Details for: DRD5

Gene ID: 1816

Symbol: DRD5

Ensembl ID: ENSG00000169676

Description: dopamine receptor D5

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 3.15
    Marker Score: 1744.5
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.15
    Marker Score: 3169
  • Cell Name: T cell (CL0000084)
    Fold Change: 2.48
    Marker Score: 4280
  • Cell Name: pericyte (CL0000669)
    Fold Change: 2.01
    Marker Score: 1175
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2
    Marker Score: 1995
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.98
    Marker Score: 2215
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1174
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 875
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.32
    Marker Score: 2494
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 860
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.19
    Marker Score: 493
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.15
    Marker Score: 7673
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4805
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.02
    Marker Score: 975
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71807
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1
    Marker Score: 514.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48031
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1
    Marker Score: 458
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.99
    Marker Score: 468
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.95
    Marker Score: 379
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.94
    Marker Score: 536
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5345
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.92
    Marker Score: 14451
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.92
    Marker Score: 331
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.92
    Marker Score: 1189.5
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.9
    Marker Score: 689
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.9
    Marker Score: 1824
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.85
    Marker Score: 490
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 402
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 468
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 183
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.66
    Marker Score: 437
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.65
    Marker Score: 1049
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.64
    Marker Score: 392
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.6
    Marker Score: 480
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.6
    Marker Score: 3588
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 152
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.56
    Marker Score: 178
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.53
    Marker Score: 317
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.52
    Marker Score: 219
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.48
    Marker Score: 227
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 282
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.45
    Marker Score: 437.5
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.4
    Marker Score: 355
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.4
    Marker Score: 493.5
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.39
    Marker Score: 814.5
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 377
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.37
    Marker Score: 195
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.35
    Marker Score: 155
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.24
    Marker Score: 61
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 67
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.23
    Marker Score: 77
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.22
    Marker Score: 117
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.2
    Marker Score: 805
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.19
    Marker Score: 184
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.18
    Marker Score: 42
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.18
    Marker Score: 45
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.18
    Marker Score: 197
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.18
    Marker Score: 57
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.15
    Marker Score: 44
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.14
    Marker Score: 39
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.14
    Marker Score: 222
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.13
    Marker Score: 91
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.13
    Marker Score: 7912
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.13
    Marker Score: 43
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.12
    Marker Score: 39
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.12
    Marker Score: 39
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.12
    Marker Score: 250
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.12
    Marker Score: 29
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.12
    Marker Score: 44
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.11
    Marker Score: 41
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.11
    Marker Score: 49.5
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.09
    Marker Score: 44
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.08
    Marker Score: 41
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.08
    Marker Score: 129
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.08
    Marker Score: 193
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.08
    Marker Score: 38
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.08
    Marker Score: 44
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.08
    Marker Score: 42
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.07
    Marker Score: 49
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 0.07
    Marker Score: 235
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.07
    Marker Score: 93
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.07
    Marker Score: 49
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.06
    Marker Score: 44
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.06
    Marker Score: 34
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.06
    Marker Score: 40
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.06
    Marker Score: 75
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.06
    Marker Score: 42
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.06
    Marker Score: 55
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.06
    Marker Score: 67
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.06
    Marker Score: 44
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.06
    Marker Score: 884
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.06
    Marker Score: 95
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.05
    Marker Score: 27

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Other Information

**Key characteristics** * DRD5 is a GPCR that is expressed in the central nervous system, the peripheral nervous system, and the endocrine system. * It is a member of the dopamine receptor D5 subfamily, which is a group of GPCRs that are expressed in the central nervous system. * DRD5 is a ligand-gated ion channel that is expressed in the plasma membrane of cells. * It is a key regulator of systemic arterial blood pressure, and its expression is regulated by a variety of hormones, including vasopressin and amphetamine. * DRD5 is also involved in the regulation of norepinephrine-epinephrine vasoconstriction. **Pathways and functions** * DRD5 is a key regulator of systemic arterial blood pressure. * It is expressed in the vascular smooth muscle of blood vessels, and its expression is increased in hypertensive patients. * DRD5 is also expressed in the central nervous system, and its expression is increased in conditions such as hypertension and stroke. * Activation of DRD5 by dopamine leads to the opening of ion channels in the plasma membrane of blood vessel endothelial cells, which leads to vasodilation and increased blood flow. * DRD5 is also involved in the regulation of norepinephrine-epinephrine vasoconstriction, which is a response to stress and exercise. **Clinical significance** * DRD5 is a potential therapeutic target for hypertension and stroke. * Blockade of DRD5 with drugs such as verapamil can lower blood pressure in hypertensive patients. * DRD5 is also a potential target for the treatment of obesity, diabetes, and cancer.

Genular Protein ID: 523063562

Symbol: DRD5_HUMAN

Name: D(1B) dopamine receptor

UniProtKB Accession Codes:

P21918 B2R9S3 Q8NEQ8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 34 DrugCentral 1 EMBL 6 EMDB 1 Ensembl 1 GO 34 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1826762

Title: Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1.

PubMed ID: 1826762

DOI: 10.1038/350614a0

PubMed ID: 1833775

Title: Multiple human D5 dopamine receptor genes: a functional receptor and two pseudogenes.

PubMed ID: 1833775

DOI: 10.1073/pnas.88.20.9175

PubMed ID: 1834671

Title: Molecular cloning and characterization of a high affinity dopamine receptor (D1 beta) and its pseudogene.

PubMed ID: 1834671

DOI: 10.1016/s0021-9258(18)54590-7

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10531415

Title: N-linked glycosylation is required for plasma membrane localization of D5, but not D1, dopamine receptors in transfected mammalian cells.

PubMed ID: 10531415

DOI: 10.1124/mol.56.5.1071

PubMed ID: 11781417

Title: A polymorphism in the dopamine receptor DRD5 is associated with blepharospasm.

PubMed ID: 11781417

DOI: 10.1212/wnl.58.1.124

PubMed ID: 7633397

Title: The D5 dopamine receptor gene in schizophrenia: identification of a nonsense change and multiple missense changes but lack of association with disease.

PubMed ID: 7633397

DOI: 10.1093/hmg/4.4.507

PubMed ID: 10391209

Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.

PubMed ID: 10391209

DOI: 10.1038/10290

Sequence Information:

  • Length: 477
  • Mass: 52951
  • Checksum: BACCB85E5A72F9CA
  • Sequence:
    • MLPPGSNGTA YPGQFALYQQ LAQGNAVGGS AGAPPLGPSQ VVTACLLTLL IIWTLLGNVL 
VCAAIVRSRH LRANMTNVFI VSLAVSDLFV ALLVMPWKAV AEVAGYWPFG AFCDVWVAFD 
IMCSTASILN LCVISVDRYW AISRPFRYKR KMTQRMALVM VGLAWTLSIL ISFIPVQLNW 
HRDQAASWGG LDLPNNLANW TPWEEDFWEP DVNAENCDSS LNRTYAISSS LISFYIPVAI 
MIVTYTRIYR IAQVQIRRIS SLERAAEHAQ SCRSSAACAP DTSLRASIKK ETKVLKTLSV 
IMGVFVCCWL PFFILNCMVP FCSGHPEGPP AGFPCVSETT FDVFVWFGWA NSSLNPVIYA 
FNADFQKVFA QLLGCSHFCS RTPVETVNIS NELISYNQDI VFHKEIAAAY IHMMPNAVTP 
GNREVDNDEE EGPFDRMFQI YQTSPDGDPV AESVWELDCE GEISLDKITP FTPNGFH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.