Details for: ASTILCS

Gene ID: 105375790

Symbol: ASTILCS

Ensembl ID: ENSG00000244998

Description: antisense transcript of PTP4A3, liver carcinoma survival associated

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.4269
    Cell Significance Index: 89.9400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.6644
    Cell Significance Index: 7.9200
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.2286
    Cell Significance Index: 3.2100
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.1090
    Cell Significance Index: 0.9600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1053
    Cell Significance Index: 4.7800
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.0960
    Cell Significance Index: 0.7400
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.0808
    Cell Significance Index: 0.9800
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.0753
    Cell Significance Index: 0.6400
  • Cell Name: bipolar neuron (CL0000103)
    Fold Change: 0.0713
    Cell Significance Index: 0.4000
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.0563
    Cell Significance Index: 0.6100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0519
    Cell Significance Index: 2.4200
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.0267
    Cell Significance Index: 0.2900
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.0182
    Cell Significance Index: 0.2200
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.0096
    Cell Significance Index: 0.1200
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.0094
    Cell Significance Index: 0.1300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0073
    Cell Significance Index: 0.1600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0072
    Cell Significance Index: 2.0600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0058
    Cell Significance Index: 0.5900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0048
    Cell Significance Index: 0.3700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0015
    Cell Significance Index: 0.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0014
    Cell Significance Index: 2.6000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0002
    Cell Significance Index: 0.0100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0000
    Cell Significance Index: 0.0200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0004
    Cell Significance Index: -0.7000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0005
    Cell Significance Index: -0.7800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0006
    Cell Significance Index: -0.8100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0007
    Cell Significance Index: -0.3000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0008
    Cell Significance Index: -0.0400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0010
    Cell Significance Index: -0.6300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0010
    Cell Significance Index: -0.5400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0010
    Cell Significance Index: -0.7300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0013
    Cell Significance Index: -0.7000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0021
    Cell Significance Index: -0.7400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0023
    Cell Significance Index: -0.4100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0026
    Cell Significance Index: -0.3900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0027
    Cell Significance Index: -0.5400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0028
    Cell Significance Index: -0.5700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0037
    Cell Significance Index: -0.4500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0038
    Cell Significance Index: -0.8000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0040
    Cell Significance Index: -0.5200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0046
    Cell Significance Index: -0.7800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0053
    Cell Significance Index: -0.7300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0057
    Cell Significance Index: -0.1400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0064
    Cell Significance Index: -0.6700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0074
    Cell Significance Index: -0.8500
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0074
    Cell Significance Index: -0.1100
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.0089
    Cell Significance Index: -0.1100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0090
    Cell Significance Index: -0.2400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0094
    Cell Significance Index: -0.3300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0109
    Cell Significance Index: -0.8100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0115
    Cell Significance Index: -0.3300
  • Cell Name: eosinophil (CL0000771)
    Fold Change: -0.0118
    Cell Significance Index: -0.1000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0121
    Cell Significance Index: -0.6800
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0124
    Cell Significance Index: -0.1400
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0125
    Cell Significance Index: -0.1600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0136
    Cell Significance Index: -0.2900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0138
    Cell Significance Index: -0.3000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0143
    Cell Significance Index: -0.2800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0147
    Cell Significance Index: -0.6900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0155
    Cell Significance Index: -0.3900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0173
    Cell Significance Index: -0.4700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0179
    Cell Significance Index: -0.7900
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0199
    Cell Significance Index: -0.3400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0202
    Cell Significance Index: -0.6600
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0205
    Cell Significance Index: -0.2600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0208
    Cell Significance Index: -0.6600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0210
    Cell Significance Index: -0.7300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0216
    Cell Significance Index: -0.7600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0235
    Cell Significance Index: -0.4100
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0240
    Cell Significance Index: -0.2700
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0247
    Cell Significance Index: -0.3600
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0249
    Cell Significance Index: -0.3000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0255
    Cell Significance Index: -0.6400
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0256
    Cell Significance Index: -0.3400
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0268
    Cell Significance Index: -0.3700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0271
    Cell Significance Index: -0.5000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0280
    Cell Significance Index: -0.5900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0289
    Cell Significance Index: -0.5000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0292
    Cell Significance Index: -0.8600
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0292
    Cell Significance Index: -0.3400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0292
    Cell Significance Index: -0.6200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0293
    Cell Significance Index: -0.8400
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.0298
    Cell Significance Index: -0.3600
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0299
    Cell Significance Index: -0.2300
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0310
    Cell Significance Index: -0.5000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0325
    Cell Significance Index: -0.8600
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0325
    Cell Significance Index: -0.4100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0326
    Cell Significance Index: -0.8700
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0327
    Cell Significance Index: -0.2700
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0328
    Cell Significance Index: -0.4200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0329
    Cell Significance Index: -0.8400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0334
    Cell Significance Index: -0.8100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0341
    Cell Significance Index: -0.8700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0342
    Cell Significance Index: -0.5200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0352
    Cell Significance Index: -0.5700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0352
    Cell Significance Index: -0.7300
  • Cell Name: flat midget bipolar cell (CL4033033)
    Fold Change: -0.0358
    Cell Significance Index: -0.4500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0359
    Cell Significance Index: -0.5300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0363
    Cell Significance Index: -0.4700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0370
    Cell Significance Index: -0.8000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ASTILCS is a non-coding antisense transcript, meaning it is a complementary RNA molecule that is transcribed from the opposite strand of the PTP4A3 gene. This antisense transcript is significantly expressed in cells of the immune system, nervous system, and epithelial tissues, including blood vessel endothelial cells, glial cells, goblet cells, intestinal crypt stem cells, B cells, cerebral cortex GABAergic interneurons, forebrain radial glial cells, absorptive cells, and transit amplifying cells. The ASTILCS gene is also aberrantly expressed in abnormal cells, including those found in liver carcinoma. **Pathways and Functions:** The ASTILCS gene is involved in regulating cellular survival and proliferation through multiple signaling pathways. Studies have shown that ASTILCS acts as a tumor suppressor by inhibiting the Wnt/β-catenin pathway, a key signaling pathway involved in cell proliferation and differentiation. Additionally, ASTILCS has been shown to interact with the PI3K/AKT pathway, which is involved in cell survival and apoptosis. The antisense transcript also regulates the expression of genes involved in cell adhesion and migration, such as E-cadherin and N-cadherin. Furthermore, ASTILCS has been shown to modulate the expression of microRNAs, which are small non-coding RNAs that regulate gene expression. **Clinical Significance:** The ASTILCS gene has significant clinical implications in cancer research and therapy. Liver carcinoma is a type of cancer that affects the liver, and it is often associated with poor prognosis and limited treatment options. Recent studies have shown that ASTILCS is downregulated in liver carcinoma, suggesting its potential as a biomarker for early detection and diagnosis. Additionally, ASTILCS has been shown to inhibit the growth of liver carcinoma cells in vitro and in vivo, suggesting its potential as a therapeutic target. Furthermore, ASTILCS may also be involved in other types of cancer, such as colon cancer and brain tumors, highlighting the need for further research into its role in cancer biology. In conclusion, the ASTILCS gene is a novel antisense transcript that plays a crucial role in regulating cellular survival and proliferation in various tissues. Its downregulation in liver carcinoma suggests its potential as a biomarker and therapeutic target. Further research into the pathways and functions of ASTILCS may lead to the development of new diagnostic and therapeutic strategies for cancer treatment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.