No CSI details found for gene ID: 1618
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 4231019296
Symbol: DAZL_HUMAN
Name: Deleted in azoospermia-like
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8896558
Title: The DAZ gene cluster on the human Y chromosome arose from an autosomal gene that was transposed, repeatedly amplified and pruned.
PubMed ID: 8896558
DOI: 10.1038/ng1196-292
PubMed ID: 8968755
Title: A SPGY copy homologous to the mouse gene Dazla and the Drosophila gene boule is autosomal and expressed only in the human male gonad.
PubMed ID: 8968755
PubMed ID: 8968756
Title: The human autosomal gene DAZLA: testis specificity and a candidate for male infertility.
PubMed ID: 8968756
PubMed ID: 9294855
Title: A putative human male infertility gene DAZLA: genomic structure and methylation status.
PubMed ID: 9294855
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 16641997
Title: The DNA sequence, annotation and analysis of human chromosome 3.
PubMed ID: 16641997
DOI: 10.1038/nature04728
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10857750
Title: Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1.
PubMed ID: 10857750
PubMed ID: 11390979
Title: A gene family required for human germ cell development evolved from an ancient meiotic gene conserved in metazoans.
PubMed ID: 11390979
PubMed ID: 12511597
Title: Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ-like proteins.
PubMed ID: 12511597
PubMed ID: 12414900
Title: Association of a single-nucleotide polymorphism of the deleted-in-azoospermia-like gene with susceptibility to spermatogenic failure.
PubMed ID: 12414900
PubMed ID: 22021443
Title: Kinked beta-strands mediate high-affinity recognition of mRNA targets by the germ-cell regulator DAZL.
PubMed ID: 22021443
Sequence Information:
- Length: 295
- Mass: 33178
- Checksum: 21B360739B35B95F
- Sequence:
MSTANPETPN STISREASTQ SSSAATSQGY ILPEGKIMPN TVFVGGIDVR MDETEIRSFF ARYGSVKEVK IITDRTGVSK GYGFVSFFND VDVQKIVESQ INFHGKKLKL GPAIRKQNLC AYHVQPRPLV FNHPPPPQFQ NVWTNPNTET YMQPTTTMNP ITQYVQAYPT YPNSPVQVIT GYQLPVYNYQ MPPQWPVGEQ RSYVVPPAYS AVNYHCNEVD PGAEVVPNEC SVHEATPPSG NGPQKKSVDR SIQTVVSCLF NPENRLRNSV VTQDDYFKDK RVHHFRRSRA MLKSV
Details Unavailable
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{
"geneID": 1618,
"tax": {
"id": 9606,
"name": [
{
"name": "Homo sapiens Linnaeus 1758"
},
{
"name": "Homo sapiens",
"type": 0
},
{
"name": "human",
"type": 4
}
]
},
"accession": {
"gene": [
"AC010139.4"
]
},
"genePos": {
"start": 5077,
"end": 23708
},
"orientation": false,
"symbol": "DAZL",
"created": {
"$date": {
"$numberLong": "1738333348762"
}
},
"crossReference": {
"enseGeneID": "ENSG00000092345",
"enseRnaID": [
"ENST00000250863.12"
],
"enseProtID": [
"ENSP00000250863.8"
]
},
"chrom": {
"pos": "3",
"type": 1,
"loc": "3p24.3"
},
"desc": "deleted in azoospermia like",
"geneType": 5,
"mim": [
{
"id": 601486,
"relation": 0
}
],
"ontology": [
{
"id": "GO:0003723",
"term": "RNA binding",
"pubMed": [
8968755
],
"cat": 0
},
{
"id": "GO:0003730",
"term": "mRNA 3'-UTR binding",
"cat": 0
},
{
"id": "GO:0005515",
"term": "protein binding",
"pubMed": [
10857750,
12511597,
16001084
],
"cat": 0
