Details for: RNF8

Gene ID: 9025

Symbol: RNF8

Ensembl ID: ENSG00000112130

Description: ring finger protein 8

Associated with

Other Information

Genular Protein ID: 3951299770

Symbol: RNF8_HUMAN

Name: N/A

UniProtKB Accession Codes:

O76064 A6NN24 A8MYC0 B4DPG0 Q53H16 Q5NKW5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EC 1 EMBL 10 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 34 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HAMAP 1 HAMAP-Rule 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 5 PIRSF 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 4 RefSeq 2 SAM 1 SASBDB 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9852682

Title: Isolation, tissue expression, and chromosomal assignment of a novel human gene which encodes a protein with RING finger motif.

PubMed ID: 9852682

DOI: 10.1007/s100380050088

PubMed ID: 16215985

Title: The RING finger protein RNF8 recruits UBC13 for lysine 63-based self polyubiquitylation.

PubMed ID: 16215985

DOI: 10.1002/jcb.20587

PubMed ID: 9734811

Title: Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9734811

DOI: 10.1093/dnares/5.3.169

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23233665

Title: Identification of RNF8 as a ubiquitin ligase involved in targeting the p12 subunit of DNA polymerase delta for degradation in response to DNA damage.

PubMed ID: 23233665

DOI: 10.1074/jbc.m112.423392

PubMed ID: 11322894

Title: N-terminally extended human ubiquitin-conjugating enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8.

PubMed ID: 11322894

DOI: 10.1046/j.1432-1327.2001.02169.x

PubMed ID: 14981089

Title: The RING finger protein, RNF8, interacts with retinoid X receptor alpha and enhances its transcription-stimulating activity.

PubMed ID: 14981089

DOI: 10.1074/jbc.m309148200

PubMed ID: 18001824

Title: RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins.

PubMed ID: 18001824

DOI: 10.1016/j.cell.2007.09.040

PubMed ID: 18077395

Title: Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage.

PubMed ID: 18077395

DOI: 10.1073/pnas.0710061104

PubMed ID: 18006705

Title: Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase.

PubMed ID: 18006705

DOI: 10.1126/science.1150034

PubMed ID: 17724460

Title: Regulation of mitotic exit by the RNF8 ubiquitin ligase.

PubMed ID: 17724460

DOI: 10.1038/sj.onc.1210782

PubMed ID: 18948756

Title: PCNA is ubiquitinated by RNF8.

PubMed ID: 18948756

DOI: 10.4161/cc.7.21.6949

PubMed ID: 18337245

Title: RNF8-dependent and RNF8-independent regulation of 53BP1 in response to DNA damage.

PubMed ID: 18337245

DOI: 10.1074/jbc.m710197200

PubMed ID: 18678647

Title: Noncanonical E2 variant-independent function of UBC13 in promoting checkpoint protein assembly.

PubMed ID: 18678647

DOI: 10.1128/mcb.00987-08

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20023648

Title: HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes.

PubMed ID: 20023648

DOI: 10.1038/ncb2008

PubMed ID: 19203578

Title: The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage.

PubMed ID: 19203578

DOI: 10.1016/j.cell.2008.12.042

PubMed ID: 19203579

Title: RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins.

PubMed ID: 19203579

DOI: 10.1016/j.cell.2008.12.041

PubMed ID: 19124460

Title: Accumulation of Pax2 transactivation domain interaction protein (PTIP) at sites of DNA breaks via RNF8-dependent pathway is required for cell survival after DNA damage.

PubMed ID: 19124460

DOI: 10.1074/jbc.m809158200

PubMed ID: 19015238

Title: Histone ubiquitination associates with BRCA1-dependent DNA damage response.

PubMed ID: 19015238

DOI: 10.1128/mcb.01302-08

PubMed ID: 19202061

Title: The Rap80-BRCC36 de-ubiquitinating enzyme complex antagonizes RNF8-Ubc13-dependent ubiquitination events at DNA double strand breaks.

PubMed ID: 19202061

DOI: 10.1073/pnas.0807485106

PubMed ID: 20550933

Title: ATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaks.

