIGLVNT MFTQFKLTVI LSSLELWSNE 
NQISTSGDAD DILQRFLAWK RDYLILRPHD IAYLLVYRKH PKYVGATFPG TVCNKSYDAG 
IAMYPDAIGL EGFSVIIAQL LGLNVGLTYD DITQCFCLRA TCIMNHEAVS ASGRKIFSNC 
SMHDYRYFVS KFETKCLQKL SNLQPLHQNQ PVCGNGILES NEECDCGNKN ECQFKKCCDY 
NTCKLKGSVK CGSGPCCTSK CELSIAGTPC RKSIDPECDF TEYCNGTSSN CVPDTYALNG 
RLCKLGTAYC YNGQCQTTDN QCAKIFGKGA QGAPFACFKE VNSLHERSEN CGFKNSQPLP 
CERKDVLCGK LACVQPHKNA NKSDAQSTVY SYIQDHVCVS IATGSSMRSD GTDNAYVADG 
TMCGPEMYCV NKTCRKVHLM GYNCNATTKC KGKGICNNFG NCQCFPGHRP PDCKFQFGSP 
GGSIDDGNFQ KSGDFYTEKG YNTHWNNWFI LSFCIFLPFF IVFTTVIFKR NEISKSCNRE 
NAEYNRNSSV VSESDDVGH

Genular Protein ID: 1201518334

Symbol: Q0VAI3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q0VAI3

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 ProteomicsDB 1 RefSeq 1 SAM 1 UCSC 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 153
  • Mass: 17245
  • Checksum: E3295D8D12F8D295
  • Sequence:
    • MRSDGTDNAY VADGTMCGPE MYCVNKTCRK VHLMGYNCNA TTKCKGKGIC NNFGNCQCFP 
GHRPPDCKFQ FGSPGGSIDD GNFQKSGDFY TEKGYNTHWN NWFILSFCIF LPFFIVFTTV 
IFKRNEISKS CNRENAEYNR NSSVVSESDD VGH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.