Details for: DAZL

Gene ID: 1618

Symbol: DAZL

Ensembl ID: ENSG00000092345

Description: deleted in azoospermia like

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 6.8802
    Cell Significance Index: 51.9500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 2.1055
    Cell Significance Index: 51.0000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.7921
    Cell Significance Index: 11.5500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.6328
    Cell Significance Index: 10.0400
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.2706
    Cell Significance Index: 3.3800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1681
    Cell Significance Index: 2.8800
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.1602
    Cell Significance Index: 1.8900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0522
    Cell Significance Index: 1.4000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0513
    Cell Significance Index: 1.3500
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.0486
    Cell Significance Index: 0.6100
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.0321
    Cell Significance Index: 0.4500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0279
    Cell Significance Index: 0.7000
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.0272
    Cell Significance Index: 0.3500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0260
    Cell Significance Index: 0.5700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0110
    Cell Significance Index: 3.1700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0077
    Cell Significance Index: 1.5200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0065
    Cell Significance Index: 1.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0061
    Cell Significance Index: 1.2300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0046
    Cell Significance Index: 8.5100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0045
    Cell Significance Index: 0.1200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0043
    Cell Significance Index: 6.5600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0041
    Cell Significance Index: 0.6000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0021
    Cell Significance Index: 0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0018
    Cell Significance Index: 3.4400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0007
    Cell Significance Index: 0.9600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0003
    Cell Significance Index: 0.1000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0007
    Cell Significance Index: -0.4400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0009
    Cell Significance Index: -0.4000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0009
    Cell Significance Index: -0.1100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0013
    Cell Significance Index: -0.9500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0017
    Cell Significance Index: -0.9600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0017
    Cell Significance Index: -1.0400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0048
    Cell Significance Index: -1.0200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0048
    Cell Significance Index: -0.3200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0052
    Cell Significance Index: -0.9300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0053
    Cell Significance Index: -0.6100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0064
    Cell Significance Index: -0.2900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0075
    Cell Significance Index: -0.2000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0076
    Cell Significance Index: -0.9300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0078
    Cell Significance Index: -0.8200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0082
    Cell Significance Index: -0.2600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0088
    Cell Significance Index: -0.5400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0088
    Cell Significance Index: -0.1200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0094
    Cell Significance Index: -1.1100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0095
    Cell Significance Index: -0.2200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0098
    Cell Significance Index: -0.7500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0102
    Cell Significance Index: -1.0400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0106
    Cell Significance Index: -0.4000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0110
    Cell Significance Index: -0.1500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0138
    Cell Significance Index: -0.2700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0147
    Cell Significance Index: -0.4200
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0150
    Cell Significance Index: -0.2000
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.0161
    Cell Significance Index: -0.1000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0164
    Cell Significance Index: -0.9200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0167
    Cell Significance Index: -1.0800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0177
    Cell Significance Index: -0.8300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0186
    Cell Significance Index: -0.6500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0202
    Cell Significance Index: -0.6600
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0203
    Cell Significance Index: -0.2100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0207
    Cell Significance Index: -0.6600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0209
    Cell Significance Index: -0.5100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0211
    Cell Significance Index: -0.3000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0212
    Cell Significance Index: -0.6100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0230
    Cell Significance Index: -0.5900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0256
    Cell Significance Index: -0.5000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0257
    Cell Significance Index: -0.3800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0258
    Cell Significance Index: -0.3300
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.0261
    Cell Significance Index: -0.2500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0265
    Cell Significance Index: -0.6600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0265
    Cell Significance Index: -0.5500
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.0278
    Cell Significance Index: -0.3900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0282
    Cell Significance Index: -0.9900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0287
    Cell Significance Index: -0.6100
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0289
    Cell Significance Index: -0.2100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0291
    Cell Significance Index: -0.4300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0296
    Cell Significance Index: -0.6400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0304
    Cell Significance Index: -0.9000
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0319
    Cell Significance Index: -0.4300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0324
    Cell Significance Index: -0.6500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0327
    Cell Significance Index: -0.3100
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0328
    Cell Significance Index: -0.4600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0334
    Cell Significance Index: -0.6600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0354
    Cell Significance Index: -0.8500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0356
    Cell Significance Index: -0.2900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0357
    Cell Significance Index: -0.6000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0377
    Cell Significance Index: -1.0800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0388
    Cell Significance Index: -0.6500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0398
    Cell Significance Index: -0.8300
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0398
    Cell Significance Index: -0.5100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0399
    Cell Significance Index: -0.5800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0426
    Cell Significance Index: -0.6900
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0427
    Cell Significance Index: -0.8400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0432
    Cell Significance Index: -1.1000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0440
    Cell Significance Index: -1.1000
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0440
    Cell Significance Index: -0.5800
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0451
    Cell Significance Index: -0.9000
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0461
    Cell Significance Index: -0.6900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0468
    Cell Significance Index: -0.8100
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0471
    Cell Significance Index: -0.7600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0472
    Cell Significance Index: -0.6300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DAZL is a protein that binds to the 3'-UTR of specific mRNAs, promoting their translation and stability. This function is critical for the proper development of germ cells, including spermatogenesis and oogenesis. Additionally, DAZL plays a role in the regulation of immune cell development, particularly in the maturation of conventional dendritic cells and the activation of innate lymphoid cells. The gene is also involved in the regulation of meiotic nuclear division and translational initiation, highlighting its importance in cell cycle regulation and protein synthesis. **Pathways and Functions:** The DAZL gene is involved in several key pathways and functions, including: 1. **3'-UTR-mediated mRNA stabilization**: DAZL binds to the 3'-UTR of specific mRNAs, promoting their translation and stability. 2. **Germ cell development**: DAZL is essential for the proper development of germ cells, including spermatogenesis and oogenesis. 3. **Immune cell development**: DAZL plays a role in the regulation of immune cell development, particularly in the maturation of conventional dendritic cells and the activation of innate lymphoid cells. 4. **Meiotic nuclear division**: DAZL regulates meiotic nuclear division, ensuring proper cell cycle progression and chromosomal segregation. 5. **Translational initiation**: DAZL promotes translational initiation, ensuring proper protein synthesis and cell function. **Clinical Significance:** The DAZL gene has significant clinical implications, particularly in the context of infertility and immune system disorders. Mutations in the DAZL gene have been associated with azoospermia, a condition characterized by the absence of sperm in the ejaculate. Additionally, DAZL has been implicated in various immune system disorders, including autoimmune diseases and immunodeficiency syndromes. Further research is needed to fully understand the mechanisms by which DAZL regulates germ cell and immune system development, and to explore its potential as a therapeutic target for these disorders. In conclusion, the DAZL gene is a critical regulator of germ cell development and immune function, and its dysregulation has significant clinical implications. Further research is needed to fully understand the mechanisms by which DAZL functions and to explore its potential as a therapeutic target for various disorders.

