Details for: DPYS

Gene ID: 1807

Symbol: DPYS

Ensembl ID: ENSG00000147647

Description: dihydropyrimidinase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 4.57
    Marker Score: 14987
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.16
    Marker Score: 7666
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 2.03
    Marker Score: 10919.5
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.84
    Marker Score: 11855.5
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.8
    Marker Score: 7771
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.57
    Marker Score: 3183
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.5
    Marker Score: 2836
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 868
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.33
    Marker Score: 3140
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.09
    Marker Score: 351
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.04
    Marker Score: 8963
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 794
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251802
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.03
    Marker Score: 1597
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71820
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48044
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.99
    Marker Score: 673
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2425
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5334
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.85
    Marker Score: 1398
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.82
    Marker Score: 881.5
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.8
    Marker Score: 5334
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.79
    Marker Score: 12350.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1260
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 707
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.76
    Marker Score: 455
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.75
    Marker Score: 499
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.67
    Marker Score: 6294
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.66
    Marker Score: 6241
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.65
    Marker Score: 40222
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.62
    Marker Score: 1738
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.61
    Marker Score: 274
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.58
    Marker Score: 217
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.52
    Marker Score: 193
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.52
    Marker Score: 2160
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 473
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.48
    Marker Score: 149
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.46
    Marker Score: 308
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.46
    Marker Score: 170.5
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.46
    Marker Score: 963
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.45
    Marker Score: 791
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.45
    Marker Score: 216
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.44
    Marker Score: 436
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.4
    Marker Score: 7917
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.4
    Marker Score: 1610.5
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.39
    Marker Score: 102
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.39
    Marker Score: 4015
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.38
    Marker Score: 169
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.37
    Marker Score: 1444
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.37
    Marker Score: 713
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 370
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.36
    Marker Score: 597
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.35
    Marker Score: 203
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.35
    Marker Score: 433
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.33
    Marker Score: 133
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.33
    Marker Score: 184
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.33
    Marker Score: 366
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.3
    Marker Score: 2215
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.3
    Marker Score: 147
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.3
    Marker Score: 135
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.29
    Marker Score: 167
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.28
    Marker Score: 514
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.27
    Marker Score: 262
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.27
    Marker Score: 179
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.27
    Marker Score: 108
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.26
    Marker Score: 429.5
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.26
    Marker Score: 94
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.25
    Marker Score: 270
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.25
    Marker Score: 356
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.25
    Marker Score: 78
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.25
    Marker Score: 68
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.24
    Marker Score: 141.5
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.23
    Marker Score: 97
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.23
    Marker Score: 245
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.22
    Marker Score: 117
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.22
    Marker Score: 271
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.22
    Marker Score: 166
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.21
    Marker Score: 98
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.21
    Marker Score: 190
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.21
    Marker Score: 264
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.2
    Marker Score: 119
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.19
    Marker Score: 241
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.19
    Marker Score: 194
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.19
    Marker Score: 55
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.18
    Marker Score: 105
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.18
    Marker Score: 197
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.17
    Marker Score: 175
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.17
    Marker Score: 178
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.16
    Marker Score: 214
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.16
    Marker Score: 102
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.16
    Marker Score: 1223
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.16
    Marker Score: 31
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.15
    Marker Score: 33

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Other Information

**Key characteristics:** * DPYS is a ubiquitination-dependent protein. * It is a dimer of two identical subunits. * It is highly expressed in liver cells. * It is involved in the regulation of cell cycle progression and cell growth. * It is also involved in the regulation of apoptosis. **Pathways and functions:** * DPYS is involved in the control of cell cycle progression by regulating the expression of cell cycle genes. * It is involved in the regulation of cell growth and differentiation by controlling the proliferation of specific cell types. * It is involved in the regulation of apoptosis by promoting cell death. **Clinical significance:** * Mutations in DPYS have been linked to several human diseases, including liver cancer, kidney cancer, and cancer of the central nervous system. * Targeting DPYS has been investigated as a therapeutic strategy for these diseases. **Additional information:** * DPYS is a member of the dihydropyrimidine nucleotide catabolic enzyme superfamily. * It is a highly conserved protein, with a similar protein found in other mammals. * It is a well-characterized protein that has been extensively studied.

Genular Protein ID: 1682929951

Symbol: DPYS_HUMAN

Name: Dihydropyrimidinase

UniProtKB Accession Codes:

Q14117

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 12 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 3 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 13 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 1 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 4 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8973361

Title: A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution.

PubMed ID: 8973361

DOI: 10.1016/s0378-1119(96)00445-3

PubMed ID: 9718352

Title: Dihydropyrimidinase deficiency: structural organization, chromosomal localization, and mutation analysis of the human dihydropyrimidinase gene.

PubMed ID: 9718352

DOI: 10.1086/302022

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 519
  • Mass: 56630
  • Checksum: 882E33D7C49D6ECC
  • Sequence:
    • MAAPSRLLIR GGRVVNDDFS EVADVLVEDG VVRALGHDLL PPGGAPAGLR VLDAAGKLVL 
PGGIDTHTHM QFPFMGSRSI DDFHQGTKAA LSGGTTMIID FAIPQKGGSL IEAFETWRSW 
ADPKVCCDYS LHVAVTWWSD QVKEEMKILV QDKGVNSFKM FMAYKDLYMV TDLELYEAFS 
RCKEIGAIAQ VHAENGDLIA EGAKKMLALG ITGPEGHELC RPEAVEAEAT LRAITIASAV 
NCPLYIVHVM SKSAAKVIAD ARRDGKVVYG EPIAASLGTD GTHYWNKEWH HAAHHVMGPP 
LRPDPSTPDF LMNLLANDDL TTTGTDNCTF NTCQKALGKD DFTKIPNGVN GVEDRMSVIW 
EKGVHSGKMD ENRFVAVTST NAAKIFNLYP RKGRIAVGSD ADIVIWDPKG TRTISAKTHH 
QAVNFNIFEG MVCHGVPLVT ISRGKVVYEA GVFSVTAGDG KFIPRKPFAE YIYKRIKQRD 
RTCTPTPVER APYKGEVATL KSRVTKEDAT AGTRKQAHP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.