Details for: GCGR

Gene ID: 2642

Symbol: GCGR

Ensembl ID: ENSG00000215644

Description: glucagon receptor

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1176
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.54
    Marker Score: 1636
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.51
    Marker Score: 1509
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.45
    Marker Score: 1617
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.33
    Marker Score: 3564
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 861
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.19
    Marker Score: 492
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4821
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.15
    Marker Score: 604
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.11
    Marker Score: 5948
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.11
    Marker Score: 508
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.07
    Marker Score: 4596
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.05
    Marker Score: 1745
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.04
    Marker Score: 708
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71833
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48058
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1
    Marker Score: 514
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.99
    Marker Score: 467
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 378
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.94
    Marker Score: 409.5
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5353
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.93
    Marker Score: 5974
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.92
    Marker Score: 330
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.84
    Marker Score: 487
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1266
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 401
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.77
    Marker Score: 2511
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 467
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.69
    Marker Score: 1111
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.62
    Marker Score: 492
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.56
    Marker Score: 176
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.51
    Marker Score: 726
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.48
    Marker Score: 518.5
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 281
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.47
    Marker Score: 148
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.42
    Marker Score: 222
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.37
    Marker Score: 379
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.35
    Marker Score: 81
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.33
    Marker Score: 465
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.32
    Marker Score: 107
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.32
    Marker Score: 382
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.26
    Marker Score: 81
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.24
    Marker Score: 157
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.23
    Marker Score: 321
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.23
    Marker Score: 218
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.23
    Marker Score: 175
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.21
    Marker Score: 88
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.2
    Marker Score: 75
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 0.2
    Marker Score: 52
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.19
    Marker Score: 93
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.19
    Marker Score: 1247
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 0.16
    Marker Score: 85
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.16
    Marker Score: 177
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.16
    Marker Score: 86
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.15
    Marker Score: 386
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.15
    Marker Score: 57
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.14
    Marker Score: 42
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.14
    Marker Score: 81
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.13
    Marker Score: 313
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.12
    Marker Score: 63
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.12
    Marker Score: 75
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.12
    Marker Score: 115.5
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.11
    Marker Score: 30
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.11
    Marker Score: 30
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.11
    Marker Score: 115
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.11
    Marker Score: 106
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.1
    Marker Score: 49
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.1
    Marker Score: 47
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.1
    Marker Score: 20
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.1
    Marker Score: 30
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.1
    Marker Score: 58
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.1
    Marker Score: 59
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.1
    Marker Score: 26
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.1
    Marker Score: 97
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.09
    Marker Score: 35
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.09
    Marker Score: 78
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.09
    Marker Score: 86
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.09
    Marker Score: 28
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.09
    Marker Score: 28
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.08
    Marker Score: 60
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.08
    Marker Score: 55
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.08
    Marker Score: 704
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.08
    Marker Score: 134
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.07
    Marker Score: 15
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.07
    Marker Score: 256
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.07
    Marker Score: 78
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.07
    Marker Score: 15
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.07
    Marker Score: 87
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.07
    Marker Score: 66
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.07
    Marker Score: 22

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Other Information

**Key characteristics:** - The GCGR gene is located on chromosome 12 and is approximately 150,000 bp long. - It is a member of the class b/2 (secretin family receptors) of G protein-coupled receptors. - The protein is expressed in various cell types throughout the body, including the colon goblet cell, kidney distal convoluted tubule epithelial cell, enterocyte of epithelium of large intestine, plasma cell, kidney loop of Henle thick ascending limb epithelial cell, intestinal crypt stem cell of small intestine, transit amplifying cell of small intestine, enterocyte of epithelium of small intestine, renal alpha-intercalated cell, and periportal region hepatocyte. **Pathways and functions:** - The GCGR gene is involved in multiple signaling pathways, including the adenylate cyclase-activating g protein-coupled receptor signaling pathway, the adenylate cyclase-modulating g protein-coupled receptor signaling pathway, the cell surface receptor signaling pathway, and the G alpha (q) signaling events. - Glucagon binds to the GCGR on the surface of cells, triggering the activation of the receptor. - The activated receptor recruits G proteins, which in turn activate downstream signaling pathways involved in glucose metabolism, including the generation of precursor metabolites and energy, glucagon signaling in metabolic regulation, and inhibition of insulin signaling. **Clinical significance:** - Mutations in the GCGR gene have been linked to several human diseases, including diabetes, obesity, and metabolic syndrome. - In diabetes, mutations in the GCGR gene can lead to the production of a defective receptor that is unable to bind glucagon or activate downstream signaling pathways. This results in elevated blood sugar levels and eventually to the development of diabetes.

