Details for: DAZL

Gene ID: 1618

Symbol: DAZL

Ensembl ID: ENSG00000092345

Description: deleted in azoospermia like

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 8.23
    Marker Score: 53059
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.38
    Marker Score: 3415.5
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 2.25
    Marker Score: 4266
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.19
    Marker Score: 1511
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.15
    Marker Score: 2166
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.62
    Marker Score: 400
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.46
    Marker Score: 1827
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 870
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.36
    Marker Score: 393
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.2
    Marker Score: 2431
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.15
    Marker Score: 18031
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.13
    Marker Score: 7509
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 796
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71824
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48048
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5355
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.84
    Marker Score: 1743
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.83
    Marker Score: 499
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.82
    Marker Score: 474
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.72
    Marker Score: 228
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.67
    Marker Score: 747
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.67
    Marker Score: 742
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.64
    Marker Score: 199
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.59
    Marker Score: 473
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 234
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.55
    Marker Score: 423
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.51
    Marker Score: 270
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.49
    Marker Score: 233
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 279
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.42
    Marker Score: 409.5
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.38
    Marker Score: 216
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 373
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.37
    Marker Score: 586
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.35
    Marker Score: 112
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.31
    Marker Score: 137
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.29
    Marker Score: 128
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.28
    Marker Score: 73
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.27
    Marker Score: 163
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.26
    Marker Score: 503.5
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.25
    Marker Score: 165
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.22
    Marker Score: 117
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.17
    Marker Score: 408
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.16
    Marker Score: 95
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.16
    Marker Score: 59
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.15
    Marker Score: 61
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.15
    Marker Score: 50
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.13
    Marker Score: 47
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.13
    Marker Score: 220
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.13
    Marker Score: 27.5
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.13
    Marker Score: 163
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.12
    Marker Score: 27.5
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.12
    Marker Score: 54
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.11
    Marker Score: 100
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.11
    Marker Score: 27.5
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.1
    Marker Score: 122
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.1
    Marker Score: 99
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.09
    Marker Score: 27.5
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.09
    Marker Score: 57
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.09
    Marker Score: 79
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.09
    Marker Score: 22.5
  • Cell Name: mesothelial fibroblast (CL4023054)
    Fold Change: 0.09
    Marker Score: 26
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.09
    Marker Score: 25.5
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.09
    Marker Score: 87
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.09
    Marker Score: 115
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.08
    Marker Score: 25.5
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.08
    Marker Score: 56
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.08
    Marker Score: 96
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.08
    Marker Score: 25
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.07
    Marker Score: 26
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.07
    Marker Score: 26
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.07
    Marker Score: 48
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.07
    Marker Score: 26.5
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.07
    Marker Score: 22
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.07
    Marker Score: 24.5
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.07
    Marker Score: 410
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.07
    Marker Score: 15.5
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.06
    Marker Score: 27.5
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.06
    Marker Score: 25.5
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.06
    Marker Score: 28
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.06
    Marker Score: 24.5
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.06
    Marker Score: 57
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.06
    Marker Score: 20.5
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.06
    Marker Score: 96
  • Cell Name: follicular dendritic cell (CL0000442)
    Fold Change: 0.05
    Marker Score: 19.5
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.05
    Marker Score: 26
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.05
    Marker Score: 21.5
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.05
    Marker Score: 19
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.05
    Marker Score: 24
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.05
    Marker Score: 27
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.05
    Marker Score: 56
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.05
    Marker Score: 501

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Other Information

**Key characteristics:** * The DAZL gene is located on chromosome 18p11.2. * It is a homeobox gene, which is a family of genes that are involved in tissue development. * The DAZL gene product is a protein that is involved in the regulation of meiotic nuclear division. **Pathways and functions:** * The DAZL gene is involved in the regulation of female meiosis. * It is expressed in a variety of cell types that are involved in female reproduction. * The DAZL gene product is required for the development of the oocyte and for the maintenance of female fertility. **Clinical significance:** * Mutations in the DAZL gene have been linked to azoospermia-like syndrome, a genetic disorder that affects fertility. * The DAZL gene is a potential target for therapy in azoospermia-like syndrome. * Studies of the DAZL gene have also shown that it is involved in other reproductive disorders, such as endometriosis and polycystic ovary syndrome. **Additional information:** * The DAZL gene is also known as ZFHX1. * The DAZL gene product is a member of the ZFHX family of homeobox genes. * The DAZL gene is expressed in a pattern that is consistent with its role in female meiosis. * Mutations in the DAZL gene have been shown to be associated with a number of human diseases, including azoospermia-like syndrome, endometriosis, and polycystic ovary syndrome.

Genular Protein ID: 4231019296

Symbol: DAZL_HUMAN

Name: Deleted in azoospermia-like

UniProtKB Accession Codes:

Q92904 O15396 Q5HYB4 Q92909

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 18 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8896558

Title: The DAZ gene cluster on the human Y chromosome arose from an autosomal gene that was transposed, repeatedly amplified and pruned.

PubMed ID: 8896558

DOI: 10.1038/ng1196-292

PubMed ID: 8968755

Title: A SPGY copy homologous to the mouse gene Dazla and the Drosophila gene boule is autosomal and expressed only in the human male gonad.

PubMed ID: 8968755

DOI: 10.1093/hmg/5.12.2005

PubMed ID: 8968756

Title: The human autosomal gene DAZLA: testis specificity and a candidate for male infertility.

PubMed ID: 8968756

DOI: 10.1093/hmg/5.12.2013

PubMed ID: 9294855

Title: A putative human male infertility gene DAZLA: genomic structure and methylation status.

PubMed ID: 9294855

DOI: 10.1093/molehr/3.8.705

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10857750

Title: Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1.

PubMed ID: 10857750

DOI: 10.1006/geno.2000.6169

PubMed ID: 11390979

Title: A gene family required for human germ cell development evolved from an ancient meiotic gene conserved in metazoans.

PubMed ID: 11390979

DOI: 10.1073/pnas.131090498

PubMed ID: 12511597

Title: Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ-like proteins.

PubMed ID: 12511597

DOI: 10.1073/pnas.0234478100

PubMed ID: 12414900

Title: Association of a single-nucleotide polymorphism of the deleted-in-azoospermia-like gene with susceptibility to spermatogenic failure.

PubMed ID: 12414900

DOI: 10.1210/jc.2002-020016

PubMed ID: 22021443

Title: Kinked beta-strands mediate high-affinity recognition of mRNA targets by the germ-cell regulator DAZL.

PubMed ID: 22021443

DOI: 10.1073/pnas.1105211108

Sequence Information:

  • Length: 295
  • Mass: 33178
  • Checksum: 21B360739B35B95F
  • Sequence:
    • MSTANPETPN STISREASTQ SSSAATSQGY ILPEGKIMPN TVFVGGIDVR MDETEIRSFF 
ARYGSVKEVK IITDRTGVSK GYGFVSFFND VDVQKIVESQ INFHGKKLKL GPAIRKQNLC 
AYHVQPRPLV FNHPPPPQFQ NVWTNPNTET YMQPTTTMNP ITQYVQAYPT YPNSPVQVIT 
GYQLPVYNYQ MPPQWPVGEQ RSYVVPPAYS AVNYHCNEVD PGAEVVPNEC SVHEATPPSG 
NGPQKKSVDR SIQTVVSCLF NPENRLRNSV VTQDDYFKDK RVHHFRRSRA MLKSV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.