CRH | ENSG00000147571 | NCBI 1392

Details for: CRH

Gene ID: 1392

Symbol: CRH

Ensembl ID: ENSG00000147571

Description: corticotropin releasing hormone

Associated with

Class b/2 (secretin family receptors)
(R-HSA-373080)
G alpha (s) signalling events
(R-HSA-418555)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Mecp2 regulates transcription of neuronal ligands
(R-HSA-9022702)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by gpcr
(R-HSA-372790)
Transcriptional regulation by mecp2
(R-HSA-8986944)
Adrenal gland development
(GO:0030325)
Associative learning
(GO:0008306)
Cellular response to cocaine
(GO:0071314)
Cellular response to dexamethasone stimulus
(GO:0071549)
Chemical synaptic transmission
(GO:0007268)
Corticotropin-releasing hormone activity
(GO:0017045)
Corticotropin-releasing hormone receptor 1 binding
(GO:0051430)
Corticotropin-releasing hormone receptor 2 binding
(GO:0051431)
Diterpenoid metabolic process
(GO:0016101)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Female pregnancy
(GO:0007565)
Glucocorticoid biosynthetic process
(GO:0006704)
Hormone-mediated apoptotic signaling pathway
(GO:0008628)
Hormone activity
(GO:0005179)
Hypothalamus development
(GO:0021854)
Inflammatory response
(GO:0006954)
Learning or memory
(GO:0007611)
Locomotory exploration behavior
(GO:0035641)
Long-term synaptic potentiation
(GO:0060291)
Lung development
(GO:0030324)
Monoatomic ion homeostasis
(GO:0050801)
Negative regulation of circadian sleep/wake cycle, rem sleep
(GO:0042322)
Negative regulation of epinephrine secretion
(GO:0032811)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of glucagon secretion
(GO:0070093)
Negative regulation of luteinizing hormone secretion
(GO:0033685)
Negative regulation of norepinephrine secretion
(GO:0010700)
Negative regulation of systemic arterial blood pressure
(GO:0003085)
Neuronal dense core vesicle lumen
(GO:0099013)
Neuron apoptotic process
(GO:0051402)
Neuropeptide hormone activity
(GO:0005184)
Parturition
(GO:0007567)
Perikaryon
(GO:0043204)
Positive regulation of behavioral fear response
(GO:2000987)
Positive regulation of calcium ion import
(GO:0090280)
Positive regulation of camp-mediated signaling
(GO:0043950)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of circadian sleep/wake cycle, wakefulness
(GO:0010841)
Positive regulation of corticosterone secretion
(GO:2000854)
Positive regulation of corticotropin secretion
(GO:0051461)
Positive regulation of cortisol secretion
(GO:0051464)
Positive regulation of digestive system process
(GO:0060456)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of insulin secretion involved in cellular response to glucose stimulus
(GO:0035774)
Protein binding
(GO:0005515)
Regulation of nmda receptor activity
(GO:2000310)
Regulation of serotonin secretion
(GO:0014062)
Response to aldosterone
(GO:1904044)
Response to corticosterone
(GO:0051412)
Response to estrogen
(GO:0043627)
Response to ethanol
(GO:0045471)
Response to ether
(GO:0045472)
Response to immobilization stress
(GO:0035902)
Response to pain
(GO:0048265)
Response to xenobiotic stimulus
(GO:0009410)
Signaling receptor binding
(GO:0005102)
Signal transduction
(GO:0007165)
Synapse
(GO:0045202)
Synaptic transmission, dopaminergic
(GO:0001963)
Varicosity
(GO:0043196)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 5.7146
Cell Significance Index: 97.6900
Cell Name: precursor B cell (CL0000817)
Fold Change: 3.7767
Cell Significance Index: 48.8700
Cell Name: chandelier cell (CL4023083)
Fold Change: 1.4243
Cell Significance Index: 11.5000
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 1.2468
Cell Significance Index: 30.2000
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.4184
Cell Significance Index: 150.0900
Cell Name: hippocampal interneuron (CL1001569)
Fold Change: 0.2884
Cell Significance Index: 3.7400
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 0.1285
Cell Significance Index: 1.2300
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.0906
Cell Significance Index: 5.5700
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.0721
Cell Significance Index: 45.0500
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: 0.0593
Cell Significance Index: 1.1900
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 0.0455
Cell Significance Index: 0.9500
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.0441
Cell Significance Index: 0.6400
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0356
Cell Significance Index: 24.6000
Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.0325
Cell Significance Index: 0.7800
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.0177
Cell Significance Index: 0.9200
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.0046
Cell Significance Index: 3.4200
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.0025
Cell Significance Index: 1.4000
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.0023
Cell Significance Index: 0.0500
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0019
Cell Significance Index: 0.3800
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0004
Cell Significance Index: -0.0800
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0030
Cell Significance Index: -0.0800
