Details for: OR8G1

Gene ID: 26494

Symbol: OR8G1

Ensembl ID: ENSG00000197849

Description: olfactory receptor family 8 subfamily G member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1260
    Cell Significance Index: 2.7600
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.0692
    Cell Significance Index: 0.7800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0381
    Cell Significance Index: 0.6400
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.0367
    Cell Significance Index: 0.2000
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: 0.0229
    Cell Significance Index: 0.1200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0213
    Cell Significance Index: 0.5700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0213
    Cell Significance Index: 0.2200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0087
    Cell Significance Index: 0.1600
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: 0.0079
    Cell Significance Index: 0.0800
  • Cell Name: adipocyte (CL0000136)
    Fold Change: 0.0037
    Cell Significance Index: 0.0500
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.0021
    Cell Significance Index: 0.0200
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.0015
    Cell Significance Index: 0.0200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0006
    Cell Significance Index: 0.0300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0002
    Cell Significance Index: 0.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0002
    Cell Significance Index: 0.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0001
    Cell Significance Index: -0.2000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0002
    Cell Significance Index: -0.3100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0003
    Cell Significance Index: -0.4900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0003
    Cell Significance Index: -0.2400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0004
    Cell Significance Index: -0.2100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0009
    Cell Significance Index: -0.6000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0011
    Cell Significance Index: -0.5100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0011
    Cell Significance Index: -0.2300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0013
    Cell Significance Index: -0.2200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0015
    Cell Significance Index: -0.0700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0018
    Cell Significance Index: -0.3500
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.0032
    Cell Significance Index: -0.0200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0044
    Cell Significance Index: -0.0600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0056
    Cell Significance Index: -0.1500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0061
    Cell Significance Index: -0.4100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0087
    Cell Significance Index: -0.4900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0097
    Cell Significance Index: -0.4300
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.0101
    Cell Significance Index: -0.1100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0104
    Cell Significance Index: -0.3400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0106
    Cell Significance Index: -0.4000
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0106
    Cell Significance Index: -0.1300
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: -0.0109
    Cell Significance Index: -0.1200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0111
    Cell Significance Index: -0.5200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0112
    Cell Significance Index: -0.3000
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0123
    Cell Significance Index: -0.1500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0129
    Cell Significance Index: -0.4100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0132
    Cell Significance Index: -0.2600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0144
    Cell Significance Index: -0.4100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0163
    Cell Significance Index: -0.3400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0168
    Cell Significance Index: -0.4200
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.0173
    Cell Significance Index: -0.1800
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0179
    Cell Significance Index: -0.1700
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0181
    Cell Significance Index: -0.2400
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0187
    Cell Significance Index: -0.2100
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0191
    Cell Significance Index: -0.2500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0194
    Cell Significance Index: -0.4200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0198
    Cell Significance Index: -0.4200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0204
    Cell Significance Index: -0.4100
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.0206
    Cell Significance Index: -0.2200
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0208
    Cell Significance Index: -0.2600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0211
    Cell Significance Index: -0.4200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0212
    Cell Significance Index: -0.4200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0212
    Cell Significance Index: -0.3600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0215
    Cell Significance Index: -0.6200
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0218
    Cell Significance Index: -0.1600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0233
    Cell Significance Index: -0.1900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0237
    Cell Significance Index: -0.3400
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0238
    Cell Significance Index: -0.3000
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0239
    Cell Significance Index: -0.2400
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.0245
    Cell Significance Index: -0.1800
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0246
    Cell Significance Index: -0.2600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0248
    Cell Significance Index: -0.1500
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0248
    Cell Significance Index: -0.2800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0249
    Cell Significance Index: -0.4300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0254
    Cell Significance Index: -0.6100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0256
    Cell Significance Index: -0.5000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0256
    Cell Significance Index: -0.6200
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.0256
    Cell Significance Index: -0.2500
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0260
    Cell Significance Index: -0.1800
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0261
    Cell Significance Index: -0.3300
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.0262
    Cell Significance Index: -0.2800
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0268
    Cell Significance Index: -0.2900
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0274
    Cell Significance Index: -0.2500
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0275
    Cell Significance Index: -0.3200
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0290
    Cell Significance Index: -0.3500
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.0290
    Cell Significance Index: -0.1800
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0291
    Cell Significance Index: -0.3800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0294
    Cell Significance Index: -0.3200
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0296
    Cell Significance Index: -0.3700
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0299
    Cell Significance Index: -0.1600
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0303
    Cell Significance Index: -0.4200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0305
    Cell Significance Index: -0.4500
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0308
    Cell Significance Index: -0.4500
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0312
    Cell Significance Index: -0.4100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0320
    Cell Significance Index: -0.4600
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0322
    Cell Significance Index: -0.3800
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.0324
    Cell Significance Index: -0.4200
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0330
    Cell Significance Index: -0.3900
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0332
    Cell Significance Index: -0.3900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0341
    Cell Significance Index: -0.5700
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0347
    Cell Significance Index: -0.4100
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0348
    Cell Significance Index: -0.4700
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0351
    Cell Significance Index: -0.4200
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0353
    Cell Significance Index: -0.3600
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0363
    Cell Significance Index: -0.4400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Olfactory Receptor Function:** OR8G1 is a G protein-coupled receptor that binds to odorants, triggering a signaling cascade that ultimately leads to the perception of smell. 2. **Expression Pattern:** OR8G1 is expressed in multiple cell types, including B cells, dendritic cells, and cardiac endothelial cells, suggesting a broad range of olfactory signaling capabilities. 3. **Cellular Localization:** OR8G1 is primarily localized to the plasma membrane, where it can interact with odorants and initiate signaling pathways. 4. **Gene Ontology:** OR8G1 is classified under the gene ontology categories of "Detection of chemical stimulus involved in sensory perception of smell" and "Olfactory receptor activity." **Pathways and Functions:** 1. **Olfactory Signaling Pathway:** OR8G1 is involved in the detection of chemical stimuli involved in sensory perception of smell, which is mediated by the olfactory signaling pathway. 2. **G Protein-Coupled Receptor Signaling Pathway:** OR8G1 activates the G protein-coupled receptor signaling pathway, which involves the activation of G proteins and subsequent downstream signaling events. 3. **Odorant Binding:** OR8G1 binds to odorants, triggering a conformational change in the receptor that ultimately leads to the activation of downstream signaling pathways. 4. **Cellular Signaling:** OR8G1 plays a crucial role in cellular signaling, influencing various cellular processes, including immune responses and cardiovascular functions. **Clinical Significance:** 1. **Olfactory Dysfunction:** OR8G1 dysfunction has been implicated in olfactory dysfunction, which is a common symptom of various neurological disorders, including Alzheimer's disease and Parkinson's disease. 2. **Immune System Modulation:** OR8G1 has been shown to modulate the immune system, influencing the function of immune cells, such as dendritic cells and B cells. 3. **Cardiovascular Diseases:** OR8G1 has been implicated in cardiovascular diseases, including hypertension and atherosclerosis, highlighting its potential role in cardiovascular health. 4. **Neurological Disorders:** OR8G1 has been shown to be involved in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis, suggesting its potential role in neurological health. In conclusion, OR8G1 is a critical component of the olfactory signaling pathway, playing a vital role in the detection of chemical stimuli involved in sensory perception of smell. Its widespread expression in various cell types and its involvement in multiple signaling pathways highlight its importance in immune system modulation, cardiovascular health, and neurological function. Further research is needed to fully elucidate the mechanisms underlying OR8G1 function and its clinical significance.

