Genular: Defining Cellular Identity and Function

Details for: SETD1B

Gene ID: 23067

Symbol: SETD1B

Ensembl ID: ENSG00000139718

Description: SET domain containing 1B, histone lysine methyltransferase

Associated with

Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Epigenetic regulation of gene expression
(R-HSA-212165)
Formation of wdr5-containing histone-modifying complexes
(R-HSA-9772755)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Pkmts methylate histone lysines
(R-HSA-3214841)
Rna polymerase ii transcription
(R-HSA-73857)
Runx1 regulates genes involved in megakaryocyte differentiation and platelet function
(R-HSA-8936459)
Transcriptional regulation by runx1
(R-HSA-8878171)
Chromatin remodeling
(GO:0006338)
Chromosome
(GO:0005694)
Histone h3 methyltransferase activity
(GO:0140938)
Histone h3k4 methyltransferase activity
(GO:0042800)
Histone h3k4 monomethyltransferase activity
(GO:0140945)
Histone h3k4 trimethyltransferase activity
(GO:0140999)
Histone methyltransferase complex
(GO:0035097)
Methylation
(GO:0032259)
Nuclear speck
(GO:0016607)
Nucleoplasm
(GO:0005654)
Protein binding
(GO:0005515)
Rna binding
(GO:0003723)
Set1c/compass complex
(GO:0048188)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.24
Marker Score: 2,526
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.22
Marker Score: 2,308
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.17
Marker Score: 18,335
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,749
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47,974
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,400
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,404
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.94
Marker Score: 482
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.92
Marker Score: 436
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.92
Marker Score: 2,160
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2,716
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.89
Marker Score: 533
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,293
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.87
Marker Score: 4,971
Cell Name: germ cell (CL0000586)
Fold Change: 0.87
Marker Score: 1,521
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.85
Marker Score: 307
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.8
Marker Score: 6,882
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.8
Marker Score: 249
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 0.79
Marker Score: 535
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.79
Marker Score: 4,719
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.77
Marker Score: 1,256
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.75
Marker Score: 1,656
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.75
Marker Score: 241
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.74
Marker Score: 563
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.72
Marker Score: 289
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.72
Marker Score: 372
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.71
Marker Score: 337
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.7
Marker Score: 2,706
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.69
Marker Score: 42,671
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.68
Marker Score: 1,056
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.68
Marker Score: 2,858
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 0.67
Marker Score: 6,331
Cell Name: brush cell (CL0002204)
Fold Change: 0.67
Marker Score: 608
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.66
Marker Score: 170
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 0.65
Marker Score: 6,117
Cell Name: neuron (CL0000540)
Fold Change: 0.65
Marker Score: 2,642
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.64
Marker Score: 9,519
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 0.61
Marker Score: 23,024
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.6
Marker Score: 1,466
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.59
Marker Score: 6,073
Cell Name: mesangial cell (CL0000650)
Fold Change: 0.59
Marker Score: 708
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.57
Marker Score: 597
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 0.56
Marker Score: 4,328
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 0.56
Marker Score: 20,775
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 0.56
Marker Score: 2,308
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.55
Marker Score: 573
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.55
Marker Score: 1,161
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.55
Marker Score: 10,940
Cell Name: ependymal cell (CL0000065)
Fold Change: 0.54
Marker Score: 190
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.54
Marker Score: 240
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.53
Marker Score: 424
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 0.53
Marker Score: 27,831
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.52
Marker Score: 507
Cell Name: interneuron (CL0000099)
Fold Change: 0.51
Marker Score: 232
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.51
Marker Score: 28,392
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.51
Marker Score: 335
Cell Name: Unknown (CL0002371)
Fold Change: 0.5
Marker Score: 533
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.49
Marker Score: 533
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.49
Marker Score: 126
Cell Name: oogonial cell (CL0000024)
Fold Change: 0.48
Marker Score: 688
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.47
Marker Score: 196
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.47
Marker Score: 3,013
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.47
Marker Score: 4,732
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.46
Marker Score: 460
Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 0.46
Marker Score: 1,974
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 0.46
Marker Score: 144
Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 0.45
Marker Score: 252
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 0.44
Marker Score: 9,466
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.44
Marker Score: 116
Cell Name: adventitial cell (CL0002503)
Fold Change: 0.44
Marker Score: 108
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 0.44
Marker Score: 1,815
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 0.43
Marker Score: 211
Cell Name: erythroblast (CL0000765)
Fold Change: 0.43
Marker Score: 267
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.42
Marker Score: 389
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 0.42
Marker Score: 484
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.42
Marker Score: 171
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 0.42
Marker Score: 805
Cell Name: cholangiocyte (CL1000488)
Fold Change: 0.42
Marker Score: 156
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 0.42
Marker Score: 3,103
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.42
Marker Score: 459
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 0.41
Marker Score: 394
Cell Name: keratocyte (CL0002363)
Fold Change: 0.41
Marker Score: 95
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 0.41
Marker Score: 105
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.41
Marker Score: 234
Cell Name: naive regulatory T cell (CL0002677)
Fold Change: 0.41
Marker Score: 124
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 0.4
Marker Score: 1,868
Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
Fold Change: 0.4
Marker Score: 91
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 0.4
Marker Score: 321
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.4
Marker Score: 909
Cell Name: mesenchymal lymphangioblast (CL0005021)
Fold Change: 0.4
Marker Score: 89
Cell Name: acinar cell (CL0000622)
Fold Change: 0.4
Marker Score: 280
Cell Name: melanocyte (CL0000148)
Fold Change: 0.39
Marker Score: 160
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.39
Marker Score: 1,637
Cell Name: progenitor cell of endocrine pancreas (CL0002351)
Fold Change: 0.39
Marker Score: 85
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.39
Marker Score: 573
Cell Name: memory regulatory T cell (CL0002678)
Fold Change: 0.39
Marker Score: 135
Cell Name: cardiac mesenchymal cell (CL0000569)
Fold Change: 0.39
Marker Score: 95
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.38
Marker Score: 121
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 0.38
Marker Score: 191
Cell Name: bronchial epithelial cell (CL0002328)
Fold Change: 0.38
Marker Score: 101