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0065
Cell Significance Index: -1.1100
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0077
Cell Significance Index: -5.6100
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0083
Cell Significance Index: -0.3600
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0100
Cell Significance Index: -5.4600
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0103
Cell Significance Index: -1.1800
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0108
Cell Significance Index: -6.8800
Cell Name: trophoblast giant cell (CL0002488)
Fold Change: -0.0139
Cell Significance Index: -0.1000
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.0160
Cell Significance Index: -1.8300
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0164
Cell Significance Index: -4.7200
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0189
Cell Significance Index: -3.7600
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0249
Cell Significance Index: -2.9000
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0291
Cell Significance Index: -5.2500
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0405
Cell Significance Index: -5.5600
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0442
Cell Significance Index: -4.5100
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0462
Cell Significance Index: -5.6800
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0469
Cell Significance Index: -6.8200
Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -0.0486
Cell Significance Index: -0.9700
Cell Name: neural cell (CL0002319)
Fold Change: -0.0557
Cell Significance Index: -0.6500
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0621
Cell Significance Index: -0.8900
Cell Name: neuron (CL0000540)
Fold Change: -0.0622
Cell Significance Index: -0.5900
Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
Fold Change: -0.0703
Cell Significance Index: -0.7700
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0787
Cell Significance Index: -5.2900
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -0.0789
Cell Significance Index: -1.5500
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0846
Cell Significance Index: -4.4400
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0943
Cell Significance Index: -5.2900
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.1028
Cell Significance Index: -1.4100
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1085
Cell Significance Index: -5.1000
Cell Name: GABAergic neuron (CL0000617)
Fold Change: -0.1094
Cell Significance Index: -1.3800
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.1150
Cell Significance Index: -5.9900
Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: -0.1226
Cell Significance Index: -2.0200
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.1290
Cell Significance Index: -2.0900
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.1298
Cell Significance Index: -5.7400
Cell Name: progenitor cell (CL0011026)
Fold Change: -0.1365
Cell Significance Index: -1.4500
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.1390
Cell Significance Index: -2.9500
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.1464
Cell Significance Index: -5.1300
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.1516
Cell Significance Index: -5.7400
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.1556
Cell Significance Index: -5.1000
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.1604
Cell Significance Index: -5.1100
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: -0.1756
Cell Significance Index: -2.1000
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.1778
Cell Significance Index: -4.5300
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.1863
Cell Significance Index: -3.9000
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.1891
Cell Significance Index: -5.4000
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.1960
Cell Significance Index: -2.7900
Cell Name: endocrine cell (CL0000163)
Fold Change: -0.1986
Cell Significance Index: -2.4000
Cell Name: preadipocyte (CL0002334)
Fold Change: -0.2014
Cell Significance Index: -3.9300
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.2041
Cell Significance Index: -5.0900
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: -0.2045
Cell Significance Index: -2.0600
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.2052
Cell Significance Index: -7.1300
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.2120
Cell Significance Index: -5.6800
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.2124
Cell Significance Index: -4.2000
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.2137
Cell Significance Index: -5.6200
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.2294
Cell Significance Index: -3.1300
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.2364
Cell Significance Index: -4.8100
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.2366
Cell Significance Index: -6.9700
Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.2410
Cell Significance Index: -5.8800
Cell Name: neural progenitor cell (CL0011020)
Fold Change: -0.2456
Cell Significance Index: -2.4300
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.2522
