Details for: KRT25

Gene ID: 147183

Symbol: KRT25

Ensembl ID: ENSG00000204897

Description: keratin 25

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granular cell of epidermis (CL0002189)
    Fold Change: 49.5404
    Cell Significance Index: 57.0300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.5378
    Cell Significance Index: 37.2500
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.4304
    Cell Significance Index: 4.8100
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.3715
    Cell Significance Index: 4.2800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3287
    Cell Significance Index: 145.3300
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.2504
    Cell Significance Index: 3.6500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1257
    Cell Significance Index: 1.7200
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.1039
    Cell Significance Index: 1.4300
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: 0.1014
    Cell Significance Index: 0.7300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0971
    Cell Significance Index: 1.3900
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.0943
    Cell Significance Index: 1.1200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0876
    Cell Significance Index: 1.3900
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: 0.0511
    Cell Significance Index: 0.3100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0499
    Cell Significance Index: 0.7300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: 0.0444
    Cell Significance Index: 0.8900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.0244
    Cell Significance Index: 0.6100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0129
    Cell Significance Index: 0.9200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.0105
    Cell Significance Index: 0.1600
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0065
    Cell Significance Index: 0.0800
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.0054
    Cell Significance Index: 0.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0003
    Cell Significance Index: -0.2200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0005
    Cell Significance Index: -0.9100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0014
    Cell Significance Index: -0.7800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0022
    Cell Significance Index: -0.2500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0024
    Cell Significance Index: -1.3800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0025
    Cell Significance Index: -0.1300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0035
    Cell Significance Index: -1.6100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0038
    Cell Significance Index: -0.1500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0053
    Cell Significance Index: -1.0700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0062
    Cell Significance Index: -0.8500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0070
    Cell Significance Index: -1.3800
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0070
    Cell Significance Index: -0.0800
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0076
    Cell Significance Index: -0.0900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0077
    Cell Significance Index: -0.1000
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0078
    Cell Significance Index: -0.0800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0080
    Cell Significance Index: -1.3700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0097
    Cell Significance Index: -0.9900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0119
    Cell Significance Index: -0.2500
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0143
    Cell Significance Index: -0.1700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0151
    Cell Significance Index: -1.0200
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.0162
    Cell Significance Index: -0.2200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0202
    Cell Significance Index: -0.5400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0221
    Cell Significance Index: -1.1500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0272
    Cell Significance Index: -0.4600
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.0289
    Cell Significance Index: -0.2800
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.0293
    Cell Significance Index: -0.2800
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0307
    Cell Significance Index: -0.3800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0349
    Cell Significance Index: -1.1100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0354
    Cell Significance Index: -1.1600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0355
    Cell Significance Index: -0.9500
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0368
    Cell Significance Index: -0.4600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0368
    Cell Significance Index: -1.2900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0377
    Cell Significance Index: -0.9400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0409
    Cell Significance Index: -0.8000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0418
    Cell Significance Index: -1.1000
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.0419
    Cell Significance Index: -0.2500
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0435
    Cell Significance Index: -0.5500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0446
    Cell Significance Index: -0.6400
  • Cell Name: peridermal cell (CL0000078)
    Fold Change: -0.0479
    Cell Significance Index: -0.3000
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0489
    Cell Significance Index: -0.8300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0493
    Cell Significance Index: -0.8300
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0510
    Cell Significance Index: -0.6000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0528
    Cell Significance Index: -1.1200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0530
    Cell Significance Index: -1.3500
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0533
    Cell Significance Index: -0.6300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0543
    Cell Significance Index: -1.1900
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0543
    Cell Significance Index: -0.5500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0575
    Cell Significance Index: -1.3800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0578
    Cell Significance Index: -1.1600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0581
    Cell Significance Index: -0.7600
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0582
    Cell Significance Index: -0.6300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0583
    Cell Significance Index: -1.2600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0612
    Cell Significance Index: -1.2100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0614
    Cell Significance Index: -1.6400
  • Cell Name: surface ectodermal cell (CL0000114)
    Fold Change: -0.0621
    Cell Significance Index: -0.4900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0622
    Cell Significance Index: -0.7900
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0634
    Cell Significance Index: -0.8500
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0634
    Cell Significance Index: -0.9100
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0638
    Cell Significance Index: -0.8200
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0643
    Cell Significance Index: -0.8200
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0647
    Cell Significance Index: -0.8800
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0648
    Cell Significance Index: -0.8700
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0648
    Cell Significance Index: -0.7800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0650
    Cell Significance Index: -0.9600
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0655
    Cell Significance Index: -0.7500
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0656
    Cell Significance Index: -0.9600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0656
    Cell Significance Index: -1.8800
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0680
    Cell Significance Index: -0.8000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0690
    Cell Significance Index: -1.4400
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0693
    Cell Significance Index: -0.9400
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0697
    Cell Significance Index: -0.8700
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0705
    Cell Significance Index: -0.9200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0712
    Cell Significance Index: -1.3900
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0713
    Cell Significance Index: -0.8200
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0714
    Cell Significance Index: -0.8100
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0734
    Cell Significance Index: -0.7100
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0735
    Cell Significance Index: -0.9200
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0738
    Cell Significance Index: -0.7300
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0739
    Cell Significance Index: -0.6100
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0741
    Cell Significance Index: -0.7800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** KRT25 is a type I keratin, which distinguishes it from type II keratins. Type I keratins are primarily found in the skin, hair, and nails, whereas type II keratins are more abundant in the epithelial lining of organs and glands. KRT25 is highly expressed in various cell types, including progenitor cells, microglial cells, and goblet cells, highlighting its broad functional significance. Notably, KRT25 is also found in the extracellular exosome and plays a role in keratinization, a process essential for the formation of the cornified envelope, a key component of the skin's barrier function. **Pathways and Functions:** KRT25 is involved in various cellular processes, including: 1. **Cytoskeleton organization**: KRT25 interacts with other keratin proteins to form intermediate filaments, which provide mechanical support and stability to cells. 2. **Keratinization**: KRT25 is essential for the formation of the cornified envelope, a process critical for maintaining the skin's barrier function and preventing water loss. 3. **Epithelial cell differentiation**: KRT25 plays a role in the differentiation of epithelial cells, particularly during the development of the skin and hair follicles. 4. **Protein binding and heterodimerization**: KRT25 interacts with other keratin proteins and non-keratin proteins to form heterodimers, which regulate protein function and localization. **Clinical Significance:** KRT25's involvement in various immunological contexts highlights its potential as a biomarker for various diseases: 1. **Autoimmune disorders**: Abnormal expression of KRT25 has been linked to autoimmune diseases, such as psoriasis and pemphigus, where keratinization is disrupted. 2. **Cancer**: KRT25's role in keratinization and epithelial cell differentiation makes it a potential biomarker for cancer diagnosis and prognosis. 3. **Neurological disorders**: KRT25's expression in microglial cells and cerebral cortex GABAergic interneurons suggests its involvement in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, KRT25 is a complex protein with a wide range of functional and clinical significance. Further research is needed to fully elucidate its role in various immunological contexts and to explore its potential as a biomarker for various diseases.

