Details for: DPYS

Gene ID: 1807

Symbol: DPYS

Ensembl ID: ENSG00000147647

Description: dihydropyrimidinase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 5.8509
    Cell Significance Index: 49.7300
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 4.0223
    Cell Significance Index: 37.3300
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 3.6278
    Cell Significance Index: 9.5700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.7468
    Cell Significance Index: 46.2700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.4916
    Cell Significance Index: 296.0200
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.3467
    Cell Significance Index: 14.7300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.8955
    Cell Significance Index: 7.1500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.5342
    Cell Significance Index: 8.2700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.4640
    Cell Significance Index: 17.5700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3870
    Cell Significance Index: 17.1200
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.3677
    Cell Significance Index: 1.3900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.3550
    Cell Significance Index: 5.2400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2825
    Cell Significance Index: 56.6700
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.2388
    Cell Significance Index: 1.3800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2080
    Cell Significance Index: 74.5900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.1653
    Cell Significance Index: 2.7800
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.1546
    Cell Significance Index: 1.3300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0666
    Cell Significance Index: 1.9000
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.0517
    Cell Significance Index: 0.5100
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: 0.0480
    Cell Significance Index: 0.6400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0442
    Cell Significance Index: 83.2000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0334
    Cell Significance Index: 4.8600
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.0327
    Cell Significance Index: 0.2500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.0327
    Cell Significance Index: 2.5900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0318
    Cell Significance Index: 2.1400
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.0273
    Cell Significance Index: 0.2300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0074
    Cell Significance Index: 0.9500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0042
    Cell Significance Index: 0.0600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0008
    Cell Significance Index: 0.4800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0022
    Cell Significance Index: -3.4300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0028
    Cell Significance Index: -5.2300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0039
    Cell Significance Index: -2.8900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0047
    Cell Significance Index: -6.3800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0070
    Cell Significance Index: -5.2100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0071
    Cell Significance Index: -5.3800
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0073
    Cell Significance Index: -0.0800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0087
    Cell Significance Index: -5.4200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0094
    Cell Significance Index: -5.2800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0098
    Cell Significance Index: -5.3400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0119
    Cell Significance Index: -5.4200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0125
    Cell Significance Index: -3.6000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0157
    Cell Significance Index: -1.6000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0223
    Cell Significance Index: -0.7100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0255
    Cell Significance Index: -5.3700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0263
    Cell Significance Index: -4.7400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0264
    Cell Significance Index: -4.5100
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0277
    Cell Significance Index: -0.3100
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0292
    Cell Significance Index: -0.3900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0312
    Cell Significance Index: -3.5800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0339
    Cell Significance Index: -0.6700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0390
    Cell Significance Index: -5.3600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0400
    Cell Significance Index: -1.3100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0416
    Cell Significance Index: -5.3800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0420
    Cell Significance Index: -5.1700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0430
    Cell Significance Index: -4.4800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0531
    Cell Significance Index: -0.9100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0599
    Cell Significance Index: -4.6000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0702
    Cell Significance Index: -2.4600
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.0723
    Cell Significance Index: -1.0200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0729
    Cell Significance Index: -3.4000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0733
    Cell Significance Index: -5.4600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0823
    Cell Significance Index: -5.0600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0833
    Cell Significance Index: -3.6200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0862
    Cell Significance Index: -2.1500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0904
    Cell Significance Index: -4.2500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0934
    Cell Significance Index: -5.2400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0937
    Cell Significance Index: -2.3400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0948
    Cell Significance Index: -4.9400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1011
    Cell Significance Index: -2.7100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1038
    Cell Significance Index: -2.9000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1114
    Cell Significance Index: -5.8500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1123
    Cell Significance Index: -1.8500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1165
    Cell Significance Index: -5.2800
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: -0.1265
    Cell Significance Index: -0.9700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1385
    Cell Significance Index: -3.9700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1487
    Cell Significance Index: -5.4600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1561
    Cell Significance Index: -1.4800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1572
    Cell Significance Index: -4.6300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1642
    Cell Significance Index: -5.7700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1671
    Cell Significance Index: -1.8200
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.1672
    Cell Significance Index: -1.7300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1729
    Cell Significance Index: -4.6300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1758
    Cell Significance Index: -6.1100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1793
    Cell Significance Index: -5.6700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1805
    Cell Significance Index: -4.6400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1814
    Cell Significance Index: -3.9200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1824
    Cell Significance Index: -4.8700
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.1829
    Cell Significance Index: -1.7400
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1838
    Cell Significance Index: -3.7400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1875
    Cell Significance Index: -3.6600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1897
    Cell Significance Index: -3.9600
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1932
    Cell Significance Index: -2.6800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1946
    Cell Significance Index: -4.1300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1972
    Cell Significance Index: -5.1900
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.1988
    Cell Significance Index: -1.8900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1996
    Cell Significance Index: -5.7500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.2022
    Cell Significance Index: -3.9800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2040
    Cell Significance Index: -1.3800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2073
    Cell Significance Index: -4.3400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2095
    Cell Significance Index: -4.2100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DPYS is a member of the dihydropyrimidinase family, which consists of enzymes responsible for the degradation of pyrimidine nucleotides. DPYS is specifically involved in the breakdown of uracil, thymine, and cytosine, converting them into their corresponding pyrimidine bases. This enzyme is ubiquitously expressed in various tissues, including the liver, kidney, and immune cells, highlighting its importance in maintaining cellular homeostasis. **Pathways and Functions:** DPYS is involved in several metabolic pathways, including: 1. **Pyrimidine Catabolism**: DPYS plays a central role in the degradation of pyrimidine nucleotides, converting them into their corresponding bases, which can then be reused in nucleotide synthesis. 2. **Cytosol**: DPYS is primarily localized in the cytosol, where it can interact with other enzymes and proteins involved in pyrimidine metabolism. 3. **Extracellular Exosome**: DPYS has been detected in extracellular exosomes, suggesting its potential role in intercellular communication and the regulation of pyrimidine metabolism. **Clinical Significance:** Dysregulation of DPYS has been implicated in various diseases, including: 1. **Thymic Dysplasia**: DPYS mutations have been linked to thymic dysplasia, a condition characterized by impaired thymic development and function, leading to immunodeficiency. 2. **Cancer**: Aberrant expression of DPYS has been observed in various cancers, including leukemia and lymphoma, suggesting its potential role as a tumor suppressor. 3. **Neurological Disorders**: DPYS has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease, where its dysregulation can lead to impaired pyrimidine metabolism. **Conclusion:** In conclusion, DPYS is a vital enzyme in the catabolism of pyrimidine nucleotides, playing a crucial role in maintaining cellular homeostasis. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into its mechanisms and potential therapeutic applications. As an expert immunologist, I believe that a deeper understanding of DPYS will provide valuable insights into the regulation of pyrimidine metabolism and the development of novel therapeutic strategies for various diseases.

