Details for: GBP1

Gene ID: 2633

Symbol: GBP1

Ensembl ID: ENSG00000117228

Description: guanylate binding protein 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.79
    Marker Score: 7738
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 1.54
    Marker Score: 1508
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.54
    Marker Score: 15239
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.54
    Marker Score: 3621
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.53
    Marker Score: 2109
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.52
    Marker Score: 635
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167864
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.44
    Marker Score: 9192
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.36
    Marker Score: 1963
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.35
    Marker Score: 2210
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.33
    Marker Score: 15518.5
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.25
    Marker Score: 474
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.22
    Marker Score: 274
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.21
    Marker Score: 13591
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.19
    Marker Score: 4397
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.17
    Marker Score: 65366
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.14
    Marker Score: 2774.5
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.13
    Marker Score: 2877
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.1
    Marker Score: 2144
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.1
    Marker Score: 28071
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.07
    Marker Score: 1092
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.04
    Marker Score: 1115
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.04
    Marker Score: 1004
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1
    Marker Score: 860
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1
    Marker Score: 574
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1
    Marker Score: 33932
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71700
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47926
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.98
    Marker Score: 3857
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.98
    Marker Score: 2369
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30394
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.98
    Marker Score: 1920
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.97
    Marker Score: 232
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.96
    Marker Score: 1186
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.96
    Marker Score: 696
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2398
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 481
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 438
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.92
    Marker Score: 783
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2727
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.91
    Marker Score: 1726
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.9
    Marker Score: 7813
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.89
    Marker Score: 355
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 311
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.86
    Marker Score: 5232
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.86
    Marker Score: 1245
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.85
    Marker Score: 2698
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.85
    Marker Score: 722
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.85
    Marker Score: 2376
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.84
    Marker Score: 4803
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.84
    Marker Score: 1502.5
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.84
    Marker Score: 657
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.83
    Marker Score: 44053
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.82
    Marker Score: 623
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.81
    Marker Score: 2794
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.79
    Marker Score: 1165
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.76
    Marker Score: 521
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.76
    Marker Score: 1241
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.76
    Marker Score: 3750
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.74
    Marker Score: 666
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 0.74
    Marker Score: 168
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.74
    Marker Score: 658
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.74
    Marker Score: 335
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 377
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.72
    Marker Score: 1447
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.72
    Marker Score: 495
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.72
    Marker Score: 464
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.71
    Marker Score: 293
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.7
    Marker Score: 441
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.69
    Marker Score: 509
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.69
    Marker Score: 609
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 0.69
    Marker Score: 184
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.68
    Marker Score: 625
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.68
    Marker Score: 400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2856.5
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.68
    Marker Score: 1152
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.68
    Marker Score: 148
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 0.67
    Marker Score: 234
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.66
    Marker Score: 638
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.66
    Marker Score: 586
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.66
    Marker Score: 730
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.65
    Marker Score: 1711
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.65
    Marker Score: 543
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.64
    Marker Score: 145
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.64
    Marker Score: 221
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.63
    Marker Score: 1289
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.63
    Marker Score: 1197
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.63
    Marker Score: 427
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.63
    Marker Score: 697
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.63
    Marker Score: 3826
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.63
    Marker Score: 142
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.63
    Marker Score: 1528
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.63
    Marker Score: 680
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.62
    Marker Score: 584
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.62
    Marker Score: 1000
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.62
    Marker Score: 235
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.62
    Marker Score: 548
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.61
    Marker Score: 282
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.61
    Marker Score: 276

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Other Information

**Key characteristics:** * GBP1 is a glycoprotein with a molecular weight of approximately 130 kDa. * It is a transmembrane protein with a conserved cysteine-rich domain and a hydrophilic domain. * GBP1 is a key regulator of the innate immune response and is involved in the regulation of inflammation, cell migration, and apoptosis. **Pathways and functions:** * GBP1 is a key regulator of the innate immune response. It is expressed in high levels in immune cells, including macrophages, dendritic cells, and neutrophils. * GBP1 binds to DNA and acts as a transcription factor, regulating the expression of various genes involved in inflammation, cell migration, and apoptosis. * GBP1 also binds to the G protein-coupled receptor (GPCR) GP130, which is expressed in immune cells. * The binding of GBP1 to GP130 triggers a signaling cascade that leads to the activation of the MAPK signaling pathway. * GBP1 also binds to the G protein-coupled receptor (GPCR) GP130, which is expressed in immune cells. * This binding triggers a signaling cascade that leads to the activation of the MAPK signaling pathway, which is involved in inflammation and cell migration. **Clinical significance:** * GBP1 mutations have been linked to several autoimmune diseases, including rheumatoid arthritis, Crohn's disease, and lupus. * GBP1 is also a potential therapeutic target for autoimmune diseases. * Studies have shown that blocking GBP1 signaling can suppress inflammation and improve disease activity in animal models of autoimmune diseases. **Other important points:** * GBP1 is a highly conserved protein, with a similar sequence found in mammals, birds, and reptiles. * GBP1 is a multi-functional protein that can bind to DNA, proteins, and G proteins. * GBP1 is a key regulator of inflammation and cell migration, and its dysregulation can lead to the development of autoimmune diseases.

Genular Protein ID: 1025977360

Symbol: GBP1_HUMAN

Name: Guanine nucleotide-binding protein 1

UniProtKB Accession Codes:

P32455 D3DT26 Q5T8M1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 13 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EPD 1 Ensembl 1 EvolutionaryTrace 1 GO 41 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 22 PDBsum 10 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 4 SASBDB 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1715024

Title: Interferon-induced guanylate-binding proteins lack an N(T)KXD consensus motif and bind GMP in addition to GDP and GTP.

