Details for: BPIFB4

Gene ID: 149954

Symbol: BPIFB4

Ensembl ID: ENSG00000186191

Description: BPI fold containing family B member 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.1085
    Cell Significance Index: 26.8500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.7924
    Cell Significance Index: 17.3500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.4166
    Cell Significance Index: 6.6100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.3887
    Cell Significance Index: 5.6700
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 0.0846
    Cell Significance Index: 1.7700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0476
    Cell Significance Index: 5.5500
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0458
    Cell Significance Index: 0.5800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0381
    Cell Significance Index: 0.9500
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.0310
    Cell Significance Index: 0.3800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.0236
    Cell Significance Index: 0.7500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0216
    Cell Significance Index: 0.3700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0214
    Cell Significance Index: 0.2700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0162
    Cell Significance Index: 2.3500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0116
    Cell Significance Index: 0.3100
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.0107
    Cell Significance Index: 0.1600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0102
    Cell Significance Index: 0.5300
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.0097
    Cell Significance Index: 0.1000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0084
    Cell Significance Index: 1.6700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.0060
    Cell Significance Index: 0.1500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0047
    Cell Significance Index: 0.4800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0044
    Cell Significance Index: 0.8800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0036
    Cell Significance Index: 1.0500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0030
    Cell Significance Index: 0.0500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0017
    Cell Significance Index: 0.9300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0007
    Cell Significance Index: 0.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0003
    Cell Significance Index: 0.1000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0003
    Cell Significance Index: 0.5800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0001
    Cell Significance Index: 0.1300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0001
    Cell Significance Index: 0.0800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0002
    Cell Significance Index: -0.2800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0008
    Cell Significance Index: -0.4900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0010
    Cell Significance Index: -0.7500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0011
    Cell Significance Index: -0.8500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0014
    Cell Significance Index: -0.6400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0015
    Cell Significance Index: -0.8200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0022
    Cell Significance Index: -0.0900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0028
    Cell Significance Index: -0.1300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0030
    Cell Significance Index: -0.5200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0041
    Cell Significance Index: -0.7400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0042
    Cell Significance Index: -0.8900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0049
    Cell Significance Index: -0.6000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0049
    Cell Significance Index: -0.6700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0065
    Cell Significance Index: -0.7500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0085
    Cell Significance Index: -0.5700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0098
    Cell Significance Index: -0.7500
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.0116
    Cell Significance Index: -0.1200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0119
    Cell Significance Index: -0.7300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0120
    Cell Significance Index: -0.5300
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0136
    Cell Significance Index: -0.1600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0137
    Cell Significance Index: -0.5200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0143
    Cell Significance Index: -0.3700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0152
    Cell Significance Index: -0.3800
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: -0.0154
    Cell Significance Index: -0.1400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0159
    Cell Significance Index: -0.8900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0160
    Cell Significance Index: -0.5100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0162
    Cell Significance Index: -0.5300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0170
    Cell Significance Index: -0.8000
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: -0.0182
    Cell Significance Index: -0.1600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0183
    Cell Significance Index: -0.6400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0184
    Cell Significance Index: -0.3900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0195
    Cell Significance Index: -0.3800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0207
    Cell Significance Index: -0.7600
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.0215
    Cell Significance Index: -0.2300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0227
    Cell Significance Index: -0.6400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0230
    Cell Significance Index: -0.3400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0232
    Cell Significance Index: -0.2200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0243
    Cell Significance Index: -0.4800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0245
    Cell Significance Index: -0.8600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0255
    Cell Significance Index: -0.5500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0256
    Cell Significance Index: -0.5200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0258
    Cell Significance Index: -0.5100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0259
    Cell Significance Index: -0.7400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0264
    Cell Significance Index: -0.7600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0268
    Cell Significance Index: -0.5600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0269
    Cell Significance Index: -0.5400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0272
    Cell Significance Index: -0.7300
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0274
    Cell Significance Index: -0.2800
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.0298
    Cell Significance Index: -0.3600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0303
    Cell Significance Index: -0.8700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0309
    Cell Significance Index: -0.5200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0318
    Cell Significance Index: -0.4700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0323
    Cell Significance Index: -0.8500
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0325
    Cell Significance Index: -0.4500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0330
    Cell Significance Index: -0.6500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0334
    Cell Significance Index: -0.7000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0340
    Cell Significance Index: -1.0000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0340
    Cell Significance Index: -0.8300
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0341
    Cell Significance Index: -0.4600
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0348
    Cell Significance Index: -0.4700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0349
    Cell Significance Index: -0.8900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0350
    Cell Significance Index: -0.8400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0351
    Cell Significance Index: -1.7700
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0353
    Cell Significance Index: -0.4200
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0353
    Cell Significance Index: -0.4700
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0360
    Cell Significance Index: -0.4200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0364
    Cell Significance Index: -0.6300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0365
    Cell Significance Index: -0.4600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0368
    Cell Significance Index: -0.5900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0370
    Cell Significance Index: -0.3900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0377
    Cell Significance Index: -0.4500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The BPIFB4 gene exhibits the following key characteristics: 1. **BPI fold-containing structure:** The BPI fold is a characteristic structural motif found in antimicrobial peptides, which is also present in the BPIFB4 protein. This fold is thought to contribute to the protein's ability to interact with and bind to various ligands. 2. **Multifaceted expression pattern:** BPIFB4 is expressed in a wide range of cell types, including progenitor cells, endothelial cells, plasma cells, and certain types of neurons. This suggests that the gene plays a role in regulating cell development and differentiation. 3. **Antimicrobial peptide-like properties:** The BPI fold-containing structure of BPIFB4 may confer antimicrobial peptide-like properties, which could be involved in immune system regulation and antimicrobial defense. **Pathways and Functions:** BPIFB4 is involved in various cellular processes, including: 1. **Immune system regulation:** BPIFB4 is expressed in immune cells and may play a role in regulating immune responses, including the production of antimicrobial peptides. 2. **Actin cytoskeleton regulation:** The BPIFB4 protein interacts with the actin cytoskeleton, which is essential for cell shape, movement, and signaling. 3. **Cell differentiation and development:** BPIFB4 is expressed in progenitor cells and may contribute to the regulation of cell differentiation and development. 4. **Antimicrobial defense:** The antimicrobial peptide-like properties of BPIFB4 may be involved in protecting against microbial infections. **Clinical Significance:** The clinical significance of BPIFB4 is multifaceted and may include: 1. **Immune disorders:** Abnormal expression or function of BPIFB4 may contribute to the development of immune disorders, such as autoimmune diseases or immunodeficiency syndromes. 2. **Cancer progression:** The role of BPIFB4 in cell differentiation and development may also be relevant to cancer progression, as altered expression of this gene could contribute to tumorigenesis. 3. **Neurological disorders:** BPIFB4's expression in certain types of neurons suggests that this gene may play a role in neurological disorders, such as neurodegenerative diseases or cognitive impairments. In conclusion, BPIFB4 is a gene with multifaceted roles in immune system regulation, cell development, and antimicrobial defense. Further investigation into the molecular mechanisms underlying this gene's functions will provide valuable insights into its clinical significance and potential therapeutic applications.