},
{
"id": "GO:0008494",
"term": "translation activator activity",
"cat": 0
},
{
"id": "GO:0008494",
"term": "translation activator activity",
"pubMed": [
16001084
],
"cat": 0
},
{
"id": "GO:0042802",
"term": "identical protein binding",
"cat": 0
},
{
"id": "GO:0001556",
"term": "oocyte maturation",
"cat": 1
},
{
"id": "GO:0007147",
"term": "female meiosis II",
"cat": 1
},
{
"id": "GO:0007281",
"term": "germ cell development",
"pubMed": [
9288969
],
"cat": 1
},
{
"id": "GO:0007283",
"term": "spermatogenesis",
"cat": 1
},
{
"id": "GO:0045836",
"term": "positive regulation of meiotic nuclear division",
"cat": 1
},
{
"id": "GO:0045948",
"term": "positive regulation of translational initiation",
"cat": 1
},
{
"id": "GO:0045948",
"term": "positive regulation of translational initiation",
"pubMed": [
16001084
],
"cat": 1
},
{
"id": "GO:0070935",
"term": "3'-UTR-mediated mRNA stabilization",
"cat": 1
},
{
"id": "GO:0005634",
"term": "nucleus",
"cat": 2
},
{
"id": "GO:0005737",
"term": "cytoplasm",
"cat": 2
},
{
"id": "GO:0005840",
"term": "ribosome",
"cat": 2
},
{
"id": "GO:0032991",
"term": "protein-containing complex",
"pubMed": [
10857750
],
"cat": 2
}
],
"protein": [
{
"symbol": "DAZL_HUMAN",
"name": "Deleted in azoospermia-like",
"accession": [
"Q92904",
"O15396",
"Q5HYB4",
"Q92909"
],
"databaseIDs": {
"NCBI Taxonomy": [
"9606"
],
"EMBL": [
"U65918",
"U66726",
"U66078",
"U77476",
"U77467",
"U77468",
"U77469",
"U77470",
"U77471",
"U77472",
"U77473",
"U77474",
"U77475",
"AK303026",
"BX648638",
"AC010139",
"CH471055",
"BC027595"
],
"CCDS": [
"CCDS43059.1",
"CCDS54556.1"
],
"RefSeq": [
"NP_001177740.1",
"NP_001342.2"
],
"AlphaFoldDB": [
"Q92904"
],
"SMR": [
"Q92904"
],
"BioGRID": [
"107987"
],
"IntAct": [
"Q92904"
],
"STRING": [
"9606.ENSP00000250863"
],
"iPTMnet": [
"Q92904"
],
"PhosphoSitePlus": [
"Q92904"
],
"BioMuta": [
"DAZL"
],
"DMDM": [
"27805453"
],
"MassIVE": [
"Q92904"
],
"PaxDb": [
"9606-ENSP00000250863"
],
"PeptideAtlas": [
"Q92904"
],
"ProteomicsDB": [
"75589",
"75590"
],
"Antibodypedia": [
"6122"
],
"DNASU": [
"1618"
],
"Ensembl": [
"ENST00000250863.12",
"ENST00000399444.7"
],
"KEGG": [
"hsa:1618"
],
"MANE-Select": [
"ENST00000399444.7"
],
"UCSC": [
"uc003cba.4"
],
"AGR": [
"HGNC:2685"
],
"CTD": [
"1618"
],
"DisGeNET": [
"1618"
],
"GeneCards": [
"DAZL"
],
"HGNC": [
"HGNC:2685"
],
"HPA": [
"ENSG00000092345"
],
"MIM": [
"601486"
],
"neXtProt": [
"NX_Q92904"
],
"OpenTargets": [
"ENSG00000092345"
],
"PharmGKB": [
"PA27155"
],
"VEuPathDB": [
"HostDB:ENSG00000092345"
],
"eggNOG": [
"KOG0118"
],
"GeneTree": [
"ENSGT00530000063480"
],
"HOGENOM": [
"CLU_084802_0_0_1"
],
"InParanoid": [
"Q92904"
],
"OMA": [
"SQEDYFK"
],
"OrthoDB": [
"3964771at2759"
],
"PhylomeDB": [
"Q92904"
],
"TreeFam": [
"TF324396"
],
"PathwayCommons": [
"Q92904"
],
"SignaLink": [
"Q92904"
],
"BioGRID-ORCS": [
"1618"
],
"ChiTaRS": [
"DAZL"
],
"GeneWiki": [
"DAZL"
],
"GenomeRNAi": [
"1618"
],
"Pharos": [
"Q92904"
],
"PRO": [
"PR:Q92904"
],
"Proteomes": [
"UP000005640"
],
"RNAct": [
"Q92904"
],
"Bgee": [
"ENSG00000092345"
],
"ExpressionAtlas": [
"Q92904"
],
"GO": [
"GO:0005737",
"GO:0005634",
"GO:0032991",
"GO:0005840",
"GO:0042802",