PubMed ID: 1715024

DOI: 10.1128/mcb.11.9.4717-4725.1991

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7512561

Title: The interferon-induced 67-kDa guanylate-binding protein (hGBP1) is a GTPase that converts GTP to GMP.

PubMed ID: 7512561

DOI: 10.1016/s0021-9258(19)78125-3

PubMed ID: 8830800

Title: Prenylation of an interferon-gamma-induced GTP-binding protein: the human guanylate binding protein, huGBP1.

PubMed ID: 8830800

DOI: 10.1002/jlb.60.3.423

PubMed ID: 15937107

Title: Golgi targeting of human guanylate-binding protein-1 requires nucleotide binding, isoprenylation, and an IFN-gamma-inducible cofactor.

PubMed ID: 15937107

DOI: 10.1073/pnas.0503227102

PubMed ID: 16936281

Title: Human guanylate binding protein-1 is a secreted GTPase present in increased concentrations in the cerebrospinal fluid of patients with bacterial meningitis.

PubMed ID: 16936281

DOI: 10.2353/ajpath.2006.060244

PubMed ID: 17266443

Title: Unique features of different members of the human guanylate-binding protein family.

PubMed ID: 17266443

DOI: 10.1089/jir.2007.0086

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21151871

Title: Intracellular trafficking of guanylate-binding proteins is regulated by heterodimerization in a hierarchical manner.

PubMed ID: 21151871

DOI: 10.1371/journal.pone.0014246

PubMed ID: 22106366

Title: A new splice variant of the human guanylate-binding protein 3 mediates anti-influenza activity through inhibition of viral transcription and replication.

PubMed ID: 22106366

DOI: 10.1096/fj.11-189886

PubMed ID: 28645896

Title: Nucleotide-dependent farnesyl switch orchestrates polymerization and membrane binding of human guanylate-binding protein 1.

PubMed ID: 28645896

DOI: 10.1073/pnas.1620959114

PubMed ID: 29024643

Title: GBPs inhibit motility of Shigella flexneri but are targeted for degradation by the bacterial ubiquitin ligase IpaH9.8.

PubMed ID: 29024643

DOI: 10.1016/j.chom.2017.09.007

PubMed ID: 29233899

Title: Detection of cytosolic Shigella flexneri via a C-terminal triple-arginine motif of GBP1 inhibits actin-based motility.

PubMed ID: 29233899

DOI: 10.1128/mbio.01979-17

PubMed ID: 29144452

Title: Ubiquitination and degradation of GBPs by a Shigella effector to suppress host defence.

PubMed ID: 29144452

DOI: 10.1038/nature24467

PubMed ID: 31268602

Title: Human GBP1 is a microbe-specific gatekeeper of macrophage apoptosis and pyroptosis.

PubMed ID: 31268602

DOI: 10.15252/embj.2018100926

PubMed ID: 10676968

Title: Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteins.

PubMed ID: 10676968

DOI: 10.1038/35000617

PubMed ID: 10970849

Title: Triphosphate structure of guanylate-binding protein 1 and implications for nucleotide binding and GTPase mechanism.

PubMed ID: 10970849

DOI: 10.1093/emboj/19.17.4555

PubMed ID: 16511497

Title: How guanylate-binding proteins achieve assembly-stimulated processive cleavage of GTP to GMP.

PubMed ID: 16511497

DOI: 10.1038/nature04510

PubMed ID: 31216343

Title: Structural mechanism for guanylate-binding proteins (GBPs) targeting by the Shigella E3 ligase IpaH9.8.

PubMed ID: 31216343

DOI: 10.1371/journal.ppat.1007876

PubMed ID: 33303953

Title: Substrate-binding destabilizes the hydrophobic cluster to relieve the autoinhibition of bacterial ubiquitin ligase IpaH9.8.

PubMed ID: 33303953

DOI: 10.1038/s42003-020-01492-1

Sequence Information:

  • Length: 592
  • Mass: 67931
  • Checksum: 3A06741218360732
  • Sequence:
    • MASEIHMTGP MCLIENTNGR LMANPEALKI LSAITQPMVV VAIVGLYRTG KSYLMNKLAG 
KKKGFSLGST VQSHTKGIWM WCVPHPKKPG HILVLLDTEG LGDVEKGDNQ NDSWIFALAV 
LLSSTFVYNS IGTINQQAMD QLYYVTELTH RIRSKSSPDE NENEVEDSAD FVSFFPDFVW 
TLRDFSLDLE ADGQPLTPDE YLTYSLKLKK GTSQKDETFN LPRLCIRKFF PKKKCFVFDR 
PVHRRKLAQL EKLQDEELDP EFVQQVADFC SYIFSNSKTK TLSGGIQVNG PRLESLVLTY 
VNAISSGDLP CMENAVLALA QIENSAAVQK AIAHYEQQMG QKVQLPTETL QELLDLHRDS 
EREAIEVFIR SSFKDVDHLF QKELAAQLEK KRDDFCKQNQ EASSDRCSAL LQVIFSPLEE 
EVKAGIYSKP GGYRLFVQKL QDLKKKYYEE PRKGIQAEEI LQTYLKSKES MTDAILQTDQ 
TLTEKEKEIE VERVKAESAQ ASAKMLQEMQ RKNEQMMEQK ERSYQEHLKQ LTEKMENDRV 
QLLKEQERTL ALKLQEQEQL LKEGFQKESR IMKNEIQDLQ TKMRRRKACT IS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.