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

Description

**Key Characteristics:** 1. **Histone Lysine Methyltransferase Activity:** SETD1B possesses specific histone lysine methyltransferase activity, which enables it to modify histone H3 and H4 residues, leading to changes in chromatin structure and gene expression. 2. **Epigenetic Regulation:** SETD1B plays a crucial role in epigenetic regulation by influencing chromatin organization, gene expression, and transcriptional control. 3. **Cell Type-Specific Expression:** SETD1B is highly expressed in various cell types, including immature innate lymphoid cells, cardiac endothelial cells, and intestinal epithelial cells. 4. **Interactions with Other Proteins:** SETD1B interacts with other proteins, such as WDR5, to form histone-modifying complexes that regulate gene expression. **Pathways and Functions:** 1. **Chromatin Modifying Enzymes:** SETD1B is involved in chromatin modifying enzymes, which regulate chromatin structure and gene expression. 2. **Chromatin Organization:** SETD1B plays a role in chromatin organization, which is critical for maintaining genome stability and regulating gene expression. 3. **Epigenetic Regulation of Gene Expression:** SETD1B influences epigenetic regulation of gene expression by modifying histone residues and regulating chromatin structure. 4. **Histone H3 Methyltransferase Activity:** SETD1B possesses histone H3 methyltransferase activity, which enables it to modify histone H3 residues and regulate gene expression. 5. **Gene Expression (Transcription):** SETD1B regulates gene expression by influencing chromatin structure and transcriptional control. **Clinical Significance:** 1. **Cancer:** Aberrant SETD1B expression has been implicated in various cancers, including leukemia, lymphoma, and solid tumors. 2. **Autoimmune Disorders:** SETD1B has been linked to autoimmune disorders, such as rheumatoid arthritis and lupus, where epigenetic dysregulation contributes to disease pathogenesis. 3. **Neurological Disorders:** SETD1B has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease, where epigenetic dysregulation contributes to disease progression. 4. **Immunological Disorders:** SETD1B plays a critical role in immune cell development and function, making it a potential target for immunotherapies in autoimmune disorders. In conclusion, the SETD1B gene is a critical regulator of epigenetic modifications and transcriptional control, with implications for various diseases, including cancer, autoimmune disorders, and neurological disorders. Further studies are needed to fully elucidate the mechanisms by which SETD1B regulates gene expression and to explore its potential as a therapeutic target.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.