Details for: OR5P2

Gene ID: 120065

Symbol: OR5P2

Ensembl ID: ENSG00000183303

Description: olfactory receptor family 5 subfamily P member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 14.1068
    Cell Significance Index: 228.4800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.4629
    Cell Significance Index: 155.2300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.0390
    Cell Significance Index: 14.7900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3221
    Cell Significance Index: 16.7300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2844
    Cell Significance Index: 3.8800
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.2033
    Cell Significance Index: 2.8200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.1887
    Cell Significance Index: 2.7400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0688
    Cell Significance Index: 0.8200
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.0667
    Cell Significance Index: 0.8500
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: 0.0427
    Cell Significance Index: 0.5300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0138
    Cell Significance Index: 2.5000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.0120
    Cell Significance Index: 0.1600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0031
    Cell Significance Index: -2.3300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0042
    Cell Significance Index: -0.2700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0044
    Cell Significance Index: -0.5400
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0067
    Cell Significance Index: -0.0800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0102
    Cell Significance Index: -2.0400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0163
    Cell Significance Index: -0.4400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0195
    Cell Significance Index: -0.5300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0279
    Cell Significance Index: -0.7100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0296
    Cell Significance Index: -3.3900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0323
    Cell Significance Index: -1.8100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0370
    Cell Significance Index: -1.7400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0384
    Cell Significance Index: -1.7900
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0503
    Cell Significance Index: -0.8600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0596
    Cell Significance Index: -1.7600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0612
    Cell Significance Index: -1.9500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0620
    Cell Significance Index: -0.8500
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0659
    Cell Significance Index: -0.7000
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0753
    Cell Significance Index: -0.8900
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0759
    Cell Significance Index: -1.0500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0825
    Cell Significance Index: -2.0600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0877
    Cell Significance Index: -1.7500
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0925
    Cell Significance Index: -1.1100
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0934
    Cell Significance Index: -1.2600
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0959
    Cell Significance Index: -1.2300
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0999
    Cell Significance Index: -1.3200
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1017
    Cell Significance Index: -1.2100
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.1040
    Cell Significance Index: -1.1800
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.1077
    Cell Significance Index: -1.1600
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.1103
    Cell Significance Index: -1.3100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1111
    Cell Significance Index: -1.5900
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1117
    Cell Significance Index: -1.3400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1171
    Cell Significance Index: -1.9600
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: -0.1208
    Cell Significance Index: -1.3200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1211
    Cell Significance Index: -2.3900
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1215
    Cell Significance Index: -1.6000
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: -0.1219
    Cell Significance Index: -1.2900
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1256
    Cell Significance Index: -1.3500
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.1256
    Cell Significance Index: -1.3200
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.1287
    Cell Significance Index: -1.4900
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.1355
    Cell Significance Index: -1.7500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1360
    Cell Significance Index: -2.6600
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.1369
    Cell Significance Index: -1.5900
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.1386
    Cell Significance Index: -1.7300
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.1388
    Cell Significance Index: -1.8500
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.1433
    Cell Significance Index: -1.5100
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.1434
    Cell Significance Index: -1.8000
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.1447
    Cell Significance Index: -1.5600
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1450
    Cell Significance Index: -1.8300
  • Cell Name: H1 horizontal cell (CL0004217)
    Fold Change: -0.1456
    Cell Significance Index: -1.8300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1459
    Cell Significance Index: -1.8100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1460
    Cell Significance Index: -1.5400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1468
    Cell Significance Index: -1.8300
  • Cell Name: flat midget bipolar cell (CL4033033)
    Fold Change: -0.1472
    Cell Significance Index: -1.8300
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1473
    Cell Significance Index: -1.8100
  • Cell Name: invaginating midget bipolar cell (CL4033034)
    Fold Change: -0.1475
    Cell Significance Index: -1.8200
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.1486
    Cell Significance Index: -1.9400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1496
    Cell Significance Index: -1.6300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1500
    Cell Significance Index: -2.2800
  • Cell Name: diffuse bipolar 4 cell (CL4033031)
    Fold Change: -0.1504
    Cell Significance Index: -1.8300
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -0.1518
    Cell Significance Index: -1.7400
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.1533
    Cell Significance Index: -1.9200
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1540
    Cell Significance Index: -1.7600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1553
    Cell Significance Index: -1.9600
  • Cell Name: S cone cell (CL0003050)
    Fold Change: -0.1561
    Cell Significance Index: -1.8200
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.1572
    Cell Significance Index: -1.7200
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: -0.1572
    Cell Significance Index: -1.5600
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.1576
    Cell Significance Index: -1.9100
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.1605
    Cell Significance Index: -1.6400
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.1612
    Cell Significance Index: -1.6900
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1646
    Cell Significance Index: -2.8000
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.1657
    Cell Significance Index: -1.5100
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: -0.1667
    Cell Significance Index: -1.8000
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.1670
    Cell Significance Index: -1.8200
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.1675
    Cell Significance Index: -1.7000
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: -0.1681
    Cell Significance Index: -1.8300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1689
    Cell Significance Index: -1.5600
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.1691
    Cell Significance Index: -1.8300
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: -0.1693
    Cell Significance Index: -1.8200
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.1694
    Cell Significance Index: -1.3000
  • Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
    Fold Change: -0.1702
    Cell Significance Index: -1.2600
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.1704
    Cell Significance Index: -1.8700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1704
    Cell Significance Index: -2.8100
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.1706
    Cell Significance Index: -1.7600
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.1726
    Cell Significance Index: -2.7800
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1731
    Cell Significance Index: -2.4600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1750
    Cell Significance Index: -2.5500
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1752
    Cell Significance Index: -2.0600
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.1753
    Cell Significance Index: -1.5800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** OR5P2 is a G protein-coupled receptor (GPCR) that belongs to the olfactory receptor family. As a GPCR, it is characterized by its ability to bind to odorant molecules, which triggers a signaling cascade that ultimately leads to the perception of a specific smell. The OR5P2 gene is specifically expressed in the following cell types: * Erythrocytes (red blood cells) * Megakaryocytes (bone marrow cells responsible for producing platelets) * Hematopoietic stem cells (precursor cells that give rise to blood cells) * Double negative thymocytes (immature T cells) * Megakaryocyte-erythroid progenitor cells (cells that differentiate into platelets and red blood cells) * Goblet cells (mucous-producing cells in the respiratory and gastrointestinal tracts) * Mast cells (immune cells involved in allergic reactions) * Neoplastic cells (cancerous cells) * Abnormal cells (abnormal or cancerous cells) **Pathways and Functions** The OR5P2 gene is involved in the following pathways: 1. **Detection of chemical stimulus involved in sensory perception of smell**: OR5P2 binds to odorant molecules, triggering a signaling cascade that ultimately leads to the perception of a specific smell. 2. **Expression and translocation of olfactory receptors**: OR5P2 is involved in the expression and translocation of olfactory receptors to the plasma membrane, where they can bind to odorant molecules. 3. **G protein-coupled receptor activity**: OR5P2 is a GPCR that activates a signaling cascade when bound to an odorant molecule. 4. **G protein-coupled receptor signaling pathway**: OR5P2 is involved in the G protein-coupled receptor signaling pathway, which is a complex signaling cascade that regulates various cellular processes. 5. **Odorant binding**: OR5P2 binds to odorant molecules, which triggers a signaling cascade that ultimately leads to the perception of a specific smell. 6. **Olfactory receptor activity**: OR5P2 is involved in the olfactory receptor activity, which is essential for the perception of different odors. 7. **Olfactory signaling pathway**: OR5P2 is involved in the olfactory signaling pathway, which is a complex signaling cascade that regulates various cellular processes. **Clinical Significance** OR5P2 has been implicated in various diseases and disorders, including: 1. **Olfactory disorders**: OR5P2 has been linked to olfactory disorders, such as anosmia (loss of smell) and hyposmia (reduced sense of smell). 2. **Cancer**: OR5P2 has been found to be overexpressed in certain types of cancer, including breast cancer and lung cancer. 3. **Immune system disorders**: OR5P2 has been implicated in immune system disorders, such as allergic reactions and autoimmune diseases. 4. **Neurological disorders**: OR5P2 has been linked to neurological disorders, such as Parkinson's disease and Alzheimer's disease. In conclusion, the OR5P2 gene plays a crucial role in the detection of chemical stimuli involved in sensory perception of smell, and its dysregulation has been implicated in various diseases and disorders. Further research is needed to fully understand the functional and clinical significance of OR5P2.

