Details for: DRD5

Gene ID: 1816

Symbol: DRD5

Ensembl ID: ENSG00000169676

Description: dopamine receptor D5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 4.3259
    Cell Significance Index: 64.8200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.4733
    Cell Significance Index: 8.0900
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.3686
    Cell Significance Index: 4.1200
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.3315
    Cell Significance Index: 3.1600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3308
    Cell Significance Index: 19.8600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2984
    Cell Significance Index: 6.4700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2717
    Cell Significance Index: 44.1900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.2275
    Cell Significance Index: 3.6100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2084
    Cell Significance Index: 14.4200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1359
    Cell Significance Index: 2.9000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0738
    Cell Significance Index: 1.0500
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.0572
    Cell Significance Index: 0.6500
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.0483
    Cell Significance Index: 0.5500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0426
    Cell Significance Index: 0.6100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0270
    Cell Significance Index: 5.4200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0198
    Cell Significance Index: 13.7200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0091
    Cell Significance Index: 0.2600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0037
    Cell Significance Index: 1.3400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.0022
    Cell Significance Index: 0.0300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0002
    Cell Significance Index: -0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0008
    Cell Significance Index: -1.5400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0016
    Cell Significance Index: -0.9100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0029
    Cell Significance Index: -1.3400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0034
    Cell Significance Index: -0.0700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0038
    Cell Significance Index: -1.0900
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0039
    Cell Significance Index: -0.0400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0042
    Cell Significance Index: -0.8300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0047
    Cell Significance Index: -1.0000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0072
    Cell Significance Index: -0.8300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0079
    Cell Significance Index: -1.0900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0088
    Cell Significance Index: -0.4600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0095
    Cell Significance Index: -0.0900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0125
    Cell Significance Index: -0.4000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0138
    Cell Significance Index: -2.0000
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0165
    Cell Significance Index: -0.2200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0166
    Cell Significance Index: -0.4900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0177
    Cell Significance Index: -0.5100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0184
    Cell Significance Index: -1.2400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0193
    Cell Significance Index: -0.2500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0199
    Cell Significance Index: -0.3000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0204
    Cell Significance Index: -0.4400
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0211
    Cell Significance Index: -0.2700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0221
    Cell Significance Index: -0.7800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0222
    Cell Significance Index: -0.3600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0230
    Cell Significance Index: -0.2900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0251
    Cell Significance Index: -0.6400
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0260
    Cell Significance Index: -0.3400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0289
    Cell Significance Index: -1.6200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0290
    Cell Significance Index: -1.7900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0304
    Cell Significance Index: -0.7600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0321
    Cell Significance Index: -1.5100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0324
    Cell Significance Index: -1.1400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0339
    Cell Significance Index: -0.6800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0339
    Cell Significance Index: -0.7100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0344
    Cell Significance Index: -1.5200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0354
    Cell Significance Index: -1.1600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0366
    Cell Significance Index: -0.9800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0393
    Cell Significance Index: -1.0500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0399
    Cell Significance Index: -1.5100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0409
    Cell Significance Index: -1.5000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0411
    Cell Significance Index: -2.1400
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0419
    Cell Significance Index: -0.5100
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.0423
    Cell Significance Index: -0.4700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0424
    Cell Significance Index: -1.3500
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0459
    Cell Significance Index: -0.5400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0479
    Cell Significance Index: -2.4200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0489
    Cell Significance Index: -1.7000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0498
    Cell Significance Index: -1.0900
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.0508
    Cell Significance Index: -0.6400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0517
    Cell Significance Index: -1.2900
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0530
    Cell Significance Index: -0.5700
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0538
    Cell Significance Index: -0.6500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0558
    Cell Significance Index: -2.2900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0568
    Cell Significance Index: -0.8300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0582
    Cell Significance Index: -1.5300
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0608
    Cell Significance Index: -0.7700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0613
    Cell Significance Index: -1.2800
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0616
    Cell Significance Index: -0.8100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0621
    Cell Significance Index: -1.4900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0622
    Cell Significance Index: -1.2300
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0623
    Cell Significance Index: -0.7500
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0623
    Cell Significance Index: -0.8300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0627
    Cell Significance Index: -1.2500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0642
    Cell Significance Index: -1.0600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0650
    Cell Significance Index: -1.2700
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.0664
    Cell Significance Index: -0.6400
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.0672
    Cell Significance Index: -0.9200
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0688
    Cell Significance Index: -0.8100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0690
    Cell Significance Index: -1.1600
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0701
    Cell Significance Index: -1.3800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0711
    Cell Significance Index: -1.5100
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0715
    Cell Significance Index: -0.5900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0720
    Cell Significance Index: -0.7600
  • Cell Name: peptic cell (CL0000155)
    Fold Change: -0.0720
    Cell Significance Index: -0.6400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0725
    Cell Significance Index: -0.7900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0727
    Cell Significance Index: -0.7900
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0728
    Cell Significance Index: -0.9000
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.0742
    Cell Significance Index: -0.8100
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0772
    Cell Significance Index: -0.8200
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0804
    Cell Significance Index: -0.9100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Dopamine Receptor**: The DRD5 gene is a G protein-coupled receptor (GPCR) that binds to dopamine, a neurotransmitter involved in various cognitive and motor functions. 2. **Expression**: The DRD5 gene is primarily expressed in the brain, particularly in areas such as the basal ganglia, hippocampus, and prefrontal cortex, as well as in peripheral tissues such as blood vessels and immune cells. 3. **Function**: The DRD5 receptor is involved in regulating dopamine signaling, which is crucial for modulating mood, motivation, reward, and motor control. **Pathways and Functions:** 1. **Adenylate Cyclase Activation**: The DRD5 receptor activates adenylate cyclase, an enzyme that converts ATP into cyclic AMP (cAMP), a secondary messenger involved in various cellular processes, including gene expression and protein phosphorylation. 2. **Dopamine Signaling**: The DRD5 receptor is coupled to the Gs protein, which activates adenylate cyclase and increases cAMP levels, leading to the activation of downstream signaling pathways. 3. **Neurotransmission**: The DRD5 receptor plays a critical role in regulating neurotransmission, particularly in the dopamine system, which is involved in controlling movement, motivation, and reward. 4. **Immune Response**: The DRD5 receptor is also expressed on immune cells, such as T cells and granulocytes, where it modulates immune responses and inflammation. **Clinical Significance:** 1. **Psychiatric Disorders**: Alterations in DRD5 expression and function have been implicated in various psychiatric disorders, including schizophrenia, bipolar disorder, and attention deficit hyperactivity disorder (ADHD). 2. **Neurodegenerative Diseases**: The DRD5 receptor has been implicated in neurodegenerative diseases, such as Parkinson's disease and Huntington's disease, where dopamine signaling is disrupted. 3. **Cancer**: The DRD5 receptor has been found to be overexpressed in certain types of cancer, including breast and prostate cancer, where it may play a role in tumor growth and metastasis. 4. **Cardiovascular Disease**: The DRD5 receptor has been implicated in regulating blood pressure and cardiovascular disease, where it may play a role in modulating the renin-angiotensin-aldosterone system. In conclusion, the DRD5 gene is a critical component of the dopamine system that plays a pivotal role in regulating various physiological and psychological processes. Further research into the DRD5 gene and its functions may provide valuable insights into the development of novel therapeutic strategies for various diseases, including psychiatric disorders, neurodegenerative diseases, and cardiovascular disease.