Genular Protein ID: 1925159222

Symbol: K1C25_HUMAN

Name: Keratin, type I cytoskeletal 25

UniProtKB Accession Codes:

Q7Z3Z0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 1 GO 11 Gene3D 3 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15617563

Title: The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain.

PubMed ID: 15617563

DOI: 10.1111/j.1432-0436.2004.07209006.x

PubMed ID: 16874310

Title: K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), and K28 (K25irs4) represent the type I inner root sheath keratins of the human hair follicle.

PubMed ID: 16874310

DOI: 10.1038/sj.jid.5700494

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 26160856

Title: A homozygous missense variant in type I keratin KRT25 causes autosomal recessive woolly hair.

PubMed ID: 26160856

DOI: 10.1136/jmedgenet-2015-103255

PubMed ID: 26902920

Title: Autosomal recessive hypotrichosis with woolly hair caused by a mutation in the keratin 25 gene expressed in hair follicles.

PubMed ID: 26902920

DOI: 10.1016/j.jid.2016.01.037

PubMed ID: 28899683

Title: A missense mutation within the helix termination motif of KRT25 causes autosomal dominant woolly hair/hypotrichosis.

PubMed ID: 28899683

DOI: 10.1016/j.jid.2017.08.035

Sequence Information:

  • Length: 450
  • Mass: 49318
  • Checksum: 12AB5BF74BA426FF
  • Sequence:
    • MSLRLSSASR RSCPRPTTGS LRLYGGGTSF GTGNSCGISG IGSGFSSAFG GSSSGGNTGG 
GNPCAGFTVN ERGLLSGNEK VTMQNLNDRL ASYLDSVHAL EEANADLEQK IKGWYEKFGP 
GSCRGLDHDY SRYFPIIDDL KNQIIASTTS NANAVLQIDN ARLTADDFRL KYENELALHQ 
SVEADVNGLR RVLDEITLCR TDLEIQYETL SEEMTYLKKN HKEEMQVLQC AAGGNVNVEM 
NAAPGVDLTV LLNNMRAEYE ALAEQNRRDA EAWFNEKSAS LQQQISEDVG ATTSARNELT 
EMKRTLQTLE IELQSLLATK HSLECSLTET ESNYCAQLAQ IQAQIGALEE QLHQVRTETE 
GQKLEYEQLL DIKLHLEKEI ETYCLLIGGD DGACKSGGYK SKDYGSGNVG SQVKDPAKAI 
VVKKVLEEVD QRSKILTTRL HSLEEKSQSN

Genular Protein ID: 233503290

Symbol: Q6ZPD6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6ZPD6

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 Gene3D 2 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 SAM 2 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 379
  • Mass: 41379
  • Checksum: 67B8D2A520D27616
  • Sequence:
    • MSLRLSSASR RSCPRPTTGS LRLYGGGTSF GTGNSCGISG IGSGFSSAFG GSSSGGNTGG 
GNPCAAFTVN ERGLLSGNEK VTMQNLNDRL ASYLDSVHAL EEANADLEQK IKGWYEKFGP 
GSCRGLDHDY SRYFPIIDDL KNQIIASTTS NANAVLQIDN ARLTADDFRL KYENELALHQ 
SVEADVNGLR RVLDEITLCR TDLEIQYETL SEEMTYLKKN HKEEMQVLQC AAGGNVNVEI 
ELQSLLATKH SLECSLTETE SNYCAQLAQI QAQIGALEEQ LHQVRTETEG QKLEYEQLLD 
IKLHLEKEIE TYCLLIGGDD GACKSGGYKS KDYGSGNVGS QVKDPAKAIV VKKVLEEVDQ 
RSKILTTRLH SLEEKSQSN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.