Details for: CSAG1

Gene ID: 158511

Symbol: CSAG1

Ensembl ID: ENSG00000198930

Description: chondrosarcoma associated gene 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.7515
    Cell Significance Index: 3.4600
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.1490
    Cell Significance Index: 1.2800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0934
    Cell Significance Index: 1.3300
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 0.0563
    Cell Significance Index: 0.2100
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.0444
    Cell Significance Index: 0.5400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0357
    Cell Significance Index: 0.6000
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0283
    Cell Significance Index: 0.2800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0128
    Cell Significance Index: 0.2100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: 0.0055
    Cell Significance Index: 0.1100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0004
    Cell Significance Index: -0.2400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0004
    Cell Significance Index: -0.3200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0010
    Cell Significance Index: -0.1100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0015
    Cell Significance Index: -0.8400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0023
    Cell Significance Index: -0.1000
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.0032
    Cell Significance Index: -0.0400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0043
    Cell Significance Index: -0.7800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0044
    Cell Significance Index: -0.8900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0048
    Cell Significance Index: -0.4900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0052
    Cell Significance Index: -0.6400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0066
    Cell Significance Index: -0.9000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0087
    Cell Significance Index: -0.2400
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.0094
    Cell Significance Index: -0.0600
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0114
    Cell Significance Index: -0.1200
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0138
    Cell Significance Index: -0.1700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0147
    Cell Significance Index: -0.3200
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.0197
    Cell Significance Index: -0.2200
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.0206
    Cell Significance Index: -0.2400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0217
    Cell Significance Index: -0.5800
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0221
    Cell Significance Index: -0.3300
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.0224
    Cell Significance Index: -0.2500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0236
    Cell Significance Index: -0.4800
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.0246
    Cell Significance Index: -0.2000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0251
    Cell Significance Index: -0.6400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0265
    Cell Significance Index: -0.3800
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0271
    Cell Significance Index: -0.3300
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0285
    Cell Significance Index: -0.3800
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.0293
    Cell Significance Index: -0.2100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0309
    Cell Significance Index: -0.9100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0325
    Cell Significance Index: -0.8100
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0330
    Cell Significance Index: -0.3800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0373
    Cell Significance Index: -0.9800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0410
    Cell Significance Index: -0.8100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0443
    Cell Significance Index: -0.7100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0462
    Cell Significance Index: -0.7900
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0475
    Cell Significance Index: -0.5700
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0476
    Cell Significance Index: -0.5800
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0485
    Cell Significance Index: -0.5800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0487
    Cell Significance Index: -0.9000
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0496
    Cell Significance Index: -0.5900
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0506
    Cell Significance Index: -0.8200
  • Cell Name: differentiation-committed oligodendrocyte precursor (CL4023059)
    Fold Change: -0.0514
    Cell Significance Index: -0.6100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0519
    Cell Significance Index: -1.0200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0526
    Cell Significance Index: -0.8800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0536
    Cell Significance Index: -0.8300
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0542
    Cell Significance Index: -0.6400
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0556
    Cell Significance Index: -0.5900
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0561
    Cell Significance Index: -0.7700
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0561
    Cell Significance Index: -0.7200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0563
    Cell Significance Index: -0.7100
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0570
    Cell Significance Index: -0.7500
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0575
    Cell Significance Index: -0.7000
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0587
    Cell Significance Index: -0.6900
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.0593
    Cell Significance Index: -0.6300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0601
    Cell Significance Index: -1.0400
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0606
    Cell Significance Index: -0.8400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0610
    Cell Significance Index: -0.6700
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0613
    Cell Significance Index: -0.8000
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0620
    Cell Significance Index: -0.7200
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0622
    Cell Significance Index: -0.7700
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0635
    Cell Significance Index: -0.7500
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0636
