No CSI details found for gene ID: 1816
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 523063562
Symbol: DRD5_HUMAN
Name: D(1B) dopamine receptor
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1826762
Title: Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1.
PubMed ID: 1826762
DOI: 10.1038/350614a0
PubMed ID: 1833775
Title: Multiple human D5 dopamine receptor genes: a functional receptor and two pseudogenes.
PubMed ID: 1833775
PubMed ID: 1834671
Title: Molecular cloning and characterization of a high affinity dopamine receptor (D1 beta) and its pseudogene.
PubMed ID: 1834671
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10531415
Title: N-linked glycosylation is required for plasma membrane localization of D5, but not D1, dopamine receptors in transfected mammalian cells.
PubMed ID: 10531415
PubMed ID: 11781417
Title: A polymorphism in the dopamine receptor DRD5 is associated with blepharospasm.
PubMed ID: 11781417
DOI: 10.1212/wnl.58.1.124
PubMed ID: 7633397
Title: The D5 dopamine receptor gene in schizophrenia: identification of a nonsense change and multiple missense changes but lack of association with disease.
PubMed ID: 7633397
DOI: 10.1093/hmg/4.4.507
PubMed ID: 10391209
Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.
PubMed ID: 10391209
DOI: 10.1038/10290
Sequence Information:
- Length: 477
- Mass: 52951
- Checksum: BACCB85E5A72F9CA
- Sequence:
MLPPGSNGTA YPGQFALYQQ LAQGNAVGGS AGAPPLGPSQ VVTACLLTLL IIWTLLGNVL VCAAIVRSRH LRANMTNVFI VSLAVSDLFV ALLVMPWKAV AEVAGYWPFG AFCDVWVAFD IMCSTASILN LCVISVDRYW AISRPFRYKR KMTQRMALVM VGLAWTLSIL ISFIPVQLNW HRDQAASWGG LDLPNNLANW TPWEEDFWEP DVNAENCDSS LNRTYAISSS LISFYIPVAI MIVTYTRIYR IAQVQIRRIS SLERAAEHAQ SCRSSAACAP DTSLRASIKK ETKVLKTLSV IMGVFVCCWL PFFILNCMVP FCSGHPEGPP AGFPCVSETT FDVFVWFGWA NSSLNPVIYA FNADFQKVFA QLLGCSHFCS RTPVETVNIS NELISYNQDI VFHKEIAAAY IHMMPNAVTP GNREVDNDEE EGPFDRMFQI YQTSPDGDPV AESVWELDCE GEISLDKITP FTPNGFH
Details Unavailable
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{
"geneID": 1816,
"tax": {
"id": 9606,
"name": [
{
"name": "Homo sapiens Linnaeus 1758"
},
{
"name": "Homo sapiens",
"type": 0
},
{
"name": "human",
"type": 4
}
]
},
"accession": {
"gene": [
"AC098976.2"
]
},
"genePos": {
"start": 5001,
"end": 7376
},
"orientation": true,
"symbol": "DRD5",
"created": {
"$date": {
"$numberLong": "1738333348767"
}
},
"crossReference": {
"enseGeneID": "ENSG00000169676",
"enseRnaID": [
"ENST00000304374.4"
],
"enseProtID": [
"ENSP00000306129.2"
]
},
"chrom": {
"pos": "4",
"type": 1,
"loc": "4p16.1"
},
"desc": "dopamine receptor D5",
"geneType": 5,
"mim": [
{
"id": 126453,
"relation": 0
}
],
"ontology": [
{
"id": "R-HSA-162582",
"term": "Signal Transduction",
"cat": 10
},
{
"id": "R-HSA-372790",
"term": "Signaling by GPCR",
"cat": 11
},
{
"id": "R-HSA-388396",
"term": "GPCR downstream signalling",
"cat": 12
},
{
"id": "R-HSA-500792",
"term": "GPCR ligand binding",
"cat": 12
},
{
"id": "R-HSA-373076",
"term": "Class A\/1 (Rhodopsin-like receptors)",
"cat": 13
},
{
"id": "R-HSA-418555",
"term": "G alpha (s) signalling events",
"cat": 13
},
{
"id": "R-HSA-375280",
