Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: cord blood hematopoietic stem cell (CL2000095)
Fold Change: 6.9
Marker Score: 5,206 - Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 6.51
Marker Score: 5,093 - Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 6.09
Marker Score: 1,785 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 6.09
Marker Score: 80,959 - Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: 6.01
Marker Score: 4,020 - Cell Name: malignant cell (CL0001064)
Fold Change: 5.45
Marker Score: 73,220 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 5.2
Marker Score: 3,673 - Cell Name: mature T cell (CL0002419)
Fold Change: 5.16
Marker Score: 51,084 - Cell Name: early promyelocyte (CL0002154)
Fold Change: 5.14
Marker Score: 4,117 - Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 4.98
Marker Score: 14,548 - Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 4.98
Marker Score: 6,490 - Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 4.95
Marker Score: 12,581 - Cell Name: radial glial cell (CL0000681)
Fold Change: 4.83
Marker Score: 1,781 - Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 4.64
Marker Score: 3,943 - Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 4.62
Marker Score: 14,594 - Cell Name: myeloid dendritic cell (CL0000782)
Fold Change: 4.58
Marker Score: 2,780 - Cell Name: mesodermal cell (CL0000222)
Fold Change: 4.55
Marker Score: 60,053 - Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 4.43
Marker Score: 28,258 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 4.38
Marker Score: 244,873 - Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 4.36
Marker Score: 230,288 - Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 4.33
Marker Score: 6,662 - Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 4.29
Marker Score: 4,770 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 4.23
Marker Score: 5,112 - Cell Name: theca cell (CL0000503)
Fold Change: 4.23
Marker Score: 3,031 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 4.22
Marker Score: 37,037 - Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 4.22
Marker Score: 11,650 - Cell Name: blood cell (CL0000081)
Fold Change: 4.2
Marker Score: 48,794 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 4.17
Marker Score: 141,926 - Cell Name: naive T cell (CL0000898)
Fold Change: 4.17
Marker Score: 2,684 - Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 4.16
Marker Score: 2,836 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 4.15
Marker Score: 10,137 - Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 4.15
Marker Score: 10,460 - Cell Name: germinal center B cell (CL0000844)
Fold Change: 4.14
Marker Score: 2,521 - Cell Name: chondrocyte (CL0000138)
Fold Change: 4.11
Marker Score: 1,851 - Cell Name: type I pneumocyte (CL0002062)
Fold Change: 4.1
Marker Score: 4,943 - Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: 4.09
Marker Score: 2,112 - Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 4.08
Marker Score: 11,432 - Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 4.07
Marker Score: 4,909 - Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 4.05
Marker Score: 3,917 - Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 4.05
Marker Score: 5,862 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 4.04
Marker Score: 965 - Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 4.03
Marker Score: 6,908 - Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 3.99
Marker Score: 2,891 - Cell Name: granulocyte (CL0000094)
Fold Change: 3.97
Marker Score: 1,780 - Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 3.97
Marker Score: 3,745 - Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 3.96
Marker Score: 4,231 - Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 3.95
Marker Score: 10,596 - Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 3.93
Marker Score: 20,676 - Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 3.93
Marker Score: 29,280 - Cell Name: neutrophil (CL0000775)
Fold Change: 3.93
Marker Score: 2,394 - Cell Name: Mueller cell (CL0000636)
Fold Change: 3.91
Marker Score: 5,424 - Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 3.9
Marker Score: 16,739 - Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 3.9
Marker Score: 2,771 - Cell Name: smooth muscle cell (CL0000192)
Fold Change: 3.86
Marker Score: 2,541 - Cell Name: supporting cell (CL0000630)
Fold Change: 3.84
Marker Score: 7,219 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 3.82
