FGF6 | ENSG00000111241 | NCBI 2251

Details for: FGF6

Gene ID: 2251

Symbol: FGF6

Ensembl ID: ENSG00000111241

Description: fibroblast growth factor 6

Associated with

Activated point mutants of fgfr2
(R-HSA-2033519)
Constitutive signaling by aberrant pi3k in cancer
(R-HSA-2219530)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Downstream signaling of activated fgfr1
(R-HSA-5654687)
Downstream signaling of activated fgfr2
(R-HSA-5654696)
Downstream signaling of activated fgfr4
(R-HSA-5654716)
Fgfr1 ligand binding and activation
(R-HSA-190242)
Fgfr1 mutant receptor activation
(R-HSA-1839124)
Fgfr1c ligand binding and activation
(R-HSA-190373)
Fgfr2 ligand binding and activation
(R-HSA-190241)
Fgfr2 mutant receptor activation
(R-HSA-1839126)
Fgfr2c ligand binding and activation
(R-HSA-190375)
Fgfr4 ligand binding and activation
(R-HSA-190322)
Frs-mediated fgfr1 signaling
(R-HSA-5654693)
Frs-mediated fgfr2 signaling
(R-HSA-5654700)
Frs-mediated fgfr4 signaling
(R-HSA-5654712)
Igf1r signaling cascade
(R-HSA-2428924)
Insulin receptor signalling cascade
(R-HSA-74751)
Intracellular signaling by second messengers
(R-HSA-9006925)
Irs-mediated signalling
(R-HSA-112399)
Irs-related events triggered by igf1r
(R-HSA-2428928)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Negative regulation of fgfr1 signaling
(R-HSA-5654726)
Negative regulation of fgfr2 signaling
(R-HSA-5654727)
Negative regulation of fgfr4 signaling
(R-HSA-5654733)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Phospholipase c-mediated cascade: fgfr1
(R-HSA-5654219)
Phospholipase c-mediated cascade; fgfr2
(R-HSA-5654221)
Phospholipase c-mediated cascade; fgfr4
(R-HSA-5654228)
Pi-3k cascade:fgfr1
(R-HSA-5654689)
Pi-3k cascade:fgfr2
(R-HSA-5654695)
Pi-3k cascade:fgfr4
(R-HSA-5654720)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pi3k cascade
(R-HSA-109704)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pip3 activates akt signaling
(R-HSA-1257604)
Raf/map kinase cascade
(R-HSA-5673001)
Shc-mediated cascade:fgfr1
(R-HSA-5654688)
Shc-mediated cascade:fgfr2
(R-HSA-5654699)
Shc-mediated cascade:fgfr4
(R-HSA-5654719)
Signaling by activated point mutants of fgfr1
(R-HSA-1839122)
Signaling by fgfr
(R-HSA-190236)
Signaling by fgfr1
(R-HSA-5654736)
Signaling by fgfr1 in disease
(R-HSA-5655302)
Signaling by fgfr2
(R-HSA-5654738)
Signaling by fgfr2 in disease
(R-HSA-5655253)
Signaling by fgfr4
(R-HSA-5654743)
Signaling by fgfr in disease
(R-HSA-1226099)
Signaling by insulin receptor
(R-HSA-74752)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
(R-HSA-2404192)
Signal transduction
(R-HSA-162582)
Angiogenesis
(GO:0001525)
Cartilage condensation
(GO:0001502)
Cytoplasm
(GO:0005737)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Fibroblast growth factor receptor binding
(GO:0005104)
Fibroblast growth factor receptor signaling pathway
(GO:0008543)
Growth factor activity
(GO:0008083)
Myoblast differentiation
(GO:0045445)
Neurogenesis
(GO:0022008)
Positive regulation of cell division
(GO:0051781)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of mapk cascade
(GO:0043410)
Protein binding
(GO:0005515)
Regulation of cell migration
(GO:0030334)
Sarcolemma
(GO:0042383)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 7.5597
Cell Significance Index: 129.2300
Cell Name: precursor B cell (CL0000817)
Fold Change: 5.8896
Cell Significance Index: 76.2100
Cell Name: progenitor cell (CL0011026)
Fold Change: 3.8690
Cell Significance Index: 41.1000
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.5427
Cell Significance Index: 13.1500
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.5124
Cell Significance Index: 7.4400
Cell Name: cytotoxic T cell (CL0000910)
Fold Change: 0.4089
Cell Significance Index: 5.9600
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.1198
Cell Significance Index: 1.2400
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.0622
Cell Significance Index: 1.6000
Cell Name: fast muscle cell (CL0000190)
Fold Change: 0.0611
Cell Significance Index: 0.8000
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.0352
Cell Significance Index: 0.5700
Cell Name: type I muscle cell (CL0002211)
Fold Change: 0.0324
Cell Significance Index: 0.7900
Cell Name: slow muscle cell (CL0000189)
Fold Change: 0.0234
Cell Significance Index: 0.3500
Cell Name: type II muscle cell (CL0002212)
Fold Change: 0.0223
Cell Significance Index: 0.3600
Cell Name: cell of skeletal muscle (CL0000188)
Fold Change: 0.0039
Cell Significance Index: 0.0500
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.0022
Cell Significance Index: 0.0300
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0007
Cell Significance Index: 0.1400
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0000
Cell Significance Index: -0.0100
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0000
Cell Significance Index: 0.0100
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0002
Cell Significance Index: -0.2900
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0003
Cell Significance Index: -0.1000
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0003
Cell Significance Index: -0.3500
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0008
Cell Significance Index: -0.1500
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0010
Cell Significance Index: -0.6600
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0011
Cell Significance Index: -0.8500
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0014
Cell Significance Index: -0.6600
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0015
Cell Significance Index: -0.8200
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0016
Cell Significance Index: -0.4500
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0021
Cell Significance Index: -0.0300
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0023
Cell Significance Index: -0.3400
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0026
Cell Significance Index: -0.4700
Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.0027
Cell Significance Index: -0.0400
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0029
Cell Significance Index: -0.5000
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.0035
Cell Significance Index: -0.0900
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0040
Cell Significance Index: -0.8500
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0058
Cell Significance Index: -0.6700
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.0062
Cell Significance Index: -0.1400
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0062
Cell Significance Index: -0.6500
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0066
Cell Significance Index: -0.8100
Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: -0.0071
Cell Significance Index: -0.1000
Cell Name: double negative thymocyte (CL0002489)
Fold Change: -0.0076
Cell Significance Index: -0.0900
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0077
Cell Significance Index: -0.5200
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.0078
Cell Significance Index: -0.2100
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0096
Cell Significance Index: -0.7400
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0102
Cell Significance Index: -0.6300
Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
Fold Change: -0.0105
Cell Significance Index: -0.1400
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0106
Cell Significance Index: -0.4700
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.0108
Cell Significance Index: -0.2700
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0116