Genular Protein ID: 156066341

Symbol: OR8G1_HUMAN

Name: Olfactory receptor 8G1

UniProtKB Accession Codes:

Q15617 Q8NG88

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9119360

Title: Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species.

PubMed ID: 9119360

DOI: 10.1006/geno.1996.4490

PubMed ID: 12213199

Title: DEFOG: a practical scheme for deciphering families of genes.

PubMed ID: 12213199

DOI: 10.1006/geno.2002.6830

PubMed ID: 14983052

Title: The human olfactory receptor gene family.

PubMed ID: 14983052

DOI: 10.1073/pnas.0307882100

PubMed ID: 17973576

Title: Genetic elucidation of human hyperosmia to isovaleric acid.

PubMed ID: 17973576

DOI: 10.1371/journal.pbio.0050284

Sequence Information:

  • Length: 311
  • Mass: 34904
  • Checksum: 0E28F95C37960C3E
  • Sequence:
    • MSGENNSSVT EFILAGLSEQ PELQLPLFLL FLGIYVVTVV GNLGMTTLIW LSSHLHTPMY 
YFLSSLSFID FCHSTVITPK MLVNFVTEKN IISYPECMTQ LYFFLVFAIA ECHMLAAMAY 
DRYMAICSPL LYSVIISNKA CFSLILGVYI IGLVCASVHT GCMFRVQFCK FDLINHYFCD 
LLPLLKLSCS SIYVNKLLIL CVGAFNILVP SLTILCSYIF IIASILHIRS TEGRSKAFST 
CSSHMLAVVI FFGSAAFMYL QPSSISSMDQ GKVSSVFYTI IVPMLNPLIY SLRNKDVHVS 
LKKMLQRRTL L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.