"term": "Amine ligand-binding receptors",
"cat": 14
},
{
"id": "R-HSA-390651",
"term": "Dopamine receptors",
"cat": 15
},
{
"id": "GO:0001588",
"term": "dopamine neurotransmitter receptor activity, coupled via Gs",
"cat": 0
},
{
"id": "GO:0001588",
"term": "dopamine neurotransmitter receptor activity, coupled via Gs",
"pubMed": [
9457173
],
"cat": 0
},
{
"id": "GO:0004930",
"term": "G protein-coupled receptor activity",
"cat": 0
},
{
"id": "GO:0004952",
"term": "dopamine neurotransmitter receptor activity",
"pubMed": [
1826762
],
"cat": 0
},
{
"id": "GO:0005515",
"term": "protein binding",
"pubMed": [
32296183
],
"cat": 0
},
{
"id": "GO:0035240",
"term": "dopamine binding",
"pubMed": [
1826762
],
"cat": 0
},
{
"id": "GO:0001963",
"term": "synaptic transmission, dopaminergic",
"pubMed": [
11036203
],
"cat": 1
},
{
"id": "GO:0001975",
"term": "response to amphetamine",
"cat": 1
},
{
"id": "GO:0001992",
"term": "regulation of systemic arterial blood pressure by vasopressin",
"cat": 1
},
{
"id": "GO:0001994",
"term": "norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure",
"cat": 1
},
{
"id": "GO:0006874",
"term": "intracellular calcium ion homeostasis",
"pubMed": [
9457173
],
"cat": 1
},
{
"id": "GO:0007189",
"term": "adenylate cyclase-activating G protein-coupled receptor signaling pathway",
"pubMed": [
11500503
],
"cat": 1
},
{
"id": "GO:0007190",
"term": "activation of adenylate cyclase activity",
"pubMed": [
9457173
],
"cat": 1
},
{
"id": "GO:0007191",
"term": "adenylate cyclase-activating dopamine receptor signaling pathway",
"pubMed": [
1826762,
18403039
],
"cat": 1
},
{
"id": "GO:0007212",
"term": "G protein-coupled dopamine receptor signaling pathway",
"cat": 1
},
{
"id": "GO:0007268",
"term": "chemical synaptic transmission",
"pubMed": [
7727453
],
"cat": 1
},
{
"id": "GO:0008306",
"term": "associative learning",
"cat": 1
},
{
"id": "GO:0019226",
"term": "transmission of nerve impulse",
"cat": 1
},
{
"id": "GO:0033861",
"term": "negative regulation of NAD(P)H oxidase activity",
"pubMed": [
16352863
],
"cat": 1
},
{
"id": "GO:0042060",
"term": "wound healing",
"cat": 1
},
{
"id": "GO:0042220",
"term": "response to cocaine",
"cat": 1
},
{
"id": "GO:0043410",
"term": "positive regulation of MAPK cascade",
"cat": 1
},
{
"id": "GO:0045762",
"term": "positive regulation of adenylate cyclase activity",
"pubMed": [
7727453
],
"cat": 1
},
{
"id": "GO:0045776",
"term": "negative regulation of blood pressure",
"cat": 1
},
{
"id": "GO:0045924",
"term": "regulation of female receptivity",
"cat": 1
},
{
"id": "GO:0046960",
"term": "sensitization",
"cat": 1
},
{
"id": "GO:0060158",
"term": "phospholipase C-activating dopamine receptor signaling pathway",
"pubMed": [
9457173
],
"cat": 1
},
{
"id": "GO:0060292",
"term": "long-term synaptic depression",
"cat": 1
},
{
"id": "GO:0071870",
"term": "cellular response to catecholamine stimulus",
"pubMed": [
18403039
],
"cat": 1
},
{
"id": "GO:0071880",
"term": "adenylate cyclase-activating adrenergic receptor signaling pathway",
"cat": 1
},
{
"id": "GO:0072593",
"term": "reactive oxygen species metabolic process",