Cell Significance Index: -0.4400
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0122
Cell Significance Index: -0.3900
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.0129
Cell Significance Index: -0.1900
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0137
Cell Significance Index: -0.3800
Cell Name: neural cell (CL0002319)
Fold Change: -0.0146
Cell Significance Index: -0.1700
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0146
Cell Significance Index: -0.5100
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0148
Cell Significance Index: -0.8300
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.0154
Cell Significance Index: -0.2600
Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.0155
Cell Significance Index: -0.4900
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0156
Cell Significance Index: -0.5100
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0157
Cell Significance Index: -0.5500
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0162
Cell Significance Index: -0.7600
Cell Name: ciliated cell (CL0000064)
Fold Change: -0.0162
Cell Significance Index: -0.1800
Cell Name: muscle cell (CL0000187)
Fold Change: -0.0167
Cell Significance Index: -0.1600
Cell Name: neuron (CL0000540)
Fold Change: -0.0190
Cell Significance Index: -0.1800
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0191
Cell Significance Index: -0.5500
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.0192
Cell Significance Index: -0.4800
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0197
Cell Significance Index: -0.3300
Cell Name: endocrine cell (CL0000163)
Fold Change: -0.0207
Cell Significance Index: -0.2500
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: -0.0214
Cell Significance Index: -0.2600
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.0217
Cell Significance Index: -0.6200
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.0220
Cell Significance Index: -0.5500
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0220
Cell Significance Index: -0.5500
Cell Name: hepatoblast (CL0005026)
Fold Change: -0.0226
Cell Significance Index: -0.3800
Cell Name: ependymal cell (CL0000065)
Fold Change: -0.0229
Cell Significance Index: -0.2700
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0231
Cell Significance Index: -0.4800
Cell Name: differentiation-committed oligodendrocyte precursor (CL4023059)
Fold Change: -0.0236
Cell Significance Index: -0.2800
Cell Name: mesangial cell (CL0000650)
Fold Change: -0.0237
Cell Significance Index: -0.3000
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: -0.0240
Cell Significance Index: -0.2600
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: -0.0251
Cell Significance Index: -0.3300
Cell Name: medium spiny neuron (CL1001474)
Fold Change: -0.0252
Cell Significance Index: -0.3400
Cell Name: neural crest cell (CL0011012)
Fold Change: -0.0258
Cell Significance Index: -0.2800
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0280
Cell Significance Index: -0.7500
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.0282
Cell Significance Index: -0.6100
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.0289
Cell Significance Index: -0.5700
Cell Name: stem cell (CL0000034)
Fold Change: -0.0289
Cell Significance Index: -0.2100
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.0291
Cell Significance Index: -0.3800
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.0301
Cell Significance Index: -0.6100
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.0304
Cell Significance Index: -0.6500
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0306
Cell Significance Index: -1.2500
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0314
Cell Significance Index: -1.5900
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.0325
Cell Significance Index: -0.7800
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: -0.0326
Cell Significance Index: -0.3100
Cell Name: melanocyte of skin (CL1000458)
Fold Change: -0.0327
Cell Significance Index: -0.4600
Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
Fold Change: -0.0328
Cell Significance Index: -0.3600
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.0340
Cell Significance Index: -0.7100
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.0349
Cell Significance Index: -0.3800
Cell Name: inflammatory macrophage (CL0000863)
Fold Change: -0.0351
Cell Significance Index: -0.2700
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.0354
Cell Significance Index: -0.7000
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -0.0356
Cell Significance Index: -0.7000
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.0359
Cell Significance Index: -0.3900
Cell Name: stromal cell (CL0000499)
Fold Change: -0.0362
Cell Significance Index: -0.3700
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.0365
Cell Significance Index: -0.5500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** FGF6 shares structural and sequence similarities with other FGFs, including FGF2, FGF3, and FGF4. However, FGF6 has distinct differences in its ligand-binding domain and intracellular tail, which may influence its signaling properties. FGF6 is a 16-kDa protein, consisting of 147 amino acids. Its expression is highly regulated, with significant changes observed in various disease states, including cancer. **Pathways and Functions** FGF6 signaling involves the binding of FGF6 to its specific FGFRs, including FGFR1, FGFR2, and FGFR4. This binding activates a cascade of downstream signaling events, including the activation of phospholipase C (PLC), protein kinase B (Akt), and mitogen-activated protein kinases (MAPKs). The FGF6/FGFR pathway is involved in various cellular processes, including: 1. Cell proliferation and differentiation: FGF6 signaling regulates the proliferation and differentiation of hematopoietic cells, including megakaryocytes and erythrocytes. 2. Angiogenesis: FGF6 is involved in the regulation of angiogenesis, the formation of new blood vessels, which is essential for tissue development and wound healing. 3. Cartilage condensation: FGF6 signaling plays a role in the regulation of cartilage condensation, a process essential for bone development and growth. 4. Cell migration: FGF6 is involved in the regulation of cell migration, which is essential for tissue repair and immune responses. **Clinical Significance** Dysregulation of FGF6 signaling has been implicated in various disease states, including: 1. Cancer: FGF6 is overexpressed in several types of cancer, including breast, lung, and colon cancer, and is associated with tumor progression and metastasis. 2. Hematological disorders: FGF6 is involved in the regulation of hematopoiesis, and its dysregulation may contribute to hematological disorders, such as anemia and leukemia. 3. Cardiovascular disease: FGF6 signaling is involved in the regulation of angiogenesis, and its dysregulation may contribute to cardiovascular disease. 4. Bone disorders: FGF6 is involved in the regulation of cartilage condensation, and its dysregulation may contribute to bone disorders, such as osteoporosis. In conclusion, FGF6 is a key regulator of cellular processes, including cell proliferation, differentiation, and migration. Its dysregulation has been implicated in various disease states, highlighting the importance of FGF6 signaling in maintaining tissue homeostasis and preventing disease. Further studies are needed to fully elucidate the mechanisms of FGF6 signaling and its role in disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Fibroblast growth factor 6

