Details for: FGF6

Gene ID: 2251

Symbol: FGF6

Ensembl ID: ENSG00000111241

Description: fibroblast growth factor 6

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 11.05
    Marker Score: 6119
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 5.28
    Marker Score: 3000
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 4.95
    Marker Score: 6826
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 3.7
    Marker Score: 1947
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 2.29
    Marker Score: 959
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.98
    Marker Score: 2213.5
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 1.78
    Marker Score: 1177
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.11
    Marker Score: 2112
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.09
    Marker Score: 7279
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30404
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5351
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.92
    Marker Score: 2651
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5286
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.77
    Marker Score: 450
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.76
    Marker Score: 442
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.72
    Marker Score: 1162
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.67
    Marker Score: 1371
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.64
    Marker Score: 513
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.61
    Marker Score: 465
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.55
    Marker Score: 8597
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.45
    Marker Score: 432
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.42
    Marker Score: 253
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.41
    Marker Score: 710
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.36
    Marker Score: 398
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.31
    Marker Score: 239.5
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.3
    Marker Score: 471
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.29
    Marker Score: 137
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.27
    Marker Score: 120
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.23
    Marker Score: 126
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.2
    Marker Score: 197
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.19
    Marker Score: 62
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.18
    Marker Score: 370.5
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.14
    Marker Score: 89
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.13
    Marker Score: 149
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.13
    Marker Score: 113
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.12
    Marker Score: 62
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.11
    Marker Score: 28
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.1
    Marker Score: 110
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1
    Marker Score: 28
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.09
    Marker Score: 606
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.09
    Marker Score: 29
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.09
    Marker Score: 157
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.08
    Marker Score: 25
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.08
    Marker Score: 26
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.08
    Marker Score: 24
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.07
    Marker Score: 54
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.07
    Marker Score: 28
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.07
    Marker Score: 391.5
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.06
    Marker Score: 26
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.06
    Marker Score: 21
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.06
    Marker Score: 27
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.06
    Marker Score: 29
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.06
    Marker Score: 21
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.05
    Marker Score: 28
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.05
    Marker Score: 19
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.05
    Marker Score: 203
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.05
    Marker Score: 24
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.05
    Marker Score: 27
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.05
    Marker Score: 21
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.04
    Marker Score: 104.5
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.04
    Marker Score: 25
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.04
    Marker Score: 37
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.04
    Marker Score: 26
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.04
    Marker Score: 98
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.04
    Marker Score: 24
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.04
    Marker Score: 28
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.04
    Marker Score: 16
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.04
    Marker Score: 39
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.04
    Marker Score: 25
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.03
    Marker Score: 91
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.03
    Marker Score: 23
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.03
    Marker Score: 29
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.03
    Marker Score: 252
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.03
    Marker Score: 40
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.03
    Marker Score: 23
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.02
    Marker Score: 27
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.02
    Marker Score: 207
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.02
    Marker Score: 31
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.02
    Marker Score: 81
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.02
    Marker Score: 25
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.02
    Marker Score: 28
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.02
    Marker Score: 25
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.02
    Marker Score: 27
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.02
    Marker Score: 289
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.02
    Marker Score: 1289
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.02
    Marker Score: 51
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.02
    Marker Score: 26
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.02
    Marker Score: 27
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.02
    Marker Score: 23
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.02
    Marker Score: 21
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.02
    Marker Score: 24
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.02
    Marker Score: 26
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.02
    Marker Score: 22

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Other Information

**Key characteristics:** - FGF6 is a secreted protein that is produced by various cell types. - It is a potent mitogen that promotes cell growth, survival, and proliferation. - It is involved in various cellular processes, including cell migration, differentiation, and angiogenesis. **Pathways and functions:** - FGF6 signaling is primarily mediated through the PI3K/Akt pathway. - It also plays a role in the MAPK signaling pathway and the FGFR signaling pathway. - It has been implicated in various human diseases, including cancer, cardiovascular diseases, and diabetes. **Clinical significance:** - FGF6 is a promising target for cancer therapy. - Inhibition of FGF6 signaling has been shown to inhibit cancer growth and metastasis. - Therefore, FGF6 is a potential therapeutic target for various cancers. **Additional notes:** - FGF6 is a highly conserved protein with significant expression in humans. - It is involved in both normal and pathological conditions, making it a potential therapeutic target for various diseases. - Further research is needed to fully understand the role of FGF6 in human health and disease.

Genular Protein ID: 2207016248

Symbol: FGF6_HUMAN

Name: Fibroblast growth factor 6

UniProtKB Accession Codes:

P10767 Q0VAE1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 1 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 28 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 1886714

Title: Putative structure of the FGF6 gene product and role of the signal peptide.

PubMed ID: 1886714

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1549352

Title: Human hst-2 (FGF-6) oncogene: cDNA cloning and characterization.

PubMed ID: 1549352

PubMed ID: 2649847

Title: Characterization of the HST-related FGF.6 gene, a new member of the fibroblast growth factor gene family.

PubMed ID: 2649847

PubMed ID: 8663044

Title: Receptor specificity of the fibroblast growth factor family.

PubMed ID: 8663044

DOI: 10.1074/jbc.271.25.15292

PubMed ID: 20094046

Title: Fibroblast growth factor signalling: from development to cancer.

PubMed ID: 20094046

DOI: 10.1038/nrc2780

Sequence Information:

  • Length: 208
  • Mass: 22905
  • Checksum: 79EF44685B324322
  • Sequence:
    • MALGQKLFIT MSRGAGRLQG TLWALVFLGI LVGMVVPSPA GTRANNTLLD SRGWGTLLSR 
SRAGLAGEIA GVNWESGYLV GIKRQRRLYC NVGIGFHLQV LPDGRISGTH EENPYSLLEI 
STVERGVVSL FGVRSALFVA MNSKGRLYAT PSFQEECKFR ETLLPNNYNA YESDLYQGTY 
IALSKYGRVK RGSKVSPIMT VTHFLPRI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.