"pubMed": [
16352863
],
"cat": 1
},
{
"id": "GO:0005886",
"term": "plasma membrane",
"cat": 2
},
{
"id": "GO:0005886",
"term": "plasma membrane",
"pubMed": [
10531415,
11500503
],
"cat": 2
},
{
"id": "GO:0005886",
"term": "plasma membrane",
"pubMed": [
1826762
],
"cat": 2
},
{
"id": "GO:0005886",
"term": "plasma membrane",
"pubMed": [
9457173
],
"cat": 2
},
{
"id": "GO:0005929",
"term": "cilium",
"pubMed": [
28154160
],
"cat": 2
},
{
"id": "GO:0031526",
"term": "brush border membrane",
"cat": 2
},
{
"id": "GO:0045202",
"term": "synapse",
"cat": 2
},
{
"id": "GO:0060170",
"term": "ciliary membrane",
"pubMed": [
20531939
],
"cat": 2
},
{
"id": "GO:0097730",
"term": "non-motile cilium",
"pubMed": [
20531939
],
"cat": 2
}
],
"geneRelations": [
{
"type": 8,
"similarGenes": [
"101060524"
]
}
],
"protein": [
{
"symbol": "DRD5_HUMAN",
"name": "D(1B) dopamine receptor",
"accession": [
"P21918",
"B2R9S3",
"Q8NEQ8"
],
"databaseIDs": {
"NCBI Taxonomy": [
"9606"
],
"MIM": [
"606798",
"126453",
"606798"
],
"EMBL": [
"X58454",
"M67439",
"AY136750",
"AK313897",
"CH471069",
"BC009748"
],
"CCDS": [
"CCDS3405.1"
],
"PIR": [
"S15080"
],
"RefSeq": [
"NP_000789.1"
],
"PDB": [
"8IRV"
],
"PDBsum": [
"8IRV"
],
"AlphaFoldDB": [
"P21918"
],
"EMDB": [
"EMD-35687"
],
"SMR": [
"P21918"
],
"BioGRID": [
"108150"
],
"IntAct": [
"P21918"
],
"STRING": [
"9606.ENSP00000306129"
],
"BindingDB": [
"P21918"
],
"ChEMBL": [
"CHEMBL1850"
],
"DrugBank": [
"DB00714",
"DB01238",
"DB14185",
"DB01200",
"DB00248",
"DB01038",
"DB00477",
"DB00568",
"DB00363",
"DB11274",
"DB13345",
"DB00988",
"DB11275",
"DB01049",
"DB00696",
"DB00800",
"DB00458",
"DB00555",
"DB01235",
"DB00589",
"DB00408",
"DB01403",
"DB06148",
"DB08804",
"DB00334",
"DB00715",
"DB01186",
"DB11584",
"DB01224",
"DB09097",
"DB05271",
"DB00726",
"DB00246",
"DB09225",
"DB01624"
],
"DrugCentral": [
"P21918"
],
"GuidetoPHARMACOLOGY": [
"218"
],
"GlyCosmos": [
"P21918"
],
"GlyGen": [
"P21918"
],
"iPTMnet": [
"P21918"
],
"PhosphoSitePlus": [
"P21918"
],
"BioMuta": [
"DRD5"
],
"DMDM": [
"118214"
],
"jPOST": [
"P21918"
],
"MassIVE": [
"P21918"
],
"PaxDb": [
"9606-ENSP00000306129"
],
"PeptideAtlas": [
"P21918"
],
"Antibodypedia": [
"9652"
],
"DNASU": [
"1816"
],
"Ensembl": [
"ENST00000304374.4"
],
"KEGG": [
"hsa:1816"
],
"MANE-Select": [
"ENST00000304374.4"
],
"UCSC": [
"uc003gmb.5"
],
"AGR": [
"HGNC:3026"
],
"CTD": [
"1816"
],
"DisGeNET": [
"1816"
],
"GeneCards": [
"DRD5"
],
"HGNC": [
"HGNC:3026"
],
"HPA": [
"ENSG00000169676"
],
"MalaCards": [
"DRD5"
],
"neXtProt": [
"NX_P21918"
],
"OpenTargets": [
"ENSG00000169676"
],
"PharmGKB": [
"PA148"
],
"VEuPathDB": [
"HostDB:ENSG00000169676"
],
"eggNOG": [
"KOG3656"
],
"GeneTree": [
"ENSGT00940000157037"
],
"HOGENOM": [
"CLU_009579_11_0_1"
],
"InParanoid": [
"P21918"
],
"OMA": [
"HWHRDKA"
],
"OrthoDB": [
"2900736at2759"
],
"PhylomeDB": [
"P21918"
],
"TreeFam": [
"TF325181"
],
"PathwayCommons": [
"P21918"
],
"Reactome": [
"R-HSA-390651",
"R-HSA-418555"
],
"SignaLink": [
"P21918"
],
"SIGNOR": [
"P21918"
],
"BioGRID-ORCS": [
"1816"
],
"GeneWiki": [
"Dopamine_receptor_D5"
],
"GenomeRNAi": [
"1816"
],
"Pharos": [