Genular Protein ID: 4231019296

Symbol: DAZL_HUMAN

Name: Deleted in azoospermia-like

UniProtKB Accession Codes:

Q92904 O15396 Q5HYB4 Q92909

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 18 Ensembl 2 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8896558

Title: The DAZ gene cluster on the human Y chromosome arose from an autosomal gene that was transposed, repeatedly amplified and pruned.

PubMed ID: 8896558

DOI: 10.1038/ng1196-292

PubMed ID: 8968755

Title: A SPGY copy homologous to the mouse gene Dazla and the Drosophila gene boule is autosomal and expressed only in the human male gonad.

PubMed ID: 8968755

DOI: 10.1093/hmg/5.12.2005

PubMed ID: 8968756

Title: The human autosomal gene DAZLA: testis specificity and a candidate for male infertility.

PubMed ID: 8968756

DOI: 10.1093/hmg/5.12.2013

PubMed ID: 9294855

Title: A putative human male infertility gene DAZLA: genomic structure and methylation status.

PubMed ID: 9294855

DOI: 10.1093/molehr/3.8.705

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10857750

Title: Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1.

PubMed ID: 10857750

DOI: 10.1006/geno.2000.6169

PubMed ID: 11390979

Title: A gene family required for human germ cell development evolved from an ancient meiotic gene conserved in metazoans.

PubMed ID: 11390979

DOI: 10.1073/pnas.131090498

PubMed ID: 12511597

Title: Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ-like proteins.

PubMed ID: 12511597

DOI: 10.1073/pnas.0234478100

PubMed ID: 12414900

Title: Association of a single-nucleotide polymorphism of the deleted-in-azoospermia-like gene with susceptibility to spermatogenic failure.

PubMed ID: 12414900

DOI: 10.1210/jc.2002-020016

PubMed ID: 22021443

Title: Kinked beta-strands mediate high-affinity recognition of mRNA targets by the germ-cell regulator DAZL.

PubMed ID: 22021443

DOI: 10.1073/pnas.1105211108

Sequence Information:

  • Length: 295
  • Mass: 33178
  • Checksum: 21B360739B35B95F
  • Sequence:
    • MSTANPETPN STISREASTQ SSSAATSQGY ILPEGKIMPN TVFVGGIDVR MDETEIRSFF 
ARYGSVKEVK IITDRTGVSK GYGFVSFFND VDVQKIVESQ INFHGKKLKL GPAIRKQNLC 
AYHVQPRPLV FNHPPPPQFQ NVWTNPNTET YMQPTTTMNP ITQYVQAYPT YPNSPVQVIT 
GYQLPVYNYQ MPPQWPVGEQ RSYVVPPAYS AVNYHCNEVD PGAEVVPNEC SVHEATPPSG 
NGPQKKSVDR SIQTVVSCLF NPENRLRNSV VTQDDYFKDK RVHHFRRSRA MLKSV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.