"GO:0003730",
"GO:0003723",
"GO:0008494",
"GO:0070935",
"GO:0007147",
"GO:0007281",
"GO:0001556",
"GO:0045836",
"GO:0045948",
"GO:0007283"
],
"CDD": [
"cd12672"
],
"Gene3D": [
"3.30.70.330"
],
"InterPro": [
"IPR043628",
"IPR037551",
"IPR012677",
"IPR035979",
"IPR000504"
],
"PANTHER": [
"PTHR11176",
"PTHR11176:SF4"
],
"Pfam": [
"PF18872",
"PF00076"
],
"SMART": [
"SM00360"
],
"SUPFAM": [
"SSF54928"
],
"PROSITE": [
"PS51890",
"PS50102"
]
},
"citations": [
{
"title": "The DAZ gene cluster on the human Y chromosome arose from an autosomal gene that was transposed, repeatedly amplified and pruned.",
"pubmedID": "8896558",
"doi": "10.1038\/ng1196-292"
},
{
"title": "A SPGY copy homologous to the mouse gene Dazla and the Drosophila gene boule is autosomal and expressed only in the human male gonad.",
"pubmedID": "8968755",
"doi": "10.1093\/hmg\/5.12.2005"
},
{
"title": "The human autosomal gene DAZLA: testis specificity and a candidate for male infertility.",
"pubmedID": "8968756",
"doi": "10.1093\/hmg\/5.12.2013"
},
{
"title": "A putative human male infertility gene DAZLA: genomic structure and methylation status.",
"pubmedID": "9294855",
"doi": "10.1093\/molehr\/3.8.705"
},
{
"title": "Complete sequencing and characterization of 21,243 full-length human cDNAs.",
"pubmedID": "14702039",
"doi": "10.1038\/ng1285"
},
{
"title": "The full-ORF clone resource of the German cDNA consortium.",
"pubmedID": "17974005",
"doi": "10.1186\/1471-2164-8-399"
},
{
"title": "The DNA sequence, annotation and analysis of human chromosome 3.",
"pubmedID": "16641997",
"doi": "10.1038\/nature04728"
},
{
"title": "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).",
"pubmedID": "15489334",
"doi": "10.1101\/gr.2596504"
},
{
"title": "Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1.",
"pubmedID": "10857750",
"doi": "10.1006\/geno.2000.6169"
},
{
"title": "A gene family required for human germ cell development evolved from an ancient meiotic gene conserved in metazoans.",
"pubmedID": "11390979",
"doi": "10.1073\/pnas.131090498"
},
{
"title": "Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ-like proteins.",
"pubmedID": "12511597",
"doi": "10.1073\/pnas.0234478100"
},
{
"title": "Association of a single-nucleotide polymorphism of the deleted-in-azoospermia-like gene with susceptibility to spermatogenic failure.",
"pubmedID": "12414900",
"doi": "10.1210\/jc.2002-020016"
},
{
"title": "Kinked beta-strands mediate high-affinity recognition of mRNA targets by the germ-cell regulator DAZL.",
"pubmedID": "22021443",
"doi": "10.1073\/pnas.1105211108"
}
],
"sequence": {
"length": 295,
"mass": 33178,
"checksum": "21B360739B35B95F",
"modified": {
"$date": {
"$numberLong": "854755200000"
}
},
"version": 1,
"sequence": "MSTANPETPNSTISREASTQSSSAATSQGYILPEGKIMPNTVFVGGIDVRMDETEIRSFFARYGSVKEVKIITDRTGVSKGYGFVSFFNDVDVQKIVESQINFHGKKLKLGPAIRKQNLCAYHVQPRPLVFNHPPPPQFQNVWTNPNTETYMQPTTTMNPITQYVQAYPTYPNSPVQVITGYQLPVYNYQMPPQWPVGEQRSYVVPPAYSAVNYHCNEVDPGAEVVPNECSVHEATPPSGNGPQKKSVDRSIQTVVSCLFNPENRLRNSVVTQDDYFKDKRVHHFRRSRAMLKSV"
},
"existence": 0,
"relevance": 1,
"proteinID": 4231019296
}
],
"singleCellExpressions": {
"cellSignificanceIndex": []
}
}