"P21918"
],
"PRO": [
"PR:P21918"
],
"Proteomes": [
"UP000005640"
],
"RNAct": [
"P21918"
],
"Bgee": [
"ENSG00000169676"
],
"GO": [
"GO:0031526",
"GO:0060170",
"GO:0005929",
"GO:0097730",
"GO:0005886",
"GO:0045202",
"GO:0035240",
"GO:0004952",
"GO:0001588",
"GO:0004930",
"GO:0007190",
"GO:0071880",
"GO:0007191",
"GO:0007189",
"GO:0008306",
"GO:0071870",
"GO:0007268",
"GO:0007212",
"GO:0006874",
"GO:0060292",
"GO:0045776",
"GO:0033861",
"GO:0001994",
"GO:0060158",
"GO:0045762",
"GO:0043410",
"GO:0072593",
"GO:0045924",
"GO:0001992",
"GO:0001975",
"GO:0042220",
"GO:0046960",
"GO:0001963",
"GO:0019226",
"GO:0042060"
],
"Gene3D": [
"1.20.1070.10"
],
"InterPro": [
"IPR000497",
"IPR000929",
"IPR000276",
"IPR017452"
],
"PANTHER": [
"PTHR24248",
"PTHR24248:SF136"
],
"Pfam": [
"PF00001"
],
"PRINTS": [
"PR00566",
"PR00242",
"PR00237"
],
"SMART": [
"SM01381"
],
"SUPFAM": [
"SSF81321"
],
"PROSITE": [
"PS00237",
"PS50262"
]
},
"citations": [
{
"title": "Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1.",
"pubmedID": "1826762",
"doi": "10.1038\/350614a0"
},
{
"title": "Multiple human D5 dopamine receptor genes: a functional receptor and two pseudogenes.",
"pubmedID": "1833775",
"doi": "10.1073\/pnas.88.20.9175"
},
{
"title": "Molecular cloning and characterization of a high affinity dopamine receptor (D1 beta) and its pseudogene.",
"pubmedID": "1834671",
"doi": "10.1016\/s0021-9258(18)54590-7"
},
{
"title": "Complete sequencing and characterization of 21,243 full-length human cDNAs.",
"pubmedID": "14702039",
"doi": "10.1038\/ng1285"
},
{
"title": "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).",
"pubmedID": "15489334",
"doi": "10.1101\/gr.2596504"
},
{
"title": "N-linked glycosylation is required for plasma membrane localization of D5, but not D1, dopamine receptors in transfected mammalian cells.",
"pubmedID": "10531415",
"doi": "10.1124\/mol.56.5.1071"
},
{
"title": "A polymorphism in the dopamine receptor DRD5 is associated with blepharospasm.",
"pubmedID": "11781417",
"doi": "10.1212\/wnl.58.1.124"
},
{
"title": "The D5 dopamine receptor gene in schizophrenia: identification of a nonsense change and multiple missense changes but lack of association with disease.",
"pubmedID": "7633397",
"doi": "10.1093\/hmg\/4.4.507"
},
{
"title": "Characterization of single-nucleotide polymorphisms in coding regions of human genes.",
"pubmedID": "10391209",
"doi": "10.1038\/10290"
}
],
"sequence": {
"length": 477,
"mass": 52951,
"checksum": "BACCB85E5A72F9CA",
"modified": {
"$date": {
"$numberLong": "699408000000"
}
},
"version": 2,
"sequence": "MLPPGSNGTAYPGQFALYQQLAQGNAVGGSAGAPPLGPSQVVTACLLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGAFCDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVMVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSSAACAPDTSLRASIKKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYAFNADFQKVFAQLLGCSHFCSRTPVETVNISNELISYNQDIVFHKEIAAAYIHMMPNAVTPGNREVDNDEEEGPFDRMFQIYQTSPDGDPVAESVWELDCEGEISLDKITPFTPNGFH"
},
"existence": 0,
"relevance": 1,
"proteinID": 523063562
}
],
"singleCellExpressions": {
"cellSignificanceIndex": []
}
}