Marker Score: 13,570 - Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 3.82
Marker Score: 5,621 - Cell Name: classical monocyte (CL0000860)
Fold Change: 3.82
Marker Score: 15,852 - Cell Name: type I NK T cell (CL0000921)
Fold Change: 3.81
Marker Score: 2,990 - Cell Name: hematopoietic cell (CL0000988)
Fold Change: 3.79
Marker Score: 2,519 - Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 3.79
Marker Score: 3,228 - Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 3.77
Marker Score: 18,503 - Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 3.76
Marker Score: 3,585 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 3.73
Marker Score: 24,275 - Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 3.72
Marker Score: 1,195 - Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 3.72
Marker Score: 1,911 - Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 3.7
Marker Score: 3,978 - Cell Name: megakaryocyte (CL0000556)
Fold Change: 3.69
Marker Score: 2,098 - Cell Name: colon epithelial cell (CL0011108)
Fold Change: 3.69
Marker Score: 11,588 - Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 3.69
Marker Score: 3,289 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: 3.65
Marker Score: 2,036 - Cell Name: type II pneumocyte (CL0002063)
Fold Change: 3.61
Marker Score: 23,552 - Cell Name: Sertoli cell (CL0000216)
Fold Change: 3.61
Marker Score: 21,399 - Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 3.59
Marker Score: 3,087 - Cell Name: lung macrophage (CL1001603)
Fold Change: 3.59
Marker Score: 4,102 - Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 3.57
Marker Score: 1,851 - Cell Name: bronchial epithelial cell (CL0002328)
Fold Change: 3.56
Marker Score: 943 - Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 3.56
Marker Score: 2,996 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 3.56
Marker Score: 27,780 - Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 3.56
Marker Score: 1,226 - Cell Name: myelocyte (CL0002193)
Fold Change: 3.52
Marker Score: 1,521 - Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: 3.52
Marker Score: 1,941 - Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 3.49
Marker Score: 3,100 - Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 3.49
Marker Score: 5,716 - Cell Name: T follicular helper cell (CL0002038)
Fold Change: 3.47
Marker Score: 2,885 - Cell Name: mucous neck cell (CL0000651)
Fold Change: 3.47
Marker Score: 7,877 - Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
Fold Change: 3.47
Marker Score: 1,127 - Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 3.46
Marker Score: 794 - Cell Name: fibroblast of lung (CL0002553)
Fold Change: 3.45
Marker Score: 9,032 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 3.44
Marker Score: 3,572 - Cell Name: reticular cell (CL0000432)
Fold Change: 3.44
Marker Score: 1,254 - Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 3.42
Marker Score: 1,396 - Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 3.42
Marker Score: 900 - Cell Name: ependymal cell (CL0000065)
Fold Change: 3.42
Marker Score: 1,192 - Cell Name: intestine goblet cell (CL0019031)
Fold Change: 3.41
Marker Score: 3,272 - Cell Name: late promyelocyte (CL0002151)
Fold Change: 3.41
Marker Score: 854 - Cell Name: late pro-B cell (CL0002048)
Fold Change: 3.39
Marker Score: 3,997 - Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 3.38
Marker Score: 4,647 - Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: 3.38
Marker Score: 2,440 - Cell Name: enterocyte (CL0000584)
Fold Change: 3.38
Marker Score: 16,198
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1163596488
Symbol: ACTG_HUMAN
Name: Actin, cytoplasmic 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3737401
Title: Nucleotide sequence of the human gamma cytoskeletal actin mRNA: anomalous evolution of vertebrate non-muscle actin genes.
PubMed ID: 3737401
PubMed ID: 2837653
Title: Structure, chromosome location, and expression of the human gamma-actin gene: differential evolution, location, and expression of the cytoskeletal beta- and gamma-actin genes.
PubMed ID: 2837653
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12665801
Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
PubMed ID: 12665801
DOI: 10.1038/nbt810
PubMed ID: 3472224
Title: Gamma-actin: unusual mRNA 3'-untranslated sequence conservation and amino acid substitutions that may be cancer related.
PubMed ID: 3472224
PubMed ID: 14654843
Title: Proteomic characterization of the human centrosome by protein correlation profiling.