Cell Significance Index: -6.2900
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: -0.2569
Cell Significance Index: -2.4400
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: -0.2627
Cell Significance Index: -3.2000
Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
Fold Change: -0.2663
Cell Significance Index: -3.5500
Cell Name: cytotoxic T cell (CL0000910)
Fold Change: -0.2751
Cell Significance Index: -4.0100
Cell Name: interneuron (CL0000099)
Fold Change: -0.2808
Cell Significance Index: -3.2800
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.2834
Cell Significance Index: -4.9000
Cell Name: tendon cell (CL0000388)
Fold Change: -0.2861
Cell Significance Index: -3.8900
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.2898
Cell Significance Index: -4.8500
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.2901
Cell Significance Index: -6.2000
Cell Name: Schwann cell (CL0002573)
Fold Change: -0.2953
Cell Significance Index: -3.3100
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.3014
Cell Significance Index: -6.6000
Cell Name: decidual cell (CL2000002)
Fold Change: -0.3092
Cell Significance Index: -4.9600
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: -0.3107
Cell Significance Index: -3.7800
Cell Name: L5 intratelencephalic projecting glutamatergic neuron (CL4030064)
Fold Change: -0.3252
Cell Significance Index: -3.5100
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.3253
Cell Significance Index: -6.3600
Cell Name: hepatoblast (CL0005026)
Fold Change: -0.3312
Cell Significance Index: -5.5700
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: -0.3322
Cell Significance Index: -4.9700
Cell Name: chondrocyte (CL0000138)
Fold Change: -0.3375
Cell Significance Index: -3.8900
Cell Name: mast cell (CL0000097)
Fold Change: -0.3427
Cell Significance Index: -4.5100
Cell Name: suprabasal keratinocyte (CL4033013)
Fold Change: -0.3439
Cell Significance Index: -5.5300
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.3507
Cell Significance Index: -4.3500
Cell Name: pancreatic epsilon cell (CL0005019)
Fold Change: -0.3518
Cell Significance Index: -3.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** The CRH gene encodes for a 40-amino acid peptide hormone that plays a pivotal role in the hypothalamic-pituitary-adrenal (HPA) axis, a complex neuroendocrine system that regulates the body's response to stress. CRH is produced by the hypothalamic paraventricular nucleus (PVN) and the supraoptic nucleus (SON) and is released into the bloodstream, where it stimulates the pituitary gland to release adrenocorticotropic hormone (ACTH), leading to the production of cortisol and other glucocorticoids. **Pathways and Functions:** CRH is involved in various signaling pathways, including: 1. **HPA axis regulation**: CRH stimulates the release of ACTH, which in turn regulates the production of cortisol and other glucocorticoids. 2. **Immune system regulation**: CRH modulates the immune response by regulating the production of cytokines and the activation of immune cells, such as T cells and macrophages. 3. **Neurotransmitter regulation**: CRH interacts with various neurotransmitters, including dopamine, serotonin, and acetylcholine, to modulate mood, behavior, and cognitive function. 4. **Developmental processes**: CRH is involved in the regulation of embryonic development, including the development of the adrenal gland, kidney, and reproductive organs. **Clinical Significance:** The CRH gene has significant implications for various clinical conditions, including: 1. **Stress disorders**: Dysregulation of the CRH gene has been implicated in stress-related disorders, such as post-traumatic stress disorder (PTSD) and anxiety disorders. 2. **Autoimmune diseases**: CRH has been shown to modulate the immune response and has been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Cancer**: CRH has been shown to stimulate the growth and proliferation of certain cancer cells, including those of the adrenal gland and kidney. 4. **Neurological disorders**: CRH has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. **Significantly Expressed Cells:** The CRH gene is expressed in various cell types, including: 1. **Megakaryocytes**: CRH is expressed in megakaryocytes, which are responsible for producing platelets. 2. **Hematopoietic stem cells**: CRH is expressed in hematopoietic stem cells, which give rise to all blood cell types. 3. **Blood vessel endothelial cells**: CRH is expressed in blood vessel endothelial cells, which play a crucial role in maintaining vascular homeostasis. 4. **T cells**: CRH is expressed in T cells, which are central to the adaptive immune response. **Proteins:** The CRH gene encodes for a single protein, Corticoliberin (CRF_HUMAN), which is a 40-amino acid peptide hormone. In conclusion, the CRH gene is a critical regulator of various physiological processes, including stress response, immunity, and development. Its dysregulation has significant implications for various clinical conditions, highlighting the importance of further research into the molecular mechanisms underlying CRH function.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Corticoliberin