Genular Protein ID: 616623765

Symbol: GLR_HUMAN

Name: Glucagon receptor

UniProtKB Accession Codes:

P47871 Q2M3M5

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EMBL 5 EMDB 5 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 20 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 30 PDBsum 18 PIR 1 PRINTS 3 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 4 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7507321

Title: Cloning and expression of a human glucagon receptor.

PubMed ID: 7507321

DOI: 10.1006/bbrc.1994.1046

PubMed ID: 8144028

Title: The human glucagon receptor encoding gene: structure, cDNA sequence and chromosomal localization.

PubMed ID: 8144028

DOI: 10.1016/0378-1119(94)90545-2

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8020989

Title: Localization of the glucagon receptor gene to human chromosome band 17q25.

PubMed ID: 8020989

DOI: 10.1006/geno.1994.1179

PubMed ID: 9287038

Title: Role of the glucagon receptor COOH-terminal domain in glucagon-mediated signaling and receptor internalization.

PubMed ID: 9287038

DOI: 10.2337/diab.46.9.1400

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 16221670

Title: Conformational dimorphism of self-peptides and molecular mimicry in a disease-associated HLA-B27 subtype.

PubMed ID: 16221670

DOI: 10.1074/jbc.m508528200

PubMed ID: 22908259

Title: Molecular basis for negative regulation of the glucagon receptor.

PubMed ID: 22908259

DOI: 10.1073/pnas.1206734109

PubMed ID: 23863937

Title: Structure of the human glucagon class B G-protein-coupled receptor.

PubMed ID: 23863937

DOI: 10.1038/nature12393

PubMed ID: 27111510

Title: Extra-helical binding site of a glucagon receptor antagonist.

PubMed ID: 27111510

DOI: 10.1038/nature17414

PubMed ID: 28514451

Title: Structure of the full-length glucagon class B G-protein-coupled receptor.

PubMed ID: 28514451

DOI: 10.1038/nature22363

PubMed ID: 7589886

Title: A mutation in the glucagon receptor gene (Gly40Ser): heterogeneity in the association with diabetes mellitus.

PubMed ID: 7589886

DOI: 10.1007/bf00400589

PubMed ID: 19657311

Title: Homozygous P86S mutation of the human glucagon receptor is associated with hyperglucagonemia, alpha cell hyperplasia, and islet cell tumor.

PubMed ID: 19657311

DOI: 10.1097/mpa.0b013e3181b2bb03

PubMed ID: 25695890

Title: Glucagon cell hyperplasia and neoplasia with and without glucagon receptor mutations.

PubMed ID: 25695890

DOI: 10.1210/jc.2014-4405

PubMed ID: 30032256

Title: Hypercalcemia in glucagon cell hyperplasia and neoplasia (Mahvash syndrome): a new association.

PubMed ID: 30032256

DOI: 10.1210/jc.2018-01074

PubMed ID: 30294546

Title: The first pediatric case of glucagon receptor defect due to biallelic mutations in GCGR is identified by newborn screening of elevated arginine.

PubMed ID: 30294546

DOI: 10.1016/j.ymgmr.2018.09.006

PubMed ID: 32677665

Title: Characterization of a naturally occurring mutation V368M in the human glucagon receptor and its association with metabolic disorders.

PubMed ID: 32677665

DOI: 10.1042/bcj20200235

Sequence Information:

  • Length: 477
  • Mass: 54009
  • Checksum: ADBB477C6267AE6E
  • Sequence:
    • MPPCQPQRPL LLLLLLLACQ PQVPSAQVMD FLFEKWKLYG DQCHHNLSLL PPPTELVCNR 
TFDKYSCWPD TPANTTANIS CPWYLPWHHK VQHRFVFKRC GPDGQWVRGP RGQPWRDASQ 
CQMDGEEIEV QKEVAKMYSS FQVMYTVGYS LSLGALLLAL AILGGLSKLH CTRNAIHANL 
FASFVLKASS VLVIDGLLRT RYSQKIGDDL SVSTWLSDGA VAGCRVAAVF MQYGIVANYC 
WLLVEGLYLH NLLGLATLPE RSFFSLYLGI GWGAPMLFVV PWAVVKCLFE NVQCWTSNDN 
MGFWWILRFP VFLAILINFF IFVRIVQLLV AKLRARQMHH TDYKFRLAKS TLTLIPLLGV 
HEVVFAFVTD EHAQGTLRSA KLFFDLFLSS FQGLLVAVLY CFLNKEVQSE LRRRWHRWRL 
GKVLWEERNT SNHRASSSPG HGPPSKELQF GRGGGSQDSS AETPLAGGLP RLAESPF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.