PubMed ID: 14654843
DOI: 10.1038/nature02166
PubMed ID: 19015515
Title: Connecting actin monomers by iso-peptide bond is a toxicity mechanism of the Vibrio cholerae MARTX toxin.
PubMed ID: 19015515
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23673617
Title: ALKBH4-dependent demethylation of actin regulates actomyosin dynamics.
PubMed ID: 23673617
DOI: 10.1038/ncomms2863
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 26228148
Title: ACD toxin-produced actin oligomers poison formin-controlled actin polymerization.
PubMed ID: 26228148
PubMed ID: 30028079
Title: NAT6 acetylates the N-terminus of different forms of actin.
PubMed ID: 30028079
DOI: 10.1111/febs.14605
PubMed ID: 29581253
Title: NAA80 is actin's N-terminal acetyltransferase and regulates cytoskeleton assembly and cell motility.
PubMed ID: 29581253
PubMed ID: 30626964
Title: SETD3 is an actin histidine methyltransferase that prevents primary dystocia.
PubMed ID: 30626964
PubMed ID: 36173861
Title: Actin maturation requires the ACTMAP/C19orf54 protease.
PubMed ID: 36173861
PubMed ID: 13680526
Title: Mutations in the gamma-actin gene (ACTG1) are associated with dominant progressive deafness (DFNA20/26).
PubMed ID: 13680526
DOI: 10.1086/379286
PubMed ID: 14684684
Title: A mutation in the gamma actin 1 (ACTG1) gene causes autosomal dominant hearing loss (DFNA20/26).
PubMed ID: 14684684
PubMed ID: 16773128
Title: A novel missense mutation in ACTG1 causes dominant deafness in a Norwegian DFNA20/26 family, but ACTG1 mutations are not frequent among families with hereditary hearing impairment.
PubMed ID: 16773128
PubMed ID: 18804074
Title: Novel ACTG1 mutation causing autosomal dominant non-syndromic hearing impairment in a Chinese family.
PubMed ID: 18804074
PubMed ID: 19477959
Title: In vivo and in vitro effects of two novel gamma-actin (ACTG1) mutations that cause DFNA20/26 hearing impairment.
PubMed ID: 19477959
DOI: 10.1093/hmg/ddp249
PubMed ID: 22366783
Title: De novo mutations in the actin genes ACTB and ACTG1 cause Baraitser-Winter syndrome.
PubMed ID: 22366783
DOI: 10.1038/ng.1091
PubMed ID: 22938506
Title: Targeted massive parallel sequencing: the effective detection of novel causative mutations associated with hearing loss in small families.
PubMed ID: 22938506
PubMed ID: 25388789
Title: Targeted genomic capture and massively parallel sequencing to identify novel variants causing Chinese hereditary hearing loss.
PubMed ID: 25388789
PubMed ID: 28493397
Title: A recurrent de novo mutation in ACTG1 causes isolated ocular coloboma.
PubMed ID: 28493397
DOI: 10.1002/humu.23246
Sequence Information:
- Length: 375
- Mass: 41793
- Checksum: 54D08F986964EFD5
- Sequence:
MEEEIAALVI DNGSGMCKAG FAGDDAPRAV FPSIVGRPRH QGVMVGMGQK DSYVGDEAQS KRGILTLKYP IEHGIVTNWD DMEKIWHHTF YNELRVAPEE HPVLLTEAPL NPKANREKMT QIMFETFNTP AMYVAIQAVL SLYASGRTTG IVMDSGDGVT HTVPIYEGYA LPHAILRLDL AGRDLTDYLM KILTERGYSF TTTAEREIVR DIKEKLCYVA LDFEQEMATA ASSSSLEKSY ELPDGQVITI GNERFRCPEA LFQPSFLGME SCGIHETTFN SIMKCDVDIR KDLYANTVLS GGTTMYPGIA DRMQKEITAL APSTMKIKII APPERKYSVW IGGSILASLS TFQQMWISKQ EYDESGPSIV HRKCF
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.