Genular Protein ID: 2289268616

Symbol: CRF_HUMAN

Name: Corticoliberin

UniProtKB Accession Codes:

P06850 B3KQS4

Database IDs:

Citations:

PubMed ID: 6605851

Title: Isolation and sequence analysis of the human corticotropin-releasing factor precursor gene.

PubMed ID: 6605851

DOI: 10.1002/j.1460-2075.1983.tb01499.x

PubMed ID: 2783917

Title: Preprocorticotropin releasing hormone: cDNA sequence and in vitro processing.

PubMed ID: 2783917

DOI: 10.1016/0303-7207(89)90128-7

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3262120

Title: Isolation and characterization of a corticotropin-releasing hormone-like peptide from human placenta.

PubMed ID: 3262120

DOI: 10.1210/jcem-67-4-768

PubMed ID: 8386360

Title: Solution structure of human corticotropin releasing factor by 1H NMR and distance geometry with restrained molecular dynamics.

PubMed ID: 8386360

DOI: 10.1093/protein/6.2.149

PubMed ID: 18801728

Title: Molecular recognition of corticotropin-releasing factor by its G-protein-coupled receptor CRFR1.

PubMed ID: 18801728

DOI: 10.1074/jbc.m805749200

PubMed ID: 23593457

Title: Functional characterization of a CRH missense mutation identified in an ADNFLE family.

PubMed ID: 23593457

DOI: 10.1371/journal.pone.0061306

Sequence Information:

Length: 196
Mass: 21422
Checksum: 0CCDFF05BE364E92
Sequence:

MRLPLLVSAG VLLVALLPCP PCRALLSRGP VPGARQAPQH PQPLDFFQPP PQSEQPQQPQ 
ARPVLLRMGE EYFLRLGNLN KSPAAPLSPA SSLLAGGSGS RPSPEQATAN FFRVLLQQLL 
LPRRSLDSPA ALAERGARNA LGGHQEAPER ERRSEEPPIS LDLTFHLLRE VLEMARAEQL 
AQQAHSNRKL MEIIGK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CRH

Associated with

Cells (max top 100)

Other Information

Isolation and sequence analysis of the human corticotropin-releasing factor precursor gene. PubMed ID: 6605851

Preprocorticotropin releasing hormone: cDNA sequence and in vitro processing. PubMed ID: 2783917

Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. PubMed ID: 16303743

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Isolation and characterization of a corticotropin-releasing hormone-like peptide from human placenta. PubMed ID: 3262120

Solution structure of human corticotropin releasing factor by 1H NMR and distance geometry with restrained molecular dynamics. PubMed ID: 8386360

Molecular recognition of corticotropin-releasing factor by its G-protein-coupled receptor CRFR1. PubMed ID: 18801728

Functional characterization of a CRH missense mutation identified in an ADNFLE family. PubMed ID: 23593457