Details for: DLX1

Gene ID: 1745

Symbol: DLX1

Ensembl ID: ENSG00000144355

Description: distal-less homeobox 1

Associated with

  • Cell differentiation
    (GO:0030154)
  • Cellular response to bmp stimulus
    (GO:0071773)
  • Cellular response to transforming growth factor beta stimulus
    (GO:0071560)
  • Cerebral cortex gabaergic interneuron fate commitment
    (GO:0021893)
  • Chromatin
    (GO:0000785)
  • Chromatin binding
    (GO:0003682)
  • Cytosol
    (GO:0005829)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Embryonic skeletal system development
    (GO:0048706)
  • Forebrain neuron differentiation
    (GO:0021879)
  • Hippocampus development
    (GO:0021766)
  • Intracellular membrane-bounded organelle
    (GO:0043231)
  • Negative regulation of bmp signaling pathway
    (GO:0030514)
  • Negative regulation of cellular response to transforming growth factor beta stimulus
    (GO:1903845)
  • Negative regulation of neuron apoptotic process
    (GO:0043524)
  • Negative regulation of notch signaling pathway
    (GO:0045746)
  • Negative regulation of oligodendrocyte differentiation
    (GO:0048715)
  • Negative regulation of photoreceptor cell differentiation
    (GO:0046533)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Neuroblast differentiation
    (GO:0014016)
  • Neuron apoptotic process
    (GO:0051402)
  • Notch signaling pathway
    (GO:0007219)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Odontogenesis of dentin-containing tooth
    (GO:0042475)
  • Oligodendrocyte differentiation
    (GO:0048709)
  • Positive regulation of amacrine cell differentiation
    (GO:1902871)
  • Positive regulation of cell differentiation
    (GO:0045597)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Proximal/distal pattern formation
    (GO:0009954)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Subpallium development
    (GO:0021544)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.0078
    Cell Significance Index: 129.1900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7390
    Cell Significance Index: 265.0800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.5222
    Cell Significance Index: 12.6500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1329
    Cell Significance Index: 91.9400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1319
    Cell Significance Index: 26.1800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.1001
    Cell Significance Index: 1.9800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.0618
    Cell Significance Index: 1.2400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0487
    Cell Significance Index: 21.5300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0009
    Cell Significance Index: -0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0046
    Cell Significance Index: -8.6400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0108
    Cell Significance Index: -0.2300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0115
    Cell Significance Index: -8.5200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0116
    Cell Significance Index: -7.3500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0142
    Cell Significance Index: -7.7600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0157
    Cell Significance Index: -0.3400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0160
    Cell Significance Index: -3.2000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0202
    Cell Significance Index: -9.1700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0212
    Cell Significance Index: -1.1900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0223
    Cell Significance Index: -0.3200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0272
    Cell Significance Index: -7.8300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0285
    Cell Significance Index: -0.3600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0407
    Cell Significance Index: -8.5700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0504
    Cell Significance Index: -7.3200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0558
    Cell Significance Index: -9.5300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0609
    Cell Significance Index: -8.3600
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0619
    Cell Significance Index: -0.7400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0632
    Cell Significance Index: -7.3700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0659
    Cell Significance Index: -8.5100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0667
    Cell Significance Index: -7.6400
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: -0.0695
    Cell Significance Index: -0.7000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0704
    Cell Significance Index: -7.1900
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: -0.0801
    Cell Significance Index: -0.5800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0804
    Cell Significance Index: -9.4800
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0847
    Cell Significance Index: -1.6900
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0884
    Cell Significance Index: -1.7400
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0943
    Cell Significance Index: -1.1000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1076
    Cell Significance Index: -1.0200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1126
    Cell Significance Index: -8.3900
  • Cell Name: non-myelinating Schwann cell (CL0002376)
    Fold Change: -0.1149
    Cell Significance Index: -0.7400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1303
    Cell Significance Index: -2.7200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1374
    Cell Significance Index: -6.2300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1584
    Cell Significance Index: -7.4500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1774
    Cell Significance Index: -7.8500
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.1807
    Cell Significance Index: -1.8200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1918
    Cell Significance Index: -6.7200
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: -0.2033
    Cell Significance Index: -1.5800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2068
    Cell Significance Index: -7.8300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2080
    Cell Significance Index: -6.8100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2251
    Cell Significance Index: -7.1700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2480
    Cell Significance Index: -7.3100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2492
    Cell Significance Index: -6.2300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2525
    Cell Significance Index: -6.4900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2554
    Cell Significance Index: -5.4600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.2566
    Cell Significance Index: -3.7400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2629
    Cell Significance Index: -9.6500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2770
    Cell Significance Index: -7.4100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2794
    Cell Significance Index: -6.9700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2843
    Cell Significance Index: -7.5900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2894
    Cell Significance Index: -7.6100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2976
    Cell Significance Index: -8.5300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2998
    Cell Significance Index: -7.6600
  • Cell Name: interneuron (CL0000099)
    Fold Change: -0.3069
    Cell Significance Index: -3.5900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3075
    Cell Significance Index: -8.2400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3144
    Cell Significance Index: -6.5800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3160
    Cell Significance Index: -8.0500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.3165
    Cell Significance Index: -6.4400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3396
    Cell Significance Index: -9.2500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3439
    Cell Significance Index: -7.5300
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.3644
    Cell Significance Index: -3.6100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3673
    Cell Significance Index: -7.6200
  • Cell Name: medial ganglionic eminence derived GABAergic cortical interneuron (CL4023069)
    Fold Change: -0.3674
    Cell Significance Index: -3.4700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.3742
    Cell Significance Index: -6.4700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3762
    Cell Significance Index: -9.1800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.3972
    Cell Significance Index: -7.7700
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.4164
    Cell Significance Index: -6.2300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4165
    Cell Significance Index: -6.9700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4231
    Cell Significance Index: -7.8200
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: -0.4265
    Cell Significance Index: -4.6300
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.4349
    Cell Significance Index: -4.7500
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.4425
    Cell Significance Index: -4.2100
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.4499
    Cell Significance Index: -4.0900
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.4545
    Cell Significance Index: -7.7700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.4718
    Cell Significance Index: -7.9400
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: -0.4721
    Cell Significance Index: -3.7500
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: -0.4859
    Cell Significance Index: -4.4100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.4930
    Cell Significance Index: -7.9900
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.4937
    Cell Significance Index: -6.7700
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.5075
    Cell Significance Index: -6.7700
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.5206
    Cell Significance Index: -7.4600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.5213
    Cell Significance Index: -8.5900
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.5216
    Cell Significance Index: -5.8400
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.5324
    Cell Significance Index: -6.6800
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.5326
    Cell Significance Index: -7.4700
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.5333
    Cell Significance Index: -6.0500
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.5365
    Cell Significance Index: -7.0400
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.5454
    Cell Significance Index: -7.3600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.5490
    Cell Significance Index: -7.1800
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.5533
    Cell Significance Index: -6.7300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.5558
    Cell Significance Index: -7.8000
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.5667
    Cell Significance Index: -7.8600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Homeobox Gene**: DLX1 is a member of the homeobox gene family, which encodes transcription factors that regulate gene expression during embryonic development. 2. **Transcription Factor**: DLX1 acts as a transcription factor, binding to specific DNA sequences and regulating the expression of target genes. 3. **Regulatory Role**: DLX1 plays a regulatory role in various developmental processes, including cell differentiation, embryonic development, and organogenesis. 4. **Cell Type-Specific Expression**: DLX1 is highly expressed in specific cell types, such as neural crest cells, neurons, and progenitor cells, and its expression patterns are essential for the proper development of multiple tissues and organs. **Pathways and Functions** 1. **Cell Differentiation**: DLX1 regulates cell differentiation by binding to specific DNA sequences and activating or repressing the expression of target genes. 2. **Embryonic Development**: DLX1 is involved in embryonic development, regulating the expression of genes involved in organogenesis and tissue formation. 3. **Chromatin Remodeling**: DLX1 interacts with chromatin remodeling complexes, influencing chromatin structure and gene expression. 4. **Signaling Pathways**: DLX1 regulates signaling pathways, including the BMP and TGF-β signaling pathways, which are essential for cell differentiation and development. 5. **Neurodevelopment**: DLX1 plays a critical role in neurodevelopment, regulating the expression of genes involved in neuronal differentiation and patterning. **Clinical Significance** 1. **Neurodevelopmental Disorders**: DLX1 mutations have been associated with neurodevelopmental disorders, such as autism spectrum disorder and intellectual disability. 2. **Cancer**: DLX1 is involved in cancer development and progression, particularly in brain tumors and lymphomas. 3. **Neurological Disorders**: DLX1 is implicated in various neurological disorders, including Parkinson's disease, Alzheimer's disease, and multiple sclerosis. 4. **Regenerative Medicine**: DLX1 has potential applications in regenerative medicine, particularly in the development of neural progenitor cells and tissue engineering. In conclusion, the DLX1 gene is a critical transcription factor involved in various developmental processes, including cell differentiation, embryonic development, and organogenesis. Its dysregulation has been implicated in neurodevelopmental disorders, cancer, and neurological disorders, highlighting the importance of DLX1 in human health and disease.