PubMed ID: 20550933

DOI: 10.1016/j.cell.2010.04.038

PubMed ID: 21558560

Title: Critical roles of ring finger protein RNF8 in replication stress responses.

PubMed ID: 21558560

DOI: 10.1074/jbc.m111.232041

PubMed ID: 21857671

Title: DNA-damage response and repair activities at uncapped telomeres depend on RNF8.

PubMed ID: 21857671

DOI: 10.1038/ncb2326

PubMed ID: 22865450

Title: RNF8 regulates assembly of RAD51 at DNA double-strand breaks in the absence of BRCA1 and 53BP1.

PubMed ID: 22865450

DOI: 10.1158/0008-5472.can-12-1057

PubMed ID: 22373579

Title: RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites.

PubMed ID: 22373579

DOI: 10.1038/emboj.2012.47

PubMed ID: 22531782

Title: A new non-catalytic role for ubiquitin ligase RNF8 in unfolding higher-order chromatin structure.

PubMed ID: 22531782

DOI: 10.1038/emboj.2012.104

PubMed ID: 22405594

Title: Viral E3 ubiquitin ligase-mediated degradation of a cellular E3: viral mimicry of a cellular phosphorylation mark targets the RNF8 FHA domain.

PubMed ID: 22405594

DOI: 10.1016/j.molcel.2012.02.004

PubMed ID: 22705371

Title: A ubiquitin-binding protein, FAAP20, links RNF8-mediated ubiquitination to the Fanconi anemia DNA repair network.

PubMed ID: 22705371

DOI: 10.1016/j.molcel.2012.05.026

PubMed ID: 22266820

Title: The E3 ligase RNF8 regulates KU80 removal and NHEJ repair.

PubMed ID: 22266820

DOI: 10.1038/nsmb.2211

PubMed ID: 21911360

Title: Differential regulation of RNF8-mediated Lys48- and Lys63-based poly-ubiquitylation.

PubMed ID: 21911360

DOI: 10.1093/nar/gkr655

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25512560

Title: The scaffold protein WRAP53beta orchestrates the ubiquitin response critical for DNA double-strand break repair.

PubMed ID: 25512560

DOI: 10.1101/gad.246546.114

PubMed ID: 18001825

Title: RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly.

PubMed ID: 18001825

DOI: 10.1016/j.cell.2007.09.041

PubMed ID: 22980979

Title: RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA Damage signaling.

PubMed ID: 22980979

DOI: 10.1016/j.cell.2012.08.005

PubMed ID: 22589545

Title: Molecular insights into the function of RING Finger (RNF)-containing proteins hRNF8 and hRNF168 in Ubc13/Mms2-dependent ubiquitylation.

PubMed ID: 22589545

DOI: 10.1074/jbc.m112.359653

Sequence Information:

  • Length: 485
  • Mass: 55518
  • Checksum: 54650B2FFC9948B1
  • Sequence:
    • MGEPGFFVTG DRAGGRSWCL RRVGMSAGWL LLEDGCEVTV GRGFGVTYQL VSKICPLMIS 
RNHCVLKQNP EGQWTIMDNK SLNGVWLNRA RLEPLRVYSI HQGDYIQLGV PLENKENAEY 
EYEVTEEDWE TIYPCLSPKN DQMIEKNKEL RTKRKFSLDE LAGPGAEGPS NLKSKINKVS 
CESGQPVKSQ GKGEVASTPS DNLDPKLTAL EPSKTTGAPI YPGFPKVTEV HHEQKASNSS 
ASQRSLQMFK VTMSRILRLK IQMQEKHEAV MNVKKQTQKG NSKKVVQMEQ ELQDLQSQLC 
AEQAQQQARV EQLEKTFQEE EQHLQGLEIA QGEKDLKQQL AQALQEHWAL MEELNRSKKD 
FEAIIQAKNK ELEQTKEEKE KMQAQKEEVL SHMNDVLENE LQCIICSEYF IEAVTLNCAH 
SFCSYCINEW MKRKIECPIC RKDIKSKTYS LVLDNCINKM VNNLSSEVKE RRIVLIRERK 
AKRLF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.