Genular Protein ID: 1682929951

Symbol: DPYS_HUMAN

Name: Dihydropyrimidinase

UniProtKB Accession Codes:

Q14117

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 12 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 3 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 13 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8973361

Title: A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution.

PubMed ID: 8973361

DOI: 10.1016/s0378-1119(96)00445-3

PubMed ID: 9718352

Title: Dihydropyrimidinase deficiency: structural organization, chromosomal localization, and mutation analysis of the human dihydropyrimidinase gene.

PubMed ID: 9718352

DOI: 10.1086/302022

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 519
  • Mass: 56630
  • Checksum: 882E33D7C49D6ECC
  • Sequence:
    • MAAPSRLLIR GGRVVNDDFS EVADVLVEDG VVRALGHDLL PPGGAPAGLR VLDAAGKLVL 
PGGIDTHTHM QFPFMGSRSI DDFHQGTKAA LSGGTTMIID FAIPQKGGSL IEAFETWRSW 
ADPKVCCDYS LHVAVTWWSD QVKEEMKILV QDKGVNSFKM FMAYKDLYMV TDLELYEAFS 
RCKEIGAIAQ VHAENGDLIA EGAKKMLALG ITGPEGHELC RPEAVEAEAT LRAITIASAV 
NCPLYIVHVM SKSAAKVIAD ARRDGKVVYG EPIAASLGTD GTHYWNKEWH HAAHHVMGPP 
LRPDPSTPDF LMNLLANDDL TTTGTDNCTF NTCQKALGKD DFTKIPNGVN GVEDRMSVIW 
EKGVHSGKMD ENRFVAVTST NAAKIFNLYP RKGRIAVGSD ADIVIWDPKG TRTISAKTHH 
QAVNFNIFEG MVCHGVPLVT ISRGKVVYEA GVFSVTAGDG KFIPRKPFAE YIYKRIKQRD 
RTCTPTPVER APYKGEVATL KSRVTKEDAT AGTRKQAHP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.