Genular Protein ID: 2129516328

Symbol: DLX1_HUMAN

Name: Homeobox protein DLX-1

UniProtKB Accession Codes:

P56177 D3DPD7 Q53ZU4 Q7Z724 Q8IYB2

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 4 ExpressionAtlas 1 GO 33 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 14671321

Title: Homeoprotein DLX-1 interacts with Smad4 and blocks a signaling pathway from activin A in hematopoietic cells.

PubMed ID: 14671321

DOI: 10.1073/pnas.2536757100

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7907794

Title: Cloning and characterization of two members of the vertebrate Dlx gene family.

PubMed ID: 7907794

DOI: 10.1073/pnas.91.6.2250

Sequence Information:

  • Length: 255
  • Mass: 27320
  • Checksum: 99B468315FBFE7BD
  • Sequence:
    • MTMTTMPESL NSPVSGKAVF MEFGPPNQQM SPSPMSHGHY SMHCLHSAGH SQPDGAYSSA 
SSFSRPLGYP YVNSVSSHAS SPYISSVQSY PGSASLAQSR LEDPGADSEK STVVEGGEVR 
FNGKGKKIRK PRTIYSSLQL QALNRRFQQT QYLALPERAE LAASLGLTQT QVKIWFQNKR 
SKFKKLMKQG GAALEGSALA NGRALSAGSP PVPPGWNPNS SSGKGSGGNA GSYIPSYTSW 
YPSAHQEAMQ QPQLM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.