Genular Protein ID: 523063562

Symbol: DRD5_HUMAN

Name: D(1B) dopamine receptor

UniProtKB Accession Codes:

P21918 B2R9S3 Q8NEQ8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 35 DrugCentral 1 EMBL 6 EMDB 1 Ensembl 1 GO 35 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1826762

Title: Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1.

PubMed ID: 1826762

DOI: 10.1038/350614a0

PubMed ID: 1833775

Title: Multiple human D5 dopamine receptor genes: a functional receptor and two pseudogenes.

PubMed ID: 1833775

DOI: 10.1073/pnas.88.20.9175

PubMed ID: 1834671

Title: Molecular cloning and characterization of a high affinity dopamine receptor (D1 beta) and its pseudogene.

PubMed ID: 1834671

DOI: 10.1016/s0021-9258(18)54590-7

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10531415

Title: N-linked glycosylation is required for plasma membrane localization of D5, but not D1, dopamine receptors in transfected mammalian cells.

PubMed ID: 10531415

DOI: 10.1124/mol.56.5.1071

PubMed ID: 11781417

Title: A polymorphism in the dopamine receptor DRD5 is associated with blepharospasm.

PubMed ID: 11781417

DOI: 10.1212/wnl.58.1.124

PubMed ID: 7633397

Title: The D5 dopamine receptor gene in schizophrenia: identification of a nonsense change and multiple missense changes but lack of association with disease.

PubMed ID: 7633397

DOI: 10.1093/hmg/4.4.507

PubMed ID: 10391209

Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.

PubMed ID: 10391209

DOI: 10.1038/10290

Sequence Information:

  • Length: 477
  • Mass: 52951
  • Checksum: BACCB85E5A72F9CA
  • Sequence:
    • MLPPGSNGTA YPGQFALYQQ LAQGNAVGGS AGAPPLGPSQ VVTACLLTLL IIWTLLGNVL 
VCAAIVRSRH LRANMTNVFI VSLAVSDLFV ALLVMPWKAV AEVAGYWPFG AFCDVWVAFD 
IMCSTASILN LCVISVDRYW AISRPFRYKR KMTQRMALVM VGLAWTLSIL ISFIPVQLNW 
HRDQAASWGG LDLPNNLANW TPWEEDFWEP DVNAENCDSS LNRTYAISSS LISFYIPVAI 
MIVTYTRIYR IAQVQIRRIS SLERAAEHAQ SCRSSAACAP DTSLRASIKK ETKVLKTLSV 
IMGVFVCCWL PFFILNCMVP FCSGHPEGPP AGFPCVSETT FDVFVWFGWA NSSLNPVIYA 
FNADFQKVFA QLLGCSHFCS RTPVETVNIS NELISYNQDI VFHKEIAAAY IHMMPNAVTP 
GNREVDNDEE EGPFDRMFQI YQTSPDGDPV AESVWELDCE GEISLDKITP FTPNGFH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.