Details for: DPYS

Gene ID: 1807

Symbol: DPYS

Ensembl ID: ENSG00000147647

Description: dihydropyrimidinase

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 4.57
    Marker Score: 14,987
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.16
    Marker Score: 7,666
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 2.03
    Marker Score: 10,920
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.84
    Marker Score: 11,856
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.8
    Marker Score: 7,771
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.57
    Marker Score: 3,183
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.5
    Marker Score: 2,836
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 868
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.33
    Marker Score: 3,140
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.09
    Marker Score: 351
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.04
    Marker Score: 8,963
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 794
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,802
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.03
    Marker Score: 1,597
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,820
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,044
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.99
    Marker Score: 673
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,425
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,334
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,741
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,296
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.85
    Marker Score: 1,398
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.82
    Marker Score: 882
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.8
    Marker Score: 5,334
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.79
    Marker Score: 12,351
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,260
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 707
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.76
    Marker Score: 455
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.75
    Marker Score: 499
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.67
    Marker Score: 6,294
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.66
    Marker Score: 6,241
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.65
    Marker Score: 40,222
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.62
    Marker Score: 1,738
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.61
    Marker Score: 274
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.58
    Marker Score: 217
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.52
    Marker Score: 193
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.52
    Marker Score: 2,160
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 473
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.48
    Marker Score: 149
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.46
    Marker Score: 308
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.46
    Marker Score: 171
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.46
    Marker Score: 963
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.45
    Marker Score: 791
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.45
    Marker Score: 216
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.44
    Marker Score: 436
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.4
    Marker Score: 7,917
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.4
    Marker Score: 1,611
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.39
    Marker Score: 102
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.39
    Marker Score: 4,015
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.38
    Marker Score: 169
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.37
    Marker Score: 1,444
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.37
    Marker Score: 713
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 370
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.36
    Marker Score: 597
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.35
    Marker Score: 203
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.35
    Marker Score: 433
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.33
    Marker Score: 133
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.33
    Marker Score: 184
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.33
    Marker Score: 366
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.3
    Marker Score: 2,215
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.3
    Marker Score: 147
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.3
    Marker Score: 135
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.29
    Marker Score: 167
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.28
    Marker Score: 514
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.27
    Marker Score: 262
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.27
    Marker Score: 179
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.27
    Marker Score: 108
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.26
    Marker Score: 430
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.26
    Marker Score: 94
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.25
    Marker Score: 270
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.25
    Marker Score: 356
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.25
    Marker Score: 78
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.25
    Marker Score: 68
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.24
    Marker Score: 142
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.23
    Marker Score: 97
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.23
    Marker Score: 245
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.22
    Marker Score: 117
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.22
    Marker Score: 271
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.22
    Marker Score: 166
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.21
    Marker Score: 98
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.21
    Marker Score: 190
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.21
    Marker Score: 264
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.2
    Marker Score: 119
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.19
    Marker Score: 241
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.19
    Marker Score: 194
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.19
    Marker Score: 55
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.18
    Marker Score: 105
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.18
    Marker Score: 197
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.17
    Marker Score: 175
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.17
    Marker Score: 178
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.16
    Marker Score: 214
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.16
    Marker Score: 102
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.16
    Marker Score: 1,223
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.16
    Marker Score: 31
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.15
    Marker Score: 33

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DPYS is a member of the dihydropyrimidinase family, which consists of enzymes responsible for the degradation of pyrimidine nucleotides. DPYS is specifically involved in the breakdown of uracil, thymine, and cytosine, converting them into their corresponding pyrimidine bases. This enzyme is ubiquitously expressed in various tissues, including the liver, kidney, and immune cells, highlighting its importance in maintaining cellular homeostasis. **Pathways and Functions:** DPYS is involved in several metabolic pathways, including: 1. **Pyrimidine Catabolism**: DPYS plays a central role in the degradation of pyrimidine nucleotides, converting them into their corresponding bases, which can then be reused in nucleotide synthesis. 2. **Cytosol**: DPYS is primarily localized in the cytosol, where it can interact with other enzymes and proteins involved in pyrimidine metabolism. 3. **Extracellular Exosome**: DPYS has been detected in extracellular exosomes, suggesting its potential role in intercellular communication and the regulation of pyrimidine metabolism. **Clinical Significance:** Dysregulation of DPYS has been implicated in various diseases, including: 1. **Thymic Dysplasia**: DPYS mutations have been linked to thymic dysplasia, a condition characterized by impaired thymic development and function, leading to immunodeficiency. 2. **Cancer**: Aberrant expression of DPYS has been observed in various cancers, including leukemia and lymphoma, suggesting its potential role as a tumor suppressor. 3. **Neurological Disorders**: DPYS has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease, where its dysregulation can lead to impaired pyrimidine metabolism. **Conclusion:** In conclusion, DPYS is a vital enzyme in the catabolism of pyrimidine nucleotides, playing a crucial role in maintaining cellular homeostasis. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into its mechanisms and potential therapeutic applications. As an expert immunologist, I believe that a deeper understanding of DPYS will provide valuable insights into the regulation of pyrimidine metabolism and the development of novel therapeutic strategies for various diseases.

Genular Protein ID: 1682929951

Symbol: DPYS_HUMAN

Name: Dihydropyrimidinase

UniProtKB Accession Codes:

Q14117

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 12 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 3 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 13 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 1 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 4 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8973361

Title: A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution.

PubMed ID: 8973361

DOI: 10.1016/s0378-1119(96)00445-3

PubMed ID: 9718352

Title: Dihydropyrimidinase deficiency: structural organization, chromosomal localization, and mutation analysis of the human dihydropyrimidinase gene.

PubMed ID: 9718352

DOI: 10.1086/302022

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 519
  • Mass: 56630
  • Checksum: 882E33D7C49D6ECC
  • Sequence:
    • MAAPSRLLIR GGRVVNDDFS EVADVLVEDG VVRALGHDLL PPGGAPAGLR VLDAAGKLVL 
PGGIDTHTHM QFPFMGSRSI DDFHQGTKAA LSGGTTMIID FAIPQKGGSL IEAFETWRSW 
ADPKVCCDYS LHVAVTWWSD QVKEEMKILV QDKGVNSFKM FMAYKDLYMV TDLELYEAFS 
RCKEIGAIAQ VHAENGDLIA EGAKKMLALG ITGPEGHELC RPEAVEAEAT LRAITIASAV 
NCPLYIVHVM SKSAAKVIAD ARRDGKVVYG EPIAASLGTD GTHYWNKEWH HAAHHVMGPP 
LRPDPSTPDF LMNLLANDDL TTTGTDNCTF NTCQKALGKD DFTKIPNGVN GVEDRMSVIW 
EKGVHSGKMD ENRFVAVTST NAAKIFNLYP RKGRIAVGSD ADIVIWDPKG TRTISAKTHH 
QAVNFNIFEG MVCHGVPLVT ISRGKVVYEA GVFSVTAGDG KFIPRKPFAE YIYKRIKQRD 
RTCTPTPVER APYKGEVATL KSRVTKEDAT AGTRKQAHP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.