Genular Protein ID: 2624672520

Symbol: BPIB4_HUMAN

Name: BPI fold-containing family B member 4

UniProtKB Accession Codes:

P59827 Q5TDX6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 1 ExpressionAtlas 1 GO 4 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 12837268

Title: Expansion of the BPI family by duplication on human chromosome 20: characterization of the RY gene cluster in 20q11.21 encoding olfactory transporters/antimicrobial-like peptides.

PubMed ID: 12837268

DOI: 10.1016/s0888-7543(03)00102-2

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 11971875

Title: PLUNC: a novel family of candidate host defence proteins expressed in the upper airways and nasopharynx.

PubMed ID: 11971875

DOI: 10.1093/hmg/11.8.937

PubMed ID: 14739326

Title: Phylogenetic and evolutionary analysis of the PLUNC gene family.

PubMed ID: 14739326

DOI: 10.1110/ps.03332704

Sequence Information:

  • Length: 614
  • Mass: 65055
  • Checksum: F92C542B75CB97E1
  • Sequence:
    • MWMAWCVAAL SVVAVCGTSH ETNTVLRVTK DVLSNAISGM LQQSDALHSA LREVPLGVGD 
IPYNDFHVRG PPPVYTNGKK LDGIYQYGHI ETNDNTAQLG GKYRYGEILE SEGSIRDLRN 
SGYRSAENAY GGHRGLGRYR AAPVGRLHRR ELQPGEIPPG VATGAVGPGG LLGTGGMLAA 
DGILAGQGGL LGGGGLLGDG GLLGGGGVLG VLGEGGILST VQGITGLRIV ELTLPRVSVR 
LLPGVGVYLS LYTRVAINGK SLIGFLDIAV EVNITAKVRL TMDRTGYPRL VIERCDTLLG 
GIKVKLLRGL LPNLVDNLVN RVLADVLPDL LCPIVDVVLG LVNDQLGLVD SLIPLGILGS 
VQYTFSSLPL VTGEFLELDL NTLVGEAGGG LIDYPLGWPA VSPKPMPELP PMGDNTKSQL 
AMSANFLGSV LTLLQKQHAL DLDITNGMFE ELPPLTTATL GALIPKVFQQ YPESCPLIIR 
IQVLNPPSVM LQKDKALVKV LATAEVMVSQ PKDLETTICL IDVDTEFLAS FSTEGDKLMI 
DAKLEKTSLN LRTSNVGNFD IGLMEVLVEK IFDLAFMPAM NAVLGSGVPL PKILNIDFSN 
ADIDVLEDLL VLSA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.