Genular Protein ID: 1454323753

Symbol: OR5P2_HUMAN

Name: Olfactory receptor 5P2

UniProtKB Accession Codes:

Q8WZ92 Q3MIS8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 EMBL 4 Ensembl 3 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 11705801

Title: New GPCRs from a human lingual cDNA library.

PubMed ID: 11705801

DOI: 10.1093/chemse/26.9.1157

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 322
  • Mass: 35786
  • Checksum: 0D4F4FBD4FD00FEC
  • Sequence:
    • MNSLKDGNHT ALTGFILLGL TDDPILRVIL FMIILSGNLS IIILIRISSQ LHHPMYFFLS 
HLAFADMAYS SSVTPNMLVN FLVERNTVSY LGCAIQLGSA AFFATVECVL LAAMAYDRFV 
AICSPLLYST KMSTQVSVQL LLVVYIAGFL IAVSYTTSFY FLLFCGPNQV NHFFCDFAPL 
LELSCSDISV STVVLSFSSG SIIVVTVCVI AVCYIYILIT ILKMRSTEGH HKAFSTCTSH 
LTVVTLFYGT ITFIYVMPNF SYSTDQNKVV SVLYTVVIPM LNPLIYSLRN KEIKGALKRE 
LVRKILSHDA CYFSRTSNND IT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.