Genular Protein ID: 2207016248

Symbol: FGF6_HUMAN

Name: Fibroblast growth factor 6

UniProtKB Accession Codes:

P10767 Q0VAE1

Database IDs:

Citations:

PubMed ID: 1886714

Title: Putative structure of the FGF6 gene product and role of the signal peptide.

PubMed ID: 1886714

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1549352

Title: Human hst-2 (FGF-6) oncogene: cDNA cloning and characterization.

PubMed ID: 1549352

PubMed ID: 2649847

Title: Characterization of the HST-related FGF.6 gene, a new member of the fibroblast growth factor gene family.

PubMed ID: 2649847

PubMed ID: 8663044

Title: Receptor specificity of the fibroblast growth factor family.

PubMed ID: 8663044

DOI: 10.1074/jbc.271.25.15292

PubMed ID: 20094046

Title: Fibroblast growth factor signalling: from development to cancer.

PubMed ID: 20094046

DOI: 10.1038/nrc2780

Sequence Information:

Length: 208
Mass: 22905
Checksum: 79EF44685B324322
Sequence:

MALGQKLFIT MSRGAGRLQG TLWALVFLGI LVGMVVPSPA GTRANNTLLD SRGWGTLLSR 
SRAGLAGEIA GVNWESGYLV GIKRQRRLYC NVGIGFHLQV LPDGRISGTH EENPYSLLEI 
STVERGVVSL FGVRSALFVA MNSKGRLYAT PSFQEECKFR ETLLPNNYNA YESDLYQGTY 
IALSKYGRVK RGSKVSPIMT VTHFLPRI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: FGF6

Associated with

Cells (max top 100)

Other Information

Putative structure of the FGF6 gene product and role of the signal peptide. PubMed ID: 1886714

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Human hst-2 (FGF-6) oncogene: cDNA cloning and characterization. PubMed ID: 1549352

Characterization of the HST-related FGF.6 gene, a new member of the fibroblast growth factor gene family. PubMed ID: 2649847

Receptor specificity of the fibroblast growth factor family. PubMed ID: 8663044