    Cell Significance Index: -0.6500
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0636
    Cell Significance Index: -0.8300
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: -0.0647
    Cell Significance Index: -0.4500
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0650
    Cell Significance Index: -0.6100
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0655
    Cell Significance Index: -0.7500
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: -0.0655
    Cell Significance Index: -0.6500
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0665
    Cell Significance Index: -0.8700
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0678
    Cell Significance Index: -0.7700
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0684
    Cell Significance Index: -0.8600
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0684
    Cell Significance Index: -0.6500
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0690
    Cell Significance Index: -1.1100
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0694
    Cell Significance Index: -0.8800
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0698
    Cell Significance Index: -0.9500
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0704
    Cell Significance Index: -0.7700
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0716
    Cell Significance Index: -0.8000
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.0718
    Cell Significance Index: -0.7800
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0722
    Cell Significance Index: -0.8500
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0730
    Cell Significance Index: -0.7500
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.0736
    Cell Significance Index: -0.5300
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.0737
    Cell Significance Index: -0.7600
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0738
    Cell Significance Index: -0.9500
  • Cell Name: brush cell of tracheobronchial tree (CL0002075)
    Fold Change: -0.0744
    Cell Significance Index: -0.6700
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0747
    Cell Significance Index: -0.8200
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.0747
    Cell Significance Index: -0.4700
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0749
    Cell Significance Index: -0.8900
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0755
    Cell Significance Index: -0.7500
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.0758
    Cell Significance Index: -0.8200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0760
    Cell Significance Index: -1.2900
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0762
    Cell Significance Index: -0.8300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CSAG1, also known as Cancer/Testis Antigen 24.1 (CT24.1), is a protein that is primarily expressed in cancer cells, including chondrosarcoma, as well as in certain immune cells such as T cells and B cells. Its expression is also observed in embryonic stem cells and progenitor cells, highlighting its potential role in cell proliferation and differentiation. CSAG1 is a member of the CHAD1 gene family, which consists of four genes (CHAD1, CHAD2, CHAD3, and CHAD4) that are highly expressed in cancer cells. **Pathways and Functions:** CSAG1 is involved in various cellular pathways, including the centrosome cycle, cytoplasmic organization, and spindle pole formation. These pathways are crucial for maintaining cellular homeostasis, cell division, and the regulation of cell growth and differentiation. The protein has been shown to interact with key regulators of the cell cycle, including cyclin-dependent kinases (CDKs) and cyclin-dependent kinase inhibitors (CKIs). Additionally, CSAG1 has been implicated in the regulation of apoptosis, a process essential for eliminating damaged or unwanted cells. **Clinical Significance:** CSAG1 has been identified as a potential biomarker for various cancers, including chondrosarcoma, as well as for immune-related disorders such as multiple sclerosis. Its expression is often upregulated in cancer cells, making it a potential target for immunotherapy. In addition, CSAG1 has been shown to play a role in the regulation of immune responses, including the activation of T cells and the induction of cytokine production. Furthermore, its expression has been observed in certain neurological disorders, such as Alzheimer's disease and Parkinson's disease, highlighting its potential involvement in neuroinflammatory processes. **Implications for Cancer Therapy:** The identification of CSAG1 as a potential biomarker for cancer has significant implications for cancer therapy. Its expression can be used to monitor disease progression and response to treatment, allowing for more personalized and effective treatment strategies. Additionally, targeting CSAG1 with immunotherapies or small molecule inhibitors may offer a novel approach to cancer treatment. **Conclusion:** In conclusion, CSAG1 is a protein with a complex and multifaceted role in cancer and immune regulation. Its expression in cancer cells, immune cells, and embryonic stem cells highlights its potential as a biomarker and therapeutic target. Further research is needed to fully elucidate the mechanisms by which CSAG1 regulates cellular processes and to explore its potential applications in cancer therapy and immune-related disorders. **Recommendations:** 1. Further research is needed to fully elucidate the mechanisms by which CSAG1 regulates cellular processes. 2. The development of CSAG1-based biomarkers for cancer diagnosis and monitoring is warranted. 3. Immunotherapies targeting CSAG1 may offer a novel approach to cancer treatment. 4. The study of CSAG1's role in immune regulation and neuroinflammatory processes is necessary to fully understand its clinical significance.

Genular Protein ID: 907323794

Symbol: CSAG1_HUMAN

Name: Cancer/testis antigen 24.1

UniProtKB Accession Codes:

Q6PB30 A0A024RC18 A6NE22

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 4 ExpressionAtlas 1 GO 4 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 2 STRING 1 SignaLink 1 TreeFam 1 UCSC 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 12039054

Title: Cancer/testis antigen CSAGE is concurrently expressed with MAGE in chondrosarcoma.

PubMed ID: 12039054

DOI: 10.1016/s0378-1119(02)00395-5

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 32295846

Title: CSAG1 maintains the integrity of the mitotic centrosome in cells with defective p53.

PubMed ID: 32295846

DOI: 10.1242/jcs.239723

Sequence Information:

  • Length: 78
  • Mass: 8697
  • Checksum: 643C38BDDB554575
  • Sequence:
    • MSATTACWPA FTVLGEARGD QVDWSRLYRD TGLVKMSRKP RASSPFSNNH PSTPKRFPRQ 
PRREKGPVKE VPGTKGSP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.